Abdelaati EL KHIAT

Abdelaati EL KHIAT

Université Cadi Ayyad

H-index: 6

Africa-Morocco

Abdelaati EL KHIAT Information

University

Université Cadi Ayyad

Position

PhD Faculty of Sciences Semlalia/ Neurosciences

Citations(all)

136

Citations(since 2020)

136

Cited By

39

hIndex(all)

6

hIndex(since 2020)

6

i10Index(all)

6

i10Index(since 2020)

6

Email

University Profile Page

Université Cadi Ayyad

Abdelaati EL KHIAT Skills & Research Interests

hepatic encephalopathy

Epileptic Disorders

Neurobiology and Brain Physiology

Pharmaceutical and Biomedical Analysis

Top articles of Abdelaati EL KHIAT

Prevalence of musculoskeletal disorders among healthcare professionals: A hospital-based study

Background Musculoskeletal disorders (MSD) represent one of the most common occupational health problems in both developed and developing countries. Objective To determine the prevalence of MSD among health cae workers in Shiraz NIOC Health Organization in 2010. Methods In a cross-sectional study, 130 randomly selected health care workers were studied for MSD. Standardized Nordic questionnaire was used for analysis of MSD symptoms. Results Of 130 questionnaires distributed, 112 (86.2%) were completed and analyzed. The mean age of participants was 40 years; they had a mean service length of 14.8 years. 83 (74.1%) and 74 (66%) health care workers reported pain in at least one site during past year and last week, respectively. The prevalence of knee pain, low back pain, and neck painwas respectively, 48.2%, 44.6%, and 38.4% during last year, and 35.7%, 34%, and 26% during last week. Personnel of dentistry unit (87.5%) and, nursing and midwifery (82%) were those mostly complained of MSD. Conclusion Personnel of dentistry are at high risk of MSD.

Authors

M MADDAHI,AA NASIHATKON,M KESHAVARZI

Published Date

2012/1/1

Motivational profiles of nursing students in Morocco: a descriptive study

Métodos: Este es un estudio transversal realizado en 2022 en el Instituto Superior de Profesiones de Enfermería y Técnicas de Salud en Ouarzazate, en el sureste de Marruecos. La población objetivo para este estudio fueron todos los estudiantes (n= 242).

Authors

Driss Ait Ali,Hasna Agouzoul,Khadija Ouahmane,Zahra Ait Baja,Abdelaati El Khiat,Brahim El Houate,Mohamed El Koutbi,Fatima Senhaji,Hicham Khabbache

Journal

Academic Journal of Health Sciences: Medicina Balear

Published Date

2024

Deep Learning Approaches in the Early Diagnosis of Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PD is characterized by motor and non-motor symptoms. It is highly established that PD is mainly caused by the degeneration of dopamine (DA) producing neurons in the substantia nigra pars compacta of the midbrain leading to nigro-striatal pathway dysregulation. The diagnosis of PD is difficult since its symptoms are quite similar to those of other disorders and current assessments of symptoms have many limitations. Moreover, there are currently no effective biomarkers for diagnosing this condition or tracking its progression. Recently, digital technologies including artificial intelligence (AI) methods have emerged. Indeed, machine learning and deep learning models can help in the diagnosis and management of PD. Deep learning models have shown promising results in the diagnosis of PD even at the early stages of the …

Authors

Bilal El-Mansoury,Youssef Ait Hamdan,Kamal Smimih,Abdelaati El Khiat,Ahmed Draoui,Mohamed Hammani,Arumugam Radhakrishnan Jayakumar,Omar El Hiba

Published Date

2024

Hepatic Encephalopathy as a Gliopathy: The Mechanisms of Alzheimer Type II Astrocytosis

Hepatic encephalopathy (HE) is defined as a wide spectrum of neuropsychiatric abnormalities caused by liver dysfunction (acute or chronic) and/or portal-systemic shunting. The histopathologic hallmark of HE is astrocyte swelling following acute liver failure (ALF) or the presence of the so-called Alzheimer type 2 astrocytosis under chronic liver disease. HE can be classified according to the undelaying cause into three types: type A as an essential component of acute liver failure, type B as a consequence of porto-systemic shunts in the absence of liver dysfunction, and type C in patients with liver cirrhosis and porto-systemic bypass. While ammonia, manganese, proinflammatory cytokines, and other precipitating factors play a role in the pathogenesis of HE, the exact mechanisms leading to the development of HE are not fully elucidated. This chapter provides a brief overview of HE with a focus on the mechanisms of …

Authors

Bilal El-Mansoury,Omar El Hiba,Abdelaati El Khiat,Arumugam Radhakrishnan Jayakumar

