Abdelaziz Abdelaal

Abdelaziz Abdelaal

Tanta University

H-index: 18

Africa-Egypt

Abdelaziz Abdelaal Information

University

Tanta University

Position

Faculty of Medicine

Citations(all)

1271

Citations(since 2020)

1237

Cited By

216

hIndex(all)

18

hIndex(since 2020)

18

i10Index(all)

22

i10Index(since 2020)

22

Email

University Profile Page

Tanta University

Abdelaziz Abdelaal Skills & Research Interests

Glaucoma - Clinical Research

Top articles of Abdelaziz Abdelaal

Safety and Efficacy of Brolucizumab in the Treatment of Diabetic Macular Edema and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

PurposeTo investigate the efficacy and safety of brolucizumab in diabetic macular edema (DME) and diabetic retinopathy (DR).MethodsIn this systematic review and meta-analysis, an electronic search was done to acquire all articles describing brolucizumab use in patients with DME and DR. The review was prospectively registered on PROSPERO (CRD42022382625). Collected articles were filtered through two stages by independent reviewers. Data were extracted from the included articles and then analyzed accordingly.ResultsBrolucizumab induced significant improvement in best-corrected visual acuity and was either better or non-inferior to other types of anti-VEGF (MD −0.64 mu, 95% CI [−1.15, −0.13], P = .01); the same observation was noted with regards to central subfield macular thickness (CSMT) (MD −138.6 mu, 95% CI [−151.9, −125.3], P = .00001). Brolucizumab was reported to be relatively safe …

Authors

Hashem Abu Serhan,Mohammad JJ Taha,Mohammad T Abuawwad,Abdelaziz Abdelaal,Sara Irshaidat,Leen Abu Serhan,Qusai Faisal Abu Salim,Nour Awamleh,Basel Abdelazeem,Ayman G Elnahry

Published Date

2024/5/18

Monkeypox viral detection in semen specimens of confirmed cases: a systematic review and meta‐analysis

The current literature shows increasing concerns about potential seminal transmission of monkeypox virus (MPXV). Accordingly, we aimed to understand better the potential presence of MPXV in the seminal fluids and others specimens obtained from MPX cases. On June 26, 2022, a systematic search of the literature was conducted to find articles that examine the presence of MPXV in the seminal fluid of confirmed cases. The search was updated once on August 12 and another on October 12, 2022, to include newly published articles. The prevalence of MPXV DNA presence in the seminal fluid and other specimens was pooled in a meta‐analysis (from studies with sample size > 5 to reduce overestimation) and results were presented as effect sizes (ES) and their corresponding 95% confidence intervals (CI). Nine articles were included. Only five studies were eligible for a meta‐analysis, and the pooled …

Authors

Abdullah Reda,Abdelaziz Abdelaal,Aml M Brakat,Basant Ismail Lashin,Moustafa Abouelkheir,Basel Abdelazeem,Alfonso J Rodriguez‐Morales,Ranjit Sah

Published Date

2023/1

Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in …

Background This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO 2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO 2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results High FiO 2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO 2 was $216 compared with $222 for low FiO 2 leading to a− $6 (95% confidence interval [CI]:− $13 to− $1) difference in costs. In India, the average cost for high FiO 2 …

Authors

GlobalSurg Collaborative,Mwayi Kachapila,Mark Monahan,Adesoji O Ademuyiwa,Yakubu Momohsani Adinoyi,Bruce M Biccard,Christina George,Dhruva N Ghosh,James Glasbey,Dion G Morton,Osaheni Osayomwanbo,Rupert Pearse,Tracy E Roberts,Atul Suroy,Saidu Yusuf Yakubu,Raymond Oppong,Aneel Bhangu,Maria Lorena Aguilera,Philip Alexander,Sara W Al-Saqqa,Giuliano Borda-Luque,Ainhoa Costas-Chavarri,Thomas M Drake,Faustin Ntirenganya,J Edward Fitzgerald,Stuart J Fergusson,JC Allen Ingabire,Lawani Ismaïl,Hosni Khairy Salem,Anyomih Theophilus Teddy Kojo,Marie Carmela Lapitan,Richard Lilford,Andre L Mihaljevic,Dion Morton,Alphonse Zeta Mutabazi,Dmitri Nepogodiev,Adewale O Adisa,Riinu Ots,Francesco Pata,Thomas Pinkney,Tomas Poškus,Ahmad Uzair Qureshi,Antonio Ramos-De la Medina,Sarah Rayne,Catherine A Shaw,Sebastian Shu,Richard Spence,Neil Smart,Stephen Tabiri,Ewen M Harrison,Azmina Verjee,Emmy Runigamugabo,Chetan Khatri,Midhun Mohan,Zahra Jaffry,Afnan Altamini,Andrew Kirby,Kjetil Søreide,Gustavo Recinos,Jen Cornick,Maria Marta Modolo,Dushyant Iyer,Sebastian King,Tom Arthur,Sayeda Nazmum Nahar,Ade Waterman,Michael Walsh,Arnav Agarwal,Augusto Zani,Mohammed Firdouse,Tyler Rouse,Qinyang Liu,Juan Camilo Correa,Peep Talving,Mengistu Worku,Alexis Arnaud,Vassilis Kalles,Basant Kumar,Sunil Kumar,Radhian Amandito,Roy Quek,Luca Ansaloni,Ahmed Altibi,Donatas Venskutonis,Justas Zilinskas,Tomas Poskus,John Whitaker,Vanessa Msosa,Yong Yong Tew,Alexia Farrugia,Elaine Borg,Zineb Bentounsi,Tanzeela Gala,Ibrahim Al-Slaibi,Haya Tahboub,Osaid H Alser,Diego Romani,Sebestian Shu,Piotr Major,Aurel Mironescu,Matei Bratu,Amar Kourdouli,Aliyu Ndajiwo,Abdulaziz Altwijri,Mohammed Ubaid Alsaggaf,Ahmad Gudal,Sam Seisay,Bettina Lieske,Irene Ortega,Jenifa Jeyakumar,Kithsiri J Senanayake,Omar Abdulbagi,Yucel Cengiz,Dmitri Raptis,Yuksel Altinel,Chia Kong,Ella Teasdale,Gareth Irwin,Michael Stoddart,Rakan Kabariti,Sukrit Suresh,Katherine Gash,Ragavan Narayanan,Mayaba Maimbo,Besmir Grizhja,Shpetim Ymeri,Gezim Galiqi,Roberto Klappenbach,Diego Antezana,Alvaro Enrique Mendoza Beleño,Cecilia Costa,Belen Sanchez,Susan Aviles,Claudio Gabriel Fermani,Rubén Balmaceda,Santiago Villalobos,Juan Manuel Carmona,Daniel Hamill,Peter Deutschmann,Simone Sandler,Daniel Cox,Ram Nataraja,Claire Sharpin,Damir Ljuhar,Demi Gray,Morgan Haines,Dush Iyer,Nithya Niranjan,Scott D'Amours,Morvarid Ashtari

Journal

BJA open

Published Date

2023/9/1

Monkeypox-Associated Manifestations and Complications Involving the Eye: A Systematic Review and Meta-Analysis of Previous and Current Outbreaks

Purpose:The purpose of this study was to pool the prevalence rate of monkeypox-associated eye manifestations and/or complications during the current and previous outbreaks.Design:A systematic review and meta-analysis.Materials and Methods:On August 7, 2022, PubMed, Scopus, Web of Science, EMBASE, and Google Scholar were searched for relevant articles. We included all studies that reported the involvement of the eye (either as a manifestation or a complication) among patients with monkeypox. The primary outcome included pooling the effect size (ES) of reported manifestations and complications, and the secondary outcome included the conduct of a subgroup analysis based on the timing of the monkeypox outbreak (before vs. during 2022).Results:Eleven studies reporting 3179 monkeypox-confirmed cases were included. Eye manifestations included conjunctivitis, corneal, conjunctival, and eyelid …

Authors

Abdelaziz Abdelaal,Abdullah Reda,Abdul Rhman Hassan,Abdelhafeez Mashaal,Hashem Abu Serhan,Basant E Katamesh,Basel Abdelazeem,Aroop Mohanty,Bijaya K Padhi,Alfonso J Rodriguez-Morales,Ranjit Sah

Published Date

2023/5/1

Oral manifestations of mpox: A common presentation?

