abdalla awidi

abdalla awidi

University of Jordan

H-index: 28

Asia-Jordan

About abdalla awidi

abdalla awidi, With an exceptional h-index of 28 and a recent h-index of 19 (since 2020), a distinguished researcher at University of Jordan, specializes in the field of Hematology, Oncology, Stem cells and Regenerative medicine.

His recent articles reflect a diverse array of research interests and contributions to the field:

Myelodysplastic Syndromes and Myelodysplastic Syndromes/Myeloproliferative Neoplasms: A Real-World Experience From a Developing Country

Functional Role of Human-Derived Stem Cells in Bone Tissue Regeneration

Safety and potential efficacy of expanded mesenchymal stromal cells of bone marrow and umbilical cord origins in patients with chronic spinal cord injuries: A phase I/II study

Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study

Phytochemical Analysis and Anticancer Properties of Drimia maritima Bulb Extracts on Colorectal Cancer Cells

Hemophilia in Jordan: An Economic Burden Dilemma of Rare Disease

Corrigendum to" Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer"[Life Sci., 329 (2023) 121964]

Influence of Diabetes Mellitus Type 2 on the angiogenic potential of Bone Marrow derived Mesenchymal Stem Cells

abdalla awidi Information

University

University of Jordan

Position

___

Citations(all)

2921

Citations(since 2020)

1565

Cited By

1798

hIndex(all)

28

hIndex(since 2020)

19

i10Index(all)

82

i10Index(since 2020)

40

Email

University Profile Page

University of Jordan

abdalla awidi Skills & Research Interests

Hematology

Oncology

Stem cells and Regenerative medicine

Top articles of abdalla awidi

Myelodysplastic Syndromes and Myelodysplastic Syndromes/Myeloproliferative Neoplasms: A Real-World Experience From a Developing Country

Authors

Abdalla Awidi,Marah Alzu'bi,Nada Odeh,Jawad Alrawabdeh,Muntaser Al Zyoud,Yazan Hamadneh,Hisham Bawa'neh,Ahmad Magableh,Alaa Alshorman,Feras Al-Fararjeh,Tariq Aladily,Amer M Zeidan

Journal

JCO Global Oncology

Published Date

2024/2

PURPOSEMyelodysplastic syndromes (MDS) include a heterogeneous group of clonal bone marrow disorders characterized by ineffective hematopoiesis. They manifest as dysplasia in bone marrow hemopoietic elements associated with peripheral cytopenias with variable risk of AML transformation.PATIENTS AND METHODSWe analyzed retrospectively registry data collected prospectively from patients with primary MDS and patients with MDS/myeloproliferative neoplasm (MPN) in the Jordan University Hospital between January 2007 and September 2021. The registry captured epidemiologic information such as date of diagnosis, age, gender, date of AML transformation, cytogenetics, MDS subtype, risk group according to Revised International Prognostic Scoring System, and survival. The registry also captured baseline ferritin, B12, and lactate dehydrogenase levels.RESULTSA total of 112 patients with MDS …

Functional Role of Human-Derived Stem Cells in Bone Tissue Regeneration

Authors

Duaa Abuarqoub,Abdalla Awidi,Walhan Alshaer,Mohammad S Mubarak

Published Date

2024/1/1

With increasing life expectancy, stem cell-based therapy and bone tissue engineering are becoming more significant, and these fields are considered very promising therapeutic tools in translational medicine. Different human stem cells have been characterized and classified according to their differentiation potential into bone progenitor cells. This chapter will cover the most recent advances in cellular signaling guiding bone tissue generation, novel functionalized scaffolds and materials, and various human-derived stem cell sources used for bone regeneration. Hence, this review will provide a multifaceted, up-to-date, and illustrative overview of bone tissue engineering alongside its molecular mechanism of regeneration. In addition, this review covers the literature relevant to the subject, which we hope to be a great help to researchers in the field.

