Abdalla Wedn

Abdalla Wedn

Alexandria University

H-index: 6

Africa-Egypt

About Abdalla Wedn

Abdalla Wedn, With an exceptional h-index of 6 and a recent h-index of 6 (since 2020), a distinguished researcher at Alexandria University, specializes in the field of Cancer, Hormone driven cancers - Renal Pharmacology, sepsis, cholinergic anti-inflammatory pathway.

His recent articles reflect a diverse array of research interests and contributions to the field:

Abstract B014: Bioinformatic and in-vitro analyses identify cAMP/PKA/CREB signaling as a major molecular alteration in invasive lobular breast cancer

IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic …

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Promising biotherapeutic prospects of different probiotics and their derived postbiotic metabolites: in-vitro and histopathological investigation

Abstract P6-14-02: Hope for OTHERS–An organ donation program for metastatic breast cancer research

Fetomaternal Cardiovascular and Renal Adverse Outcomes of Recurrent Preeclampsia in Rats

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives

Abdalla Wedn Information

University

Alexandria University

Position

Department of Pharmacology and Toxicology Faculty of Pharmacy

Citations(all)

84

Citations(since 2020)

84

Cited By

24

hIndex(all)

6

hIndex(since 2020)

6

i10Index(all)

4

i10Index(since 2020)

4

Email

University Profile Page

Alexandria University

Abdalla Wedn Skills & Research Interests

Cancer

Hormone driven cancers - Renal Pharmacology

sepsis

cholinergic anti-inflammatory pathway

Top articles of Abdalla Wedn

Abstract B014: Bioinformatic and in-vitro analyses identify cAMP/PKA/CREB signaling as a major molecular alteration in invasive lobular breast cancer

Authors

Abdalla Wedn,Susrutha Puthanmadhom-Narayanan,Adrian Lee,Steffi Oesterreich

Journal

Cancer Research

Published Date

2024/2/1

Invasive lobular cancer (ILC) is the second most common subtype of breast cancers after invasive carcinoma of no special type (NST) but associated with worse outcomes. Despite the known molecular differences between ILC and NST, ILC treatment is the same as stage matched NST making the development of ILC targeted therapies an urgent need. Therefore, this study was conducted to identify novel molecular alterations in ILC that could be exploited for therapeutic purposes. Differential gene expression and Geneset Enrichment and Variation analyses were performed on RNA-seq data from three large public breast cancer databases – the Sweden Cancerome Analysis Network-Breast (SCAN-B), The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). Pathways enriched in overlapping differentially expressed genes from these datasets were …

IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities

Authors

Xu He,Abdalla Wedn,Jian Wang,Yanlun Gu,Hongjin Liu,Juqi Zhang,Zhiqiang Lin,Renpeng Zhou,Xiaocong Pang,Yimin Cui

Published Date

2024/1/11

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways to defend the host. Recent studies have revealed additional regulatory functions of STING beyond its innate immune-related activities, including the regulation of cellular metabolism, DNA repair, cellular senescence, autophagy and various cell deaths. These findings highlight the broader implications of STING in cellular physiology beyond its role in innate immunity. Currently, approximately 10 STING agonists have entered the clinical stage. Unlike inhibitors, which have a maximum inhibition limit, agonists have the potential for infinite amplification. STING signaling is a complex process that requires precise regulation of STING to ensure balanced immune responses and prevent detrimental autoinflammation. Recent research on the …

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic …

Authors

Osama Shiraz Shah,Fangyuan Chen,Abdalla Wedn,Anokhi Kashiparekh,Beth Knapick,Jian Chen,Laura Savariau,Ben Clifford,Jagmohan Hooda,Matthias Christgen,Jenny Xavier,Steffi Oesterreich,Adrian V Lee