Published Date

2024

Astrocytes Reprogramming for Neurodegenerative Disease Management

Neurodegenerative disorders (NDD) are chronic conditions that lead to nerve cells degeneration in the central nervous system. The most common NDD are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington's disease (HD). Parkinson's disease (PD) is recognized as the second most common neurodegenerative disease after Alzheimer's disease (AD) and Huntington disease (HD). Astrocytes reprogramming has been recently proposed as one of the most important treatments to stop the progression of these neurological diseases. By targeting the microRNA, astrocytes in the animal brain could be reprogrammed into various functional neural systems. Activation of endogenous genes could be a revolutionary therapeutic approach for treating neurological diseases. Reprogrammed astrocytes could also be used to generate various types of …

Authors

Lahcen Tamegart,Rabii Hilali,Hajar Ouaki,Fatima Rachidi,Ibtissam Chakir,Rabia Ajana,Dia Eddine Oudghiri,Ahmed Draoui,Mjid Oukhrib,Hafida El Ghachi,Abdelali Ben Maloui,Abdelaati El Khiat,Halima Gamrani

Published Date

2024

Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy

Hepatic encephalopathy (HE) is a major neuropsychological condition that occursas a result of impaired liver function. It is frequently observed in patients with advanced liver disease or cirrhosis. Memory impairment is among the symptoms of HE; the pathophysiologic mechanism for this enervating condition remains unclear. However, it is possible that neuroinflammation may be involved, as recent studies have emphasized such phenomena. Therefore, the aim of the present study is to assess short working memory (SWM) and examine the involvement of microglia in a chronic model of HE. The study was carried out with male Wistar rats that were induced by repeated thioacetamide (TAA) administration (100 mg/kg i.p injection for 10 days). SWM function was assessed through Y-maze, T-Maze, and novel object recognition (NOR) tests, together with an immunofluorescence study of microglia activation within the hippocampal areas. Our data showed impaired SWM in TAA-treated rats that was associated with microglial activation in the three hippocampal regions, and which contributed to cognitive impairment.

Authors

Bilal El-Mansoury,Kamal Smimih,Abdelaati El Khiat,Ahmed Draoui,Abdelmohcine Aimrane,Redouane Chatoui,Abdesslam Ferssiwi,Abdelali Bitar,Halima Gamrani,Arumugam R Jayakumar,Omar El Hiba

Journal

Metabolites

Published Date

2024/3/29

Trace Elements and Neurodegenerative Diseases

Lead, copper, and aluminum neurotoxicity is associated with numerous alterations including behavioral and neurochemical disruptions. Many studies evaluate the possible neurochemical disruption in the brain structures after acute and chronic Pb, Cu, and Mn-exposures and the possible effect on brain structures. Trace elements are related to neurobehavioral alterations. Using immunohistochemical stainings, many studies compared both acute and chronic exposures to heavy metals. The two models of Pb, Cu, and Mn-exposure showed obvious disruptions of many structures.

Authors

Lahcen Tamegart,Mjid Oukhrib,Hafida El Ghachi,Abdelali Ben Maloui,Abdelaati El khiat,Halima Gamrani

Published Date

2023/6/11

Potential Role of Probiotics and Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease

Parkinson disease (PD) is the second most common neurodegenerative disease worldwide. It is characterized by both motor and non-motor symptoms. The histopathological hallmark of PD is the loss of dopaminergic neurons from the substantia nigra combined with Lewy bodies (LBs) and Lewy neurites, together termed Lewy pathology. However, the exact pathophysiological mechanism underpinning PD remains undetermined. Compelling evidence highlights the potential involvement of gut microbiota dysbiosis in the pathogenesis of PD and point toward potential pathological mechanisms between the gastrointestinal tract and the brain. In this regard, microbiota-targeted interventions such as probiotics and fecal microbiota transplantation (FMT) have been recently demonstrated to have a beneficial role in alleviating PD symptoms and providing neuroprotection. This chapter briefly provides an overview of …

Authors

Bilal El-Mansoury,Kamal Smimih,Abdelaati El Khiat,Hanane El Fatimi,Abdelmohcine Aimrane,Soraia El Baz,Abdessamad Elmourid,Fatima Ez-zahraa Saad,Hafida El Ghachi,Manal Khanouchi,Arumugam Radhakrishnan Jayakumar,Abdeljalil Zoubadi

Published Date

2023

Motivational factors influencing nurses’ participation in continuing education sessions: A hospital-based study

