Abdelfatah Farag

Abdelfatah Farag

Helwan University

H-index: 26

Africa-Egypt

Abdelfatah Farag Information

University

Helwan University

Position

Professor Chemistry Department

Citations(all)

2858

Citations(since 2020)

705

Cited By

1965

hIndex(all)

26

hIndex(since 2020)

15

i10Index(all)

78

i10Index(since 2020)

26

Email

University Profile Page

Helwan University

Abdelfatah Farag Skills & Research Interests

Analytical Chemistry

Top articles of Abdelfatah Farag

Facile one-pot strategy for radiocoplexation of [99mTc]-nitrido-nebracetam for brain imaging: Biological evaluation, Optimized chromatographic separation and labeling conditions.

Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are central to regulating excitatory synaptic transmission in the central nervous system (CNS) Therefore, the aim of this research is to study the biodistribution to demonstrate the concentration of [99 mTc]-nitrido-nebracetam in the target organ (brain) using healthy groups of Swiss albino mice. The radiotracer [99mTc]-nitrido-nebracetam ([99mTc]-N-Neb) complex was labelled using the core [99mTc≡N] 2+.Many factors have been studied to optimize high radiochemical yields (>97.5).Quality control studies were made perfectly. A process of biodistribution indicated that this complex, [99mTc]-N-tamsulosin, was washed out through the urinary pathway within 3 hours after injection. In addition, the brain uptake of this complex was 11.88% after 30 min post-injection as a novel probe for (AMPA) receptor targeting. Hence, the radiotracer of [99mTc]-N-Neb could be used as a radiotracer for brain imaging through the AMPA receptor.

Authors

Abdelfatah Bastawy Farag,Mahmoud H Sanad,Omaima Hussain

Journal

Egyptian Journal of Chemistry

Published Date

2024/1/24

Facile one-pot strategy for radio prepration of radioiodinated phenylpiracetam as a new highly selective radiotracer for brain imaging

The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizing agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.

Authors

MH Sanad,AB Farag,Gomaa N Abdel-Rahman,Ahmed SM Fouzy

Journal

Egyptian Journal of Chemistry

Published Date

2024/1/24

Radioiodinated Procainamide as Radiotracer for Myocardial Perfusion Imaging in Mice

This work focuses on the synthesis and preliminary biological evaluation of [125I]iodoprocainamide ([125I]iodoPA) as a potential heart-imaging agent. [125I]iodoPAwas synthesized by procainamide labeling with [125I]iodide in high radiochemical yield and high radiochemical purity of both ≥98%. These results were obtained under optimized reaction conditions using chloramine-T as oxidizing agent within 30 min incubation period at pH 8 and 37°C reaction temperature. Ahigh uptake of 37.33 ± 0.15 percentage injected dose/g organ (%ID/ g) was found in the heart which confirmed the suitability of [125I]iodoPA as a potential radiotracer for heart imaging.

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag,SFA Rizvi

Journal

Pharmaceutical Chemistry Journal

Published Date

2023/7

Radiocomplexation, Biological Evaluation, and Characterization of [99mTc]-5-[(3-Carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic Acid as a Novel Agent for …

A procedure was developed for preparing [99mTc]-tricarbonyl-5-[(3-carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic acid complex ([99mTc]-tricarbonyl-Olsalazine), for ulcerative colitis (UC) imaging. High yield and 98.5% radiochemical purity of [99mTc]-tricarbonyl-Olsalazine were reached under optimized conditions. Thin layer chromatography (TLC) was used for the purification of the labeled compound. Reversed-phase high-performance liquid chromatography (RP-HPLC) was also used. A biodistribution study performed with a microbial mouse model of UC showed that the colon localization of [99mTc]-tricarbonyl-Olsalazine was the highest (77 ± 1.7% ID/g) at 120 min post injection. The agent was still present in the ulcerated colon for up to 24 h post injection (75% ID/g). Such level was not reached in previous studies. Thus, [99mTc]-tricarbonyl-Olsalazine can be used as a radiotracer for UC imaging in mice.