Journal

bioRxiv

Published Date

2023/9/28

Invasive lobular carcinoma (ILC), the most common histological “special type”, accounts for ∼10-15% of all BC diagnoses, is characterized by unique features such as E-cadherin loss/deficiency, lower grade, hormone receptor positivity, larger diffuse tumors, and specific metastatic patterns. Despite ILC being acknowledged as a disease with distinct biology that necessitates specialized and precision medicine treatments, the further exploration of its molecular alterations with the goal of discovering new treatments has been hindered due to the scarcity of well-characterized cell line models for studying this disease. To address this, we generated the ILC Cell Line Encyclopedia (ICLE), providing a comprehensive multi-omic characterization of ILC and ILC-like cell lines. Using consensus multi-omic subtyping, we confirmed luminal status of previously established ILC cell lines and uncovered additional ILC/ILC-like cell lines with luminal features for modeling ILC disease. Furthermore, most of these luminal ILC/ILC-like cell lines also showed RNA and copy number similarity to ILC patient tumors. Similarly, ILC/ILC-like cell lines also retained molecular alterations in key ILC genes at similar frequency to both primary and metastatic ILC tumors. Importantly, ILC/ILC-like cell lines recapitulated the CDH1 alteration landscape of ILC patient tumors including enrichment of truncating mutations in and biallelic inactivation of CDH1 gene. Using whole-genome optical mapping, we uncovered novel genomic-rearrangements including novel structural variations in CDH1 and functional gene fusions and characterized breast cancer specific patterns of …

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Authors

Yang Wu,Zheqi Li,Abdalla M Wedn,Allison N Casey,Daniel Brown,Shalini V Rao,Soleilmane Omarjee,Jagmohan Hooda,Jason S Carroll,Jason Gertz,Jennifer M Atkinson,Adrian V Lee,Steffi Oesterreich

Journal

Molecular Cancer Research

Published Date

2023/6/1

Estrogen receptor alpha (ER/ESR1) mutations occur in 30% to 40% of endocrine resistant ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor mediating ER–chromatin interactions and endocrine response in ER+ breast cancer, but its role in ESR1-mutant breast cancer remains unclear. Our previous FOXA1 chromatin immunoprecipitation sequencing (ChIP-seq) identified a large portion of redistributed binding sites in T47D genome-edited Y537S and D538G ESR1–mutant cells. Here, we further integrated FOXA1 genomic binding profile with the isogenic ER cistrome, accessible genome, and transcriptome data of T47D cell model. FOXA1 redistribution was significantly associated with transcriptomic alterations caused by ESR1 mutations. Furthermore, in ESR1-mutant cells, FOXA1-binding sites less frequently overlapped with ER, and differential gene expression …

Promising biotherapeutic prospects of different probiotics and their derived postbiotic metabolites: in-vitro and histopathological investigation

Authors

Mona S El Far,Azza S Zakaria,Mervat A Kassem,Abdalla Wedn,Maha Guimei,Eva A Edward

Journal

BMC microbiology

Published Date

2023/5/3

BackgroundProbiotics and their derived postbiotics, as cell-free supernatants (CFS), are gaining a solid reputation owing to their prodigious health-promoting effects. Probiotics play a valuable role in the alleviation of various diseases among which are infectious diseases and inflammatory disorders. In this study, three probiotic strains, Lactiplantibacillus plantarum, Lacticaseibacillus rhamnosus, and Pediococcus acidilactici, were isolated from marketed dietary supplements. The antimicrobial activity of the isolated probiotic strains as well as their CFS was investigated. The neutralized CFS of the isolated probiotics were tested for their antibiofilm potential. The anti-inflammatory activity of the isolated Lactobacillus spp., together with their CFS, was studied in the carrageenan-induced rat paw edema model in male Wistar rats. To the best of our knowledge, such a model was not previously experimented to evaluate the …

Abstract P6-14-02: Hope for OTHERS–An organ donation program for metastatic breast cancer research

Authors

Steffi Oesterreich,Lori Miller,Margaret Q Rosenzweig,Tanner L Bartholow,Megan Yates,Ashuvinee Elangovan,Laura Savariau,Allison N Casey,Nolan Priedigkeit,Kai Ding,Abdalla Wedn,Jie Bin Liu,Daniel D Brown,Tara Hyder,Geoffrey Pecar,Neil Carleton,Humberto Trejo Bittar,Daniel Geisler,Oscar Lopez-Nunez,Amanda M Clark,Alan Wells,Partha Roy,Shannon Puhalla,Naomi Howard,Christine Needles,Susan Trent,Stephanie Walker,Christine Hodgdon,Rohit Bhargava,Jennifer M Atkinson,Adrian V Lee

Journal

Cancer Research

Published Date

2023/3/1

Background: Previous studies have shown that rapid autopsies (RA) provide a unique opportunity for tissue collection from patients who succumb to the disease. Because cancer patients are unable to donate their organs to other people, this program provides the patient an opportunity to leave a legacy by donating their body to research. These donations are vital for advancing breast cancer research. The UPMC/Pitt RA group revamped an existing program in 2018 through the formation of a larger multidisciplinary team that includes breast cancer laboratory and clinical researchers, pathologists, nurses, bioinformaticians, and tissue bankers. Because recruitment to the RA program was a challenge, we recently added patient advocates to the team to provide their essential perspective, and a dedicated research coordinator who serves as an ambassador for the program. Methods: Autopsy is performed by the …