Mpox (formerly known as “monkeypox”) virus (MPXV) started to appear in humans in 1970 after the eradication of smallpox in 1968. The first outbreak of the disease was reported in the Democratic Republic of the Congo, and since then it has spread mainly in the central and western regions of Africa. MPXV is a double-stranded DNA virus of the Orthopoxvirus genus of the Poxviridae family. Mpox (MPX) was first known as a zoonotic disease transmitted from tree squirrels, rope squirrels, Gambian pouched rats, and other animals. However, evidence has not confirmed a particular reservoir. The disease can be transmitted from animals to humans through direct contact with body fluids or contagious lesions on the animal. It can also be shared between humans through direct contact with skin lesions and contaminated objects. In places of prolonged personal contact (that is, in households), it can be transmitted through …

Authors

Ranjit Sah,Abdelmonem Siddiq,Abdullah Reda,Abdelaziz Abdelaal,Bijaya Kumar Padhi,Aroop Mohanty,Mohammed Amir Rais,Antonio Cascio,Alfonso J Rodriguez-Morales

Journal

The Journal of the American Dental Association

Published Date

2023/4/1

Unravelling COVID-19 vaccination attributes worldwide: an extensive review regarding uptake, hesitancy, and future implication

Since the declaration of the coronavirus disease 2019 pandemic, all efforts were directed towards limiting the transfer of the disease and preventing severe disease forms from occurring. In this regard, numerous vaccines were quickly developed to limit the associated morbidity and mortality of the disease and to reduce the burden on healthcare systems worldwide. However, to date, vaccine hesitancy remains a major limitation to vaccine distribution, with varying degrees in different countries. Therefore, the authors conducted this literature review to highlight the magnitude of this issue throughout the globe and summarize some of its major causes (ie governmental, healthcare system-related, population-related, and vaccine-related) and contributing factors (ie knowledge/awareness, social media, etc.). In addition, the authors highlighted some of the main motivating factors that can minimize the burden of vaccine …

Authors

Hossam T Ali,Yara Ashour,Mohammed A Rais,Mostafa Barakat,Tasnim A Rezeq,Mohamed M Sharkawy,Mina Lapic,Ziad A Soliman,Ahmed Abdullah,Abdulrahman Allahham,Abdelaziz Abdelaal,Samar A Amer,Ranjana Rohilla,Aroop Mohanty,Ranjit Sah

Published Date

2023/7/1

Preferred Practice Patterns of Congenital Nasolacrimal Duct Obstruction in Jordan

PurposeCongenital nasolacrimal duct obstruction (CNLDO) is fairly common in newborns. The main aim of this cross-sectional study is to assess the preferred practice patterns of CNLDO among ophthalmologists in Jordan.MethodsThis cross-sectional study was conducted across all ophthalmological practices in Jordan, using convenience sampling. An online questionnaire, designed through Google Forms, was distributed through social media. The survey contained four domains: baseline characteristics of participants and the diagnosis (7 items), medical management (3 items), and surgical management (11 items) of CNLDO. Descriptive statistics were conducted using SPSS (IBM SPSS Corp, SPSS Statistics ver. 26, USA).ResultsEighty-three physicians responded to the survey, with an average age of 40.6 ± 8.6. More than half of the participants (53.0%, n = 44) were general ophthalmologists. Only 37.3% of our …

Authors

Hashem Abu Serhan,Jehad Feras AlSamhori,Abdelmonem Siddiq,Abdul Rhman Hassan,Sara Irshaidat,Leen Abu Serhan,Abdullah Alawadhi,Abdelaziz Abdelaal,Wejdan Al-Thawabieh

Journal

Clinical Ophthalmology

Published Date

2023/12/31

Protection against the recent Monkeypox outbreaks: what options do we have? Correspondence

Since the reporting of the first case of monkeypox (MPX) in the UK on May 7, 2022, it has infected about 62,406 confirmed cases by September 19, 2022, in 97 countries that have not historically reported MPX, including Spain, and the United Kingdom (UK), Portugal, Germany, and Canada. However, 20 total deaths have been reported so far. Most of the cases in the UK were males with a history of sexual intercourse either with other men or bisexual men, and the age lies between 20 to 49 years. Furthermore, most affected cases without a history of travel to endemic regions [1, 2].Monkeypox virus (MPXV) is a double-stranded DNA virus closely related to the smallpox virus since they belong to the same genus, Orthopoxvirus [3]. However, MPXV is associated with a lower mortality rate of 10% for the Congo Basin clade (and around 3% for the West Africa clade) versus 30% for smallpox (variola major)[4]. Furthermore …

Authors

Ramadan Abdelmoez Farahat,Amira Y Benmelouka,Emery Manirambona,Amro A El-Sakka,Tareq Al-Ahdal,Khaled Albakri,Abdelaziz Abdelaal,Basel Abdelazeem,Ranjit Sah,Alfonso J Rodriguez-Morales

Journal

International Journal of Surgery

Published Date

2023/3/17

Are There Clinically-Significant Intraocular Pressure Changes in the Fellow Untreated Eye Following Laser Peripheral Iridotomy of the Diseased Eye?

Purpose: There are no guidelines regarding the monitoring of the intraocular pressure (IOP) of untreated eyes following glaucoma surgery. This meta-analysis studies the IOP change in fellow untreated eyes after laser peripheral iridotomy (LPI).Methods: Nine randomized controlled trials (3146 patients, 6292 eyes) were included following a systematic search of 9 databases [protocol: CRD42022364618]. The primary outcome included pre-vs. post-operative IOP change. A clinically significant difference was defined as≤ 2 mmHg change. Secondary outcomes included the prevalence of composite outcome (acute angle closure glaucoma (AACG), acute angle closure (AAC), or both) or peripheral anterior synechia (PAS), as well as the change in angle width and limbal anterior chamber depth (ACD). The revised Cochrane tool was used to assess the risk of bias (ROB). Analyses were conducted using STATA. The crude mean difference (MD) was calculated for continuous outcomes, and the pooled effect size (ES) was used to calculate the prevalence. The assessment of publication bias was not applicable, and the sensitivity analysis revealed no significant changes in reported estimates.Results: All trials were of low ROB. No statistically nor clinically significant IOP changes were noted [6 studies/3048 eyes, MD=-0.17; 95% CI:-1.05: 0.70; I 2= 96.58%]. This change remained insignificant throughout follow-up [6-54 months]. IOP rise by at least 5, 8, or 10 mmHg occurred in 5%[3 studies/3390 eyes, 95% CI: 4-6%; I 2= 0%], 1%[2 studies/3246 eyes, 95% CI: 0-1%; I 2= 0%], and 0%[2 studies/3246 eyes] of eyes, respectively. The composite outcome rarely …

Authors

Abdul Rhman Hassan,Ramadan Abdelmoez Farahat,Kawthar Djebabria,Mohamed Ebrahim,Menna M Aboelkhier,Amro El-Sakka,Miral Farid Shokry Ataya,Mohamed Elsady,Basel Abdelazeem,Hashem Abu Serhan,Basant Katamesh,Abdelaziz Abdelaal

Journal

Investigative Ophthalmology & Visual Science

Published Date

2023/6/1

The Efficacy and Safety of Canaloplasty Vs Trabeculectomy Either Standalone or Combined with Cataract Surgery: An Updated Meta-Analysis

