Abbas Shahi

About Abbas Shahi

Abbas Shahi, With an exceptional h-index of 9 and a recent h-index of 8 (since 2020), a distinguished researcher at Tehran University of Medical Sciences, specializes in the field of Inflammation, Autoimmune diseases, Transplant Immunology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Potential roles of inflammasomes in the pathophysiology of Psoriasis: A comprehensive review

The potential roles of Th17 cells in the pathogenesis of oral lichen planus

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 axis: a potential novel pathway to regulate immune response against COVID-19

Potential roles of long noncoding RNAs as therapeutic targets in organ transplantation

Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer

Natural killer cells and killer cell immunoglobulin-like receptors in solid organ transplantation: Protectors or opponents?

Evaluation of thymic output and regulatory T cells in kidney transplant recipients with chronic antibody-mediated rejection

Abbas Shahi Information

University

Tehran University of Medical Sciences

Position

Department of Immunology School of Medicine

Citations(all)

278

Citations(since 2020)

256

Cited By

106

hIndex(all)

9

hIndex(since 2020)

8

i10Index(all)

8

i10Index(since 2020)

6

Email

University Profile Page

Tehran University of Medical Sciences

Abbas Shahi Skills & Research Interests

Inflammation

Autoimmune diseases

Transplant Immunology

Top articles of Abbas Shahi

Potential roles of inflammasomes in the pathophysiology of Psoriasis: A comprehensive review

Authors

Abbas Shahi,Shima Afzali,Aliakbar Amirzargar,Poopak Mohaghegh,Saeedeh Salehi,Yaser Mansoori

Published Date

2023/9/1

Psoriasis is an inflammatory skin disease whose pathophysiology is attributed to both innate and adaptive immune cells and molecules. Despite the crucial roles of the immune system in psoriasis, it cannot be categorized as an autoimmune disease because of the lack of main signs of autoimmunity, such as specific antibodies, well-defined antigens, and autoimmune genetic risk factors. The presence of some cellular and molecular properties, such as the presence of neutrophils in skin lesions and the activation of the innate immune system, attributes psoriasis to a group of diseases called autoinflammatory disorders. Autoinflammatory diseases refer to a group of inherited disorders whose main manifestations are recurrent fever, a high level of acute-phase reactant, and a tendency for inflammation of the skin, joints, and other organs like the nervous system. In most autoinflammatory disorders, it has been seen that …

The potential roles of Th17 cells in the pathogenesis of oral lichen planus

Authors

Shima Afzali,Elham Mohammadisoleimani,Yaser Mansoori,Poopak Mohaghegh,Maryam Bahmanyar,Behnam Mansoori,Babak Pezeshki,Ghasem Nikfar,Alireza Tavassoli,Abbas Shahi,Ali Moravej

Published Date

2023/7

BackgroundOral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease, whose pathogenesis and etiology are not entirely understood. OLP is characterized by subepithelial lymphocyte infiltration and elevated intra-epithelial lymphocytes. The majority of lamina propria lymphocytes are CD4+ T cells. CD4+ helper T (Th) cells play a crucial role in activating CD8+ cytotoxic T cells (CTLs) through interactions and cytokine production. Th1 and Th2 cells are well-accepted to be associated with OLP pathogenesis. However, OLP treatment is challenging yet, the more information we have about the pathology of OLP, the easier it will be treated. With the discovery of Th17 cells in recent years and the demonstration of their role in autoimmune disease, many researchers started to investigate the role of Th17 in the pathogenesis of OLP.MethodsTo make up this review, studies covering the role of TH17 in …

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Authors

Abbas Shahi,Shima Afzali,Zahra Firoozi,Poopak Mohaghegh,Ali Moravej,Ali Hosseinipour,Maryam Bahmanyar,Yaser Mansoori

Published Date

2023/3

There is a heterogeneous group of rare illnesses that fall into the vasculitis category and are characterized mostly by blood vessel inflammation. Ischemia and disrupted blood flow will cause harm to the organs whose blood arteries become inflamed. Kawasaki disease (KD) is the most prevalent kind of vasculitis in children aged 5 years or younger. Because KD's cardiovascular problems might persist into adulthood, it is no longer thought of as a self‐limiting disease. KD is a systemic vasculitis with unknown initiating factors. Numerous factors, such as genetic predisposition and infectious pathogens, are implicated in the etiology of KD. As endothelial cell damage and inflammation can lead to coronary endothelial dysfunction in KD, some studies hypothesized the crucial role of pyroptosis in the pathogenesis of KD. Additionally, pyroptosis‐related proteins like caspase‐1, apoptosis‐associated speck‐like protein …

Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 axis: a potential novel pathway to regulate immune response against COVID-19

Authors

Zahra Firoozi,Elham Mohammadisoleimani,Abbas Shahi,Mohammad Mehdi Naghizadeh,Ebrahim Mirzaei,Ali Ghanbari Asad,Zahra Salmanpour,Seyed Mohamad Javad Nouri,Yaser Mansoori

Journal

Canadian Journal of Infectious Diseases and Medical Microbiology

Published Date

2022/8/30

Background. COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic and mortality of people around the world. Some circular RNAs (circRNAs), one of the new types of noncoding RNAs (ncRNAs), act as competing endogenous RNAs (ceRNAs) and compete with mRNAs for shared miRNAs, to regulate gene expression. In the present study, we aimed to evaluate the expression and roles of hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 in COVID-19 infection. Materials and Methods. After extraction of total RNA from peripheral blood mononuclear cells (PBMC) of 50 patients with symptomatic COVID-19, 50 patients with nonsymptomatic COVID-19, and 50 normal controls, cDNA synthesis was performed. Online in silico tools were applied to evaluate the interaction between the genes in the hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 axis, and its role in COVID-19-related pathways. Quantification of the expression of these genes and confirmation of their interaction was done using the quantitative real-time PCR (qRT-PCR) technique. Results. The expression levels of hsa_circ_0000479, RIG-I, and IL-6 were increased in COVID-19 patients compared to healthy controls, while hsa-miR-149-5p expression was decreased. Moreover, there was a significant negative correlation between hsa-miR-149-5p and hsa_circ_0000479, RIG-I, IL-6 expressions, and also a positive expression correlation between hsa_circ_0000479 and IL-6, RIG-I. Then, bioinformatics tools revealed the role of hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 axis in PI3K-AKT and STAT3 signaling …

Potential roles of long noncoding RNAs as therapeutic targets in organ transplantation

Authors

Saeedeh Salehi,Shima Afzali,Abbas Shahi,Ali Akbar Amirzargar,Yaser Mansoori

Published Date

2022/4/12

Organ transplantation is the most preferred treatment option for end-stage organ diseases; however, allograft rejection is the major hurdle in successful long-term transplant survival. In spite of developing better HLA matching and more effective immunosuppressive regimen, one-year graft survival has been increased by nearly 90% and the incidence of acute rejection by one-year post-transplantation has been decreased by 12.2% in the last decades, chronic allograft rejection has remained as one of the major obstacles to the long-lasting survival of the transplanted allograft. Therefore, seemingly preventing the allograft rejection and inducing immunological tolerance against transplanted allografts is one of the primary goals in transplantation research to enable long-lasting graft survival. Various mechanisms such as long noncoding RNAs (lncRNAs) have been proposed that induce immune tolerance by modulating the gene expression and regulating innate and adaptive immune responses during transplantation. Besides, because of involvement in regulating epigenetic, transcriptional, and post-translational mechanisms, lncRNAs could affect allograft status. Therefore, these molecules could be considered as the potential targets for prediction, prognosis, diagnosis, and treatment of graft rejection. It is suggested that the noninvasive predictive biomarkers hold promise to overcome the current limitations of conventional tissue biopsy in the diagnosis of rejection. Hence, this review aims to provide a comprehensive overview of lncRNAs and their function to facilitate diagnosis, prognosis, and prediction of the risk of graft rejection, and the …

Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer

Authors

Zahra Firoozi,Elham Mohammadisoleimani,Abbas Shahi,Hosein Mansoori,Mohammad Mehdi Naghizadeh,Milad Bastami,Ziba Nariman‐Saleh‐Fam,Abdolreza Daraei,Atefeh Raoofat,Yaser Mansoori

Journal

Journal of Clinical Laboratory Analysis

Published Date

2022/3

Background Breast cancer (BC) is one of the leading causes of death among women around the world. Circular RNAs (circRNAs) are a newly discovered group of non‐coding RNAs that their roles are being investigated in BC and other cancer types. In this study, we evaluated the association of hsa_circ_0005986 and hsa_circ_000839 in tumor and adjacent normal tissues of BC patients with their clinicopathological characteristics. Materials and methods Total RNA was extracted from tumors and adjacent non‐tumor tissues by the Trizol isolation reagent, and cDNA was synthesized using First Strand cDNA Synthesis Kit (Thermo Scientific). The expression level of hsa_circ_0005986 and hsa_circ_000839 was quantified using RT‐qPCR. Online in silico tools were used for identifying potentially important competing endogenous RNA (ceRNA) networks of these two circRNAs. Results The expression level of …

Natural killer cells and killer cell immunoglobulin-like receptors in solid organ transplantation: Protectors or opponents?