Fetomaternal Cardiovascular and Renal Adverse Outcomes of Recurrent Preeclampsia in Rats

Authors

Abdalla M Wedn,Sahar M El‐Gowilly,Mahmoud M El‐Mas

Journal

The FASEB Journal

Published Date

2022/5

Preeclampsia (PE) is a serious pregnancy‐related disorder associated with considerable maternal and neonatal morbidity. Preeclamptic women have increased risk of PE recurrency during subsequent pregnancies. Clinically, recurrent PE is accompanied by more frequent maternal and fetal complications compared with the initial PE episode. Here, we investigated the impact of recurrent PE episode on the cardiovascular and renal profiles of female rats and their offspring. PE was induced by oral L‐NAME administration (50 mg/kg/day, gestation days 14‐21) for either single pregnancy or two consecutive pregnancies. Maternal and fetal abnormalities were compared with corresponding pregnancy controls. Recurrent and single PE caused similar increases in systolic blood pressure of mothers over last week of pregnancy and decreases in average weight of pubs. However, recurrent PE was associated with new …

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives

Authors

Abdalla M Wedn,Hany M El-Bassossy,Ali H Eid,Mahmoud M El-Mas

Published Date

2021/10/1

The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of CAP have been shown to be critically involved in dampening the inflammatory reaction in a wide array of inflammatory disorders. Additionally, emerging evidence supports a key role for CAP in the regulation of the female reproductive system during gestation as well as in the advent of serious pregnancy-related inflammatory insults such as preeclampsia (PE). Within this framework, the modulatory action of CAP encompasses the perinatal maternal and fetal adverse consequences that surface due to antenatal PE programming. Albeit, a considerable gap still exists in our knowledge of the precise cellular and molecular underpinnings of PE/CAP interaction, which hampered global efforts in …

Maternal and Fetal Defects of Gestational Angiotensin 1‐7 Receptor Antagonism: A Possible Preclinical Model of Preeclampsia

Authors

Abdalla Wedn,Salwa Abuiessa,Sahar El‐Gowilly,Mahmoud El‐Mas

Journal

The FASEB Journal

Published Date

2021/5

Preeclampsia (PE) is a complex pathological state associated with serious adverse maternal and fetal consequences. Imbalances of the pressor ACE/Ang II and depressor ACE2/Ang 1‐7 arms of renin‐angiotensin system are implicated in PE pathophysiology. The current experimental study investigated whether the blockade of Ang 1‐7 receptors (Mas receptors) during late pregnancy would replicate clinical features of PE. Two different dosing regimens of A779 (Mas receptor antagonist, 0.750 and 1.3 mg/kg/day s.c.) were administered daily to pregnant rats for 7 consecutive days starting from gestational day 14. The developed maternal and fetal abnormalities were compared to those produced by gestational L‐NAME administration (50 mg/kg/day for 7 days), a standard model of PE in rodents. Gestational administration of L‐NAME or A779 reduced weight and number of placentas and pups and increased death …

Time and sex dependency of hemodynamic, renal, and survivability effects of endotoxemia in rats

Authors

Abdalla M Wedn,Sahar M El-Gowilly,Mahmoud M El-Mas

Journal

Saudi Pharmaceutical Journal

Published Date

2020/1/1

Widely different exposure times to endotoxic insults have been employed in reported studies. The current experimental study systematically evaluated the time-course and sex influences of endotoxic insult on survivability and cardiovascular and renal functions. Rats received i.p. lipopolysaccharide (LPS, 5 mg/kg) once or twice (over 2 successive days). Systolic blood pressure (SBP), biomarkers of renal function and inflammation, and vasodilator responsiveness of isolated perfused kidneys to acetylcholine (ACh) or N-ethylcarboxamidoadenosine (NECA) were evaluated 6 hr after first LPS injection or 1, 2, or 6 days later. A single 6-hr LPS challenge caused (i) sex-unrelated elevations in serum urea and creatinine and reductions in NECA, but not ACh, vasodilations, (ii) more increases in renal NF-κB/iNOS expressions in male than in female rats, and (iii) hypotension and tachycardia only in male rats. These …

Pre-eclamptic fetal programming alters neuroinflammatory and cardiovascular consequences of endotoxemia in sex-specific manners