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag,A Elrefaei,ASM Fouzy,SB Challan

Journal

Radiochemistry

Published Date

2023/6

Preparation and Bioevaluation of [99mTc] Tricarbonyl Omeprazole for Gastric Ulcer Localization in Mice

[99mTc]Tricarbonyl Omeprazole was prepared using [99mTc]tricarbonyl core. The radiochemical conversion of 98.0% was reached under optimized reaction conditions: substrate amount 100 µg, pH 8, reaction time 30 min, 100°C. Three different groups of mice models were used in biodistribution studies of [99mTc]tricarbonyl Omeprazole: normal group, microbial model group (using Helicobacter pylori), and induced ulcerated mice (chemical model). The stomach uptake in three models was 10.5, 38.7, and 29.6% ID/g at 1 h post injection. This, [99mTc]tricarbonyl Omeprazole can be considered as a highly selective radiotracer for peptic ulcer imaging, especially in microbial model group.

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag

Journal

Radiochemistry

Published Date

2022/1

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: in silico study and preclinical evaluation

PurposeZearalenone (ZEN) which is one of the known fusarium species mycotoxin, produced primarily on many cereal crops. Consequently, the current study aims to estimate the possibility of labeling zearalenone and the pattern of accumulation of the produced labeled zearalenone [125I]-ZEN in different mice tissues, and the possible protective effect of Lactobacillus plantarum to reduce organ accumulation of Zearalenone.Materials and methodsthe experiment was conducted on two groups of mice were used; the two groups received [125I] Zearalenone administered by tail vein injection, the first group receive nothing else while the second group received also L. plantarum (as a control agent) orally. The mice were kept under observation for 120 min to monitor zearalenone distribution.Resultsby monitoring the zearalenone distribution the maximum concentration was found to be mainly primarily in the intestine …

Authors

MH Sanad,AB Farag,Sabry A Bassem,FA Marzook

Journal

Toxicology Reports

Published Date

2022/1/1

Green magnetic clay nanocomposite based on graphene oxide nanosheet as a synthetic low-cost adsorbent for oil droplets removal from produced water

Green magnetic clay nanocomposite based on graphene oxide nanosheet as a synthetic low-cost adsorbent for oil droplets removal f Page 1 * Corresponding authors. 1944-3994/1944-3986 © 2022 Desalination Publications. All rights reserved. Desalination and Water Treatment www.deswater.com doi: 10.5004/dwt.2022.29031 280 (2022) 206–223 December Green magnetic clay nanocomposite based on graphene oxide nanosheet as a synthetic low-cost adsorbent for oil droplets removal from produced water Alshimaa M. Ahmeda,*, R. Hosnyb,*, Mahmoud F. Mubarakc,*, Ahmed A. Younesa, AB Faraga aChemistry Department, Faculty of Science, Helwan University, Cairo, Egypt, email: alshimaamaher2014@yahoo.com (AM Ahmed) bProduction Department, Egyptian Petroleum Research Institute (EPRI), 1 Ahmed El-Zomor, PO 11727, Nasr City, Cairo, Egypt, Tel.: +(202)22747847; Fax: +(202)22747433; email: …

Authors

Alshimaa M Ahmed,R Hosny,Mahmoud F Mubarak,Ahmed A Younes,AB Farag

Journal

Desalination and Water Treatment

Published Date

2022/12/1

In-Silico Study, Preparation and Biological Evaluation of 99MTC-Mesalamine Complex as Radiotracer for Diagnostics and Monitoring of Ulcerative Colitis in Mice

This work centralizes on pursuit ulcerative colitis localized in mice. High radiolabeling and purity were ensured during the formation of a radiotracer, [99mTc]nitrido-mesalamine complex, due to inspecting many parameters under optimum conditions including pH of the reaction mixture (pH 6), reducing agent content (tin(II), 50 μg), reaction time (30 min), mesalamine content (200 μg), Tc-99m (200 – 350 MBq), stability in rat serum (24 h), and reaction temperature (37°C) giving high radiolabeling yield of 98%. In silico molecular docking study was performed to evaluate the possible mechanism of action on the target peroxisome proliferator-activated receptor gamma (PPARγ). Results of biological studies obtained in this work illuminate the usefulness of [99mTc]nitrido-mesalamine complex as a radiotracer that can be used for ulcerative colitis imaging up to 24 h in microbial model (76% dose/g organ (ID/g)) as …

Authors

MH Sanad,SFA Rizvi,FA Marzook,AB Farag

Journal

Pharmaceutical Chemistry Journal

Published Date

2022/9

In silico and in vivo study of radio-iodinated nefiracetam as a radiotracer for brain imaging in mice

