Abdelaziz SA Abuelsaad

Abdelaziz SA Abuelsaad

Beni-Suef University

H-index: 14

Africa-Egypt

Abdelaziz SA Abuelsaad Information

University

Beni-Suef University

Position

Zoology Dept. Faculty of Science + Microbiology Department College of

Citations(all)

671

Citations(since 2020)

358

Cited By

440

hIndex(all)

14

hIndex(since 2020)

12

i10Index(all)

18

i10Index(since 2020)

13

Email

University Profile Page

Beni-Suef University

Abdelaziz SA Abuelsaad Skills & Research Interests

Mucosal Immunology

Immunity to Parasite

Immunomodulation by natural products

Human Resource Develpment Programs

Top articles of Abdelaziz SA Abuelsaad

Evaluation of MMP-13 and Micro RNA-138 as prognostic biomarkers for breast cancer in Egyptian women patients

BackgroundElevated serum levels of MMP-13 are linked to tumor growth and metastasis, while miR-138 dysregulation is observed in breast cancer cases. The aim of this study is to investigate the expression of miR-138 and MMP-13 levels as potential biomarkers for the prognosis of breast cancer.Patients and MethodIn this retrospective case-control study, 119 female subjects were recruited and divided into three groups. MMP-13 level was measured using Enzyme Linked Immunosorbent Assay (ELISA), while real-time PCR technique was employed to quantify miR-138 expression.ResultsBoth non-metastatic and metastatic groups showed significantly higher levels of serum MMP-13 compared to other groups. MMP-13 levels are significantly increased among patients with advanced tumor size, lymph node metastasis, and triple-negative breast cancer cases. An inverse significant association between MMP-13 …

Authors

Hossam Elmasry,Sally M Khadrawy,Mahmoud M Kamel,Mona H Ibrahim,Abdelaziz SA Abuelsaad,Mohamed I Zanaty

Journal

Pathology-Research and Practice

Published Date

2024/1/1

Assessment of Biochemical and Neuroactivities of Cultural Filtrate from Trichoderma harzianum in Adjusting Electrolytes and Neurotransmitters in Hippocampus of …

Background Epilepsy is a serious chronic neurological disorder, which is accompanied by recurrent seizures. Repeated seizures cause physical injuries and neuronal dysfunction and may be a risk of cancer and vascular diseases. However, many antiepileptic drugs (AEDs) have side effects of mood alteration or neurocognitive function, a reduction in neuron excitation, and the inhibition of normal activity. Therefore, the present study aimed to evaluate the effect of secondary metabolites of Trichoderma harzianum cultural filtrate (ThCF) when adjusting different electrolytes and neurotransmitters in the hippocampus of epileptic rats. Methods Cytotoxicity of ThCF against LS-174T cancer cells was assessed using a sulforhodamine B (SRB) assay. Quantitative estimation for some neurotransmitters, electrolytes in sera or homogenate of hippocampi tissues, and mRNA gene expression for ion or voltage gates was assessed by quantitative Real-Time PCR. Results Treatment with ThCF reduces the proliferative percentage of LS-174T cells in a concentration-dependent manner. ThCF administration improves hyponatremia, hyperkalemia, and hypocalcemia in the sera of the epilepticus model. ThCF rebalances the elevated levels of many neurotransmitters and reduces the release of GABA and acetylcholine-esterase. Also, treatments with ThCF ameliorate the downregulation of mRNA gene expression for some gate receptors in hippocampal homogenate tissues and recorded a highly significant elevation in the expression of SCN1A, CACNA1S, and NMDA. Conclusion Secondary metabolites of Trichoderma (ThCF) have cytotoxic activity against LS-174T …

Authors

Atef A Abd El-Rahman,Sally MA El-Shafei,Gaber MG Shehab,Lamjed Mansour,Abdelaziz SA Abuelsaad,Rania A Gad

Journal

Life

Published Date

2023/8/28

Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics

The unrelenting progression of neurodegenerative diseases has a negative impact on affected individuals, their families, and society. Recurrent epileptic seizures are the hallmark of epilepsy, and treating it effectively remains difficult. Clarify and understanding effects of the antiepileptic drugs (AEDs) in epilepsy by comparing the therapeutic effects between rats receiving valproic acid (VPA) and Bee venom (BV) was aimed throughout the present study. Four male Wistar rat groups were included: control, epileptic group receiving pilocarpine (PILO), epileptic group treated with VPA and BV respectively. Cognitive functions were assessed by evaluating latency time in hot plate, despair swim test, grooming, rearing and ambulation frequency in the open field. BV has ameliorative effect on electrolytes balancing, assured by decreasing lipid peroxidation, nitric oxide and increasing catalase, superoxide dismutase and …

Authors

Esraa K Aly,Hanan S Mahmoud,Dalal Hussien M Alkhalifah,Gaber MG Shehab,Abdelaziz SA Abuelsaad,Eman S Abdel-Rehiem,Manal Abdul-Hamid