In order to stay up-to-date in the nursing field, nurses must pursue continuous education. This study examined nurses’ motivations to take part in continuing education activities by conducting a survey amongst a sample of nurses employed in two hospitals in south-east Morocco. The survey was carried out using a two-part self-administered questionnaire. Out of 144 nurses who received the questionnaire, 118 (84%) replied. The results showed that the majority of nurses have never participated in a continuing education session in the last 3 years. Respondents’ motivation for continuing education was mainly intrinsic, with the emphasis on factors related to professional competence and knowledge seeking. The use of such results can therefore be of great use to both managers and practitioners in planning continuing education programmes. However, it is desirable that more studies take place to investigate further …

Authors

Driss Ait Ali,Mohamed Fazaz,Brahim Ounaceur,Brahim El Houate,Mohamed El Koutbi,Abdelaati El Khiat,Fatima Senhaji

Journal

Journal of Adult and Continuing Education

Published Date

2023/11

Current Concepts in the Understanding and Management of Developmental Language Disorder in Children

Developmental language disorder (DLD) is a neurodevelopmental disorder associated with significant language difficulties. It is one of the most common developmental disorders that interferes with acquiring, comprehending, and utilizing language and its impact persists into adulthood. DLD is suspected when a child experiences language development issues that last into and through school age. DLD is brought on by complex interactions between genes and the environment leading to changes in brain development. The exact causes of the brain differences that lead to DLD are not well understood. Treatment approaches for DLD can be given in private clinics, outpatient hospital settings, schools, and speech-language pathology programs at universities. Although early detection and treatment of DLD in youngsters is preferred, treatment is beneficial regardless of the disorder stage. This chapter will provide an …

Authors

Bilal El-Mansoury,Samira Boulbaroud,Jawad Laadraoui,Abdelaati El Khiat,Kamal Smimih,Omar El Hiba,Arumugam Radhakrishnan Jayakumar,Abdelali Bitar

Published Date

2023

Neuropathology of Parkinson's Disease: An Update of the Recent Findings

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder of great concern of which no proven neuroprotective or neurorestorative therapies are available. It is characterized mainly by the degeneration of dopamine (DA) producing neurons in the substantia nigra (SN) pars compacta (SNpc) resulting in nigrostriatal pathway dysregulation and eventually disturbed subcortico-cortical interactions. The pathophysiological mechanisms leading to PD development are not completely understood. Several mechanisms and pathway dysfunctions have been proposed as they play a critical role in the pathogenesis of PD. These include oxidative stress, dysfunctional mitochondria, neuroinflammation, ubiquitin proteasomal dysfunction, and α-synuclein protein aggregation. This chapter will provide an overview on neuropathology, pathogenesis, and the recent pathophysiological mechanisms involved in …

Authors

Bilal El-Mansoury,Omar El Hiba,Mustapha Agnaou,Arumugam Radhakrishan Jayakumar,Abdelaati El Khiat,Kholoud Kahim,Samira Boulbaroud,Nadia Zouhairi,Oumaima Tibssirte,Hayat Bouighajd,Moulay Abdelmonaim El Hidan,Abdesslam Ferssiwi,Abdelali Bitar

Published Date

2023

P14 Altered Locomotor Behavior Associated With Purkinje Cells and Astrocytes Dysfunctions in Rat With Acute Hepatic Encephalopathy Involving the Oxidative Stress and …

Background:Hepatic encephalopathy (HE) is a wide range of neuropsychiatric abnormalities caused by acute or chronic liver failure. Studies showed that HE patients exhibit a deficit in motor coordination, which may result from cerebellar dysfunction.Methods:The aims of this study were to assess the time-dependent alteration of locomotor behavior and the glial and neuronal alterations in rat with acute HE induced chemically. The study was carried out in male Sprague-Dawley rats with thioacetamide (TAA) induced acute liver failure at different stages; 12 h, 24 h and 36 h. Hepatic and renal functions were assessed via various biochemical and histopathological examinations, while the cerebellum and the midbrain were examined using histology and immunohistochemistry for tyrosine hydroxylase (TH), cyclooxygenase-2 (COX-2) and glial fibrillary acidic protein (GFAP). We used as well, the open field and the …

Authors

Abdelaati El Khiat,Bilal El-Mansoury,Omar El Hiba,Lahcen Tamegart,Hanane Rais,Naima Fdil,Souad Sellami,Mohamed Ait El Mokhtar,Najib Kissani,Halima Gamrani

Journal

Official journal of the American College of Gastroenterology| ACG

Published Date

2023/9/1

The Interplay Between Environmental Pollutants, Gut Microbiota, and Infections: Current Concepts and Therapies

