Aaron Tobian, M.D., Ph.D

Aaron Tobian, M.D., Ph.D

Johns Hopkins University

H-index: 72

North America-United States

About Aaron Tobian, M.D., Ph.D

Aaron Tobian, M.D., Ph.D, With an exceptional h-index of 72 and a recent h-index of 51 (since 2020), a distinguished researcher at Johns Hopkins University, specializes in the field of Transfusion, Blood, Infectious Diseases, HIV.

His recent articles reflect a diverse array of research interests and contributions to the field:

Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines

Temporal dynamics and drivers of durable HIV viral load suppression and persistent high‐and low‐level viraemia during Universal Test and Treat scale‐up in Uganda: a population …

Euvolemic automated transfusion to treat severe anemia in sickle cell disease patients at risk of circulatory overload

Effect of cryopreservation on CD4+ T cell subsets in foreskin tissue

Erratum for Gebo et al.,“Early antibody treatment, inflammation, and risk of post-COVID conditions”

HIV epidemiologic trends among occupational groups in Rakai, Uganda: A population-based longitudinal study, 1999–2016

Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012

Suspected autoimmune encephalitis: A retrospective study of patients referred for therapeutic plasma exchange

Aaron Tobian, M.D., Ph.D Information

University

Johns Hopkins University

Position

Director of Transfusion Medicine Professor of Pathology Medicine and Epidemiology

Citations(all)

21296

Citations(since 2020)

13473

Cited By

10774

hIndex(all)

72

hIndex(since 2020)

51

i10Index(all)

258

i10Index(since 2020)

221

Email

University Profile Page

Johns Hopkins University

Aaron Tobian, M.D., Ph.D Skills & Research Interests

Transfusion

Blood

Infectious Diseases

HIV

Top articles of Aaron Tobian, M.D., Ph.D

Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines

Authors

Jeannie Callum,Nikolaos J Skubas,Aarti Bathla,Homa Keshavarz,Edward G Clark,Bram Rochwerg,Dean Fergusson,Sesmu Arbous,Seth R Bauer,Louise China,Mark Fung,Rachel Jug,Michael Neill,Cary Paine,Katerina Pavenski,Prakesh S Shah,Susan Robinson,Hua Shan,Zbigniew M Szczepiorkowski,Thierry Thevenot,Bovey Wu,Simon Stanworth,Nadine Shehata,Jerome Flores,Stéfanie Frappier,Yvette Hou,Lilly Jean-Pierre,Danny Jomaa,Monisha Kabir,Leo Kadota,Michelle Lam,David A Ripsman,Ryan Sandarage,Emiliyan Staykov,Angelica Venes,Melissa Wan,Arwa Al Riyami,Shubha Allard,Melissa Brouwers,James Daly,Gregory A Denomme,Lise Estcourt,Laura Green,Andreas Greinacher,Heather Hume,Richard Kaufman,Hyungsuk Kim,Vernon Louw,Tadashi Matsushita,Michael Murphy,Joanne Pink,Cynthia So-Osman,Aaron Tobian,Erica Wood

Journal

Chest

Published Date

2024/3/4

BackgroundAlbumin is used commonly across a wide range of clinical settings to improve hemodynamics, to facilitate fluid removal, and to manage complications of cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines for the use of albumin in patients requiring critical care, undergoing cardiovascular surgery, undergoing kidney replacement therapy, or experiencing complications of cirrhosis.MethodsCochairs oversaw the guideline development process and the panel included researchers, clinicians, methodologists, and a patient representative. The evidence informing this guideline arises from a systematic review of randomized clinical trials and systematic reviews, in which multiple databases were searched (inception through November 23, 2022). The panel reviewed the data and formulated the guideline recommendations using Grading of Recommendations …

Temporal dynamics and drivers of durable HIV viral load suppression and persistent high‐and low‐level viraemia during Universal Test and Treat scale‐up in Uganda: a population …