Authors

Mina Roshan Zamir,Abbas Shahi,Saeedeh Salehi,Aliakbar Amirzargar

Published Date

2022/12/1

Among all the cells of innate immunity, natural killer (NK) cells are well-known for the fight against tumors and virally-infected cells. NK cells have been implicated in the pathogenesis of immune-mediated allograft damage, but mounting evidence suggests they can potentially promote allograft tolerance as well. In addition, NK cells express a wide variety of activating and inhibiting receptors, and the signals sent by these molecules, particularly killer cell immunoglobulin-like receptors (KIRs), determine their ultimate function. The role of KIRs and their human leukocyte antigen (HLA) class I ligands have been extensively investigated in hematopoietic stem cell transplantation (HSCT). Previous studies have suggested that, in the setting of solid organ transplantation, having certain KIR genes or KIR/HLA combinations probably affects allograft survival. Therefore, it may be helpful to analyze KIR/HLA combinations in …

Evaluation of thymic output and regulatory T cells in kidney transplant recipients with chronic antibody-mediated rejection

Authors

Abbas Shahi,Saeedeh Salehi,Shima Afzali,Ladan Gol Mohammad Pour Afrakoti,Marzie Esmaeili,Farzaneh Bagherpour,Ziba Aghsaeifard,Sanaz Dehghani,Gholamreza Pourmand,Ali Akbar Amirzargar

Journal

BioMed Research International

Published Date

2021/2/10

Background. Regulatory T cells (Tregs) and recent thymic emigrants (RTEs) have an essential role in the regulation of allogeneic immune responses. However, their mechanisms of action in chronic antibody-mediated rejection (cAMR) are still unclear. In this study, we aimed to compare Treg and RTE levels between stable graft function (SGF) patients and cAMR subjects after kidney transplantation. Method. Mononuclear cells (MNs) were separated from peripheral blood, and flow cytometry analysis was performed for detection of CD4+ and CD25high as Treg markers and CD4+, CD31+, and CD45RA+ as RTE immunophenotyping markers. Result. The level of peripheral Treg cells was significantly lower in cAMR subjects in comparison to stable graft function patients. Moreover, SGF patients who had received cyclosporine A had a higher level of Treg in comparison to the tacrolimus recipients. Nevertheless, the RTE level between SGF and cAMR patients did not show any significant differences. Conclusion. It seems that Treg cells are significantly associated with transplant outcomes in cAMR patients, and prescribed immunosuppressive drugs can influence the frequency of this crucial subset of T cells. Although these drugs are beneficial and inevitable for allograft maintenance, more investigations are needed to elucidate their complete effects on different immune cell subsets which some of them like Tregs are in favor of transplant tolerance. Besides, the thymic output is seemingly not a beneficial biomarker for predicting cAMR; however, more in vivo and in vitro studies are needed for revealing the precise role of Tregs and RTEs in the …

The effect of CYP3A4 genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors in renal transplant recipients: a systematic review and meta-analysis protocol

Authors

Saeedeh Salehi,Fateme Abedini,Abbas Shahi,Shima Afzali,Simin Dashti-Khavidaki,Ali Akbar Amirzargar

Published Date

2021/3/15

BackgroundCalcineurin inhibitors (CNIs) are metabolized by CYP3A4. Polymorphisms in the CYP3A4 gene alter the activity of CYP3A4 protein and therefore affect the CNIs concentrations. Results of studies that investigated the association between CYP3A4 polymorphisms and CNIs pharmacokinetics are controversial. Therefore, this systematic review and meta-analysis will evaluate the effect of CYP3A4 polymorphisms on the pharmacokinetics of CNIs in renal transplant recipients.MethodThis protocol is developed according to the PRISMA-P guideline and registered in PROSPERO (CRD42020145219). The MeSH/Emtree terms of CYP3A4 polymorphisms and CNIs pharmacokinetics in PECO-based question will be obtained from the comprehensive literature search on PubMed/MEDLINE, Scopus, Web of Science, Embase, CENTRAL, and ProQuest without any language limitation from 1 January 1998 to 31 March 2021. Google Scholar search engine, registries, conference papers, and key journals will also be searched. Screening, selection, quality assessment, and data extraction will be performed by two independent reviewers. Statistical heterogeneity will be calculated by the Q Cochrane test and I2 statistic. Publication bias and sensitivity analysis will be evaluated by appropriate tests.Results and conclusionAccording to the meta-analysis of the aggregated data from the relevant primary studies, the association between CYP3A4 polymorphisms and CNIs pharmacokinetics will be reported, which possibly help the pharmacogenetic-guided dosing approach.