Environmental pollutants (EPs) have become an increasingly common health hazard. Several studies have sustained the impact of these EPs on human gut microbiota (GM). The human GM is made up of thousands of microbes that play a paramount role to maintain hosts' health by providing many physiological functions, as well as protecting the host from pathogens and aggressions. Considering the crucial role that the host's GM plays in maintaining health, its disruption (gut dysbiosis) by the EPs can increase extraordinary the risk of infections and lead to the development of several conditions. Therefore, interventions aimed to restore the gut microbial population are of great interest. This chapter examines the intricate relationship between EPs and GM, highlighting the profound impact of EPs on human health including the development of infections. Additionally, this chapter discusses the potential role of …

Authors

Bilal El-Mansoury,Kamal Smimih,Youssef Ait Hamdan,Abdelaati El Khiat,Samia Elouali,Hanane El Fatimi,Ahmed Draoui,Omar El Hiba,Arumugam Radhakrishnan Jayakumar

Published Date

2023

Effects of Physical Activity on Pakinson's Disease Patients

Parkinson's disease (PD) is the most common movement disorder worldwide, of which neuroprotective or neurorestorative therapy is not yet available. The current line treatments are believed to be effective in alleviating PD symptoms, but as the disease progress, various complications appear, and the treatment becomes challenging. Hence, the role of nonpharmacologic therapies in the treatment of PD is of great interest and can be useful to delay and slow the disease progression. Increasing evidence shows the important role of physical activity (PA) in the management and even the prevention of the disease. Several mechanisms are thought to explain the beneficial effect of exercise in PD. However, the exact neurobiological mechanisms underpinning this benefit are not fully understood. This chapter will discuss the benefit of exercise in PD patients and the possible molecular mechanisms by which PA could …

Authors

Kamal Smimih,Bilal El-Mansoury,Jawad Laadraoui,Fatima Ez-Zahraa Saad,Mohamed Merzouki,Lhoussaine Ammouta,Manal Khanouchi,Abdelmohcine Aimrane,Chaima Azzouhri,Nadia Zouhairi,Abdelaati El Khiat,Abdelali Bitar,Abdesslam Ferssiwi

Published Date

2023

Ataxia in Multiple Sclerosis: From Current Understanding to Therapy

Ataxia is a type of neurological disorder that affects the ability to coordinate voluntary movements, such as walking, balance, and speech. In people with multiple sclerosis (MS), ataxia is a common symptom, affecting around 80% of people with the condition. The cause of ataxia in MS is still unknown; however, it is thought to be due to damage to the part of the central nervous system (CNS) that controls balance, coordination, and movement, especially the cerebellum. Symptoms of ataxia in people with MS can range from mild to severe, and can include a lack of coordination, difficulty speaking, difficulty walking, and gait. Ataxia management in MS typically involves pharmacotherapy to improve coordination, physiotherapy to enhance strength and balance, surgical procedures to alleviate tremor as well as occupational therapy to help with everyday activities.

Authors

Bilal El-Mansoury,Jawad Laadraoui,Abdelaati El Khiat,Omar El Hiba,Arumugam R Jayakumar,Abdessalam Ferssiwi,Abdelali Bitar

Published Date

2023/7/10

Symptomatology and Clinical Features of Parkinson's Disease

Parkinson's disease (PD) is a progressive neurodegenerative disease representing the most common movement disorder worldwide. It is characterized clinically by its cardinal motor features: bradykinesia, rigidity, postural instability, and resting tremor. The clinical diagnosis of PD is mainly based on the presence of these motor symptoms which differentiate it from the other forms of parkinsonism. However, recently other symptoms known as non-motor symptoms (NMS) are ginning attention because of their negative outcome on PD patients, and they are now included in the clinical diagnosis of the disease. Current lines treatments are generally based on DA replacement and are associated with significant alleviation of motor symptoms and some NMS. However, such treatments have not been shown to decrease or halt the disease progression. Moreover, as the disease progresses, these symptomatic treatments …

Authors

Abdelaati El Khiat,Bilal El-Mansoury,Driss Ait Ali,Mohamed El Koutbi,Kamal Kaoutar,Youssef Ait Hamdan,Brahim El Houate,Lahcen Tamegart,Kamal Smimih,Adnane Hakam,Najib Kissani,Halima Gamrani

Published Date

2023

Pharmacological Treatments of Parkinson's Disease: Preventing and Curing Approaches

Parkinson's disease (PD) is recognized as the second most common neurodegenerative disease after Alzheimer's disease. Parkinson's disease is a progressive disease characterized by a progressive loss of dopaminergic neurons of the black substance (SNpc) and dopamine deficiency in the striatal region as well as motor and non-motor symptoms. The main objective of Parkinson's research is to understand the pathogenesis, targets, and development of therapeutic interventions to control disease progression. The use of various agents could be a good strategy for the treatment of PD.