Authors

Joseph Gregory Rosen,Robert Ssekubugu,Larry W Chang,Victor Ssempijja,Ronald M Galiwango,Joseph Ssekasanvu,Anthony Ndyanabo,Alice Kisakye,Gertrude Nakigozi,Katherine B Rucinski,Eshan U Patel,Caitlin E Kennedy,Fred Nalugoda,Godfrey Kigozi,Oliver Ratmann,Lisa J Nelson,Lisa A Mills,Donna Kabatesi,Aaron AR Tobian,Thomas C Quinn,Joseph Kagaayi,Steven J Reynolds,Mary Kathryn Grabowski

Journal

Journal of the International AIDS Society

Published Date

2024/2

Introduction Population‐level data on durable HIV viral load suppression (VLS) following the implementation of Universal Test and Treat (UTT) in Africa are limited. We assessed trends in durable VLS and viraemia among persons living with HIV in 40 Ugandan communities during the UTT scale‐up. Methods In 2015–2020, we measured VLS (<200 RNA copies/ml) among participants in the Rakai Community Cohort Study, a longitudinal population‐based HIV surveillance cohort in southern Uganda. Persons with unsuppressed viral loads were characterized as having low‐level (200–999 copies/ml) or high‐level (≥1000 copies/ml) viraemia. Individual virologic outcomes were assessed over two consecutive RCCS survey visits (i.e. visit‐pairs; ∼18‐month visit intervals) and classified as durable VLS (<200 copies/ml at both visits), new/renewed VLS (<200 copies/ml at follow‐up only), viral rebound (<200 copies …

Euvolemic automated transfusion to treat severe anemia in sickle cell disease patients at risk of circulatory overload

Authors

Nicolas Mercure‐Corriveau,Elizabeth P Crowe,Sonja Vozniak,Xinyi Feng,Herleen Rai,Tayler Van Denakker,Abdulhafiz Zakieh,M Kate Grabowski,Sophie Lanzkron,Aaron AR Tobian,Evan M Bloch

Journal

Transfusion

Published Date

2024/1

Background Red blood cell (RBC) transfusion remains a major treatment for sickle cell disease (SCD). Patients with SCD have a high prevalence of renal impairment and cardiorespiratory disease, conferring risk of transfusion‐associated circulatory overload (TACO). Study Design and Methods We describe an approach, titled euvolemic automated transfusion (EAT), to transfuse SCD patients with severe anemia who are at risk of TACO. In EAT, plasmapheresis is performed using donor RBCs, rather than albumin or plasma, as replacement fluid. Euvolemia is maintained. A retrospective analysis was conducted of patients with SCD who underwent EAT at our institution over a 10‐year period, to evaluate the efficacy and safety of EAT. Results Eleven SCD patients underwent 109 EAT procedures (1–59 procedures per patient). The median age was 42 years (IQR = [30–49]) and 82% (n = 9) were female. Most …

Effect of cryopreservation on CD4+ T cell subsets in foreskin tissue

Authors

Omar Almomani,James Nnamutete,Zhongtian Shao,Victoria Menya Biribawa,HenryRoger Ssemunywa,Annemarie Namuniina,Brenda Okech,Sofya Ulanova,David Zuanazzi,Cindy M Liu,Aaron AR Tobian,Ronald M Galiwango,Rupert Kaul,Jessica L Prodger

Journal

Plos one

Published Date

2024/3/1

Voluntary medical male circumcision (VMMC) reduces HIV acquisition by at least 60%, but the determinants of HIV susceptibility in foreskin tissues are incompletely understood. Flow cytometry is a powerful tool that helps us understand tissue immune defenses in mucosal tissue like the inner foreskin, but foreskin flow cytometry has only been validated using fresh tissue samples. This restricts immune analyses to timepoints immediately after surgical acquisition and hinders research in this area. We compared fresh analysis with whole tissue cryopreservation and later thawing and digestion to analyze CD4+ T cell populations relevant to HIV susceptibility (CCR5, CD25, CD127, CCR4, CXCR3, CCR6, CCR10, HLA-DR, and CD38). Eight foreskin samples from HIV-negative males aged >18 years were collected after VMMC. For each sample, half the foreskin was immediately cryopreserved for later digestion and flow cytometry analysis, while the remaining tissues were analyzed fresh. We demonstrate no significant impact of cryopreservation on CD4+ T cell expression of CD25, CCR4, CCR6, HLA-DR, CCR10, or CD127. Although expression levels of CCR5, CD38, and CXCR3 were increased after cryopreservation, the relative ranking of participants was retained. In conclusion, cryopreserved foreskin tissues may be suitable for subsequent digestion and flow cytometry phenotyping of HIV-susceptible T cell populations.