To compare the efficacy and safety between trabeculectomy (TE) and canaloplasty (CP) either as standalone or combined with phacoemulsification (PTE and PCP). Nine databases were searched for studies reporting efficacy and safety of TE/PTE and CP/PCP. Efficacy endpoints included postoperative intraocular pressure (IOP), complete, and qualified success, while safety endpoints included failure, revision surgery, and complications. STATA was used to pool the crude mean difference (MD) or log odds ratio (logOR) for continuous and categorical outcomes, respectively. Fourteen studies were included. TE/PTE was associated with lower IOP when compared to CP/PCP [MD=-2.55; 95% CI=-3.30:-1.80, I 2= 61.43%]. Similarly, TE/PTE was associated with significantly higher odds of complete [logOR= 1.20; 95% CI= 0.79: 1.61, I 2= 7.41] and qualified success [logOR= 0.64; 95% CI= 0.16: 1.13, I 2= 0%] when compared to CP/PCP, respectively. Although no significant differences in failure and revision surgery were noted between TE/PTE and CP/PCP, in the TE subgroup, a significant reduction in failure was observed as compared to CP [logOR=-0.82; 95% CI=-1.61:-0.04, I 2= 28.18%]. TE/PTE was associated with higher odds for hypotony and choroidal detachment and lower odds for Descemet’s membrane detachment and hyphema. TE/PTE has superiority over CP/PCP regarding IOP control and revision surgery rates. However, the certainty of these findings is low to very low.

Authors

Abdelaziz Abdelaal,Helmy Badr,Hashem Abu Serhan,Mohamed Elmallahy,Mohamed Ebrahim,Mohamed Abuelazm,Ahmed Abdallah,Abdulrahman Ebrahim,Basant E Katamesh,Basel Abdelazeem

Published Date

2023/2/14

Monkeypox pandemic containment: does the ACAM2000 vaccine play a role in the current outbreaks?

Abdelaziz Abdelaal Clinical Research Scholar, Harvard Medical School, Boston, MA MMSCI Candidate, Harvard Medical School, Boston, MA Research Fellow, Doheny Eye Institute, University of California, LA Founder, Tanta Research Team, El-Gharbia, Egypt Tanta University Hospitals, Tanta, El-Gharbia, Egypt Email: drabdoseliem@ gmail. com Phone:(20) 1128608660

Authors

Basant E Katamesh,Maysa Madany,Fatma Labieb,Abdelaziz Abdelaal

Published Date

2023/12/31

The Efficacy of Mindfulness Meditation in Medically-Treated Glaucoma

Purpose: Poor patient compliance to medical therapy (MT) has deemed glaucoma difficult to manage. The implementation of mindfulness meditation (MM) may provide better intraocular pressure (IOP) control. This meta-analysis tested the hypothesis that MM can result in a clinically significant reduction in IOP (≥ 2 mmHg) compared to MT alone.Methods: We analyzed 488 eyes, reported in ten randomized controlled trials, following a systematic search of nine databases [protocol: CRD42022316151]. The difference in IOP between MM and MT was our primary outcome. The magnitude of IOP change was assessed based on the type and severity of glaucoma, baseline IOP, duration of MM training, follow-up period, and laterality. Secondary outcomes included quality of life (QoL) and stress markers (cortisol and β-endorphin). STATA Software was used to pool the crude mean difference (MD) across studies, using the …

Authors

Abdelaziz Abdelaal,Mohamed Fayez Fouda,Mohamed Elmallahy,Ali Monir,Mohamed Elhabib,Abdul Rhman Hassan,Heba Fouda,Basant Katamesh,Basel Abdelazeem,Hashem Abu Serhan

Journal

Investigative Ophthalmology & Visual Science

Published Date

2023/6/1

Ophthalmic manifestations of monkeypox virus

Monkeypox virus (MPXV), a double-stranded DNA virus belonging to the Orthopox genus of the Poxviridae family, was first reported as a zoonotic infection transmitted from animals to humans in 1958, with the first human case being reported in 1970. The first human-to-human transmission outbreak was reported in 1996–1997 in the Democratic Republic of Congo through respiratory droplets and direct contact with infected individuals [1]. Then, sexual transmission in men having sex with other men (MSM) became evident [2]. Notably, MPXV re-emerged in May 2022 in multiple countries with no evident epidemiological link between reported cases. As of July 3rd, 2022, the total number of confirmed cases reached 6178 in 56 countries, being highest in Spain (N= 1196), England (N= 1185), Germany (N= 1054), France (N= 498), and the United States (N= 459)(Fig. 1). The presenting symptoms of MPXV are quite …

Authors

Abdelaziz Abdelaal,Hashem Abu Serhan,Mariam Abdelmageed Mahmoud,Alfonso J Rodriguez-Morales,Ranjit Sah

Journal

Eye

Published Date

2023/2

The prevalence and presentation patterns of microcystic macular oedema: a systematic review and meta-analysis of 2128 glaucomatous eyes

We conducted this research to determine the prevalence rate and presentation patterns with microcystic macular oedema (MMO) in glaucoma patients. The protocol was pre-registered on PROSPERO (CRD42022316367). PubMed, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, CENTRAL, clinicaltrials.gov, and Google Scholar were searched for articles reporting MMO in glaucoma patients. The primary outcome was the prevalence of MMO, while secondary outcomes included the comparison between MMO and non-MMO in terms of patients’ characteristics (age, gender), glaucoma stage, and ocular parameters (axial length (AL), intraocular pressure, mean deviation, spherical equivalent). Data are reported as mean difference (MD) or log odds ratio (logOR) along with their corresponding 95% confidence intervals (CI) for continuous and dichotomous outcomes, respectively. The quality of included …

Authors

Abdelaziz Abdelaal,Mennatullah Mohamed Eltaras,Basant E Katamesh,Hashem Abu Serhan,Ramadan Abdelmoez Farahat,Helmy Badr,Basel Abdelazeem

Published Date

2023/11

Use of Telemedicine for Postdischarge Assessment of the Surgical Wound: International Cohort Study, and Systematic Review With Meta-analysis

Objective: This study aimed to determine whether remote wound reviews using telemedicine can be safely upscaled, and if standardized assessment tools are needed.Background: Surgical site infection (SSI) is the most common complication of surgery worldwide, and frequently occurs after hospital discharge. Evidence to support implementation of telemedicine during postoperative recovery will be an essential component of pandemic recovery. Methods: The primary outcome of this study was SSI reported up to 30 days after surgery (SSI), comparing rates reported using telemedicine (telephone and/or video assessment) to those with in-person review. The first part of this study analyzed primary data from an international cohort study of adult patients undergoing abdominal surgery who were discharged from hospital before 30 days after surgery. The second part combined this data with the results of a systematic …

