Abdelbary Elhissi

Abdelbary Elhissi

Qatar University

H-index: 34

Asia-Qatar

Abdelbary Elhissi Information

University

Qatar University

Position

Professor in Pharmaceutics College of Pharmacy and Director of Research Planning

Citations(all)

4399

Citations(since 2020)

2605

Cited By

2778

hIndex(all)

34

hIndex(since 2020)

27

i10Index(all)

75

i10Index(since 2020)

69

Email

University Profile Page

Qatar University

Abdelbary Elhissi Skills & Research Interests

Clinical Pharmaceutics

Liposomes

Nanomedicine

Pharmaceutical technology

Pulmonary Drug delivery

Top articles of Abdelbary Elhissi

Albumin Nanoparticles in Cancer Therapeutics: Clinical Status, Challenges, and Future Directions

Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design to enable targeted drug delivery, nanoparticles have presented a promising avenue to overcome these limitations. Protein-based nanoparticles, particularly those based on albumin, are notable for their biocompatibility, stability, and ease of modification. The approval of Abraxane, an albumin-based nanoparticle formulation of paclitaxel, for metastatic breast cancer marked a significant milestone. However, further approvals have been slow to materialize until the recent approval of Fyarro® in 2021. This mini-review highlights the potential of albumin-based nanoparticles, focusing on their advantages, their current state, and progress in clinical use as anticancer therapeutics. We also discuss challenges impeding new approvals and future directions for unlocking the full potential of this technology.

Authors

HACHEMI KADRI,Mesk Alshatfa,Feras Z Alsalloum,Abdelbary Elhissi,Anis Daou,Mouhamad Khoder

Published Date

2024/4/24

Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that results in synovitis, cartilage destruction and loss of joint function. The frequent and long-term administration of anti-rheumatic drugs often leads to adverse effects and patient non-compliance. Hesperidin (HP) is a naturally occurring bioflavonoid having anti-inflammatory and antioxidant properties. In this study, Hesperidin loaded hybrid lecithin-folic acid silver nanoparticles (L-HP-FA-AgNPs) formulation has been developed to deliver HP to inflamed jointsspecifically.Thein vivo anti-inflammatory and anti-arthritic effectsof the formulation were validated in the CFA arthritis rat model by giving oral treatment of L-HP-FA-AgNPs (1 and 3mg/kg) which alleviated the joint swelling, cartilage destruction and reduced influx of inflammatory cells. The results showed decreased pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) in the peritoneal and …

Authors

Tooba Jabri,Talat Roome,Anam Razzak,Sabahat Aziz,Muhammad Imran,Bushra Sikandar,Abdelbary Elhissi,Shazmeen Mohammad Aslam,Muhammad RazaShah

Journal

Journal of Molecular Structure

Published Date

2023/3/15

Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next …

Drug delivery via aerosolization for localized and systemic effect is a non-invasive approach to achieving pulmonary targeting. The aim of this study was to prepare spray-dried proliposome (SDP) powder formulations to produce carrier particles for superior aerosolization performance, assessed via a next generation impactor (NGI) in combination with a dry powder inhaler. SDP powder formulations (F1-F10) were prepared using a spray dryer, employing five different types of lactose carriers (Lactose monohydrate (LMH), lactose microfine (LMF), lactose 003, lactose 220 and lactose 300) and two different dispersion media. The first dispersion medium was comprised of water and ethanol (50:50% v/v ratio), and the second dispersion medium comprised wholly of ethanol (100%). In the first dispersion medium, the lipid phase (consisting of Soya phosphatidylcholine (SPC as phospholipid) and Beclomethasone dipropionate (BDP; model drug) were dissolved in ethanol and the lactose carrier in water, followed by spray drying. Whereas in second dispersion medium, the lipid phase and lactose carrier were dispersed in ethanol only, post spray drying. SDP powder formulations (F1-F5) possessed significantly smaller particles (2.89 ± 1.24–4.48 ± 1.20 μm), when compared to SDP F6-F10 formulations (10.63 ± 3.71–19.27 ± 4.98 μm), irrespective of lactose carrier type via SEM (scanning electron microscopy). Crystallinity of the F6-F10 and amorphicity of F1-F15 formulations were confirmed by XRD (X-ray diffraction). Differences in size and crystallinity were further reflected in production yield, where significantly higher production yield was obtained for …

Authors

Iftikhar Khan,Ali Al-Hasani,Mohsin H Khan,Aamir N Khan,Fakhr-e -Alam,Sajid K Sadozai,Abdelbary Elhissi,Jehanzeb Khan,Sakib Yousaf