Safety and potential efficacy of expanded mesenchymal stromal cells of bone marrow and umbilical cord origins in patients with chronic spinal cord injuries: A phase I/II study

Authors

Abdalla Awidi,Abdulrahman Al Shudifat,Nael El Adwan,Mahmoud Alqudah,Fatima Jamali,Fathy Nazer,Halla Sroji,Hady Ahmad,Nahla Al-Quzaa,Hanan Jafar

Journal

Cytotherapy

Published Date

2024/4/10

AbtstractSpinal cord injury (SCI) affects patients' physical, psychological, and social wellbeing. Presently, treatment modalities for chronic SCI have restricted clinical effectiveness. Mesenchymal stromal cells (MSCs) demonstrate promise in addressing nervous tissue damage. This single-center, open-label, parallel-group randomized clinical trial aimed to assess the safety and efficacy of intraoperative perilesional administration of expanded autologous bone marrow-derived MSCs (BMMSCs), followed by monthly intrathecal injections, in comparison to monthly intrathecal administration of expanded allogeneic umbilical cord-derived MSCs (UCMSCs) for individuals with chronic SCI. Twenty participants, who had a minimum of one year of SCI duration, were enrolled. Each participant in Group A received perilesional BMMSCs, followed by monthly intrathecal BMMSCs for three injections, while Group B received …

Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study

Authors

Kuan-Hung Chen,Pei-Lin Shao,Yi-Chen Li,John Y Chiang,Pei-Hsun Sung,Hui-Wen Chien,Fu-Yuan Shih,Mel S Lee,Wu-Fu Chen,Hon-Kan Yip

Journal

Cell Transplantation

Published Date

2020/9/3

Intracranial hemorrhage from stroke and head trauma elicits a cascade of inflammatory and immune reactions detrimental to neurological integrity and function at cellular and molecular levels. This study tested the hypothesis that human umbilical cord–derived mesenchymal stem cell (HUCDMSC) therapy effectively protected the brain integrity and neurological function in rat after acute traumatic brain injury (TBI). Adult male Sprague-Dawley rats (n = 30) were equally divided into group 1 (sham-operated control), group 2 (TBI), and group 3 [TBI + HUCDMSC (1.2 × 106 cells/intravenous injection at 3 h after TBI)] and euthanized by day 28 after TBI procedure. The results of corner test and inclined plane test showed the neurological function was significantly progressively improved from days 3, 7, 14, and 28 in groups 1 and 3 than in group 2, and group 1 than in group 3 (all P < 0.001). By day 28, brain magnetic …

Phytochemical Analysis and Anticancer Properties of Drimia maritima Bulb Extracts on Colorectal Cancer Cells

Authors

Khairallah Al-Abdallat,Maher Obeidat,Nidaa A Ababneh,Suzan Zalloum,Sabal Al Hadidi,Yahya Al-Abdallat,Malek Zihlif,Abdalla Awidi

Journal

Molecules

Published Date

2023/1/26

Cancer is a worldwide health problem and is the second leading cause of death after heart disease. Due to the high cost and severe side effects associated with chemotherapy treatments, natural products with anticancer therapeutic potential may play a promising role in anticancer therapy. The purpose of this study was to investigate the cytotoxic and apoptotic characteristics of the aqueous Drimia maritima bulb extract on Caco-2 and COLO-205 colorectal cancer cells. In order to reach such a purpose, the chemical composition was examined using the GC-MS method, and the selective antiproliferative effect was determined in colon cancer cell lines in normal gingival fibroblasts. The intracellular ROS, mitochondrial membrane potential, and gene expression changes in selected genes (CASP8, TNF-α, and IL-6 genes) were assessed to determine the molecular mechanism of the antitumor effect of the extract. GC-MS results revealed the presence of fifty-seven compounds, and Proscillaridin A was the predominant secondary metabolite in the extract. The IC50 of D. maritima bulb extract on Caco-2, COLO-205, and the normal human gingival fibroblasts were obtained at 0.9 µg/mL, 2.3 µg/mL, and 13.1 µg/mL, respectively. The apoptotic effect assay indicated that the bulb extract induced apoptosis in both colon cancer cell lines. D. maritima bulb extract was only able to induce statistically significant ROS levels in COLO-205 cells in a dose-dependent manner. The mitochondrial membrane potential (MMP) revealed a significant decrease in the MMP of Caco-2 and COLO-205 to various concentrations of the bulb extract. At the molecular level, RT …