Authors

Salwa A Abuiessa,Abdalla M Wedn,Sahar M El-Gowilly,Mai M Helmy,Mahmoud M El-Mas

Journal

Journal of Pharmacology and Experimental Therapeutics

Published Date

2020/5/1

Pre-eclampsia (PE)-induced fetal programming predisposes offspring to health hazards in adult life. Here, we tested the hypothesis that pre-eclamptic fetal programming elicits sexually dimorphic inflammatory and cardiovascular complications to endotoxemia in adult rat offspring. PE was induced by oral administration of L-NAME (50 mg/kg per day for seven consecutive days) starting from day 14 of conception. Cardiovascular studies were performed in conscious adult male and female offspring preinstrumented with femoral indwelling catheters. Compared with non-PE male counterparts, intravenous administration of lipopolysaccharide (LPS, 5 mg/kg) to PE male offspring caused significantly greater 1) falls in blood pressure, 2) increases in heart rate, 3) rises in arterial dP/dtmax, a correlate of left ventricular contractility, and 4) decreases in time- and frequency-domain indices of heart rate variability (HRV). By …

Nicotine improves survivability, hypotension, and impaired adenosinergic renal vasodilations in endotoxic rats: role of α7-nAChRs/HO-1 pathway

Authors

Abdalla M Wedn,Sahar M El-Gowilly,Mahmoud M El-Mas

Journal

Shock

Published Date

2020/4/1

The nicotinic/cholinergic antiinflammatory pathway protects against acute kidney injury and other end-organ damages induced by endotoxemia. In this study, we tested the hypothesis that functional α7-nAChRs/heme oxygenase-1 (HO-1) pathway is imperative for the nicotine counteraction of hemodynamic and renovascular dysfunction caused by acute endotoxemia in rats. Renal vasodilations were induced by cumulative bolus injections of acetylcholine (ACh, 0.01 nmol–7.29 nmol) or ethylcarboxamidoadenosine (NECA, adenosine receptor agonist, 1.6 nmol–100 nmol) in isolated phenylephrine-preconstricted perfused kidneys. The data showed that 6-h treatment with lipopolysaccharide (LPS, 5 mg/kg ip) decreased systolic blood pressure and renal vasodilations caused by NECA but not Ach. The endotoxic insult also increased the mortality rate and elevated serum urea and creatinine. These LPS effects were …

The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats

Authors

Abdalla M Wedn,Sahar M El-Gowilly,Mahmoud M El-Mas

Journal

Inflammation Research

Published Date

2020/2

Objective The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO-1) cascade. Materials 91 male and female rats were included in the study. Treatments Lipopolysaccharide (LPS, 5 mg kg−1), nicotine (0.5–2 mg kg−1), pentoxifylline (PTX, TNFα inhibitor, 3 mg kg−1), methyllycaconitine (MLA, α7-nAChR blocker), zinc protoporphyrin (ZnPP, HO-1 inhibitor), hemin (HO-1 inducer), tricarbonyldichlororuthenium (carbon monoxide-releasing molecule, CORM-2) or bilirubin was administered before LPS. Methods Isolated perfused kidney was used to evaluate renal vasoconstriction and immunohistochemistry to assess inflammatory cytokines. Results LPS reduced renal vasoconstrictions induced by phenylephrine or …

See List of Professors in Abdalla Wedn University(Alexandria University)

Abdalla Wedn FAQs

What is Abdalla Wedn's h-index at Alexandria University?

The h-index of Abdalla Wedn has been 6 since 2020 and 6 in total.

What are Abdalla Wedn's top articles?

The articles with the titles of

Abstract B014: Bioinformatic and in-vitro analyses identify cAMP/PKA/CREB signaling as a major molecular alteration in invasive lobular breast cancer

IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic …

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Promising biotherapeutic prospects of different probiotics and their derived postbiotic metabolites: in-vitro and histopathological investigation

Abstract P6-14-02: Hope for OTHERS–An organ donation program for metastatic breast cancer research

Fetomaternal Cardiovascular and Renal Adverse Outcomes of Recurrent Preeclampsia in Rats

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives

...

are the top articles of Abdalla Wedn at Alexandria University.

What are Abdalla Wedn's research interests?

The research interests of Abdalla Wedn are: Cancer, Hormone driven cancers - Renal Pharmacology, sepsis, cholinergic anti-inflammatory pathway

What is Abdalla Wedn's total number of citations?

Abdalla Wedn has 84 citations in total.

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