Authors

James Glasbey,Issi Trout,Victoria Adeyeye,Adesoji Ademuyiwa,Adewale Adisa,Alisha Bhatt,Bruce Biccard,Peter Brocklehurst,Sohini Chakrabortee,Jean De La Croix Allen Ingabire,Francis Moïse Dossou,Irani Durán,Rohini Dutta,Dhruva Ghosh,Frank Gyamfi,Pollyanna Hardy,Gabriella Hyman,Ritu Jain,Bryar Kadir,Stephen Knight,Oluwaseun Ladipo-Ajayi,Ismail Lawani,Souliath Lawani,Rachel Lillywhite,Rhiannon Macefield,Laura Magill,Janet Martin,Jonathan Mathers,Kenneth McLean,Unam Mistry,Rohin Mittal,Rachel Moore,Dion Morton,Faustin Ntirenganya,Emmanuel Ofori,Rupert Pearse,Alberto Peón,Thomas Pinkney,Antonio Ramos De La Medina,Tubasiime Ronald,David Roman,Joana Simoes,Anita Slade,Stephen Tabiri,Donna Smith,Ewen Harrison,Aneel Bhangu,Azmina Verjee Emmy Runigamugabo,Adesoji O Ademuyiwa,Adewale O Adisa,Maria Lorena Aguilera,Afnan Altamini,Philip Alexander,Sara W Al-Saqqa,Giuliano Borda-Luque,Jen Cornick,Ainhoa Costas-Chavarri,Thomas M Drake,Stuart J Fergusson,J Edward Fitzgerald,JC Allen Ingabire,Lawani Ismaïl,Zahra Jaffry,Hosni Khairy Salem,Chetan Khatri,Andrew Kirby,Anyomih Theophilus Teddy Kojo,Marie Carmela Lapitan,Richard Lilford,Andre L Mihaljevic,Midhun Mohan,Alphonse Zeta Mutabazi,Dmitri Nepogodiev,Riinu Ots,Francesco Pata,Tomas Poškus,Ahmad Uzair Qureshi,Antonio Ramos-De la Medina,Sarah Rayne,Gustavo Recinos,Kjetil Søreide,Catherine A Shaw,Sebastian Shu,Richard Spence,Neil Smart,Ewen M Harrison,Maria Marta Modolo,Dushyant Iyer,Sebastian King,Tom Arthur,Sayeda Nazmum Nahar,Ade Waterman,Michael Walsh,Arnav Agarwal,Augusto Zani,Mohammed Firdouse,Tyler Rouse,Qinyang Liu,Juan Camilo Correa,Peep Talving,Mengistu Worku,Alexis Arnaud,Vassilis Kalles,Basant Kumar,Sunil Kumar,Radhian Amandito,Roy Quek,Luca Ansaloni,Ahmed Altibi,Donatas Venskutonis,Justas Zilinskas,Tomas Poskus,John Whitaker,Vanessa Msosa,Yong Yong Tew,Alexia Farrugia,Elaine Borg,Zineb Bentounsi,Tanzeela Gala,Ibrahim Al-Slaibi,Haya Tahboub,Osaid H Alser,Diego Romani,Sebestian Shu,Piotr Major,Aurel Mironescu,Matei Bratu,Amar Kourdouli,Aliyu Ndajiwo,Abdulaziz Altwijri,Mohammed Ubaid Alsaggaf,Ahmad Gudal,Sam Seisay,Bettina Lieske,Irene Ortega,Jenifa Jeyakumar,Kithsiri J Senanayake,Omar Abdulbagi,Yucel Cengiz,Dmitri Raptis,Yuksel Altinel,Chia Kong,Ella Teasdale,Gareth Irwin,Michael Stoddart,Rakan Kabariti,Sukrit Suresh,Katherine Gash,Ragavan Narayanan,Mayaba Maimbo

Published Date

2023/6

Monkeypox reported in India–South East Asia region: health and economic challenges

South-East Asia (SEA) consists of multiple countries that differ in their economic, social, and health status. There is an urgent need for modernization of the existing infrastructure and diagnostic facilities. With the constant increase in the population of these countries, there is a huge pressure on the already exhausted healthcare system in the form of reduced healthcare workers’(HCWs) efficiency, lack of funding directed towards healthcare advancement, and the re-emergence of communicable diseases. 1 India witnessed a similar situation during the COVID-19 outbreak when the whole health system was severely affected with a substantial negative impact on HCWs’ mental health. The country was on lockdown and health facilities were overfilled with COVID-19 patients. Simultaneously, non-COVID patients could not access regular healthcare services. As the COVID-19 pandemic unraveled the exhausted …

Authors

Ranjit Sah,Aroop Mohanty,Abdelmonem Siddiq,Parul Singh,Abdelaziz Abdelaal,Najim Z Alshahrani,Kuldeep Dhama

Journal

The Lancet Regional Health-Southeast Asia

Published Date

2022/9/1

Monkeypox in children: what evidence do we have so far?

Monkeypox virus (MPX) is a double-stranded DNA virus that belongs to the Orthopoxviral genera of the Poxviridae family, which is endemic in Central and West Africa. MPX appeared in 1970, since eradication of smallpox. Apparently, smallpox provides a significant cross-protection (> 85%) with monkeypox, but probably most important in individuals with recent vaccination (< 10years). It has been suggested that older population (> 60years), vaccinated with smallpox would be partially protected. Nevertheless, this needs further careful assessment. Animal-to-human transmission (zoonotic infection) can occur through contact with blood, body fluids and skin lesions of infected animals such as arboreal and terrestrial rodents (which include squirrels). Long-term exposure to MPX results in human-to-human transmission through droplet infection, contact with an infected lesion or a contaminated object [1]. As per the …

Authors

Ranjit Sah,Alaa I Abdelrahman,Sanjit Sah,Abdelaziz Abdelaal,Abdelmonem Siddiq,Alfonso J Rodriguez-Morales

Published Date

2022/10/1

Major sporting events amid monkeypox and COVID-19 outbreaks: Considering the impact upon the traveller

2 confident they will be treated sensitively and appropriately [10]. In conclusion, organizing major sporting events must be continued, as suspending them brings extensive logistical and economic difficulties. However, countries organizing these events must not solely focus on preventive measures. They must also help alleviate the fears and concerns of travellers, help educate them, and ensure that travelling is not stressful.

Authors

Ranjit Sah,Najim Z Alshahrani,Michael G Head,Abdelaziz Abdelaal,Aroop Mohanty,Bijaya Kumar Padhi,Alfonso J Rodriguez-Morales

Journal

International journal of surgery open

Published Date

2022/12/1

Chest imaging features of Coronavirus disease 2019 pneumonia: a systematic review and meta-analysis

Unable to write in log file ../../bases/logs/gimorg/logerror.txt Chest imaging features of Coronavirus disease 2019 pneumonia: a systematic review and meta-analysis | Minerva Respiratory Medicine; 61(1):16-26, 2022. | EMBASE Conteúdo principal 1 Busca 2 Rodapé 3 +A A -A Alto contraste Base de dados da OMS sobre COVID-19 العربية 中文 (中国) english français Русский español português Notícias/Atualização/Ajuda Busca Avançada Pesquisar 1.Home 2.Pesquisa 3.Chest imaging features of Coronavirus disease 2019 pneumonia: a systematic review and meta Chest imaging features of Coronavirus disease 2019 pneumonia: a systematic review and meta-analysis Low, SK; Luu, MN; Minh, LH; Abdelaal, A.; Jia Ng, S.; Gad, AG; Nhi, LH; Le, TN; Huy, NT. Minerva Respiratory Medicine ; 61(1):16-26, 2022. Artigo em Inglês | EMBASE | ID: covidwho-1856584 Palavras-chave adult; coronavirus disease 2019; female…

Authors

SK Low,MN Luu,LH Minh,A Abdelaal,S Jia Ng,AG Gad,LH Nhi,TN Le,NT Huy

Published Date

2022

Monkeypox and its possible sexual transmission: where are we now with its evidence?

Monkeypox is a rare disease but is increasing in incidence in different countries since the first case was diagnosed in the UK by the United Kingdom (UK) Health Security Agency on 6 May 2022. As of 9 August, almost 32,000 cases have been identified in 89 countries. In endemic areas, the monkeypox virus (MPXV) is commonly transmitted through zoonosis, while in non-endemic regions, it is spread through human-to-human transmission. Symptoms can include flu-like symptoms, rash, or sores on the hands, feet, genitalia, or anus. In addition, people who did not take the smallpox vaccine were more likely to be infected than others. The exact pathogenesis and mechanisms are still unclear; however, most identified cases are reported in men who have sex with other men (MSM). According to the CDC, transmission can happen with any sexual or non-sexual contact with the infected person. However, a recent pooled meta-analysis reported that sexual contact is involved in more than 91% of cases. Moreover, it is the first time that semen analysis for many patients has shown positive monkeypox virus DNA. Therefore, in this review, we will describe transmission methods for MPXV while focusing mainly on potential sexual transmission and associated sexually transmitted infections. We will also highlight the preventive measures that can limit the spread of the diseases in this regard.