Journal

Plos one

Published Date

2023/3/13

Anti-cancer drug delivery: lipid-based nanoparticles

Cancer continues to pose significant challenges that require extensive attention and efforts from the scientific community. The battle against cancer encompasses the development of effective and safe therapeutic approaches. However, achieving this balance is highly complex for anticancer therapies, as they often exhibit intense intrinsic cytotoxicity, affecting both cancerous and healthy cells and resulting in substantial toxicity that limits their clinical utility. A promising strategy to address this challenge involves the selective guidance of therapeutic agents to the cancer site, minimizing off-target effects. Nanotechnology offers powerful tools to engineer smart and targeted therapeutics that preferentially accumulate in cancerous tissues (1). This preferential localization is achieved through the Enhanced Permeation and Retention (EPR) effect, first reported by Prof. Hiroshi Maeda in 1984 (2). The EPR effect leverages …

Authors

Alaaldin M Alkilany,Abdelbary Elhissi,Walhan Alshaer,Amit Kunwar,Jyotsnendu Giri

Journal

Frontiers in Oncology

Published Date

2023

Nanoparticle-based materials in anticancer drug delivery: Current and future prospects

The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these drugs can lead to undesirable side effects on healthy cells. To overcome this challenge and improve cancer cell targeting, many novel nanocarriers have been developed to deliver drugs directly to the cancerous cells and minimize effects on the healthy tissues. The majority of the research studies conclude that, using drugs encapsulated in nanocarriers is a much safer and more effective alternative than delivering the drug alone in its free form. This review provides a summary of the types of nanocarriers mainly studied for cancer drug delivery, namely: liposomes, polymeric micelles, dendrimers, magnetic nanoparticles, mesoporous nanoparticles, gold nanoparticles, carbon nanotubes …

Authors

Saniha Ajith,Fares Almomani,Abdelbary Elhissi,Ghaleb Husseini

Published Date

2023/10/20

Proliposomes: A Manufacturing Technology of Liposomes for Pulmonary Delivery via Nebulization

Proliposome technologies are stable phospholipid formulations that provide an approach to generating liposomes upon addition of aqueous phase prior to administration. In this monograph, the authors review the potential of proliposomes for pulmonary delivery of liposomes via nebulization using air-jet, ultrasonic and vibrating-mesh nebulizers. They explore both proliposome types, particulate-based and solvent-based. The book concludes that both types are capable of exploiting the energy of nebulization to generate liposomes within nebulizers.

Authors

Abdelbary Elhissi,Waqar Ahmed,Kevin MG Taylor,Xun Sun,Zhi-Rong Zhang,David A Phoenix

Published Date

2023

Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis

Oral aphthous stomatitis is a common disorder treated with the immunomodulatory drug Amlexanox (AMX), that was administered as a mucoadhesive paste (Aphthasol®). This product was discontinued by FDA in 2014 due to the associated undesired adverse reactions of the formulation. Here, we have developed AMX-loaded nanoliposome formulation as a potential alternative for the localised oromucosal delivery of AMX. Nanoliposomes were prepared using Soya phosphatidylcholine (SPC) and Cholesterol (Chol) mixtures at three different molar ratios to formulate vesicles using thin-film hydration, and were characterised for size, zeta potential and entrapment efficiency. The optimal formulation was found to be SPC:Chol 3:1 with drug entrapment efficiency of 94%, post sonication. To evaluate anti-inflammatory activity, macrophages developed by differentiation of human leukaemia monocytic cell line, THP-1 …

Authors

Afaf Abouzid,Abdelrhman Y Moustafa,Natalie Allcock,Mohammad Najlah,Abdelbary Elhissi,Chi Wi Stanley,Waqar Ahmed,Peter Seville,StJohn Crean,Robert T Forbes,Mohamed A Elsawy

Journal

Journal of Drug Delivery Science and Technology

Published Date

2023/1/1

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Gold nanoparticles (AuNP) have received a growing attention due to their fascinating physiochemical properties and promising range of biomedical applications including sensing, diagnosis and cancer photothermal ablation. AuNP enjoy brilliant optical properties and ability to convert light into local heat and function as a “nanoheaters” to fight cancer. However, AuNP are poor drug delivery systems as they do not have reservoirs or matrices to achieve an acceptable drug loading efficiency. On the other end, liposome-based nanocarriers do not exhibit such optical properties but are excellent platform for drug loading and they have been proven clinically with a true presence in the market since the FDA approved Doxil® in 1995. Combining the brilliant optical and photothermal properties of AuNP with the excellent drug loading capability of liposome should yield nanocomposites that enjoy the features of both modalities and enable the development of novel and smart drug delivery systems. Therefore, this review discusses the up-to date research on the AuNP-liposome nanocomposites and the current available approaches and protocols for their preparation and characterization. Finally, the biomedical applications of AuNP-liposome nanocomposites and proposed future directions in this field are discussed.