Journal

Neuropeptides

Published Date

2023/10/1

Anti‐inflammatory, antioxidant, anti‐fibrotic and schistosomicidal properties of plumbagin in murine schistosomiasis

Schistosomiasis is still a major health problem affecting nearly 250 million people worldwide and causes approximately 280,000 deaths per year. The disease causes a serious granulomatous inflammatory response that produces significant mortality. Plumbagin reportedly displays anti‐inflammatory, anti‐fibrotic, antioxidant and anthelmintic properties. This study further elucidates these properties. Mice were infected with schistosomes and divided into five groups: non‐infected untreated (C); infected untreated (IU); non‐infected treated with plumbagin (P); infected treated with plumbagin (PI) and infected treated with praziquantel (PZ). Mice treated with 20 mg plumbagin/kg body weight showed reduction of 64.28% and 59.88% in male and female animals, respectively. Also, the number of eggs/g tissue was reduced 69.39%, 68.79% and 69.11% in liver, intestine and liver/intestine combined, respectively …

Authors

Heba H Bakery,Gamal A Allam,Abdelaziz SA Abuelsaad,Mahmoud Abdel‐Latif,Ayman E Elkenawy,Rehab G Khalil

Journal

Parasite Immunology

Published Date

2022/11

Mitigating effects of Passiflora incarnata on oxidative stress and neuroinflammation in case of pilocarpine-Induced status epilepticus model

Virulent epileptogenic insult is still one of the most life-threatening deficits during the clinical consequences and neurological emergencies of epilepsy. Thus, this study is designed to determine the changes in the expression of neurotransmitters, imbalance in blood electrolytes; oxidative stress, levels of pro-/anti-inflammatory cytokines, after treatment with pasipay (Passiflora incarnata). The effect of oral administration of 200 mg/kg body weight of P. incarnata on pilocarpine-induced seizures was assessed. The correlation between seizure activity and levels of proinflammatory cytokines; anti-inflammatory cytokines; oxidative stress biomarkers, monoamines, neurotransmitters; electrolytes and Th1/Th2 activities was quantified. The present study revealed a highly significant amelioration in amino acids, neurotransmitters, blood electrolytes, antioxidants and inflammatory cytokines in epileptic-treated rats with pasipay …

Authors

Rania A Gad,Eman S Abdel-Reheim,Hossam Ebaid,Ibrahim M Alhazza,Abdelaziz SA Abuelsaad

Journal

Journal of King Saud University-Science

Published Date

2022/4/1

Evaluation of insulin resistance induced brain tissue dysfunction in obese dams and their neonates: role of ipriflavone amelioration

Background Nonalcoholic steatohepatitis (NASH) is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. A high fat high cholesterol diet (HFD) was provided to female albino rats to establish a NASH model. It is well known that the offspring of obese mothers have an increased risk of obesity and diabetes. The present study aimed at evaluating the ameliorative effects of ipriflavone (IP) as a natural food supplement on lipid metabolism, improving insulin sensitivity, reducing oxidative stress and inflammation, modifying metabolic risk factors and/or reduce brain damage, in both neonates and their dams. Materials and Methods The present aim was achieved by evaluating the oxidative stress and antioxidant defense system biomarkers, as thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH), catalase, and superoxide dismutase (SOD …

Authors

Rania A Gad,Eman S Abdel-Reheim,Gaber MG Shehab,Hani S Hafez,Abdelaziz SA Abuelsaad

Journal

Combinatorial Chemistry & High Throughput Screening

Published Date

2021/7/1

Association of metabolic syndrome components with alterations in oxidative stress and cytokines expression

Purpose Metabolically obese but normal weight (MONW) is associated with higher risk of type 2 diabetes, dyslipidemia, and hypertension. The aim of this study was to evaluate the association of metabolic syndrome components with MONW in each sex in Iranian population. Methods This cross-sectional study was performed on 417 normal weight subjects in Qazvin, Iran between September 2010 and April 2011. MONW was defined by insulin resistance (IR) using the homeostatic model assessment (HOMA). Cut off point for IR was defined as the lower limit of top quintile of HOMA-IR values in normal weight population without any metabolic risk factors. Data were analyzed using T test, Mann–Whitney U test, and multi-variant logistic regression analysis. Results Of 417 subjects, 44.3 % were female. The prevalence of …