Investigating the role of BAFF and its receptors in renal transplant recipients with chronic antibody-mediated rejection

Authors

Shima Afzali,Saeedeh Salehi,Abbas Shahi,Marzie Esmaeili,Samad Farashi Bonab,Azin Peykari,Farzaneh Bagherpour,Bita Ansaripour,Tayebeh Soleimanian,Fatemeh Pour-Reza-Gholi,Aliakbar. Amirzargar

Journal

Journal of Immunology Research

Published Date

2021/3/8

Background Kidney transplantation is the best treatment option for end stage renal disease (ESRD), but graft rejection is still a big obstacle that occurs in spite of immunosuppressive therapy. B cells are considered as the major reason for renal graft rejection because of antibody production. Due to their roles in B cell function, we intended to evaluate the B cell activating factor (BAFF) and its receptors including BAFF receptor (BAFF-R), B cell maturation antigen (BCMA), and transmembrane activator and cyclophilin ligand interactor (TACI) in renal transplant patients. Method The study included 40 kidney allograft patients with cAMR, 40 stable kidney allograft patients, and 8 healthy volunteers with normal kidney function. The percentage and absolute number of CD19+ B cells were analyzed by flow cytometry, the serum level of BAFF was analyzed by ELISA, and mRNA expressions of BAFF and BAFF receptors (BAFF-R, BCMA, and TACI) were measured using quantitative real-time PCR. Results The percentage and the absolute number of B cells decreased significantly in stable and cAMR patients compared to healthy individuals. The serum level and gene expression of BAFF, as well as the mRNA level of BCMA, were increased significantly in both cAMR and stable patients compared to healthy volunteers. There was an overexpression of TACI mRNA in cAMR patients compared to stable patients. Conclusions Both soluble protein and mRNA transcript of BAFF increased in transplant recipients. However, BAFF neither at the serum level nor at the mRNA transcript level cannot be a good biomarker for the prediction of cAMR. In addition, expression …

B cell modulation strategies in the improvement of transplantation outcomes

Authors

Shima Afzali,Saeedeh Salehi,Abbas Shahi,Aliakbar Amirzargar

Published Date

2020/9/1

Successful transplantation outcome is the final goal in most end stage and nonfunctional organs; however, despite using different therapeutic strategies, antibody-mediated rejection is still a big obstacle. B cells have a key role in transplant rejection by several functions, such as antibody production, antigen presenting, contribution in T cell activation, forming the germinal center, and tertiary lymphoid organs. Therefore, B cells modulation seems to be very crucial in transplant outcome. A double-edged sword function is considered for B cells during transplantation; On the one hand, antibody production against the transplanted organ induces antibody-mediated rejection. On the other hand, IL10 production by regulatory B (Breg) cells induces graft tolerance. Nowadays, several monoclonal antibodies (mAb) are available for B cell modulation that are routinely used in transplant recipients, among which rituximab (anti …

Transitional immature regulatory B cells and regulatory cytokines can discriminate chronic antibody-mediated rejection from stable graft function

Authors

Saeedeh Salehi,Abbas Shahi,Shima Afzali,Abbas Ali Keshtkar,Samad Farashi Bonab,Tayebeh Soleymanian,Bita Ansaripour,Ali Akbar Amirzargar

Journal

International immunopharmacology

Published Date

2020/9/1

BackgroundThe balance between inflammatory and anti-inflammatory responses of the immune system has been demonstrated to determine the fate of transplanted allografts. Here we analyzed CD19+CD24hiCD38hi immature transitional regulatory B (TRB) cells, as well as the gene and protein levels of interleukin (IL)-10 and transforming growth factor (TGF)-β in the three separate groups, include of stable transplanted subjects, chronic antibody-mediated rejection (cAMR) patients, and healthy individuals.MethodPeripheral blood mononuclear cells (PBMCs) from stable subjects (n = 36), cAMR patients (n = 36) and healthy controls (n = 18) were isolated. Flowcytometry was performed for CD19, CD24, and CD38 surface markers. ELISA and quantitative real-time PCR were performed for IL-10 and TGF-β cytokines.ResultThe percentages of immature TRB cells were significantly decrease in cAMR patients (0.98 …