Authors

Sourour Idoudi,Roua Ismail,Ousama Rachid,Abdelbary Elhissi,Alaaldin M Alkilany

Published Date

2023/6/25

In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity

Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin resistance. Therefore, we hypothesize that inhibition of GATA3 could promote adipogenesis, restore healthy fat distribution, and enhance insulin signaling. Primary human preadipocytes were treated with GATA3 inhibitor (DNAzyme hgd40). Cell proliferation, adipogenic capacity, gene expression, and insulin signaling were measured following well-established protocols. BALB/c mice were treated with DNAzyme hgd40 over a period of 2 weeks. Liposomes loaded with DNAzyme hgd40, pioglitazone (positive), or vehicle (negative) controls were administered subcutaneously every 2 days at the right thigh. At the end of the study, adipose tissues were collected and weighed from the site of injection, the opposite side, and the omental depot. Antioxidant enzyme (superoxide dismutase and catalase) activities were assessed in animals’ sera, and gene expression was measured using well-established protocols. In vitro GATA3 inhibition induced the adipogenesis of primary human preadipocytes and enhanced insulin signaling through the reduced expression of p70S6K. In vivo GATA3 inhibition promoted adipogenesis at the site of injection and reduced MCP-1 expression. GATA3 inhibition also reduced omental tissue size and PPARγ expression. These findings suggest that modulating GATA3 expression offers a potential therapeutic benefit by correcting impaired adipogenesis, promoting healthy fat distribution, improving insulin …

Authors

Hend Al-Jaber,Nura A Mohamed,Vijay K Govindharajan,Samir Taha,Jomon John,Sharique Halim,Maha Alser,Shamma Al-Muraikhy,Najeha Rizwana Anwardeen,Abdelali Agouni,Abdelbary Elhissi,Hamda A Al-Naemi,Layla Al-Mansoori,Mohamed A Elrayess

Journal

International Journal of Molecular Sciences

Published Date

2022/9/22

In vivo and in vitro validation of GATA-3 suppression for correcting impaired adipogenesis, restoring insulin sensitivity, and lowering risk of T2D

PurposeImpaired adipogenesis is associated with development of insulin resistance and increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin resistance. Therefore, we hypothesize that inhibition of GATA3 could promote adipogenesis, restore healthy fat distribution, and enhance insulin signaling.MethodsBALB/c mice were treated with GATA3 inhibitor (DNAzyme hgd40) over a period of two weeks. Liposomes loaded with DNAzyme, pioglitazone, or vehicle controls were administered subcutaneously every two days, at the right thigh. At the end of the study, adipose tissues were collected and weighed from the site of injection, the opposite side, and the omental tissues. Anti-oxidant enzyme (SOD and catalase) activities were assessed in animals’ sera, and gene expression was measured using well-established protocols. Primary human preadipocytes were treated with DNAzyme hgd40. Cell proliferation, adipogenic capacity, gene expression, and insulin signaling were measured following well-established protocols.ResultsIn vivo GATA3 inhibition promoted adipogenesis at the site of injection and reduced MCP-1 expression. GATA3 inhibition also reduced omental tissue size and PPARγ expression. Additionally, in vitro GATA3 inhibition induced adipogenesis of primary human preadipocytes, and enhanced insulin signaling through reduced expression of p70S6K.ConclusionsThese findings suggest that modulating GATA3 expression offers a potential therapeutic benefit by correcting impaired adipogenesis, promoting healthy fat distribution, restoring insulin …

Authors

Hend Al-Jaber,Nura A Mohamed,Vijay K Govindharajan,Samir Taha,Jomon John,Sharique Halim,Maha Alser,Shamma Al-Muraikhy,Najeha Anwardeen,Abdelali Agouni,Abdelbary Elhissi,Hamda A Al-Naemi,Layla Al-Mansoori,Mohamed A Elrayess

Published Date

2022/6/7

Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases

Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.

Authors

Dana Elkhalifa,Menatallah Rayan,Ahmed T Negmeldin,Abdelbary Elhissi,Ashraf Khalil

Published Date

2022/1/1

Acknowledgment to Reviewers of Pharmaceutics in 2021

Rigorous peer-reviews are the basis of high-quality academic publishing. Thanks to the great efforts of our reviewers, Pharmaceutics was able to maintain its standards for the high quality of its published papers. Thanks to the contribution of our reviewers, in 2021, the median time to first decision was 16 days and the median time to publication was 38 days. The editors would like to extend their gratitude and recognition to the following reviewers for their precious time and dedication, regardless of whether the papers they reviewed were finally published:

Authors

Pharmaceutics Editorial Office

Journal

Pharmaceutics

Published Date

2022/2

Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines

Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether beta-cyclodextrin (SBE) were prepared and investigated as an approach to enhance the apparent solubility of DDC-Cu. Formulations were prepared by simple mixing of DDC-Cu with both cyclodextrin (CDs) at room temperature. Phase solubility assessments of the resulting solutions were performed. DDC-Cu CD solutions were freeze-dried for further characterisations by DSC, thermogravimetric analysis (TGA) and FT-IR. Stability and cytotoxicity studies were also performed to investigate the maintenance of DDC-Cu anticancer activity. The phase solubility profile deviated positively from the linearity (Ap type) showing significant solubility enhancement of the DDC-Cu in both CD solutions (approximately 4 mg/mL at 20% w/w CD solutions). The DSC and TGA analysis confirmed the solid solution status of DDC-Cu in CD. The resulting solutions of DDC-Cu were stable for 28 days and conveyed the anticancer activity of DDC-Cu on chemoresistant triple negative breast cancer cell lines, with IC50 values less than 200 nM. Overall, cyclodextrin DDC-Cu complexes offer a great potential for anticancer applications, as evidenced by their very positive effects against chemoresistant triple negative breast cancer cells.

Authors

Ammar Said Suliman,Mouhamad Khoder,Ibrahim Tolaymat,Matt Webster,Raid G Alany,Weiguang Wang,Abdelbary Elhissi,Mohammad Najlah

Journal

Pharmaceutics

Published Date

2021/1/10

Impact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions

Aqueous-based film coating suspensions are associated with reliance on alkalinising reagents and poor film formation. The impact of particle size in this process and resultant film properties remains unclear. This study offers the first direct comparison of film formation properties between aqueous micro- and nano-suspensions of the enteric polymer Eudragit S100. High-pressure homogenisation was employed to produce nano-suspensions of the enteric polymer. Formed enteric suspensions (micro- and nano-) were evaluated in terms of size, morphology, and ability to form film; with resultant films analysed in terms of; film thickness, mechanical and thermoplastic properties, water uptake, weight loss, and drug permeability in acidic medium. High-pressure homogenisation yielded particles within a submicron range (150–200 nm). Produced nano-suspensions formed significantly thinner films (p < 0.01), at lower …

Authors

Sakib Saleem Yousaf,Abdullah Isreb,Iftikhar Khan,Enosh Mewsiga,Abdelbary Elhissi,Waqar Ahmed,Mohamed A Alhnan

Journal

Pharmaceutical Development and Technology

Published Date

2021/8/9

Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation

Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC loaded microcapsules and its surface modification using different polymers has become the popular approach to address the said issues. The purpose of the study was to develop new PC loaded gastro-protective polymer hybrid microspheres (PHM) with subsequent conversion to tablet dosage form having modified dissolution rate and improved bioavailability. The crystallinity of the PC loaded PHM were established through powder X-ray diffraction. The optimised microspheres, PCM1 with particle size 32±3.0µm, entrapment efficiency 83.78±2.5% and in vitro drug release 87.1±2.6% were further subjected to tablets development and in vivo evaluation. The in vitro drug release study conducted for PHM at pH media 1.2 and 6.8 demonstrated retarded and enhanced drug release rates (P<0.001) respectively. Both accelerated and real time stability studies confirmed stability of the PC loaded PHM based tablets. A substantial improvement in the drug plasma concentration 12.6±2.36 (P<0.001) was observed for the produced tablets compared to the marketed formulations.

Authors

Hajra Afeera Hamid,Shahzeb Khan,Syed Muhammad Noor Shah,Muhammad Asghar,Muhammad Shahid,Zahid Hussain,Muhammad Sohail,Barkat Ali Khan,Fazli Amin,Syed Umer Jan,Abdelbary Elhissi,Syed Muhammad Hassan Shah,Muhammad Usman Minhas,Syed Wadood Ali Shah,Naveed Ahmad

Published Date

2021

Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers

Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation and enhance bioavailability of poorly water soluble drugs. The aim of this study was to develop and optimize NLC formulations in combination with optimized airflow rates (i.e. 60 and 15 L/min) and choice of medical nebulizers including Air jet, Vibrating mesh and Ultrasonic nebulizer for superior aerosolization performance, assessed via a next generation impactor (NGI). Novel composition and combination of NLC formulations (F1 – F15) were prepared via ultrasonication method, employing five solid lipids (glycerol trimyristate (GTM), glycerol trilaurate (GTL), cetyl palmitate (CP), glycerol monostearate (GMS) and stearic acid (SA)); and three liquid lipids (glyceryl tributyrate (GTB), propylene glycol dicaprylate …

Authors

Iftikhar Khan,Sozan Hussein,Chahinez Houacine,Sajid Khan Sadozai,Yamir Islam,Ruba Bnyan,Abdelbary Elhissi,Sakib Yousaf