Authors

S Hashemipour,N Esmailzadehha,H Hamid,S Oveisi,P Yakhchaliha,A Ziaee

Journal

Journal of Endocrinological Investigation

Published Date

2015/10

Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model

Bee venom (BV) is applied in different traditional medicinal therapies and is used worldwide to prevent and treat many acute and chronic diseases. Epilepsy has various neurological effects, e.g., epileptogenic insults; thus, it is considered a life-threatening condition. Seizures and their effects add to the burden of epilepsy because they can have health effects including residual disability and even premature mortality. The use of antiinflammatory drugs to treat epilepsy is controversial; therefore, the alternative nonchemical apitherapy benefits of BV were evaluated in the present study by assessing neuroinflammatory changes in a pilocarpine-induced epilepticus model. Levels of electrolytes, neurotransmitters, and mRNA expression for some gate channels were determined. Moreover, ELISA assays were conducted to detect pro- and anti-inflammatory cytokines, whereas RT-PCR was performed to assess mRNA …

Authors

Abeer Mohamed Abd El-Hameed,Abdelaziz SA Abuelsaad,Abdelwahab Khalil

Journal

Metabolic Brain Disease

Published Date

2021/10

Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Querceti

Diethylcarbamazine citrate (DEC) is known as an effective treatment for bronchial asthma because of its ability to reduce eosinophil trafficking to the lung tissue. The current study aimed to potentiate the anti-allergic effect of the drug by passive immunization of the asthmatic model with anti-DEC antibody or prior treatment with quercetin (Qur). Eight mice groups were categorized into control, the model of lung asthma, treated with DEC, passively immunized with anti (α)-bovine serum albumin Ab, anti-DEC Ab, prior exposure to 10, 20, or 40 mg Qur/Kg. b. wt. Both eosinophil peroxidase (EPO) and eotaxin2 in the lung tissues were performed. Serum levels of cytokines, bronchoalveolar lavage fluid (BALF) IgE, rabbit anti-bovine serum albumin (anti-BSA), and DEC IgG in lung tissue homogenates were assayed by ELISA. Regarding the effect of anti-DEC Ab and Qur on DEC-induced recovery of histopathological alterations showed that the Ova group had peri-bronchial hyperplasia, mononuclear leukocyte infiltration, thickening in the wall of alveoli, and congested blood vessels. However, the reduction of inflammatory cells and thickened alveolar walls was dependent on the Qur dose. Qur40 enhanced the anti-allergic effect of DEC. Moreover, the present data revealed high levels of Th2 cytokines (IL-4 and IL-5) and IgE in the Ova group. An increased leukocyte infiltration/thickening of the alveolar wall and lung tissue EPO/eotaxin2 were also observed. Qur-40 could show an enhancement effect on DEC for the reduction of IL-4, IL-5, IgE, EPO, and eotaxin 2. Consequently, the IFN-γ/IL-4 ratio was increased. Qur at 40 mg/Kg could be recommended to …

Authors

Nosibah Abdul-Razek,Al-Mahy M El-Mallah,Abdelaziz SA Abuelsaad,Mahmoud Abdel-Latif

Journal

Iranian Journal of Allergy, Asthma and Immunology

Published Date

2020/9/2

See List of Professors in Abdelaziz SA Abuelsaad University(Beni-Suef University)

Abdelaziz SA Abuelsaad FAQs

What is Abdelaziz SA Abuelsaad's h-index at Beni-Suef University?

The h-index of Abdelaziz SA Abuelsaad has been 12 since 2020 and 14 in total.

What are Abdelaziz SA Abuelsaad's top articles?

The articles with the titles of

Evaluation of MMP-13 and Micro RNA-138 as prognostic biomarkers for breast cancer in Egyptian women patients

Assessment of Biochemical and Neuroactivities of Cultural Filtrate from Trichoderma harzianum in Adjusting Electrolytes and Neurotransmitters in Hippocampus of …

Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics

Anti‐inflammatory, antioxidant, anti‐fibrotic and schistosomicidal properties of plumbagin in murine schistosomiasis

Mitigating effects of Passiflora incarnata on oxidative stress and neuroinflammation in case of pilocarpine-Induced status epilepticus model

Evaluation of insulin resistance induced brain tissue dysfunction in obese dams and their neonates: role of ipriflavone amelioration

Association of metabolic syndrome components with alterations in oxidative stress and cytokines expression

Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model

...

are the top articles of Abdelaziz SA Abuelsaad at Beni-Suef University.

What are Abdelaziz SA Abuelsaad's research interests?

The research interests of Abdelaziz SA Abuelsaad are: Mucosal Immunology, Immunity to Parasite, Immunomodulation by natural products, Human Resource Develpment Programs

What is Abdelaziz SA Abuelsaad's total number of citations?

Abdelaziz SA Abuelsaad has 671 citations in total.

What are the co-authors of Abdelaziz SA Abuelsaad?

The co-authors of Abdelaziz SA Abuelsaad are Gamal Badr, Ahmed S. Abdel-Moneim, Gamal Allam.

    Co-Authors

    H-index: 43
    Gamal Badr

    Gamal Badr

    Assiut University

    H-index: 27
    Ahmed S. Abdel-Moneim

    Ahmed S. Abdel-Moneim

    Taif University

    H-index: 18
    Gamal Allam

    Gamal Allam

    Beni-Suef University

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