Authors

Lahcen Tamegart,Mjid Oukhrib,Dia Eddine Oudghiri,Bilal El-Mansoury,Chakir Ibtissam,Ahmed Draoui,Hafida El Ghachi,Abdelali Ben Maloui,Abdelaati El Khiat,Halima Gamrani

Published Date

2023

Trace Elements and Epilepsy

Epilepsy is a chronic neurological disease, resulting in significant mortality worldwide. Several experimental and clinical works have suggested that the normal brain function depends on the homeostasis of trace elements. However, taking antiepileptics can also modify the homeostasis of trace elements. The objective of this chapter was to carry out a bibliographical synthesis to establish the link between epilepsy and the alteration of the concentration of certain trace elements, in particular, zinc, copper, magnesium, and selenium in the blood and/or in the brain of epileptic patients. The results found during this survey reinforce the role of trace elements, whether directly or indirectly, in the pathogenesis of this disease, as well as its resistance to antiepileptic treatments.

Authors

Abdelaati El Khiat,Driss Ait Ali,Bilal El-Mansoury,Youssef Ait Hamdan,Brahim El Houate,Mohamed El Koutbi,Lahcen Tamegart,Halima Gamrani,Najib Kissani

Published Date

2023/6/11

Non-Motor Symptoms in Parkinson's Disease: The Other Side of the Disease

Parkinson's disease (PD) is a multisystem disorder considered the second most common neurodegenerative disease worldwide of which neuroprotective therapies are not yet available. PD is known mainly by its cardinal motor symptoms which are believed to be associated with dopamine deficiency in the nigrostriatal pathway as a result of DAergic neurons degeneration in the substantia nigra pars compacta of the midbrain. However, other brain structures degenerate (non-dopaminergic abnormalities) in PD resulting in other symptoms known as non-motor symptoms (NMS). NMS and non-DAergic abnormalities are sometimes present before diagnosis and almost inevitably emerge with the disease progression. Hence, they might play a tremendously important role in the management and sometimes even the diagnosis of PD. This chapter will provide an overview on the neuropathobiology of NMS in PD.

Authors

Bilal El-Mansoury,Abdelali Ben Maloui,Ahmed Draoui,Youssef Ait Hamdan,Mjid Oukhrib,Kamal Smimih,Abdessamad Elmourid,Abdelaati El Khiat,Samira Boulbaroud,Iman Meftah,Miloud Hammoud,Redouane Chatoui,Said Sabir,Halima Gamrani,Arumugam Radhakrishnan Jayakumar

Published Date

2023

Sex Dimorphism and Parkinson's Disease: What We Learned

Parkinson's disease (PD) affects the nervous system of patients in a gender-discriminative way. In regards to the epidemiological observations, amongst the 10 million people worldwide who are living with PD, recent reports have stated 1.5 times the greater incidence in men than in women. What is more, while growing evidence is showing gender as a considerable biological variable, preclinical research on PD has shown tangible explanations of epidemiological observation. Indeed, it has been shown that the symptoms are delayed in women especially because of a high dopamine level in the striatum, possibly due to the activity of estrogens. Thus, in this chapter, the authors present an overview of sexual dimorphism in PD and the possible mechanisms linking the differences observed between men and women in the incidence of PD.

Authors

Manal Khanouchi,Jawad Laadraoui,Souad El Amine,Abdelmohcine Aimrane,Bilal El-Mansoury,Kamal Smimih,Fatima Ez-Zahraa Saad,Abdelaati El Khiat,Abdeslam Ferssiwi,Abdelali Bitar,Omar Mamad

Published Date

2023

Direct contribution of Purkinje neurons death and morpho-functional astroglial changes involving oxidative stress and neuroinflammation in the pathogenesis of hepatic …

MethodsThe study was carried out in male Sprague-Dawley rats with thioacetamide (TAA) induced acute liver failure at different stages 12 h, 24 h and 36 h. Hepatic and renal functions were assessed via various biochemical and histopathological examinations, while the cerebellum and the midbrain were examined using histology and immunohistochemistry for tyrosine hydroxylase (TH), cyclooxygenase-2 (COX-2) and glial fibrillary acidic protein (GFAP). We used as well, the open field test and the Rotarod test for assessing the locomotor activity and coordination.ResultsOur data showed a progressive loss of liver function and a progressive alteration in locomotor behavior and motor coordination in acute HE rats. In the cerebellum, we noted an increase in the degeneration of cerebellar Purkinje neurons parallel to increased COX-2 immunoreactivity together with astrocytic morphology and density changes …