Authors

Ranjit Sah,Abdelaziz Abdelaal,Abdullah Reda,Basant E Katamesh,Emery Manirambona,Hanaa Abdelmonem,Rachana Mehta,Ali A Rabaan,Saad Alhumaid,Wadha A Alfouzan,Amer I Alomar,Faryal Khamis,Fadwa S Alofi,Maha H Aljohani,Amal H Alfaraj,Mubarak Alfaresi,Jumana M Al-Jishi,Jameela Alsalman,Ahlam Alynbiawi,Mohammed S Almogbel,Alfonso J Rodriguez-Morales

Published Date

2022/8/17

Successful mechanical thrombectomy in acute ischemic stroke: revascularization grade and functional independence

Most studies define the technical success of endovascular thrombectomy (EVT) as a Thrombolysis in Cerebral Infarction (TICI) revascularization grade of 2b or higher. However, growing evidence suggests that TICI 3 is the best angiographic predictor of improved functional outcomes. To assess the association between successful TICI revascularization grades and functional independence at 90 days, we performed a systematic review and network meta-analysis of thrombectomy studies that reported TICI scores and functional outcomes, measured by the modified Rankin Scale, using the semi-automated AutoLit software platform. Forty studies with 8691 patients were included in the quantitative synthesis. Across TICI, modified TICI (mTICI), and expanded TICI (eTICI), the highest rate of good functional outcomes was observed in patients with TICI 3 recanalization, followed by those with TICI 2c and TICI 2b …

Authors

Sherief Ghozy,Salah Eddine Oussama Kacimi,Ahmed Y Azzam,Ramadan Abdelmoez Farahat,Abdelaziz Abdelaal,Kevin M Kallmes,Gautam Adusumilli,Jeremy J Heit,Ramanathan Kadirvel,David F Kallmes

Published Date

2022/8/1

The emergence of cholera in multiple countries amidst current COVID-19 pandemic: situation and implications for public health and travel medicine

Cholera is an acute infection caused by Vibrio cholerae, mainly leading to secretory diarrhoea. Although most cases are asymptomatic, some patients might suffer from dehydration and electrolyte imbalance, and if not appropriately managed, these patients might die from shock. In addition, different risk factors might predispose to cholera outbreaks, including natural diseases, hot weather, contaminated water, and poor sanitation [1]. Recent reports from different worldwide countries have shown cholera outbreaks in their communities (Fig. 1). According to the European Centre for Disease Prevention and Control (ECDC), around 30,629 worldwide cases of cholera, including 36 deaths, were reported by February 16, 2022. In addition, the number of suspected cases reached 262,955 by May 31, 2022, including 63 deaths (Fig. 1)[2]. However, the accurate numbers are expected to be higher than the announced ones …

Authors

Abduallah Reda,Ranjit Sah,Abdelaziz Abdelaal,Sunil Shrestha,Alfonso J Rodriguez-Morales

Journal

Travel Medicine and Infectious Disease

Published Date

2022/9

Monkeypox and occupational exposure: Potential risk toward healthcare workers and recommended actions

Monkeypox virus (MPXV) is the microorganism responsible for causing the zoonotic disease known as Monkeypox (MPX). It is a double-stranded DNA virus belonging to the Orthopoxvirus genus of the Poxviridae family (1). Other important viruses of this family include the variola virus which causes the smallpox disease and the vaccinia virus which is utilized to manufacture the smallpox vaccine. The first case of human MPX was seen in 1970 in a pediatric patient in the Democratic Republic of Congo (DPR). Since then, the disease was limited to the African continent with only a few sporadic outbreaks outside of endemic regions. However, during the recent multi-country outbreak of MPX, more than 89 countries have been affected, and the majority of them are reporting MPX cases for the first time (2, 3).Although human-to-human transmission of the disease has become more evident in the recent outbreak, the risk of occupational exposure, particularly in healthcare settings, should be carefully addressed. A recent review highlighted that there is a low risk of exposure to MPX in non-endemic healthcare settings; however, the level of evidence remains limited (4). A dreaded picture was seen during the COVID-19 pandemic when more than 115,000 healthcare workers (HCWs) lost their life due to this fatal disease (5). Important to say, HCWs constituted a significant proportion of all COVID-19 patients. Similarly, in the present MPX outbreak, the nosocomial transmission of MXPV can occur, potentially leading to the deaths of HCWs, which can, subsequently, turn this disease into an occupational hazard.

Authors

Ranjit Sah,Aroop Mohanty,Parul Singh,Abdelaziz Abdelaal,Bijaya Kumar Padhi

Journal

Frontiers in Public Health

Published Date

2022/9/26

Current monkeypox outbreak: lessons from ancient history in Egyptian mummies?

Tracking the history and origin of an infectious disease can help to predict and better treat its modern descendants, according to paleopathology. Egyptian mummies are an ideal population in which to study the prevalence of infectious diseases in the ancient world. 1 Some of the most common organisms found in Egyptian mummies were Schistosoma haematobium, Mycobacterium tuberculosis, and variola virus. 1 The current global monkeypox outbreak has caused more than 16 000 cases in over 70 countries, and has been declared a public health emergency of international concern. 2 Monkeypox is caused by a DNA virus called monkeypox virus, belonging to the Orthopoxvirusgenus which includes the variola virus, causing smallpox—hence the similarity between both viruses in terms of genetic structure, clinical presentation, and target vaccinations. 3

Authors

Ramadan Abdelmoez Farahat,Jaffer Shah,Abdelaziz Abdelaal

Journal

The Lancet Microbe

Published Date

2022/12/1

The characteristics of COVID-19 vaccine-associated uveitis: a summative systematic review

Numerous complications following COVID-19 vaccination has been reported in the literature, with an increasing body of evidence reporting vaccination-associated uveitis (VAU). In this systematic review, we searched six electronic databases for articles reporting the occurrence of VAU following COVID-19 vaccination. Data were synthesized with emphasis on patients’ characteristics [age, gender], vaccination characteristics [type, dose], and outcome findings [type, nature, laterality, course, location, onset, underlying cause, and associated findings]. Data are presented as numbers (percentages) for categorical data and as mean (standard deviation) for continuous data. Sixty-five studies were finally included [43 case reports, 16 case series, four cohort, one cross-sectional, and one registry-based study]. VAU occurred in 1526 cases, most commonly in females (68.93%) and middle-aged individuals (41–50 years: 19.71%), following the first dose (49.35%) of vaccination, especially in those who received Pfizer (77.90%). VAU occurred acutely (71.77%) as an inflammatory reaction (88.29%) in unilateral eyes (77.69%), particularly in the anterior portion of the uvea (54.13%). Importantly, most cases had a new onset (69.92%) while only a limited portion of cases had a reactivation of previous uveitis condition. In conclusion, although rare, uveitis following COVID-19 vaccination should be considered in new-onset and recurrent cases presenting with either acute or chronic events.

Authors

Yasmine Yousra Sadok Cherif,Chakib Djeffal,Hashem Abu Serhan,Ahmed Elnahhas,Hebatallah Yousef,Basant E Katamesh,Basel Abdelazeem,Abdelaziz Abdelaal

Published Date

2022/12/28

The emergence of SARS-CoV-2 Omicron subvariants: current situation and future trends

The SARS-CoV-2 Omicron variant (B. 1.1. 529) has been the most recent variant of concern (VOC) established by the World Health Organization (WHO). Because of its greater infectivity and immune evasion, this variant quickly became the dominant type of circulating SARS-CoV-2 worldwide. Our literature review thoroughly explains the current state of Omicron emergence, particularly by comparing different omicron subvariants, including BA. 2, BA. 1, and BA. 3. Such elaboration would be based on structural variations, mutations, clinical manifestation, transmissibility, pathogenicity, and vaccination effectiveness. The most notable difference between the three subvariants is the insufficiency of deletion (Δ69-70) in the spike protein, which results in a lower detection rate of the spike (S) gene target known as (S) gene target failure (SGTF). Furthermore, BA. 2 had a stronger affinity to the human Angiotensin-converting …

Authors

Ramadan Abdelmoez Farahat,Abdelaziz Abdelaal,Tungki Pratama Umar,Amro A El-Sakka,Amira Yasmine Benmelouka,Khaled Albakri,Iftikhar Ali,Tareq Al-Ahdal,Basel Abdelazeem,Ranjit Sah,Alfonso J Rodriguez-Morales

Published Date

2022

Monkeypox: A potential pandemic at door of Asia

[3] CDC Multistate, Outbreak of monkeypox–Illinois, Indiana, and Wisconsin, MMWR 606 Morb Mortal Wkly Rep. 52 (2003) 537–540, 2003.[4] D. Kopecki, Monkeypox outbreak is primarily spreading through sex, WHO officials say (2022). https://www. cnbc. com/2022/05/23/monkeypox-outbreak-i s-primarily-spreading through-sex-who-officials-say. html.(Accessed 19 July 2022).[5] CDC, Monkeypox Outbreak Global Map, 2022. https://www. cdc. gov/poxvirus/m o nkeypox/response/2022/world-map. html.