This study presents development and characterization of a radiotracer, [125I]iodonefiracetam ([125I]iodoNEF). Labeling with high yield and radiochemical purity was achieved through the formation of a [125I]iodoNEF radiotracer after investigating many factors like oxidizing agent content (chloramines-T (Ch-T)), substrate amount (Nefiracetam (NEF)), pH of reaction mixture, reaction time and temperature. Nefiracetam (NEF) is known as nootropic agent, acting as N-methyl-d-aspartic acid receptor ligand (NMDA). The radiolabeled compound was stable, and exhibited the logarithm of the partition coefficient (log p) value of [125I]iodonefiracetam as 1.85 (lipophilic). Biodistribution studies in normal mice confirmed the suitability of the [125I]iodoNEF radiotracer as a novel tracer for brain imaging. High uptake of 8.61 ± 0.14 percent injected dose/g organ was observed in mice

Authors

MH Sanad,AB Farag,SFA Rizvi

Journal

Radiochimica Acta

Published Date

2021/7/27

Proton exchange membrane based on graphene oxide/polysulfone hybrid nano-composite for simultaneous generation of electricity and wastewater treatment

Microbial fuel cell (MFC) is a combined technology for simultaneous generation of electricity and wastewater treatment. In MFC, the proton exchange membrane (PEM) is an essential component affecting electricity generation. In the current study, two proton exchange membranes, namely sulfonated polyethersulfone (SPES) and graphene oxide/sulfonated -polyethersulfone hybrid nanocomposite (GO-SPES), were prepared and characterized using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The collected information confirmed the successful preparation of the membranes. Moreover, contact angle measurements, ion exchange capacity and degree of sulfonation of the prepared membranes were determined. The results showed that the introduction of GO nanoparticles into SPES membrane improved its proton exchange capability and resulted in better performance …

Authors

Amira KM Ali,Mohamed EA Ali,Ahmed A Younes,AB Farag

Journal

Journal of Hazardous Materials

Published Date

2021/10/5

Synthesis, characterization, and bioevaluation of 99mTc nitrido-oxiracetam as a brain imaging model

In this work, the radiotracer [99mTc]nitrido-oxiracetam complex was labeled in the presence of 99mTc-nitrido as a core. In order to get the highest radiochemical purity, many effective factors have been studied such as temperature of the reaction, time of the reaction, the pH of the reaction mixture, substrate amount, and stability to give high percent more than 99%. Finally, biodistribution studies have been indicated the convenience of [99mTc]nitrido-oxiracetam as a new radiotracer that could be used in brain imaging. Giving a maximum uptake of 10.6% at 30 min post injection.

Authors

MH Sanad,SFA Rizvi,AB Farag

Journal

Radiochimica Acta

Published Date

2021/6/25

Radiosynthesis and Biological Evaluation of 99mTc Nitrido-Levetiracetam as a Brain Imaging Agent

Abstract 99mTc nitrido-Levetiracetam was prepared using the 99mTc nitrido core for labeling. The reaction conditions were optimized to get the highest radiochemical purity (98%): substrate amount 2 mg, Sn(II) (reducing agent) amount 50 µg, pH 7, 30 min, ambient temperature. The biodistribution studies revealed high brain uptake of 99mTc nitride-Levetiracetam, reaching a maximum of 9% ID/g at 30 min post injection (p.i.). The complex deserves further analysis as a candidate brain imaging agent.

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag,SFA Rizvi,Sudip Kumar Mandal,Soumya Stuti Patnaik,ASM Fouzy,Sabry A Bassem,Francis Verpoort

Journal

Radiochemistry

Published Date

2021/10

Comparative Bioevaluation of 99mTc Tricarbonyl and 99mTc-Sn(II) Lansoprazole as a Model for Peptic Ulcer Localization

Abstract Two 99mTc cores, 99mTc tricarbonyl and 99mTc-Sn(II), are compared in labeling of Lansoprazole (Lans). The optimum conditions of Lansoprazole labeling with 99mTc in the presence of SnCl2·2H2O as a reducing agent are as follows: pH 8, 100 μg of SnCl2·2H2O, room temperature, 2 mg of lansoprazole, and 30 min; the maximum radiochemical yield was 98 ± 0.22%. The obtained 99mTc Lansoprazole complex was stable in serum for up to 16 h. The optimum conditions of Lansoprazole binding with the 99mTc tricarbonyl ([99mTc(CO)3(H2O)3]+) core are as follows: pH 8, 2 mg of Lansoprazole, 100°С, 30 min. The complex was stable in serum for up to 12 h. Biodistribution study of the first core on two different groups of mice (control group and ulcer-bearing group) showed comparatively high uptake in the ulcer group of mice, 77.8 ± 1.1% ID/g at 30 min post-injection (higher than for the …