Authors

Abdelaati El Khiat,Omar El Hiba,Lahcen Tamegart,Hanane Rais,Naima Fdil,Mohamed Ait El Mokhtar,Halima Gamrani

Published Date

2023/12/1

Therapeutic strategies for treatment of COVID-19

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by a dangerous virus named SARS-CoV-2. The most important symptoms are fever, cough, fatigue, and breathing problems. In the most serious forms of the disease, the appearance of an acute respiratory distress syndrome caused by the virus can be deadly, especially when people are fragile due to their age or in case of comorbidities. The exacerbated innate immune response could be another deadly complication. Different strategies of treatments are proposed for COVID-19 such as inhibition of virus entry by blocking ACE2 receptor used by COVID-19, inhibition of virus replication by using replication inhibitors, immunomodulatory agents to stimulate a strong immune response against COVID-19, and by using vaccines as an effective method for a long-term strategy for prevention of COVID-19.

Authors

Lahcen Tamegart,Mjid Oukhrib,Hafida El Ghachi,Abdelali Ben Maloui,Abdelaati El Khiat,Halima Gamrani

Published Date

2022

Nutritional Aspects and Neurodegenerative Disorders

During the last century, a considerable change in the way we eat has taken place in connection with the intensive industrialization of agriculture and the globalization of food. There is therefore a growing interest in the impact of our diet on health, and this interest has focused on several diseases, including neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, which are a real global health problem. These diseases are often linked to genetic causes or to exposure to certain neurotoxins. However, they are rarely linked to the constituents of our food and our eating habits. This chapter presents a review of the literature answering the following question. What interaction (prevention and risk) can there be between the constituents of our food and the state of brain health?

Authors

Ahmed Draoui,Moulay Abdelmonaim El Hidan,Hicham Chatoui,Abdelmohcine Aimrane,Lahcen Tamegart,Nadia Zouhairi,Soraia El Baz,Abdelaati El Khiat,Radouane El Fari,Zakaria Tazart,Hind Benammi,Halima Gamrani

Published Date

2022/6/29

How New Technologies Could Help Improve Healthcare, Teaching, and Sensitization During Pandemics Like COVID-19

The COVID-19 pandemic has, over the last few months, forced us to modify the way we interact with each other both in the delivery of healthcare services and in medical education. Nowadays, telehealth has globally emerged as the most appropriate approach for care, teaching, healthcare professional meetings, and advocacy. This chapter outlines the value of telemedicine, information and communication technologies during such critical situations. The authors draw in this report various experiences from countries belonging to different economic categories and describe how ICT could be a convenient solution in care, monitoring of symptom, treatment management, teaching, sensitization, and continuing education during the epidemic period of COVID-19. In conclusion, with countries facing challenges in dealing with the current situation, they need to encourage the use of ICT in remote health services and to …

Authors

Najib Kissani,Abdelaati El Khiat,Musa Mamman Watila,Ismail El Aarroumi,Hoda Mohamed Farid Wahba,Tamer Hussein Emara,Dawn Eliashiv,Ilham Kissani,Daniel Gams Massi,John N Jabang,Amany Hussein Ragab

Published Date

2022

Hepatic encephalopathy: an overview of basic concepts and mechanisms

The liver failure induced encephalopathy is commonly referred as hepatic encephalopathy (HE). For many decades, scientists have tried to describe the symptoms of this disorder revealing a spectrum with different types of HE. Studies on the mechanisms underlying the pathogenesis of HE have implicated several factors, mainly neurotoxins, including ammonia, manganese, in addition to changes in various physiological factors, especially an imbalance between true and false neurotransmitters, as well as the involvement of various pro-inflammatory mediators. Such changes impact on the brain, which promote disorders in glia and neurons. This review focuses on the most relevant basic pathophysiologic mechanisms associated with HE.

Authors

Abdelaati El Khiat,Omar El Hiba,Abdelmohcine Aimrane,Ahmed Draoui,Arumugam Radhakrishnan Jayakumar,Michael D Norenberg,Halima Gamrani

Published Date

2022/5

Time dependent alteration of locomotor behavior in rat with acute liver failure induced cerebellar neuroinflammation and neuro-astroglial damage