Authors

Ranjit Sah,Aroop Mohanty,Abdullah Reda,Basant Ismail Lashin,Abdelaziz Abdelaal,Rama Shankar Rath,Alfonso J Rodriguez-Morales

Journal

Annals of Medicine and Surgery

Published Date

2022/9/1

Prognostic factors impacting survival rates of hypopharyngeal cancer with nomogram prediction: a SEER-based study

BackgroundWe analyzed prognostic factors of hypopharyngeal carcinoma and developed a nomogram to predict survival rates in non-metastatic (M0) patients.Subjects and methodsWe included 4068 hypopharyngeal carcinoma patients identified from the Surveillance, Epidemiology, and End Results Program database between 2004 and 2015 in a retrospective cohort study. We analyzed prognostic factors of hypopharyngeal carcinoma using cause-specific and overall survival rates. We developed a nomogram to predict patients’ survival rates by multivariate Cox regression.ResultsFive-year survival rates of all stages between 2004 and 2010 were 25–35%. Radiotherapy pre- and post-surgery was the best modality of treatment according to 1-year and 5-year survival rates. The worst survival was in the posterior wall of the hypopharynx significantly (HRs [95% CI], P) (1.238 [1.045–1.466], P = 0.013). The highest …

Authors

Gehad Mohamed Tawfik,Nguyen Lam Vuong,Ahmad Helmy Zayan,Abdelaziz Abdelaal,Thuan Minh Tieu,To Kim Sang,Amr Ebied,Amr G Shafik,Nguyen Tien Huy

Journal

The Egyptian Journal of Otolaryngology

Published Date

2022/12

Ocular vascular events following COVID-19 vaccines: a systematic review

The main aim of this study is to investigate the current evidence regarding the association between COVID-19 vaccination and ocular vascular events. The protocol is registered on PROSPERO (CRD42022358133). On 18 August 2022, an electronic search was conducted through five databases. All original articles reporting individuals who were vaccinated with COVID-19 vaccines and developed ophthalmic vascular events were included. The methodological quality of the included studies was assessed using the NIH tool. A total of 49 studies with 130 ocular vascular cases were included. Venous occlusive events were the most common events (54.3%), which mostly occurred following the first dose (46.2%) and within the first five days following vaccination (46.2%). Vascular events occurred more with the Pfizer and AstraZeneca vaccines (81.6%), and mostly presented unilaterally (73.8%). The most frequently reported treatment was intravitreal anti-VEGF (n = 39, 30.4%). The majority of patients (90.1%) demonstrated either improvement (p = 0.321) or persistence (p = 0.414) in the final BCVA. Ophthalmic vascular events are serious vision-threatening side effects that have been associated with COVID-19 vaccination. Clinicians should be aware of the possible association between COVID-19 vaccines and ocular vascular events to provide early diagnosis and treatment.

Authors

Hashem Abu Serhan,Abdelaziz Abdelaal,Mohammad T Abuawwad,Mohammad JJ Taha,Sara Irshaidat,Leen Abu Serhan,Luai Abu-Ismail,Qusai Faisal Abu Salim,Basel Abdelazeem,Ayman G Elnahry

Published Date

2022/12/14

Monkeypox outbreaks during COVID-19 pandemic: are we looking at an independent phenomenon or an overlapping pandemic?

The monkeypox outbreak has emerged in 13 countries and increased alarmingly since the first confirmed case in the UK on May 7, 2022 [1]. The WHO has reported 28 suspected and 92 confirmed cases of monkeypox in 12 non-endemic countries as of May 21 [2]. Monkeypox represents a possible public health problem that needs appropriate attention to prevent an outbreak. Monkeypox is a zoonotic viral disease (Fig. 1) caused by a double-strand enveloped DNA virus, a member of the Poxviridae family under the umbrella of the Orthopoxvirus genus, including smallpox. Monkeypox is transmitted mainly by direct animal contact via bodily fluids, blood, aerosol, or infected lesions (Fig. 1). Furthermore, it can be through human-to-human close contact or respiratory secretions (Fig. 1), similar to smallpox in terms of the clinical features and formation of serologically cross-reactive immunity. Interestingly, WHO reported …

Authors

Ramadan Abdelmoez Farahat,Abdelaziz Abdelaal,Jaffer Shah,Sherief Ghozy,Ranjit Sah,D Katterine Bonilla-Aldana,Alfonso J Rodriguez-Morales,Timothy D McHugh,Hakan Leblebicioglu

Journal

Annals of clinical microbiology and antimicrobials

Published Date

2022/6/15

First Monkeypox deaths outside Africa: no room for complacency

TherapeuTic advances in infectious disease outbreaks–especially with the Congo basin strain–mortality was common among young children. 11 In those cases, researchers hypothesize the potential role of occasional co-infection with Varicella zoster virus (VZV). Experimental aerosolized MPXV infection among cynomolgus monkeys produced a fatal fibrinonecrotic bronchopneumonia 1–2 weeks after exposure. 12 In animal models, high MPXV viremias and neutropenias have been implicated in fatal gramme-positive sepsis. 13 Future autopsy histopathology analyses from fatal cases are needed to elucidate specific viral mechanisms of death.Five deaths, among 37,632 cases in non-endemic countries represents, theoretically, a case fatality rate (CFR%) of 0.01%, compared with 1.81% in endemic countries during 2022 (183 times higher)(Table 1). Nevertheless, there are regional differences (Table 1). The …

Authors

Ranjit Sah,Aroop Mohanty,Abdelaziz Abdelaal,Abdullah Reda,Alfonso J Rodriguez-Morales,Andres F Henao-Martinez

Published Date

2022/8

Monkeypox and human transmission: Are we on the verge of another pandemic?

Since the disease was discovered in 1970, monkeypox has been declared endemic in some countries, particularly in the west and central Africa [1]. The number of outbreaks increased over time, with 35 outbreaks occurring outside the Democratic Republic of the Congo (DRC), their majority have happened since 2010 [2]. The majority of cases were identified in rural areas and small villages located near tropical forests where human-animal interactions are frequent [3]. Recently, many cases have increasingly emerged in different regions of the world. The first case was documented in the United Kingdom. The total number of recorded cases since May 7th, 2022 has been 993 cases; 917 of them were confirmed within 29 countries. However, there have been no deaths during this period. The most common affected countries are UK (n= 225), Spain (n= 186), Portugal (n= 143), Canada (n= 80) and Germany (n= 67 …

Authors

Ramadan Abdelmoez Farahat,Iftikhar Ali,AL-Ahdal Tareq,Amira Yasmine Benmelouka,Khaled Albakri,Amro A El-Sakka,Abdelaziz Abdelaal,Basel Abdelazeem,Mohammed Moustapha Anwar,Rachana Mehta,Ranjana Sah,Ramhari Rouniyar,Ranjit Sah

Journal

Travel medicine and infectious disease

Published Date

2022/9

The resurfacing of hand, foot, and mouth disease: Are we on the verge of another epidemic?

