Abdelazim Ibrahim

Abdelazim Ibrahim

King Faisal University

H-index: 17

Asia-Saudi Arabia

Professor Information

University

King Faisal University

Position

Assistant professor College of Veterinary Medicine and Animal Resources

Citations(all)

1293

Citations(since 2020)

831

Cited By

683

hIndex(all)

17

hIndex(since 2020)

14

i10Index(all)

22

i10Index(since 2020)

17

Email

University Profile Page

King Faisal University

Research & Interests List

Veterinary Pathology

Oncology

Top articles of Abdelazim Ibrahim

Disseminated gamma‐delta T‐cell lymphoma in a dromedary camel

A 12‐year‐old, female dromedary camel presented with a large mass on the right eye and progressive weight loss. The animal died shortly after clinical examination, and postmortem examination revealed multiple nodules in the liver and mesenteric lymph nodes. A multicentric T‐cell lymphoma was diagnosed based on microscopic features and immunohistochemical labelling of the neoplastic cell for CD3, but not CD20. Flow cytometric analysis of collected blood showed a marked increase in the percentage of gamma‐delta (workshop cluster 1‐positive) lymphoblasts.

Authors

Abdelazim Ibrahim,Jamal Hussen,Turke Shawaf,Fahad A Al‐Hizab,Matti Kiupel

Journal

Veterinary Record Case Reports

Published Date

2023/9

Maxillary neoplasms in four dromedary camels

Four camels (Camelus dromedarius) presented to the Veterinary Teaching Hospital at King Faisal University with maxillary masses. On radiographs, the masses were multicystic and expanded the maxillary bone. The tumors were diagnosed by histopathologic examination as conventional ameloblastoma, two cases as intraosseous squamous cell carcinoma, and central odontogenic fibroma with ossification. To the authors’ knowledge, this is the first report of ameloblastoma in a camel, the first detailed description of maxillary squamous cell carcinoma in camels, and the first report of central odontogenic fibroma in any animal species.

Authors

Abdelazim Ibrahim,Mohamed Zabady,Ayman El Nahas,Ahmed Aljazzar,Fahad Al-Hizab,Mahmoud Kandeel,Brian F Porter

Journal

Frontiers in Veterinary Science

Published Date

2023

Effects of aflatoxin B1 on human breast cancer (MCF-7) cells: cytotoxicity, oxidative damage, metabolic, and immune-modulatory transcriptomic changes

Aflatoxin B1 (AFB1) is a potent mycotoxin that is commonly produced by molds such as Aspergillus (A.) flavus and A. parasiticus. AFB1 is associated with several health adverse effects in humans including mutagenesis and carcinogenesis. Aflatoxin is commonly secreted in the milk leading to deleterious effects on breast tissue and potential nursing infants. However, the effects of aflatoxins, particularly AFB1, on the breast cells are less investigated. In this study, AFB1-associated effects on human breast cancer cell lines (MCF-7) were investigated. AFB1 caused significant cytotoxicity on MCF-7 cells. Such cytotoxicity had a positive correlation with the induction of oxidative stress. In addition, AFB1 caused significant transcriptomic alterations in xenobiotics and drug-metabolizing enzymes, transporters, and antioxidant enzymes. Besides, AFB1 upregulated pro-inflammatory markers such as tumor necrosis factor-α and …

Authors

Ahmed Aljazzar,Waleed Rizk El-Ghareeb,Wageh Sobhy Darwish,Sherief M Abdel-Raheem,Abdelazim M Ibrahim,Eman E Hegazy,Esraa A Mohamed

Journal

Environmental Science and Pollution Research

Published Date

2023/1

Selecting key drivers for a successful lean construction implementation using Simos’ and WSM: the case of Egypt

Despite the use of numerous new and advanced technologies in construction projects, the industry’s efficiency remains low. This business has faced significant challenges for a long time, such as non-value-added activities, also known as waste. Lean construction (L.C.) is one method for improving the situation by reducing waste and increasing value for the client. This study provides an in-depth literature review to provide a comprehensive list of all critical drivers and groups all these drivers into one research paper in order to determine the importance (weights) of these drivers and their relative importance, and to propose an innovative methodology for ranking them using Simos’ approach. Seven construction project case studies were proposed. Their lean status was assessed, the key-list was verified using a Weighted-Sum Model as a multi-criteria decision-making technique to rank them, the best one in terms of lean implementation was found. Subsequently, a sensitivity analysis was conducted to determine the most critical criterion for the key list. The following are some of the study’s main findings: 18 key drivers were identified and ranked, a clear definition of the client’s requirements was the most global weight between factors, and the case studies demonstrated that more than 60% of the lean drivers are implemented in Egypt. Day-to-day observation and standardized work were the top two most widely used lean practices in Egypt.