Hemophilia in Jordan: An Economic Burden Dilemma of Rare Disease

Authors

Ibrahim Alabbadi,Abdel Karim Al-Oweidi,Amirah Daher,Ayah BaniHani,Abdallah Awidi

Journal

Jordan Journal of Pharmaceutical Sciences

Published Date

2023/7/24

Jordan is an upper-middle-income country with high expenditures on pharmaceuticals. The development of new rare disease (eg hemophilia) therapies has encountered significant obstacles with respect to economic the cost of the disease and treatment. The aim of this overview was to estimate current annual spending on hemophilia treatment in Jordan and estimate the financial impact of adapting a new medication (Emicizumab) recently used for treating hemophilia patients in Jordan. Methods based on the literature review, direct medical costs were quantified, required items’ costs from the actual practice in Jordan were elicited from an expert panel, and a focus group meeting with the same was conducted one month later to determine the current estimated number of hemophilia Patients in Jordan, identify current treatment on demand quantities and their prices. All related medical costs were also identified (eg bleeding, the estimated number of hospital days, and/or Intensive Care Unit per bleeding episodes). Estimation of the annual consumption of current on-demand treatment quantities and cost were calculated and compared with scenarios of adding the new therapy (Emicizumab). Results showed that the financial impact of using Emicizumab SC instead of Recombinant Factor VIIa IV on the budget of the Jordanian government will be 425,747 JOD ($601,338) annually. Conclusions the economic advantages of a new hemophilia treatment might be very substantial for patients.

Corrigendum to" Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer"[Life Sci., 329 (2023) 121964]

Authors

Mohamed El-Tanani,Angela Platt-Higgins,Hamdi Nsairat,Ismail I Matalka,Khaled Abdul-Aziz Ahmed,Shu-Dong Zhang,Walhan Alshaer,Abdalla Awidi,Kyle B Matchett,Alaa A Aljabali,Vijay Mishra,Ángel Serrano-Aroca,Murtaza M Tambuwala,Philip S Rudland

Journal

Life sciences

Published Date

2023/10/15

Corrigendum to "Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer" [Life Sci., 329 (2023) 121964] Corrigendum to "Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer" [Life Sci., 329 (2023) 121964] Life Sci. 2023 Oct 15:331:122075. doi: 10.1016/j.lfs.2023.122075. Epub 2023 Sep 10. Authors Mohamed El-Tanani 1 , Angela Platt-Higgins 2 , Hamdi Nsairat 3 , Ismail I Matalka 4 , Khaled Abdul-Aziz Ahmed 3 , Shu-Dong Zhang 5 , Walhan Alshaer 6 , Abdalla Awidi 6 , Kyle B Matchett 7 , Alaa A Aljabali 8 , Vijay Mishra 9 , Ángel Serrano-Aroca 10 , Murtaza M Tambuwala 11 , Philip S Rudland 2 Affiliations 1 College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy and Faculty of Allied …

Influence of Diabetes Mellitus Type 2 on the angiogenic potential of Bone Marrow derived Mesenchymal Stem Cells

Authors

Sofia Adwan,Hana Hammad,Mamoun Ahram,Abdalla Awidi

Journal

bioRxiv

Published Date

2023

Mesenchymal stem cells (MSCs) are used as novel therapeutic tools in cell-based therapies including diabetic complications. However, diabetes may negatively affect the therapeutic potential of autologous MSCs. In order to enhance the utilization of diabetic MSCs, better characterization of their angiogenic capacity should be performed. The aim of this study was to investigate the effect of diabetes mellitus (DM) on the angiogenic potential of bone marrow derived MSCs. MSCs were isolated from DM subjects and were compared with MSCs isolated from non-DM subjects. The angiogenic potential of MSCs was assessed in which there was insignificant difference in the proliferation and expression of angiogenic factors between the two groups. Moreover, no statistically significant change was found in the viability and angiogenic activities of endothelial cells isolated from both groups. Results indicate that the hyperglycemic milieu had no significant impact on the angiogenic-related functional properties of MSCs and they are able to survive the harsh diabetic conditions.

Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis

Authors

Marah Alzu’bi,Hisham Bawa’neh,Alaa Alshorman,Jawad Alrawabdeh,Nada Odeh,Yazan Hamadneh,Mai AlAdwan,Mahmoud Odeh,Abdalla Awidi

Journal

Plos one

Published Date

2023/7/13

Reticulocyte hemoglobin (CHr) is a measure of the amount of hemoglobin in reticulocytes and a marker of cell hemoglobinization. In this study, we aimed to find the optimal cut-off point for reticulocyte hemoglobin to diagnose iron deficiency anemia using multiple methods. A total of 309 patients were included. The median age at diagnosis was 54 years. Most were females (71.2%). 68% had iron deficiency anemia. Patients with IDA had significantly lower levels of CHr compared to those who had non-IDA (p < 0.0001). The optimal cut-off value of CHr for detecting IDA, determined using various methods, was 30.15 pg. This cut-off point had a sensitivity of 87.8% and a specificity of 77.7%. CHr showed a significant positive correlation with hemoglobin, mean corpuscular volume, serum iron, serum ferritin, and transferrin saturation and a significant negative correlation with total iron-binding capacity. CHr levels correlate with most established laboratory tests for IDA. It reliably detects IDA. Our results indicate the importance of CHr in diagnosing IDA, and that CHr should be used more widely in suspected cases of IDA since it is a cheap, fast, and reliable test.

Perilesional injections of human platelet lysate versus platelet poor plasma for the treatment of diabetic foot ulcers: A double‐blinded prospective clinical trial

Authors

Hussam Alhawari,Hanan Jafar,Mohammad Al Soudi,Lena Abu Ameereh,Maram Fawaris,Mohanad Saleh,Safwan Aladwan,Nidal Younes,Abdalla Awidi

Journal

International Wound Journal

Published Date

2023/10

Diabetic foot ulcer (DFU) is a major cause of morbidity, non‐traumatic lower limb amputation in diabetic patients and a high‐cost burden on the healthcare system. New therapeutic products are increasingly tested. Platelet‐rich plasma (PRP) and human platelet lysate (hPL) are reported to be useful. This trial was conducted to test whether the healing effect of hPL in chronic DFU was due to plasma or platelet lysates in a prospective double‐blind design. Autologous PRP was obtained from citrated blood, lysed, and used as drug 1 (active product). The platelet‐poor plasma (PPP) was used as a drug 2 (placebo). Ten patients were enrolled in arm 1 and 9 in arm 2. The drugs were injected perilesionally every 2 weeks for a total of sixinjections. Adverse events were recorded until Week 14. The DFUs were scored per the Texas and Wegner systems. No patient showed any major adverse events. Some reported local …

Safe Reversal of Motor and Sensory Deficits by Repeated High Doses of Mesenchymal Stem Cells in a Patient with Chronic Complete Spinal Cord Injury

Authors

Fatimah Jamali,Mahmoud Alqudah,Reem Rahmeh,Hisham Bawaneh,Abdulrahman Al-Shudifat,Osama Samara,Abdalla Awidi

Journal

The American Journal of Case Reports

Published Date

2023

Objective:Unusual clinical courseBackground:Spinal cord injuries (SCI) resulting from various types of accidents have a known onset, unlike other progressive neurological diseases. Nonetheless, in most cases, the resulting disability permanently affects the individual’s quality of life due to the limited outcome of available treatment options. The neurological deficit associated with SCI results from primary injury induced by the physical trauma and secondary injury involving inflammation, spinal tissue degeneration, and scar formation. Stem cells of different origins and using different treatment protocols have been tried to minimize aspects of secondary injury in the spinal cord.Case Report:In this case report, we evaluated the safety and efficacy of intrathecal injections of Wharton’s Jelly-derived mesenchymal stem cells (WJ-MSCs) in a patient with chronic traumatic complete SCI. The findings indicated that the …

Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

Authors

Hamdi Nsairat,Walhan Alshaer,Fadwa Odeh,Ezzaldeen Esawi,Dima Khater,Abeer Al Bawab,Mohamed El-Tanani,Abdalla Awidi,Mohammad S Mubarak

Published Date

2023/5/1

Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics to fulfill their potential. Liposomes have long been considered ideal platforms for systemic drugs delivery. Considering the development in cancer therapeutics, this work emphases on the current advancements in liposomes’ Nano-formulations, functionalization, and design and how it has been applied to nucleic acid therapeutics. Accordingly, this review covers the literature that deals with liposomes in nucleic acid therapy.

Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer

Authors

Mohamed El-Tanani,Angela Platt-Higgins,Hamdi Nsairat,Ismail I Matalka,Khaled Abdul-Aziz Ahmed,Shu-Dong Zhang,Walhan Alshaer,Abdalla Awidi,Kyle B Matchett,Alaa A Aljabali,Vijay Mishra,Ángel Serrano-Aroca,Murtaza M Tambuwala,Philip S Rudland

Journal

Life sciences

Published Date

2023/9/15

PurposeExisting prognostic biomarkers are inadequate for stratifying breast cancer patients with the highest risk of tumor progression at the time of diagnosis. Here, we demonstrate that the small GTPase Ran has predictive value for breast cancer (BC) patients as a whole, and for specific BC subtypes.Patients and methodsRan expression was quantified by immunohistochemistry in 263 patients with primary breast cancer diagnosed at the Breast Unit, Royal Liverpool Hospital. Additionally as an independent validation, we also analyzed the mRNA expressions of Ran, ER, PR, and Cerb-2, the triple-negative endocrine receptors, and their associations with patient survival in a combined patient cohorts of multiple public datasets (n = 1079). We analyzed the data with Spearman's rank correlation and Kaplan-Meier plots coupled with Wilcoxon-Gehan tests, respectively. All statistical tests were two-sided.ResultsRan …

Potential Effects of Photobiomodulation Therapy on Human Dental Pulp Stem Cells

Authors

Ayah A Al-Asmar,Duaa Abuarqoub,Nidaa Ababneh,Hanan Jafar,Suzan Zalloum,Mohammad Ismail,Praveen Arany,Abdalla Awidi

Journal

Applied Sciences

Published Date

2023/12/22

Background A significant clinical technology enabling the use of stem cells in dentistry is Photobiomodulation (PBM). The current study aimed to investigate various PBM treatment variables on human dental pulp stem cell proliferation, survival, and changes in cell cycle progression. Methods Human third molar samples were collected, and human Dental Pulp Stem Cells (hDPSCs) were isolated, expanded, seeded, and cultured in media containing 0, 1, 5, or 10% FBS. PBM treatments using an 810 nm diode laser at various doses were performed 24, 48, and 72 h after seeding. Cell proliferation and apoptosis were assessed. A two-way ANOVA test was performed among all treatment groups, followed by multiple comparison tests (Tukey’s test) performed between each treated group and its control untreated group. Results After 24 h, only cells cultured in 10% FBS showed a significant (p < 0.005) increase in the proliferation rate of cells treated with T7 (0.4 W × 10 s). After 48 h, hDPSCs cultured in both 5% and 10% FBS showed a significant (p < 0.005) increase in the proliferation rate of cells treated with T7 (0.4 W × 10 s) as compared to the untreated control. After 72 h, only cells cultured in 10% FBS showed a significant increase in the proliferation rate of the cells treated with T9 (1 W × 3 s) (p < 0.005) and T7 (0.4 W × 10 s) (p < 0.00005). Conclusions Low-power laser therapy at a wavelength of 810 nm induced hDPSC proliferation at the following parameters: power output 0.4 W, irradiance 0.5 W/cm2, fluence 0.416 J/cm2, exposure time 10 s.

Flow cytometric characterization of cell surface markers to differentiate between fibroblasts and mesenchymal stem cells of different origin

Authors

Suzanne A Sober,Homa Darmani,Dana Alhattab,Abdalla Awidi

Journal

Archives of Medical Science: AMS

Published Date

2023

ResultsOur results indicate that the following markers could be useful in differentiating between fibroblasts and MSCs derived from the following: adipose tissue–CD79a, CD105, CD106, CD146, and CD271; Wharton’s jelly–CD14, CD56, and CD105; bone marrow–CD105, CD106, and CD146; and placental tissue–CD14, CD105, and CD146. Furthermore, we found that, contradictory to previous studies, CD26 is not fibroblast specific.ConclusionsThe results of our study indicate that cell surface markers may prove to be a useful tool in the discrimination between MSCs of different origins and fibroblasts, and thus may be used to authenticate the identity of the isolated cells.

Effective generation of functional pancreatic β cells from human-derived dental stem cells of apical papilla and bone-marrow-derived stem cells: a comparative study

Authors

Duaa Abuarqoub,Sofia Adwan,Rand Zaza,Suha Wehaibi,Nazneen Aslam,Hanan Jafar,Nidal Qinnah,Abdalla Awidi