Journal

International Journal of Pharmaceutics

Published Date

2021/4/1

Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer

Purpose The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods Proliposome powders were prepared by the slurry method and sorbitol or mannitol carbohydrate carrier were used in a 1:10 and 1:15 w/w lipid phase to carrier ratio. Beclometasone dipropionate (BDP; 2 mol%) was incorporated in the lipid phase. Proliposome powders were compressed into tablets, and liposomes were generated from proliposome powders or tablets within the nebulizer reservoir for subsequent aerosolization. Results Comparatively, shorter sputtering times were reported for the tablet formulations (≈ < 2.7±0.45 min), indicating uniform aerosolization. Post-nebulization, liposomes size was larger in the nebulizer reservoir in the …

Authors

Iftikhar Khan,Sakib Yousaf,Mohammad Najlah,Waqar Ahmed,Abdelbary Elhissi

Journal

Journal of Pharmaceutical Investigation

Published Date

2021/1

Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone

The current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic nanoparticles (MNP-LBA). Atomic force microscopy and dynamic light scattering showed that the developed CFT-loaded MNP-LBA is spherical, with a measured hydrodynamic size of 147 ± 15.9 nm and negative zeta potential values (–35 ± 0.58 mV). Fourier transformed infrared analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiencies of 91.5 ± 2.2%, and the drug was released gradually in vitro and shows prolonged in vitro stability using simulated gastrointestinal (GI) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the …

Authors

Muhammad Kawish,Tooba Jabri,Abdelbary Elhissi,Hina Zahid,Kanwal Muhammad Iqbal,Komal Rao,Jasra Gul,Muhammad Abdullah,Muhammad Raza Shah

Journal

Pharmaceutical Development and Technology

Published Date

2021/3/16

Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting

Simple Summary Cancer is one of the leading causes of death globally. Several studies, efforts and treatment strategies have been put forth for the treatment of different types of cancers. Several chemotherapeutic agents have been discovered and utilized for the treatment of various types of cancers and tumors, which play an important role in improving the quality of life of patients. The key problems associated with the abovementioned chemotherapeutic agents are the limited target ability and non-selective toxicity. The current review focuses on the achievement of improved targeting of anticancer agents at the tumor microenvironment without affecting normal tissues. The fulfilment of the mentioned objectives by stimuli-responsive drug delivery systems, as physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems through active and passive targeting have extensively been discussed in the current review. The current review will help the wide community of researchers conducting research in targeted drug delivery systems and anticancer treatment strategies. Abstract The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective …

Authors

Muhammad Abdur Rahim,Nasrullah Jan,Safiullah Khan,Hassan Shah,Asadullah Madni,Arshad Khan,Abdul Jabar,Shahzeb Khan,Abdelbary Elhissi,Zahid Hussain,Heather C Aziz,Muhammad Sohail,Mirazam Khan,Hnin Ei Thu

Published Date

2021/2/7

Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery

The aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya phosphatidylcholine (SPC), Dimyristoly phosphatidylcholine (DMPC) and Hydrogenated soya phosphatidylcholine (HSPC)), in combination with three different surfactants (Tween 80, Span 80 and Span 20) with or without cholesterol, employing Beclomethasone dipropionate (BDP) as the model drug. Nano-transfersome formulations post-extrusion were delivered to a Two-stage Impinger (TSI) via three medical nebulizers (i.e. Air-jet, Ultrasonic and Vibrating mesh nebulizer). Based on the physicochemical properties, formulations F1 (SPC and Tween 80), F7 (DMPC and Tween 80) and F13 (HSPC and Tween 80) demonstrated significantly smaller VMD (162.34 ± 6.48, 198.66 ± 6.64, and 183.52 …

Authors

Iftikhar Khan,Rachel Needham,Sakib Yousaf,Chahinez Houacine,Yamir Islam,Ruba Bnyan,Sajid Khan Sadozai,Mohamed A Elrayess,Abdelbary Elhissi

Journal

Journal of Drug Delivery Science and Technology

Published Date

2021/12/1

Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: characterisation, in vitro and in vivo antimalarial evaluation and …

Nanocrystalization technologies have a great potential to substantially increase solubility as well as alleviate the erratic bioavailability behaviour of a range of poorly water soluble drugs. The aim of the current study was to fabricate smart nanocrystals of lumefantrine (LF) using wet milling technology (DENA DM-100) with the subsequent in vitro, in vivo evaluation and toxicity screening. This technology successfully produced nanocrystals with an average particle size (214.1 ± 0.2 nm) and PDI (0.201 ± 0.06) in a period of less than 1 h. DSC and PXRD were used to confirm crystallinity of the processed LF. The dissolution rate and saturation solubility of the processed LF was significantly (P < 0.05) increased compared to the raw and marketed tablets. The IC50 value of LF nanocrystals was significantly (P < 0.05) lower than the IC50 value of the raw drug and marketed tablets. In addition, LF nanocrystals at the same …