[1] State Reports 26 Hand, Foot & Mouth Disease Cases; Don’t Panic, Says Govt| Bhubaneswar News-Times of India nd https://timesofindia. indiatimes. com/city/bhubaneswar/state-reports-26-hand-foot-mouth-disease-cases-dont-panic-saysgovt/articleshow/91775999. cms (accessed May 28, 2022).[2] L. Yi, H. Zeng, H. Zheng, J. Peng, X. Guo, L. Liu, et al., Molecular surveillance of coxsackievirus A16 in southern China, 2008–2019, Arch. Virol. 166 (2021) 1653–1659, https://doi. org/10.1007/s00705-021-05052-8.[3] BD Kimmis, C. Downing, S. Tyring, Hand-foot-and-mouth disease caused by coxsackievirus A6 on the rise, Cutis 102 (2018) 353–356.[4] foot Hand, mouth disease, First vaccine 2022, https://www. bbc. com/news/healt h-22689593.(Accessed 28 May 2022).[5] Z. Zhao, C. Zheng, H. Qi, Y. Chen, MP Ward, F. Liu, et al., Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and …

Authors

Ramadan Abdelmoez Farahat,Nour Shaheen,Mrinmoy Kundu,Ahmed Shaheen,Abdelaziz Abdelaal

Journal

Annals of Medicine and Surgery

Published Date

2022/9/1

A potential monkeypox pandemic: Are we making the same mistakes as COVID-19

The increasing trend in monkeypox (MPX) cases raises severe concerns about the roles of 9 healthcare authorities in preventing another pandemic when the globe did not recover yet from 10 a close one; COVID-19. Therefore, it is essential to shedding light on the current mistakes in 11 fighting the MPX outbreak and potential lessons learned from the COVID-19 pandemic for 12 MPX containment (Figure 1)[1]. 13A serious issue is the massive lack of relevant data on different aspects of the disease, 14 discovered in 1958. The exact way of viral transmission that led to the current outbreak is not 15 clear. It is only based on past reports regarding animal contact (outbreaks in Africa) and has a 16 travel history to Africa (only for a few of them). A better understanding of the disease should 17 allow the dissemination of all related data, facilitating access, relieving restrictions on data 18 collection strategies, and strengthening active surveillance. 19

Authors

Ranjit Sah,Abdullah Reda,Abdelaziz Abdelaal,Aroop Mohanty,Abdelmonem Siddiq,Najim Z Alshahrani,Fatma A Amer,Alfonso J Rodriguez-Morales

Journal

New Microbes New Infect

Published Date

2022/11/1

Knowledge and attitude regarding monkeypox virus among physicians in Saudi Arabia: a cross-sectional study

The growing incidence of human monkeypox cases emphasizes the significance of prevention, early detection, and prompt responses for healthcare providers. The aim of this study was to assess the knowledge and attitudes toward monkeypox infection among physicians, a frontline healthcare worker group, in Saudi Arabia. A cross-sectional survey assessing knowledge and attitudes towards monkeypox infection on multiple-item scales was sent to physicians in Saudi Arabia. The associations between independent factors and either knowledge or attitude were assessed. The final analysis included 398 participants. Approximately 55% of the surveyed participants had a “good knowledge” score about human monkeypox. The adjusted logistic regression analysis showed that being a female physician, working in the private sector, and having information on human monkeypox during medical school or residency years were the only factors associated with a good level of knowledge about human monkeypox. However, physicians’ knowledge and attitudes regarding monkeypox infection are inadequate and influenced by various factors. There is a significant knowledge gap between the therapeutic management of monkeypox and its vaccination. Training and knowledge assessments are important, especially when studies show significant improvement in related and specific knowledge.

Authors

Najim Z Alshahrani,Mohammed R Algethami,Abdullah M Alarifi,Faris Alzahrani,Eman A Alshehri,Aishah M Alshehri,Haytham Abdulwhab Sheerah,Abdelaziz Abdelaal,Ranjit Sah,Alfonso J Rodriguez-Morales

Journal

Vaccines

Published Date

2022/12/8

Human monkeypox disease (MPX)

Monkeypox is a rare viral infection, endemic in many central and western African countries. The last international outbreak of monkeypox reported outside Africa occurred back in 2003. However, monkeypox has reemerged at a global scale with numerous confirmed cases across the globe in 2022. The rapid spread of cases through different countries has raised serious concerns among public health officials worldwide prompting accelerated investigations aimed to identify the origins and cause of the rapid expansion of cases. The current situation is reminiscent of the very early stages of the still ongoing COVID-19 pandemic. Overlapping features between these, two seemingly alike viral entities include the possibility for airborne transmission and the currently unexplained and rapid spread across borders. Early recognition of cases and timely intervention of potential transmission chains are necessary to contain …

Journal

Le Infezioni in Medicina

Published Date

2022/7/24

Monkeypox virus containment: the application of ring vaccination and possible challenges

Due to the pandemic potential of monkeypox, the application of ring vaccination would be of great value in breaking the chain of transmission as well as in preventing the occurrence of this severe disease. Accompanying challenges should be overcome to properly contain the disease before it is declared as pandemic.

Authors

Ranjit Sah,Abdelaziz Abdelaal,Ankush Asija,Soney Basnyat,Yub Raj Sedhai,Sadikshya Ghimire,Sanjit Sah,D Katterine Bonilla-Aldana,Alfonso J Rodriguez-Morales

Journal

Journal of Travel Medicine

Published Date

2022/8

Preventing the next pandemic: is live vaccine efficacious against monkeypox, or is there a need for killed virus and mRNA vaccines?

(1) Background: The monkeypox virus (MPV) is a double-stranded DNA virus belonging to the Poxviridae family, Chordopoxvirinae subfamily, and Orthopoxvirus genus. It was called monkeypox because it was first discovered in monkeys, in a Danish laboratory, in 1958. However, the actual reservoir for MPV is still unknown. (2) Methods and Results: We have reviewed the existing literature on the options for Monkeypox virus. There are three available vaccines for orthopoxviruses—ACAM2000, JYNNEOS, and LC16—with the first being a replicating vaccine and the latter being non- or minimally replicating. (3) Conclusions: Smallpox vaccinations previously provided coincidental immunity to MPV. ACAM2000 (a live-attenuated replicating vaccine) and JYNNEOS (a live-attenuated, nonreplicating vaccine) are two US FDA-approved vaccines that can prevent monkeypox. However, ACAM2000 may cause serious side effects, including cardiac problems, whereas JYNNEOS is associated with fewer complications. The recent outbreaks across the globe have once again highlighted the need for constant monitoring and the development of novel prophylactic and therapeutic modalities. Based on available data, there is still a need to develop an effective and safe new generation of vaccines specific for monkeypox that are killed or developed into a mRNA vaccine before monkeypox is declared a pandemic.

Authors

Abdelaziz Abdelaal,Abdullah Reda,Basant Ismail Lashin,Basant E Katamesh,Aml M Brakat,Balqees Mahmoud Al-Manaseer,Sayanika Kaur,Ankush Asija,Nimesh K Patel,Soney Basnyat,Ali A Rabaan,Saad Alhumaid,Hawra Albayat,Mohammed Aljeldah,Basim R Al Shammari,Amal H Al-Najjar,Ahmed K Al-Jassem,Sultan T AlShurbaji,Fatimah S Alshahrani,Ahlam Alynbiawi,Zainab H Alfaraj,Duaa H Alfaraj,Ahmed H Aldawood,Yub Raj Sedhai,Victoria Mumbo,Alfonso J Rodriguez-Morales,Ranjit Sah

Published Date

2022/8/29

Public health emergencies of international concernin the 21st century

2 possible by all countries of the world irrespective of their economic status. It should be noted that most PHEIC owe to zoonotic infections from low-to-middle income countries. The IHR declaration covers all zoonotic aspects of these diseases and also how to limit animal-human interaction. The one health strategy can be covered in order to mitigate, prevent and control these diseases. For this, resources should be allocated for research and infrastructure development for testing/diagnostic, prevention and treatment of the causative agents in every country of the world. Although high-income countries seem to be well-equipped to face such pandemics, the past ones (like COVID-19) have proven that serious efforts should still be conducted to reduce the burdens of these emergencies. We think paying more attention to countries where outbreaks of infectious diseases are reported should be prioritized. Equipping these …