Hepatic encephalopathy (HE) is a neurophysiological syndrome secondary to acute or chronic liver failure. Studies showed that HE patients exhibit a deficit in motor coordination, which may result from cerebellar functional impairment. The aim of this study is to assess the time-dependent alteration of locomotor behavior and the glial and neuronal alteration in rat with acute HE induced chemically. The study was carried out in male Sprague-Dawley rats with thioacetamide (TAA) induced acute liver failure at different stages 12 h, 24 h and 36 h. Hepatic and renal functions were assessed via various biochemical and histopathological examinations, while the cerebellum and the midbrain were examined using histology and immunohistochemistry for tyrosine hydroxylase (TH), cyclooxygenase-2 (COX-2) and glial fibrillary acidic protein (GFAP). We used as well, the open field test and the Rotarod test for assessing the …

Authors

Abdelaati El Khiat,Omar El Hiba,Lahcen Tamegart,Hanane Rais,Naima Fdil,Souad Sellami,Mohamed Ait El Mokhtar,Halima Gamrani

Journal

Journal of Chemical Neuroanatomy

Published Date

2022/1/1

Therapeutic management of COVID-19 patients: pharmacological and non-pharmacological approaches

Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCov-2) or COVID-19 is a pandemic that appeared in December 2019 in China and which is an RNA virus. It gave rise to a major health crisis at the start of 2020, with numerous hospitalizations. It was quickly important to understand the pathophysiology of this viral attack on the human body in order to be able to develop treatment. However, there is no vaccine or effective therapeutic agent against SARS-CoV-2. Most of the therapeutic strategies used to deal with this virus come from the work of previous epidemics of SARS, and other influenza viruses, such as antiviral therapies (chloroquine, hydroxychloroquine), adjuvant therapies by combining antivirals with drugs. Antibiotics or immunostimulants (vitamins C, Dm and Zinc, etc,) and several other therapies to be used depending on the region.

Authors

Abdelaati El Khiat,Youssef Ait Hamdan,Lahcen Tamegart,Ahmed Draoui,Abdessamad Aglagane,Radouane El Fari,Halima Gamrani

Published Date

2022

COVID-19: Lungs Facing the Storm

SARS-CoV-2 infection is characterized by its high contagiousness and unusual potential lethality. Microscopically, diffuse alveolar damage is the main histologic lung injury dominated by alveolar destruction. At the early stage, the authors note non-specific lesions similar to lesions of diffuse alveolar damage. In particular, the alveoli dilated and filled with exudative fibromyxoid material, the thickening of the interalveolar partitions by edema and an essentially mononuclear inflammatory infiltrate with eosinophilic hyaline membranes covering the alveoli. Viral inclusions are not generally found, and at an advanced stage, the installation of pulmonary fibrosis is noted. The place of non-invasive and/or invasive ventilation is undetermined in hypoxemic respiratory failure secondary to SARS-Cov-2 pneumonia, whereas in the most severe cases of COVID-19, the use of oxygenation by extracorporeal membrane is …

Authors

Ahmed Draoui,Hicham Chatoui,Soraia El Baz,Hanane Rais,Bilal El-Mansoury,My Abdelmonaim EL Hidan,Abdelmohcine Aimrane,Nadia Zouhairi,Mohamed Echchakery,Abdelaati El Khiat,Lahcen Tamegart,Radouane El Fari,Hind Benammi,Karima Lafhal,Miloud Hammoud,Halima Gamrani

Published Date

2022

Behaviour and therapeutic itinerary of epileptic patients in Marrakech city and surrounding regions in South Morocco

Background Epilepsy is a chronic, universal disorder with various etiologies and prognoses. It is still laden with myths in the majority of the Moroccan population. Despite the existence of well-established medicinal treatments and increasingly comprehensive care, access to antiepileptic care is still limited, especially for rural populations. We aim herein to identify the therapeutic itinerary of patients with epilepsy (or epileptic disorders) as well as the behaviour of patients and their families towards this disease in Marrakech and the surrounding region of Marrakech-Safi. Methods We carried out a retrospective study Questionnaire filled by 110 patients data was analysed with SPSS version 18. Results Our results showed that 69.96% of the patients believed in a supernatural origin of the disease and 76.4% attended for …

Authors

Abdelaati El Khiat,Najib Kissani,Abdellatif Abbaoui,Mohamed Chraa,Mohamed Loukid,Halima Gamrani,Mohamed Kamal Hilali

Journal

Acta Epileptologica

Published Date

2021/12

Epilepsy surgery in Africa: state of the art and challenges

ObjectiveEpilepsy is an important public health problem representing 0.6% of the global burden of disease that particularly impacts people living in the lowest income countries where epilepsy incidence may be 10 fold more than in the developed world. The battery of treatments designed to counteract the clinical manifestations of this disease are various and range from a wide spectrum of antiseizure medication and specific diets, to surgical techniques for resection of the epileptogenic focus. The aim of our study was to describe the State of the art of Epilepsy Surgery (ES) in Africa and examine ways to deal with the high surgical treatment gap.MethodologyIn an observational study, we prospectively disseminated questionnaires via email or directly administered to main epileptologists and neurologists involved in epilepsy care, in key African countries. We also conducted a literature search using PubMed, Google …