Authors

Syed Muhammad Hassan Shah,Syed Muhammad Mukarram Shah,Shahzeb Khan,Farhat Ullah,Syed Wadood Ali Shah,Mehreen Ghias,Muhammad Shahid,Hugh DC Smyth,Zahid Hussain,Muhammad Sohail,Abdelbary Elhissi,Mohammad Isreb

Journal

Journal of Drug Delivery Science and Technology

Published Date

2021/2/1

Norfloxacin loaded lipid polymer hybrid nanoparticles for oral administration: fabrication, characterization, in silico modelling and toxicity evaluation

Norfloxacin (NOR), widely employed as an anti-bacterial drug, has poor oral bioavailability. Nano based drug delivery systems are widely used to overcome the existing oral bioavailability challenges. Lipid–Polymer Hybrid Nanoparticles (LPHNs) exhibit the distinctive advantages of both polymeric and liposomes nanoparticles, while excluding some of their disadvantages. In the current study, NOR loaded LPHNs were prepared, and were solid amorphous in nature, followed by in vitro and in vivo evaluation. The optimized process conditions resulted in LPHNs with the acceptable particle size 121.27 nm, Polydispersity Index (PDI) of 0.214 and zeta potential of −32 mv. The addition of a helper lipid, oleic acid, and polymers, ethyl cellulose, substantially increased the encapsulation efficiency (EE%) (65% to 97%). In vitro study showed a sustained drug release profile (75% within 12 h) for NOR LPHNs. The optimized NOR LPHNs showed a significant increase (p < 0.05) in bioavailability compared to the commercial product. From the acute toxicity study, the LD50 value was found to be greater than 1600 mg/kg. The molecular modelling studies substantiated the experimental results with the best combination of polymers and surfactants that produced highly stable LPHNs. Therefore, LPHNs proved to be a promising system for the delivery of NOR, as well as for other antibiotics and hydrophobic drugs.

Authors

Muhammad Asghar Khan,Shahzeb Khan,Mohsin Kazi,Sultan M Alshehri,Muhammad Shahid,Shafi Ullah Khan,Zahid Hussain,Muhammad Sohail,Muhammad Shafique,Hajra Afeera Hamid,Mahwish Kamran,Abdelbary Elhissi,Muhammad Wasim,Hnin Ei Thu

Journal

Pharmaceutics

Published Date

2021/10/6

Spray-dried alginate microparticles for potential intranasal delivery of ropinirole hydrochloride: Development, characterization and histopathological evaluation

Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140 °C. Fourier Transform Infrared (FTIR) studies revealed the compatibility of the drug with the polymer, and scanning electron microscopy (SEM) showed that drug-loaded microparticles were spherical, and the apparent surface roughness was inversely related to the ratio of polymer to drug. Furthermore, size of the spray-dried particles were in the range of 2.5–4.37 µm, depending on formulation. All formulations had high drug encapsulation efficiencies (101–106 …

Authors

Nozad Hussein,Huner Omer,Ava Ismael,Mohamed Albed Alhnan,Abdelbary Elhissi,Waqar Ahmed

Journal

Pharmaceutical Development and Technology

Published Date

2020/3/15

Carbon nanotubes drug delivery system for cancer treatment

There has been a predominant interest in using nanotechnology for drug delivery applications, especially for cite-specific targeting. Recently, interest in the potential of carbon nanotubes (CNT) to deliver bio-molecules for a range of biomedical applications, particularly drug delivery into living systems for cancer diagnostics and therapy has massively grown. Pure CNTs have inherent limitations, such as poor solubility, which limit their use in biomedical applications. A myriad of approaches to enhance their solubility have been investigated. An attractive approach has involved the functionalization of CNTs (f-CNT) in order to improve their solubility and biocompatibility in aqueous solutions. This chapter provides an introductory overview of carbon nanotubes and their use as drug delivery systems for cancer treatment.