Authors

Ranjit Sah,Abdullah Reda,Basant Ismail Lashin,Aroop Mohanty,Abdelaziz Abdelaal,Alfonso J Rodriguez-Morales

Journal

Annals of medicine and surgery

Published Date

2022/9/1

Monkeypox emergence and hosting a safe FIFA World Cup 2022 in Qatar: Challenges and recommendations

First discovered in 1970, monkeypox (MPX) is a zoonotic viral disease caused by the monkeypox virus (MPXV) that has recently emerged in multiple non-endemic countries [1]. As of August 30, 2022, there were more than 49144 confirmed infected cases across nearly 96 countries [2]. As a large double-stranded DNA virus, MPXV is more able to correct replication errors than an RNA virus such as HIV, meaning that the current MPX strain should have only accumulated a handful of mutations since it first started circulating in 2018 [1]. Recently, it has been reported that after collecting DNA from 15 MPX viral samples and reconstructing their genetic information, researchers found that the real mutation rate was six to 12 times higher than they expected [1]. The massive jump in the MPXV rate of mutation was reported to be far more than one would expect considering previous estimates of the substitution rate for …

Authors

Ramadan Abdelmoez Farahat,Mounir Ould Setti,Amira Yasmine Benmelouka,Iftikhar Ali,Tungki Pratama Umar,Yasmeen Alabdallat,Abdelaziz Abdelaal,Ismail Dergaa

Journal

International Journal of Surgery

Published Date

2022/10/1

Marburg virus and Monkeypox virus: The concurrent outbreaks in Ghana and the lesson learned from the Marburg virus containment

Ghana, a country in the African continent experienced its first ever outbreak of Marburg Virus disease on July 2022. Prior to this, Democratic Republic of Congo and Angola were the two most severely affected countries to be affected by the same disease. Marburg Virus disease is a lethal and serious disease with an average mortality of 50% and has been seen to go as high as 90% in some cases. But despite the propensity to cause fast epidemics, the Ghana government acted swiftly and controlled its spread saving many lives. Simultaneously the country was also facing the Monkeypox outbreak and was doing its best to control the outbreak. This brief article is about the containment measures taken by the country to effectively prevent both the diseases to spread.

Authors

Ranjit Sah,Abdullah Reda,Basant Ismail Lashin,Abdelaziz Abdelaal,Aroop Mohanty,Abdelmonem Siddiq,Bijaya Kumar Padhi

Journal

J. Pure Appl. Microbiol

Published Date

2022/12/2

COVID-19 and physical inactivity: Teetering on the edge of a deadlier pandemic?

It is well-documented that regular engagement in physical activities enhances the effectiveness of the immune system [5], which would affect the severity of COVID-19. Therefore, the noticeable increase in physical inactivity and excess sedentary time could potentially lead to the deterioration of infected cases and further promote the spread of the disease. Furthermore, there are serious concerns that the documented short-term deteriorations in PA and increases in SB may become permanently fixed. This may subsequently increase the risk of obesity, diabetes, and cardiovascular diseases, as well as exacerbate the severity of existing conditions [6].Obesity and PA are linked, with an almost 4-fold increase in the risk of obesity in physically inactive individuals [7]. Obese individuals are also disproportionately affected by COVID-19 infection [8]. It is reported that obesity increases the risk of COVID-19 infection by 46 …

Authors

Sherief Ghozy,Abdelaziz Abdelaal,Jaffer Shah,Kate Elizabeth Parker,Sheikh Mohammed Shariful Islam

Journal

Journal of global health

Published Date

2021

Association between sarcoidosis and diabetes mellitus: a systematic review and meta-analysis

Background: Sarcoidosis is multisystem inflammatory granulomatosis that can potentially affect any organ of the human body. We aimed to estimate the prevalence of diabetes mellitus (DM) in sarcoidosis patients and determine the association between sarcoidosis and DM.Method: All relevant articles reporting the prevalence of DM in sarcoidosis published until September 19th, 2020, were retrieved from ten electronic databases. We used the random effect model to perform the meta-analysis.Results: After screening 2,122 records, we included 19 studies (n = 18,686,162). The prevalence of DM in sarcoidosis patients was 12.7% (95% CI 10–16.1). The prevalence was highest in North America with 21.3% (13.5–31.8), followed by Europe 10.4 (7.9–13.7) and Asia 10% (1.8–39.7). Sarcoidosis patients had higher rates of DM compared to controls (OR 1.75; 95% CI 1.49–2.05). Sensitivity analysis, after removing the …

Authors

Amira Yasmine Benmelouka,Abdelaziz Abdelaal,Ahmed Salah Eldin Mohamed,Laila Salah Shamseldin,Mahmoud Mohamed Zaki,Khaled Saad Elsaeidy,Mariam Abdelmageed Mahmoud,Amr Ehab El-Qushayri,Sherief Ghozy,Sheikh Mohammed Shariful Islam

Published Date

2021/12/2

Voice rehabilitation by voice prostheses after total laryngectomy: A systematic review and network meta-analysis for 11,918 patients

Purpose Our aim was to assess the different voice prostheses (VPs) to identify the most efficient, safest, patient-tailored, longest lifetime, and inexpensive VPs and assess the different factors affecting their quality. Method In September 2017, 15 databases were searched to include all randomized controlled trials. A new search was done in May 2019 to include all other study design articles, which include all the new-era VPs subtypes. Network meta-analysis (NMA) was applied to all 27 outcomes, besides NMA overall and partial order setting was done by using Hasse scatter plots. p values were used in NMA, where the best VPs are approaching one and the least approaches zero. Meta-analysis was done for the rest of the outcomes. Results Two hundred one articles were eligible for inclusion in our study (N = 11,918). Provox-2 was significantly the most efficient and safest device concerning the most patient …

Authors

Gehad Mohamed Tawfik,Omar Mohamed Makram,Ahmad Helmy Zayan,Sherief Ghozy,Peter Samuel Eid,Mona Hanafy Mahmoud,Abdelaziz Abdelaal,Seif Mahmoud Abdelghany,Ahmed M Sayed,To Kim Sang,Mahmoud Kassem,Quoc Le Minh Ho,Heba Hussien Eltanany,Amira Farghaly Ali,Osama Gamal Hassan,Khaled Essam Elsherbiny,Amr G Shafik,Kenji Hirayama,Nguyen Tien Huy

Published Date

2021/7/16

Abdelaziz Abdelaal FAQs

What is Abdelaziz Abdelaal's h-index at Tanta University?

The h-index of Abdelaziz Abdelaal has been 18 since 2020 and 18 in total.

What are Abdelaziz Abdelaal's top articles?

The articles with the titles of

Safety and Efficacy of Brolucizumab in the Treatment of Diabetic Macular Edema and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Monkeypox viral detection in semen specimens of confirmed cases: a systematic review and meta‐analysis

Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in …

Monkeypox-Associated Manifestations and Complications Involving the Eye: A Systematic Review and Meta-Analysis of Previous and Current Outbreaks

Oral manifestations of mpox: A common presentation?

Unravelling COVID-19 vaccination attributes worldwide: an extensive review regarding uptake, hesitancy, and future implication

Preferred Practice Patterns of Congenital Nasolacrimal Duct Obstruction in Jordan

Protection against the recent Monkeypox outbreaks: what options do we have? Correspondence

...

are the top articles of Abdelaziz Abdelaal at Tanta University.

What are Abdelaziz Abdelaal's research interests?

The research interests of Abdelaziz Abdelaal are: Glaucoma - Clinical Research

What is Abdelaziz Abdelaal's total number of citations?

Abdelaziz Abdelaal has 1,271 citations in total.

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