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag,SFA Rizvi,Sudip Kumar Mandal,Soumya Stuti Patnaik,ASM Fouzy,Sabry A Bassem,Francis Verpoort

Journal

Radiochemistry

Published Date

2021/10

Facile synthesis of silica‐polymer monoliths using nonionic triblock copolymer surfactant for efficient removal of radioactive pollutants from contaminated seawater

Here, we introduce a highly porous functional mesoscopically silica‐polymer composite based on silica monolith‐conjugated thiourea/formaldehyde copolymer. The developed nanostructure enables selective and fast removal of the radioactive pollutants strontium (Sr[II]) and cesium (Cs[I]) ions from contaminated seawater. The silica/polymer composite was synthesized by introducing thiourea/formaldehyde solution into tetramethoxy orthosilicate/triblock copolymer emulsion. The chemical and textural features of the synthesized silica/thiourea‐formaldehyde polymer composite (SiO2‐TUF) were characterized using Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscope, high‐resolution transmission electron microscope, energy dispersive X‐ray analysis, dynamic light scattering, thermal analysis, and N2 adsorption/desorption measurements. The synthesized …

Authors

Nada Abdelmageed,Waleed A El‐Said,Ahmed A Younes,Mohamed S Atrees,Abdelfatah B Farag,Emad A Elshehy,Amr M Abdelkader

Journal

Journal of Applied Polymer Science

Published Date

2021/11/15

Ester-gemini and monomeric cationic surfactants; Synthesis, characterization, surface parameters and biological activity

Gemini cationic surfactant is a promising generation of surfactants characterized by their unique surface properties and biological activities. Herein, a series of three Gemini cationic surfactants containing ester bond with different alkyl chain length and their corresponding monomeric structures have been synthesized. The monomeric surfactant were synthesized via simple esterification of different fatty acids (stearic, myrisitic, lauric acid) with 2-dimethyl amino ethanol, followed by quaternization with 1-bromohexane; while, and 1,6-dibromohexane was used to prepare the corresponding Gemini cationic surfactants. The structures of the synthesized compounds were elucidated using 1H-NMR, FTIR spectroscopy. The biological activities and surface properties have been assayed and it was found that the prepared Gemini surfactants have higher antimicrobial efficiencies than the corresponding monomeric structure.

Authors

Ismail Aiad,Eid Khalil,Adel Ahmed,Ali Abd-Elaal

Journal

Egyptian Journal of Chemistry

Published Date

2021/9/1

Optimized chromatographic separation and bioevalution of radioiodinated ilaprazole as a new labeled compound for peptic ulcer localization in mice

The paper describes the radiosynthesis of a new labelled chemical, [125I]iodoilaprazole. Several critical factors were optimized, namely, substrate concentration (100 µg), amount of oxidizing agent (50 µg, Chloramine-T), pH (pH 6), and reaction time (30 min). Under optimized conditions factors, the radiochemical yield of [125I]iodoilaprazole reached a maximum (98.5%). The biodistribution of [125I]iodoilaprazole in mice was investigated, and its significant absorption was demonstrated in stomach ulcers, reaching approximately 75.2 ± 0.7% ID/g at 30 min after injection. High concentration of [125I]iodoilaprazole in stomach ulcer makes this compound a promising new radiotracer for stomach ulcer imaging.

Authors

MH Sanad,HM Eyssa,FA Marzook,AB Farag,SFA Rizvi,SK Mandal,SS Patnaik,ASM Fouzy

Journal

Radiochemistry

Published Date

2021/11

Radioiodinated azilsartan as a new highly selective radiotracer for myocardial perfusion imaging

Abstract Azilsartan (AZ) was labeled with 131I using Chloramine-T as oxidizing agent. Factors affecting the labeling efficiency were systematically studied, and optimum conditions were found: oxidizing agent amount 100 μg, substrate amount 100 μg, pH 6, reaction time 30 min, and ambient temperature. Biodistribution studies showed that [131I]iodoAZ is concentrated in heart at 5 min post-injection to give high uptake of 29.0 ± 0.6% injected dose/g organ. Thus, iodoAZ shows promise as a radiotracer for heart imaging.

