Abdel elgawad Helmy Abdelgawad

Abdel elgawad Helmy Abdelgawad

Mansoura University

H-index: 17

Africa-Egypt

About Abdel elgawad Helmy Abdelgawad

Abdel elgawad Helmy Abdelgawad, With an exceptional h-index of 17 and a recent h-index of 14 (since 2020), a distinguished researcher at Mansoura University, specializes in the field of Pharmaceutical sciences, Ophthalmic preparations.

His recent articles reflect a diverse array of research interests and contributions to the field:

Development of Linagliptin Ultra Fine Solid Supersaturated Bio-SNEDDS Using Triangular Mixture Design for Enhancement of Oral Bioavailability: Impact of P-gp Inhibition

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Formulation and pathohistological study of mizolastine–solid lipid nanoparticles–loaded ocular hydrogels

Ocular inserts of voriconazole-loaded proniosomal gels: formulation, evaluation and microbiological studies

Abdel elgawad Helmy Abdelgawad Information

University

Mansoura University

Position

Professor of Pharmaceutics Faculty of Pharmacy

Citations(all)

865

Citations(since 2020)

446

Cited By

569

hIndex(all)

17

hIndex(since 2020)

14

i10Index(all)

21

i10Index(since 2020)

15

Email

University Profile Page

Mansoura University

Abdel elgawad Helmy Abdelgawad Skills & Research Interests

Pharmaceutical sciences

Ophthalmic preparations

Top articles of Abdel elgawad Helmy Abdelgawad

Development of Linagliptin Ultra Fine Solid Supersaturated Bio-SNEDDS Using Triangular Mixture Design for Enhancement of Oral Bioavailability: Impact of P-gp Inhibition

Authors

Hend Mohammed Mansour,Abd El-Gawad H Abd El-Gawad,Mariza Fouad Boughdady

Journal

Journal of Pharmaceutical Research International

Published Date

2023/11/21

Linagliptin (LIN) is a newly developed dipeptidyl peptidase 4 (DPP-4) inhibitor oral antidiabetic drug. LIN is considered a P-gp substrate, thus suffers from poor bioavailability (< 30%). The aim of this study was to develop and characterize LIN bioactive self-nanoemulsifying drug delivery system to circumvent its poor bioavailability and enhance its therapeutic efficacy. Methodology In this study, we developed solid supersaturated bioactive self-nanoemulsifying drug delivery system (Ss-bio-SNEDDS) of LIN, using clove oil as an oil phase, cremophor CO 40 as a surfactant, labrasol as a co-surfactant and Hydroxy-propyl-B-cyclodextrin (HPBCD) as a precipitation inhibitor (PI); all components are of established P-gp inhibition activity. Optimization was performed by means of triangular mixture design based on particle size, poly dispersity index (PDI) and percent transmittance. The two optimized formulations (F4 and F8) were designated and evaluated for stability and cloud point. Also, the effect of pH on particle size and PDI was assessed. Additionally, examination of particles’ surface morphology of the two optimized formulations was performed by transmission electron microscope (TEM). The prepared liquid supersaturated-SNEDDS (s-SNEDDS) were converted into solid supersaturated-SNEDDS (Ss-SNEDDS) via adsorption on microcrystalline cellulose (MCC). Further evaluations were carried out, including in vitro drug release, in vitro precipitation and in vivo studies. Results The optimized formulations F4 and F8 manifested promising characteristics concerning particle size (< 50 nm), PDI (< 0.3) and percent transmittance (> 99%). Stability study …

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Authors

Amira Samir Ebraheem,Abd El-Gawad Helmy Abd El-Gawad,Germeen NS Girgis

Journal

Journal of Pharmaceutical Research International

Published Date

2022/12/31

The major objective of the current study is to implement a plan to enhance the dissolution rate and oral bioavailability of a poorly water-soluble aceclofenac. The drug is classified according to the biopharmaceutical classification system as class II drug. Amorphous alkalinized aceclofenac solid dispersion was formulated as a ternary mixture. This mixture was prepared by introducing polymeric carriers [polyvinylpyrrolidone, Hydroxy propyl beta cyclodextrin or Polyethylene glycol] and an alkalizer (Na2CO3) by applying the solvent evaporation method. Optimum formulations were compressed into tablets that were subjected to in-vitro studies compared to the market product Bristaflam and free drug containing one. Finally, tablets were assessed for stability studies and carrageenan-induced rat paw edema treatment to evaluate potentiated anti-inflammatory efficacy. Results showed that optimum amorphous alkalinized aceclofenac solid dispersion formulations containing polyvinylpyrrolidone K30 or Hydroxy propyl beta cyclodextrin in 1:5 ratio have significant in-vitro dissolution improvement (>90% in 10 min) compared to untreated aceclofenac. Solid-state characterization emphasized the conversion of the crystalline drug into the amorphous form with no drug−polymers interactions. Stability and dissolution studies ensured that tablets containing amorphous alkalinized solid dispersions were stable with strikingly improving dissolution behavior compared to Bristaflam or free drug containing tablets. Moreover, regarding anti-inflammatory activity against carrageenan induced paw edema, and histopathological examination, we concluded that …