Authors

Ahmed Nouh Meshref,Elsayed Abdelfattah Ahmed Elkasaby,Abdelazim Ibrahim

Journal

Buildings

Published Date

2022/5/18

Prevalence and antimicrobial susceptibility of Campylobacter species with particular focus on the growth promoting, immunostimulant and anti-Campylobacter jejuni activities of …

Simple Summary Campylobacter species are the leading cause of foodborne bacterial enteritis worldwide. Recently, extensively drug-resistant (XDR) and multi-drug-resistant (MDR) Campylobacter spp. have caused several global crises. Therefore, the present work aims to detect the prevalence and antimicrobial resistance patterns of Campylobacter spp. from various chicken sources in Egypt, and to investigate the efficacy of a mixture of eugenol and trans-cinnamaldehyde on the performance and immunity of challenged broilers and also to assess their effects on C. jejuni load and virulence gene expression in an in vivo model. Our results showed a high prevalence of campylobacter isolates (67.3%). Of note, 25.7 and 74.3% of campylobacter isolates were XDR and MDR, respectively. Interestingly, a mixture of eugenol and trans-cinnamaldehyde had significant enhancing and antimicrobial effects through improving the growth-performance variables, minimizing the C. jejuni fecal loads, and decreasing the C. jejuni virulence genes (flaA, virB11, and wlaN) expressions in broilers challenged with C. jejuni. Moreover, the mixture of eugenol and the trans-cinnamaldehyde had immunostimulant and anti-inflammatory activities. In conclusion, our findings suggest that the utilization of the mixture of eugenol and trans-cinnamaldehyde has a growth-promoting role and can be considered as a better replacement of the antimicrobial agents for the control and treatment of campylobacter infection in broiler chickens. Abstract Campylobacter species (spp.) are one of the most important causes of human bacterial …

Authors

Ahmed Aljazzar,Marwa I Abd El-Hamid,Rania MS El-Malt,Waleed Rizk El-Gharreb,Sherief M Abdel-Raheem,Abdelazim M Ibrahim,Adel M Abdelaziz,Doaa Ibrahim

Journal

Animals

Published Date

2022/4/1

Design, Synthesis, Spectroscopic Characterization, Molecular Docking and Biological Evaluation of 9H-Carbazole Linked 4-Nitrophenol: A DFT Approach

The FT-IR and FT-Raman spectra of 3-(4-nitrophenoxy)-9,9a-dihydro-4aH-carbazole (9HCNP) molecule were recorded. The theoretical wavenumbers are in proper agreement with the observed results. The electronic properties, such as natural bond orbital study of the molecule, were confirmed using the inter/intra molecular interactions, molecular electrostatic potential, and Mulliken population analyses on the atomic charge distribution, performed by the Becke-3–Lee–Yang–Parr (CAM-B3LYP) method utilizing Gaussian 09 software. The oscillator strength of electronic transitions and energies of HOMO and LUMO molecular orbitals were carried out to evaluate the global chemical reactivity descriptors of 9HCNP. The molecular docking evaluation was carried out to evaluate the structure–activity relationship and the binding affinity of the molecule, which shows that the molecule can perform as an inhibitor of breast …

Authors

Joseph Iruthayaraj Ragavan,Ponnusamy M Anbarasan,Ammasi Arunkumar,A Ibrahim

Journal

Journal of Computational Biophysics and Chemistry

Published Date

2022/12/18

Assessment of the Immune Response of Clinically Infected Calves to Cryptosporidium parvum Infection

Cryptosporidium parvum (C. parvum) infection is one of the main causes of diarrhea in calves. The current study assessed the role of blood biomarkers (acute-phase proteins (APPs), procalcitonin, neopterin, cytokines, and oxidative stress in the pathogenesis, diagnosis, and prognosis of calves naturally infected with C. parvum. Fifty-seven calves, aged from 10 to 45 days, were detected positive for C. parvum and were allotted into the diseased group; twenty healthy calves were selected as a control group. Serum amyloid A, haptoglobin, cytokines, neopterin, procalcitonin, and stress biomarkers were tested in the diseased and healthy groups. The serum levels of APPs, cytokines, neopterin, procalcitonin, and malondialdehyde increased, whereas antioxidant levels were significantly decreased in diseased calves compared to the healthy group. Moreover, all examined biomarkers were significantly altered towards normal values in infected calves following different treatment protocols. All biomarkers examined were highly effective in discriminating between C. parvum-infected calves and healthy individuals. Furthermore, the area under the curve (AUC) showed that all tested parameters had a higher degree of prognostic accuracy in predicting the treatment response of calves naturally infected with C. parvum. Our data suggest the usefulness of the examined biomarkers in the immune pathogenesis of the C. parvum infection in calves, contributing to diagnosis and treatment efficacy.

Authors

Wael El-Deeb,Olimpia Iacob,Mahmoud Fayez,Ibrahim Elsohaby,Abdulrahman Alhaider,Hermine V Mkrtchyan,Abdelazim Ibrahim,Naser Alhumam

Journal

Agriculture

Published Date

2022/8/4

The emerging SARS‐CoV‐2 papain‐like protease: its relationship with recent coronavirus epidemics

The papain‐like protease (PLpro) is an important enzyme for coronavirus polyprotein processing, as well as for virus‐host immune suppression. Previous studies reveal that a molecular analysis of PLpro indicates the catalytic activity of viral PLpro and its interactions with ubiquitin. By using sequence comparisons, molecular models, and protein–protein interaction maps, PLpro was compared in the three recorded fatal CoV epidemics, which involved severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), severe acute respiratory syndrome CoV (SARS‐CoV), and Middle East respiratory syndrome coronavirus (MERS‐CoV). The pairwise sequence comparison of SARS‐CoV‐2 PLpro indicated similarity percentages of 82.59% and 30.06% with SARS‐CoV PLpro and MERS‐CoV PLpro, respectively. In comparison with SARS‐CoV PLpro, in SARS‐CoV‐2, the PLpro had a conserved catalytic triad of C111 …

Authors

Mahmoud Kandeel,Yukio Kitade,Mahmoud Fayez,Katharigatta N Venugopala,Abdelazim Ibrahim

Journal

Journal of medical virology

Published Date

2021/3

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