Authors

Abdallah Banu,Abdelbary Elhissi,Waqar Ahmed,Mohammad Najlah

Published Date

2020/12/31

Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization

A simplistic approach was adopted to manufacture novel paclitaxel (PTX) loaded protransfersome tablet formulations for pulmonary drug delivery. The large surface area offered by the pulmonary system acts as a desirable site for anti-cancer drug deposition; offering localized effect within the lungs. Protransfersomes are dry powder formulations, whereas transfersomes are liquid dispersions containing vesicles generated from protransfersomes upon hydration. Protransfersome powder formulations (F1–F27) (referred as Micro formulations based on transfersomes vesicles size post hydration) were prepared by employing a phospholipid (Soya phosphatidylcholine (SPC)), three different carbohydrate carriers (Lactose monohydrate, LMH; Microcrystalline cellulose, MCC; and Starch), three surfactants (i.e. Span 80, Span 20 and Tween 80) in three different lipid phase to carrier ratios (i.e. 1:05, 1:15 and 1:25 w/w), with …

Authors

Iftikhar Khan,Maria Apostolou,Ruba Bnyan,Chahinez Houacine,Abdelbary Elhissi,Sakib S Yousaf

Journal

International Journal of Pharmaceutics

Published Date

2020/2/15

Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization

Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated to generate nano-vesicles. The proniosome powders were characterized in terms of morphology using scanning electron microscopy, and drug crystallinity using differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The niosomes generated from proniosomes were characterized and compared to conventional niosomes, in terms of size, zeta potential, drug entrapment, storage stability, and drug release. All formulations had size measurements in the range of 100–194 nm, polydispersity index (PDI) values below 0.3, and zeta potential values below – 23 mV. Drug entrapment was the highest for niosomes generated from sucrose-based proniosomes (CH:T80; 1:1 …

Authors

Nada Khudair,Abdelali Agouni,Mohamed A Elrayess,Mohammad Najlah,Husam M Younes,Abdelbary Elhissi

Journal

Journal of Drug Delivery Science and Technology

Published Date

2020/8/1

Taxane anticancer formulations: challenges and achievements

Taxanes represent a prominent anticancer family. Paclitaxel and docetaxel are the most well-known taxanes owing to their activity against many types of cancers. The poor solubility of taxanes in water is a major obstacle toward the development of taxane formulations. In this chapter, an introduction about taxanes in terms of their pharmacology, solubility, and stability was provided. Then, we reviewed the traditional delivery systems of taxanes (e.g., formulations of paclitaxel solubilized in Cremophor EL) and the novel nanocarrier systems based on using lipid and polymeric materials. Commercially available formulations of paclitaxel such as Taxol, Abraxane, and Genexol-PM were discussed in this chapter.

Authors

Abdelbary MA Elhissi,Rukhsana Mahmood,Ishrat Parveen,Asma Vali,Mohammad Najlah,David A Phoenix,Waqar Ahmed

Published Date

2020/1/1

A facile and novel approach to manufacture paclitaxel-loaded proliposome tablet formulations of micro or nano vesicles for nebulization

Purpose The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Method Proliposome powder formulations (i.e. F1 – F27) were prepared employing Lactose monohydrate (LMH), Microcrystalline cellulose (MCC) or Starch as a carbohydrate carriers and Soya phosphatidylcholine (SPC), Hydrogenated soya phosphatidylcholine (HSPC) or Dimyristoly phosphatidylcholine (DMPC) as a phospholipid. Proliposome powder formulations were prepared in 1:5, 1:15 or 1:25 w/w lipid phase to carrier ratio (lipid phase; comprising of phospholipid and cholesterol in 1:1 M ratio) and Paclitaxel (PTX) was used as model anticancer drug. Results Based on flowability studies, out of 27 formulations; F3, F6, and F9 formulations were selected as they exhibited an excellent angle of repose (AOR) (17.24 ± 0.43, 16.41 ± 0.52 and 15.16 ± 0.72°), comparatively …

Authors

Iftikhar Khan,Katie Lau,Ruba Bnyan,Chahinez Houacine,Matthew Roberts,Abdullah Isreb,Abdelbary Elhissi,Sakib Yousaf

Journal

Pharmaceutical research

Published Date

2020/6

Enhancement in oral absorption of ceftriaxone by highly functionalized magnetic iron oxide nanoparticles

The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N′-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (–20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT.

Authors

Muhammad Kawish,Abdelbary Elhissi,Tooba Jabri,Kanwal Muhammad Iqbal,Hina Zahid,Muhammad Raza Shah

Journal

Pharmaceutics

Published Date

2020/5/28

Characterization of cochleate nanoparticles for delivery of the anti-asthma drug beclomethasone dipropionate

Cochleates are an exciting new class of nanocarriers derived from multilamellar liposomes. They have a “cigerette like” structures in which the phospholipid bilayers are joined together by calcium ion bridges making them more stable than liposomes and thus less prone to degradation. Cochleates offer potential for use in drug delivery. They have never been used previously for pulmonary drug delivery and formed the basis of this study with the aim of delivering beclomethasone dipropionate (BDP) to the lungs for the treatment of asthma. Cochleates have been synthesized and characterized using a variety of techniques. Their particle size, structure, zeta potential, and aerosol droplet size have been presented. Sonication was used to control the size of liposomes and cochleates which decreased dramatically from microns to the nanometer range within 6.5 min. Zeta potential of cochleates was found to be −60 mV to compared with −4 mV and −70 mV for SPC and SPS liposomes, respectively and decreased slightly after nebulization.