Authors

MH Sanad,FA Marzook,SFA Rizvi,AB Farag,ASM Fouzy

Journal

Radiochemistry

Published Date

2021/8

Synthesis, Radiolabeling, and Biological Evaluation of 99mTc-Tricarbonyl Mesalamine as a Potential Ulcerative Colitis Imaging Agent

5-HT1A receptors have been implicated in the pathogenesis of a wide variety of disorders related to the serotonin receptors. WAY100635 is a well-known high affinity 5-HT1A receptor antagonist. Many 11C and 18F radiolabeled derivatives and its radioiodinated analogues have been reported as imaging agents for 5-HT1A receptors. In this regard, the synthesis, radiolabeling and biological evaluation of a new 5-HT1A receptor radioligand, [125I]-1-(2-(benzylthio)ethyl)-4-(5-iodo-2-methoxyphenyl)piperazine ([125I]-BTE-IMPP), are described. Radioiodination of this newly synthesized compound was done by the direct aromatic electrophilic substitution via Iodo-Gen method. Radiochemical yield and radiochemical purity determined by TLC and RTLC were >70% and >95%, respectively. Biodistribution studies of [125I]-BTE-IMPP in rats displayed relatively high uptake in hippocampus (Hip) and low uptake in …

Authors

Ali Narimani,Masoud Sadeghzadeh,Mehran Kurdtabar

Journal

Radiochimica Acta

Published Date

2017/9/26

Photocatalytic degradation of organic pollutants in wastewater using different nanomaterials immobilized on polymeric beads

The present study is concerned with the photocatalytic degradation process to eliminate the organic pollutants. Sodium alginate (SA) was used as a polymeric substrate and prepared as beads form to increase the surface area and enhance the efficiency of the photocatalytic process. SA beads were doped with TiO2 with or without different nanomaterials such as ZnO, SiO2, and carbon nanotubes (CNTs). Mixing of TiO2 with these nanomaterials was achieved to extend the wavelength range to the visible wavelength region. Methyl orange (MO) was used as an example of organic pollutants in the photocatalytic process using the batch photo-reactor. The photocatalytic process was executed by using ultraviolet or sunlight beams. The characterizations of the different types of prepared beads were examined using Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermos-gravimetric analysis. Also, the effect of different parameters on the photocatalytic efficiency of the prepared nanomaterials was studied. The results showed that SA beads doped with TiO2 were able to degrade 97.9% under ultraviolet light, while in case of using SA beads doped with mixture of TiO2 and SiO2 were able to degrade 73.5% under sunlight after 5 h.

Authors

RA Elkholy,EM Khalil,AB Farag,MA El-Fadl,AM El-Aassar

Journal

Desalin Water Treat

Published Date

2020/7/1

See List of Professors in Abdelfatah Farag University(Helwan University)

Abdelfatah Farag FAQs

What is Abdelfatah Farag's h-index at Helwan University?

The h-index of Abdelfatah Farag has been 15 since 2020 and 26 in total.

What are Abdelfatah Farag's top articles?

The articles with the titles of

Facile one-pot strategy for radiocoplexation of [99mTc]-nitrido-nebracetam for brain imaging: Biological evaluation, Optimized chromatographic separation and labeling conditions.

Facile one-pot strategy for radio prepration of radioiodinated phenylpiracetam as a new highly selective radiotracer for brain imaging

Radioiodinated Procainamide as Radiotracer for Myocardial Perfusion Imaging in Mice

Radiocomplexation, Biological Evaluation, and Characterization of [99mTc]-5-[(3-Carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic Acid as a Novel Agent for …

Preparation and Bioevaluation of [99mTc] Tricarbonyl Omeprazole for Gastric Ulcer Localization in Mice

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: in silico study and preclinical evaluation

Green magnetic clay nanocomposite based on graphene oxide nanosheet as a synthetic low-cost adsorbent for oil droplets removal from produced water

In-Silico Study, Preparation and Biological Evaluation of 99MTC-Mesalamine Complex as Radiotracer for Diagnostics and Monitoring of Ulcerative Colitis in Mice

...

are the top articles of Abdelfatah Farag at Helwan University.

What are Abdelfatah Farag's research interests?

The research interests of Abdelfatah Farag are: Analytical Chemistry

What is Abdelfatah Farag's total number of citations?

Abdelfatah Farag has 2,858 citations in total.

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