Formulation and pathohistological study of mizolastine–solid lipid nanoparticles–loaded ocular hydrogels

Authors

Ghada Ahmed El-Emam,Germeen NS Girgis,Mohammed Fawzy Hamed,Osama Abd El-Azeem Soliman,Abd El Gawad H Abd El Gawad

Journal

International Journal of Nanomedicine

Published Date

2021/11/24

BackgroundMizolastine (MZL) is a dual-action nonsedating topical antihistamine anti-inflammatory agent that is used to relieve allergic conditions, such as rhinitis and conjunctivitis. Solid lipid nanoparticles (SLNs) are advanced delivery system in ophthalmology, with the merits of increasing the corneal drug absorption and hence improved bioavailability with the objective of ocular drug targeting.MethodsFirst, MZL was formulated as MZL-SLNs by hot homogenization/ultrasonication adopting a 32 full factorial design. Solid-state characterization, in vitro release, and stability studies have been performed. Then, the optimized MZL-SLNs formula has been incorporated into ocular hydrogels using 1.5% w/v Na alginate and 5% w/v polyvinylpyrrolidone K90. The gels were evaluated via in vitro release as well as in vivo studies by applying allergic conjunctivitis congestion in a rabbit-eye model.ResultsThe optimized …

Ocular inserts of voriconazole-loaded proniosomal gels: formulation, evaluation and microbiological studies

Authors

Ghada Ahmed El-Emam,Germeen NS Girgis,Mohamed M Adel El-Sokkary,Osama Abd El-Azeem Soliman,Abd El Gawad H Abd El Gawad

Journal

International Journal of Nanomedicine

Published Date

2020/10/12

BackgroundVoriconazole (VRC) is a triazole broad spectrum antifungal drug, used in the management of versatile fungal infections, particularly fungal keratitis. The obligatory use of niosomal delivery of VRC may reduce the frequency of dosing intervals resulting from its short biological half time and consequently improve patient compliance.MethodsVRC loaded proniosomes (VRC-PNs) were set by the coacervation technique and completely characterized. The developed formula was comprehensively assessed concerning in- vitro release behavior, kinetic investigation, and its conflict against refrigerated and room temperature conditions. A selected noisomal formula was incorporated into ocusert (VRC-PNs Ocu) formulated by 1% w/w hydroxypropyl methyl cellulose HPMC and 0.1% w/w carbopol 940. Eventually, in vitro antifungal activity against Candida albicans and Aspergillus nidulans was assessed by the …

See List of Professors in Abdel elgawad Helmy Abdelgawad University(Mansoura University)

Abdel elgawad Helmy Abdelgawad FAQs

What is Abdel elgawad Helmy Abdelgawad's h-index at Mansoura University?

The h-index of Abdel elgawad Helmy Abdelgawad has been 14 since 2020 and 17 in total.

What are Abdel elgawad Helmy Abdelgawad's top articles?

The articles with the titles of

Development of Linagliptin Ultra Fine Solid Supersaturated Bio-SNEDDS Using Triangular Mixture Design for Enhancement of Oral Bioavailability: Impact of P-gp Inhibition

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Formulation and pathohistological study of mizolastine–solid lipid nanoparticles–loaded ocular hydrogels

Ocular inserts of voriconazole-loaded proniosomal gels: formulation, evaluation and microbiological studies

are the top articles of Abdel elgawad Helmy Abdelgawad at Mansoura University.

What are Abdel elgawad Helmy Abdelgawad's research interests?

The research interests of Abdel elgawad Helmy Abdelgawad are: Pharmaceutical sciences, Ophthalmic preparations

What is Abdel elgawad Helmy Abdelgawad's total number of citations?

Abdel elgawad Helmy Abdelgawad has 865 citations in total.

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