Intravenous immunoglobulin therapy in myocarditis

Authors

Amir Hossein Mansourabadi,Ladan Gol Mohammad pour Afrakoti,Abbas Shabanian,Reza Shabanian,Aliakbar Amirzargar

Published Date

2020/8/25

Myocarditis is an inflammatory disease of the myocardium with lymphocyte infiltration and myocyte necrosis leading to a wide range of clinical presentations including heart failure, arrhythmia, and cardiogenic shock. Infectious and noninfectious agents may trigger the disease. The fact that immunosuppressive drugs are useful in several kinds of autoimmune myocarditis is proof of the autoimmune mechanisms involved in the development of myocarditis. Pathogenic mechanisms in myocardial inflammation are including inflammasome activation followed by myocyte destruction, myocarditis, and pericarditis. Intravenous immunoglobulin (IVIG) is a serum product made up of immunoglobulins, widely used in a variety of diseases. This product is effective in several immune-mediated pathologies. As well as the determined usage of IVIG in Kawasaki disease, IVIG may be useful in several kinds of heart failure including fulminant myocarditis, acute inflammatory cardiomyopathy, Giant Cell Myocarditis, and peripartum cardiomyopathy. Generally, IVIG is used in two different doses of low dose (200 to 400 mg/kg) and high dose (2 g/kg) regimen. The exact therapeutic effects of IVIG are not clear, however over the last decades, our knowledge about its mechanism of function has greatly enhanced. IVIG administration should be based on the accepted protocols of its transfusion. In this review article, we try to provide an overview of the different kinds of myocarditis, pathologic mechanisms and their common treatments and evaluation of the administration of IVIG in these diseases. Furthermore, we will review current protocols using IVIG in each disease …

IL-27 and autoimmune rheumatologic diseases: The good, the bad, and the ugly

Authors

Abbas Shahi,Shima Afzali,Saeedeh Salehi,Saeed Aslani,Mahdi Mahmoudi,Ahmadreza Jamshidi,Aliakbar Amirzargar

Published Date

2020/7/1

The footprint of cytokines is evident in almost every biological process, such as development, as well as the pathogenesis of the different diseases, immune responses to pathogens, etc. These small proteins are categorized into different functional classes; for instance, they can play a pro-inflammatory or anti-inflammatory role in different situations, or they can confer a polarization to the immune system. Interleukin (IL)-27 is a member of the IL-12 family. Antigen-presenting cells are the primary source of IL-27 production, which exerts its effects by bindings to the IL-27 receptor expressed on the surface of target cells. Interaction of IL-27 and IL-27 receptor leads to activation of the JAK-STAT and p38 MAPK signaling pathways. Most studies focused on the inflammatory effects of this cytokine, but gradually anti-inflammatory effects were also revealed for this cytokine, which changed the traditional perception of the …

See List of Professors in Abbas Shahi University(Tehran University of Medical Sciences)

Abbas Shahi FAQs

What is Abbas Shahi's h-index at Tehran University of Medical Sciences?

The h-index of Abbas Shahi has been 8 since 2020 and 9 in total.

What are Abbas Shahi's top articles?

The articles with the titles of

Potential roles of inflammasomes in the pathophysiology of Psoriasis: A comprehensive review

The potential roles of Th17 cells in the pathogenesis of oral lichen planus

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 axis: a potential novel pathway to regulate immune response against COVID-19

Potential roles of long noncoding RNAs as therapeutic targets in organ transplantation

Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer

Natural killer cells and killer cell immunoglobulin-like receptors in solid organ transplantation: Protectors or opponents?

Evaluation of thymic output and regulatory T cells in kidney transplant recipients with chronic antibody-mediated rejection

...

are the top articles of Abbas Shahi at Tehran University of Medical Sciences.

What are Abbas Shahi's research interests?

The research interests of Abbas Shahi are: Inflammation, Autoimmune diseases, Transplant Immunology

What is Abbas Shahi's total number of citations?

Abbas Shahi has 278 citations in total.

    academic-engine

    Useful Links