Authors

Ghauri Aisha,Imran Ghauri,Abdelbary Elhissi,Waqar Ahmed

Published Date

2020/12/31

Development, characterization and stability evaluation of ciprofloxacin-loaded parenteral nutrition nanoemulsions

In this study, two licensed total parenteral nanoemulsion formulations (Clinoleic® and Intralipid®) were loaded with ciprofloxacin (CP). The physicochemical characteristics and stability profiles of the formulations were investigated using a range of drug concentrations. Furthermore, formulation stability was evaluated over a period of six months at room temperature (RT) or 4 °C. Loading CP into nanoemulsions resulted in no significant differences in their measured droplet size, polydispersity index (PI), zeta potential, and pH. Drug entrapment efficiency (EE) was relatively high for all formulations, regardless of nanoemulsion type, and the drug release was sustained over 24 h. Stability studies of all formulations were performed at 4 °C and RT for 180 and 60 days, respectively. At 4 °C for 180 days, both Clinoleic® and Intralipid® formulations at a range of drug concentrations (1–10 mg/ml) showed high …

Authors

Ammar Said Suliman,Rose Tom,Kirsty Palmer,Ibrahim Tolaymat,Husam M Younes,Basel Arafat,Abdelbary MA Elhissi,Mohammad Najlah

Journal

Pharmaceutical Development and Technology

Published Date

2020/5/27

Advances in nasal drug delivery systems

Nasal drug delivery has been around for centuries and employed both leisure and recreations and also for the treatment of various conditions such as migraine, decongestion, sinusitis, rhinitis, and in emergency. The route is convenient and popular. It has numerous advantages such as direct delivery to the (central nervous system) CNS, high bioavailability, large surface area, needles are not used, and no special skills are required to deliver the drug. The method is non-invasive and provides direct drug transfer from nose to brain via olfactory nerve, hence it bypasses the blood-brain barrier for CNS effect and first pass effect while drug absorbed via nasal mucosa for systemic effect. It is also suitable for drugs that are unstable in an acid environment. The two main mechanisms in nasal drug delivery are discussed along with various factors involved such as physicochemical properties of the drug, formulations factors, and the physiological and anatomical characteristics. Various barriers effecting nasal drug delivery are also discussed. The delivery of microspheres and liposome formations using various nasal devices is also discussed.

Authors

Hussein Nozad Rashid,Huner Kamal Omer,Abdelbary Elhissi,Waqar Ahmed

Published Date

2020/12/31

Abdelbary Elhissi FAQs

What is Abdelbary Elhissi's h-index at Qatar University?

The h-index of Abdelbary Elhissi has been 27 since 2020 and 34 in total.

What are Abdelbary Elhissi's top articles?

The articles with the titles of

Albumin Nanoparticles in Cancer Therapeutics: Clinical Status, Challenges, and Future Directions

Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model

Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next …

Anti-cancer drug delivery: lipid-based nanoparticles

Nanoparticle-based materials in anticancer drug delivery: Current and future prospects

Proliposomes: A Manufacturing Technology of Liposomes for Pulmonary Delivery via Nebulization

Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

...

are the top articles of Abdelbary Elhissi at Qatar University.

What are Abdelbary Elhissi's research interests?

The research interests of Abdelbary Elhissi are: Clinical Pharmaceutics, Liposomes, Nanomedicine, Pharmaceutical technology, Pulmonary Drug delivery

What is Abdelbary Elhissi's total number of citations?

Abdelbary Elhissi has 4,399 citations in total.

What are the co-authors of Abdelbary Elhissi?

The co-authors of Abdelbary Elhissi are Waqar Ahmed, Kevin Taylor, Prof. Dr. M. Raza Shah, V.R.Dhanak, Mark J. Jackson, Stjohn Crean.

    Co-Authors

    H-index: 56
    Waqar Ahmed

    Waqar Ahmed

    University of Lincoln

    H-index: 52
    Kevin Taylor

    Kevin Taylor

    University College London

    H-index: 50
    Prof. Dr. M. Raza Shah

    Prof. Dr. M. Raza Shah

    University of Karachi

    H-index: 48
    V.R.Dhanak

    V.R.Dhanak

    University of Liverpool

    H-index: 38
    Mark J. Jackson

    Mark J. Jackson

    Kansas State University

    H-index: 35
    Stjohn Crean

    Stjohn Crean

    University of Central Lancashire

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