Journal

Pharmaceuticals

Published Date

2023/4/26

Diabetes Mellitus Type 1 is an autoimmune disease that occurs due to the destruction of insulin-producing cells (β cells), resulting in hyperglycemia. Therefore, diabetic patients depend on insulin treatment for the rest of their lives. Stem cells are considered a promising cellular therapy to replace the nonfunctional beta cells with functional and mature beta cells. Hence, in this study, we aimed to examine the potential of dental stem cells of apical papilla (SCAP) to differentiate into functional islet cell aggregates (ICAs), compared to the ICA generated from bone-marrow-derived stem cells (BM-MSCs). Our strategy was to induce the differentiation of SCAP and BM-MSCs into a definitive endoderm. The success of endodermal differentiation was determined by measuring the expression of definitive endodermal markers, FOXA2 and SOX-17, by flow cytometry. Next, the maturity and functionality of the differentiated cells were evaluated by measuring the amount of insulin and C-peptide secreted by the derived ICAs using ELISA. Additionally, the expression of mature beta cell markers—insulin, C-peptide, glucagon and PDX-1—was detected through confocal microscopy, while the staining of the mature islet-like clusters was detected by using diphenythiocarbazone (DTZ). Our results have shown that both SCAP and BM-MSCs were sequentially committed to a definitive pancreatic endoderm and β-cell-like cells by upregulating the expression of FOXA2 and SOX17 significantly (**** p < 0.0000 and *** p = 0.0001), respectively. Moreover, the identity of ICAs was confirmed by DTZ-positive staining, as well as by the expression of C-peptide, Pdx-1, insulin …

Biological Performance of Primary Dental Pulp Stem Cells Treated with Gold Nanoparticles

Authors

Duaa Abuarqoub,Nouf Mahmoud,Walhan Alshaer,Marwa Mohammad,Abed Alqader Ibrahim,Mairvat Al-Mrahleh,Mohammad Alnatour,Dana A Alqudah,Ezaldeen Esawi,Abdalla Awidi

Journal

Biomedicines

Published Date

2023/9/8

Gold nanoparticles (AuNPs) are one of the most stable nanoparticles that have been prevalently used as examples for biological and biomedical applications. Herein, we evaluate the effect of AuNPs on the biological processes of dental pulp stem cells derived from exfoliated deciduous teeth (SHED). Two different shapes of PEGylated AuNPs, rods (AuNR-PEG) and spheres (AuNS-PEG), were prepared and characterized. SHED cells were treated with different concentrations of AuNR-PEG and AuNS-PEG to determine their effect on the stemness profile of stem cells (SCs), proliferation, cytotoxicity, cellular uptake, and reactive oxygen species (ROS), for cells cultured in media containing-fetal bovine serum (FBS) and serum-free media (SFM). Our results showed that both nanoparticle shapes maintained the expression profile of MSC surface markers. Moreover, AuNS-PEG showed a stimulatory effect on the proliferation rate and lower toxicity on SHED, compared to AuNR-PEG. Higher concentrations of 0.5–0.125 nM of AuNR-PEG have been demonstrated to cause more toxicity in cells. Additionally, cells treated with AuNPs and cultured in FBS showed a higher proliferative rate and lower toxicity when compared to the SFM. For cellular uptake, both AuNS-PEG and AuNR-PEG were uptaken by treated cells efficiently. However, cells cultured in SFM media showed a higher percentage of cellular uptake. For ROS, AuNR-PEG showed a significant reduction in ROS at lower concentrations (<0.03 nM), while AuNS-PEG did not show any significant difference compared to the control untreated cells. Thus, our results give evidence about the optimum …

Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting …

Authors

Dana M Alhattab,Ioannis Isaioglou,Salwa Alshehri,Zainab N Khan,Hepi H Susapto,Yanyan Li,Yara Marghani,Arwa A Alghuneim,Rubén Díaz-Rúa,Sherin Abdelrahman,Shuroug Al-Bihani,Farid Ahmed,Raed I Felimban,Heba Alkhatabi,Raed Alserihi,Malak Abedalthagafi,AlShaibani AlFadel,Abdalla Awidi,Adeel Gulzar Chaudhary,Jasmeen Merzaban,Charlotte AE Hauser

Journal

Biomaterials Research

Published Date

2023/11/6

BackgroundAcute myeloid leukemia (AML) is a hematological malignancy that remains a therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking the bone marrow (BM) microenvironment are needed. This study aimed to achieve an automated fabrication process of a three-dimensional (3D) AML disease model that recapitulates the 3D spatial structure of the BM microenvironment and applies to drug screening and investigational studies.MethodsTo build this model, we investigated a unique class of tetramer peptides with an innate ability to self-assemble into stable hydrogel. An automated robotic bioprinting process was established to fabricate a 3D BM (niche-like) multicellular AML disease model comprised of leukemia cells and the BM’s stromal and endothelial cellular fractions. In addition …