Authors

Najib Kissani,Sanaa Nafia,Abdelaati El Khiat,Noureddine Bengamara,Youssoufa Maiga,Youssouf Sogoba,Eetedal Ahmed A Ibrahim,Mendinatou Agbetou,Gams Massi Daniel,Komi Assogba,Ndiaga Matar Gaye,Callixte Kuate Tegueu,Amany Hussein Ragab,Julien Razafimahefa,Jo Wilmshurst,Ansuya Naidoo,John N Jabang,Musa Watila

Published Date

2021/5/1

Chelating effect of flax seed extract in rats overloaded with chondroitin sulfate: A new path in substrate reduction therapy for mucoplysccharidosis

Chondroitin 6-sulfate (C6S); a hydrophobic polysaccharide found naturally in the body, has mostly been used to reduce pain and inflammation, to improve joint function and problems with the chewing muscles, and for slowing the progression of osteoarthritis. However, the deficiency/absence in specific enzymes involved in the intra-lysosomal degradation of C6S leads to its lysosomal accumulation, resulting in cellular dysfunction and wide range of physiological disruptions together with high urinary excretion of C6S, such features characterize a group of diseases under the name of mucopolysaccharidosis (MPS). Flaxseed (FS)(Linumusitatissimum) has attracted attention because wide range of therapeutic potentialities in curing diabetes, heart disease, colorectal, breast, and prostate cancers. The purpose of the current study is to assess the beneficial effect of total ethanolic FS extract in a non-genetic animal model …

Authors

Es-said Sabir,Karima Lafhal,Abdelaati El Khiat,Miloud Hammoud,Aicha Ezoubeiri,Abdallah Karim,Naima Fdil

Journal

Molecular Genetics and Metabolism

Published Date

2021/2/1

Parkinson's disease: from bench to bedside

Parkinson's disease is a very complex public health problem with different etiologies and a wide range of clinical features including motor and non-motor symptoms. The aim of the current report is to review the latest advances in the understanding of PD etiologies, diagnosis, epidemiology and an overview of the earlier and latest advances in the management of PD, from L-DOPA to adult astroglia reprogramming into dopaminergic neurons in vivo.

Authors

A Draoui,O El Hiba,A Aimrane,A El Khiat,H Gamrani

Published Date

2020/9/1

See List of Professors in Abdelaati EL KHIAT University(Université Cadi Ayyad)

Abdelaati EL KHIAT FAQs

What is Abdelaati EL KHIAT's h-index at Université Cadi Ayyad?

The h-index of Abdelaati EL KHIAT has been 6 since 2020 and 6 in total.

What are Abdelaati EL KHIAT's top articles?

The articles with the titles of

Prevalence of musculoskeletal disorders among healthcare professionals: A hospital-based study

Motivational profiles of nursing students in Morocco: a descriptive study

Deep Learning Approaches in the Early Diagnosis of Parkinson's Disease

Hepatic Encephalopathy as a Gliopathy: The Mechanisms of Alzheimer Type II Astrocytosis

Astrocytes Reprogramming for Neurodegenerative Disease Management

Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy

Trace Elements and Neurodegenerative Diseases

Potential Role of Probiotics and Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease

...

are the top articles of Abdelaati EL KHIAT at Université Cadi Ayyad.

What are Abdelaati EL KHIAT's research interests?

The research interests of Abdelaati EL KHIAT are: hepatic encephalopathy, Epileptic Disorders, Neurobiology and Brain Physiology, Pharmaceutical and Biomedical Analysis

What is Abdelaati EL KHIAT's total number of citations?

Abdelaati EL KHIAT has 136 citations in total.

What are the co-authors of Abdelaati EL KHIAT?

The co-authors of Abdelaati EL KHIAT are Abdellatif Abbaoui, Ahmed Draoui, Lahcen TAMEGART, Radouane EL FARI.

    Co-Authors

    H-index: 11
    Abdellatif Abbaoui

    Abdellatif Abbaoui

    Université Cadi Ayyad

    H-index: 7
    Ahmed Draoui

    Ahmed Draoui

    Université Cadi Ayyad

    H-index: 5
    Lahcen TAMEGART

    Lahcen TAMEGART

    Université Cadi Ayyad

    H-index: 4
    Radouane EL FARI

    Radouane EL FARI

    Université Cadi Ayyad

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