The osteogenic role of Biomaterials Combined with Human-Derived Dental Stem cells in bone tissue regeneration

Authors

Duaa Abuarqoub,Laith S Theeb,Mohammad B Omari,Yazan I Hamadneh,Jawad A Alrawabdeh,Nazneen Aslam,Hanan Jafar,Abdalla Awidi

Published Date

2023/4

The use of stem cells in regenerative medicine had great potential for clinical applications. However, cell delivery strategies have critical importance in stimulating the differentiation of stem cells and enhancing their potential to regenerate damaged tissues. Different strategies have been used to investigate the osteogenic potential of dental stem cells in conjunction with biomaterials through in vitro and in vivo studies. Osteogenesis has a broad implication in regenerative medicine, particularly for maxillofacial defects. This review summarizes some of the most recent developments in the field of tissue engineering using dental stem cells.

Management of breast cancer patients with BRCA gene mutations in Jordan: perspectives and challenges

Authors

Hikmat Abdel-Razeq,Salah Abbasi,Ghadeer Abdeen,Hazem Abdulelah,Jamil Debs,Sarah Al Masri,Majdi H Aljadayeh,Abdalla Awidi

Published Date

2023/8/8

BackgroundThis paper explores and discusses local challenges oncologists face for diagnosing and managing breast cancer patients with BRCA gene mutations in Jordan.MethodsA task force involving key opinion leaders, experts in the management of breast cancer, and stakeholders in healthcare systems where genetic testing is available in Jordan discussed current evidence and local real-life practice. The task force then formulated recommendations to achieve better patient outcomes and satisfaction based on evidence-based medicine and their clinical experience in BRCA-mutated breast cancer management.Results and conclusionEligibility of patients for genetic testing, physician acceptance and willingness to integrate genetic testing into routine practice is encouraging but remains restricted by testing availability and financial coverage. Until more data is available, genetic testing should be targeted for …

See List of Professors in abdalla awidi University(University of Jordan)

abdalla awidi FAQs

What is abdalla awidi's h-index at University of Jordan?

The h-index of abdalla awidi has been 19 since 2020 and 28 in total.

What are abdalla awidi's top articles?

The articles with the titles of

Myelodysplastic Syndromes and Myelodysplastic Syndromes/Myeloproliferative Neoplasms: A Real-World Experience From a Developing Country

Functional Role of Human-Derived Stem Cells in Bone Tissue Regeneration

Safety and potential efficacy of expanded mesenchymal stromal cells of bone marrow and umbilical cord origins in patients with chronic spinal cord injuries: A phase I/II study

Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study

Phytochemical Analysis and Anticancer Properties of Drimia maritima Bulb Extracts on Colorectal Cancer Cells

Hemophilia in Jordan: An Economic Burden Dilemma of Rare Disease

Corrigendum to" Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer"[Life Sci., 329 (2023) 121964]

Influence of Diabetes Mellitus Type 2 on the angiogenic potential of Bone Marrow derived Mesenchymal Stem Cells

...

are the top articles of abdalla awidi at University of Jordan.

What are abdalla awidi's research interests?

The research interests of abdalla awidi are: Hematology, Oncology, Stem cells and Regenerative medicine

What is abdalla awidi's total number of citations?

abdalla awidi has 2,921 citations in total.

What are the co-authors of abdalla awidi?

The co-authors of abdalla awidi are Edward Tuddenham, Kamel Ajlouni, Omar Khabour, Meytal Landau, Sayer Al-Azzam, Omar Shaheen.

    Co-Authors

    H-index: 87
    Edward Tuddenham

    Edward Tuddenham

    University College London

    H-index: 51
    Kamel Ajlouni

    Kamel Ajlouni

    University of Jordan

    H-index: 44
    Omar Khabour

    Omar Khabour

    Jordan University of Science and Technology

    H-index: 35
    Meytal Landau

    Meytal Landau

    Technion - Israel Institute of Technology

    H-index: 32
    Sayer Al-Azzam

    Sayer Al-Azzam

    Jordan University of Science and Technology

    H-index: 22
    Omar Shaheen

    Omar Shaheen

    University of Jordan

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