Erratum for Gebo et al.,“Early antibody treatment, inflammation, and risk of post-COVID conditions”

Authors

Kelly A Gebo,Sonya L Heath,Yuriko Fukuta,Xianming Zhu,Sheriza Baksh,Allison G Abraham,Feben Habtehyimer,David Shade,Jessica Ruff,Malathi Ram,Oliver Laeyendecker,Reinaldo E Fernandez,Eshan U Patel,Owen R Baker,Shmuel Shoham,Edward R Cachay,Judith S Currier,Jonathan M Gerber,Barry Meisenberg,Donald N Forthal,Laura L Hammitt,Moises A Huaman,Adam Levine,Giselle S Mosnaim,Bela Patel,James H Paxton,Jay S Raval,Catherine G Sutcliffe,Shweta Anjan,Thomas Gniadek,Seble Kassaye,Janis E Blair,Karen Lane,Nichol A McBee,Amy L Gawad,Piyali Das,Sabra L Klein,Andrew Pekosz,Evan M Bloch,Daniel Hanley,Arturo Casadevall,Aaron AR Tobian,David J Sullivan,CSSC-004 Consortium

Journal

Mbio

Published Date

2024/1/16

Volume 14, no. 5, e00618-23, 2023, https://journals. asm. org/doi/10.1128/mbio. 00618-23. Page 6, Table 1, last row:“3,041 (2,197, 4,208)” should read “13,774 (8,665, 21,896),” and “13,774 (8,665, 21,896)” should read “3,041 (2,197, 4,208).”

HIV epidemiologic trends among occupational groups in Rakai, Uganda: A population-based longitudinal study, 1999–2016

Authors

Victor O Popoola,Joseph Kagaayi,Joseph Ssekasanvu,Robert Ssekubugu,Grace Kigozi,Anthony Ndyanabo,Fred Nalugoda,Larry W Chang,Tom Lutalo,Aaron AR Tobian,Donna Kabatesi,Stella Alamo,Lisa A Mills,Godfrey Kigozi,Maria J Wawer,John Santelli,Ronald H Gray,Steven J Reynolds,David Serwadda,Justin Lessler,M Kate Grabowski

Journal

PLOS Global Public Health

Published Date

2024/2/20

Certain occupations have been associated with heightened risk of HIV acquisition and spread in sub-Saharan Africa, including female bar and restaurant work and male transportation work. However, data on changes in population prevalence of HIV infection and HIV incidence within occupations following mass scale-up of African HIV treatment and prevention programs is very limited. We evaluated prospective data collected between 1999 and 2016 from the Rakai Community Cohort Study, a longitudinal population-based study of 15- to 49-year-old persons in Uganda. Adjusted prevalence risk ratios for overall, treated, and untreated, prevalent HIV infection, and incidence rate ratios for HIV incidence with 95% confidence intervals were estimated using Poisson regression to assess changes in HIV outcomes by occupation. Analyses were stratified by gender. There were 33,866 participants, including 19,113 (56%) women. Overall, HIV seroprevalence declined in most occupational subgroups among men, but increased or remained mostly stable among women. In contrast, prevalence of untreated HIV substantially declined between 1999 and 2016 in most occupations, irrespective of gender, including by 70% among men (12.3 to 4.2%; adjPRR = 0.30; 95%CI:0.23–0.41) and by 78% among women (14.7 to 4.0%; adjPRR = 0.22; 95%CI:0.18–0.27) working in agriculture, the most common self-reported primary occupation. Exceptions included men working in transportation. HIV incidence similarly declined in most occupations, but there were no reductions in incidence among female bar and restaurant workers, women working in local crafts, or …

Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012

Authors

Xinyi Feng,Eshan U Patel,Jodie L White,Shilan Li,Xianming Zhu,Ni Zhao,Jianxin Shi,Daniel E Park,Cindy M Liu,Rupert Kaul,Jessica L Prodger,Thomas C Quinn,M Kate Grabowski,Aaron AR Tobian

Journal

The Journal of Infectious Diseases

Published Date

2024/1/5

Background Oral human papillomavirus (HPV) infection and the oral microbiome are associated with oropharyngeal cancer. However, population-based data on the association of oral microbiome with oral HPV infection are limited. Method A cross-sectional analysis of 5496 20–59-year-old participants in the 2009–2012 National Health and Nutrition Examination Survey was performed. Associations with oral HPV infection were assessed using multivariable logistic regression for oral microbiome α-diversity (within-sample diversity), and using principal coordinate analysis and permutational multivariate analysis of variance for β-diversity (between-sample heterogeneity). Results Overall, for α-diversity, a lower number of observed amplicon sequence variants (adjusted odds ratio [aOR] = 0.996; 95% confidence interval [CI] = .992–.999) and reduced Faith's …

Suspected autoimmune encephalitis: A retrospective study of patients referred for therapeutic plasma exchange

Authors

Elizabeth P Crowe,Luisa A Diaz‐Arias,Ralph Habis,Sonja O Vozniak,Romergryko G Geocadin,Arun Venkatesan,Aaron AR Tobian,John C Probasco,Evan M Bloch

Journal

Journal of Clinical Apheresis

Published Date

2024/6

Introduction Autoimmune encephalitis (AE) comprises a heterogeneous group of autoantibody‐mediated disorders targeting the brain parenchyma. Therapeutic plasma exchange (TPE), one of several first‐line therapies for AE, is often initiated when AE is suspected, albeit prior to an established diagnosis. We sought to characterize the role of TPE in the treatment of suspected AE. Methods A single‐center, retrospective analysis was performed of adults (≥18 years) who underwent at least one TPE procedure for “suspected AE.” The following parameters were extracted and evaluated descriptively: clinicopathologic characteristics, treatment course, TPE‐related adverse events, outcomes (e.g., modified Rankin scale [mRS]), and diagnosis once investigation was complete. Results A total of 37 patients (median age 56 years, range 28–77 years, 62.2% male) were evaluated. Autoimmune antibody testing was …

Pre-exposure prophylaxis (PrEP) knowledge, use, and discontinuation among Lake Victoria fisherfolk in Uganda: a cross-sectional population-based study

Authors

Kauthrah Ntabadde,Joseph Kagaayi,Victor Ssempijja,Xinyi Feng,Robert Kairania,Joseph Lubwama,Robert Ssekubugu,Ping Teresa Yeh,Joseph Ssekasanvu,Aaron AR Tobian,Caitlin E Kennedy,Lisa A Mills,Stella Alamo,Philip Kreniske,John Santelli,Lisa J Nelson,Steven J Reynolds,Larry W Chang,Gertrude Nakigozi,Mary K Grabowski

Journal

medRxiv

Published Date

2024

Background There are limited population-level data on the pre-exposure prophylaxis (PrEP) care continuum in eastern Africa. Here, we assessed the PrEP care continuum following PrEP rollout in a Ugandan community with ~40% HIV seroprevalence. Methods We used cross-sectional population-based data collected between September 3 and December 19, 2018 from a Lake Victoria fishing community in southern Uganda to measure levels of self-reported PrEP knowledge, ever use, and discontinuation following 2017 PrEP rollout via a U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR)-supported phased implementation program. Our analysis included HIV-seronegative persons reporting having ever received an HIV test result. We examined associations between demographic, behavioral, and health utilization factors with each outcome using age-adjusted modified Poisson regression. Results There were 1,401 HIV-seronegative participants, of whom 1,363 (97.3%) reported ever receiving an HIV test result. Median age was 29 years (IQR: 23-36), and 42.3% (n=577) were women. Most (85.5%; n=1,166) participants reported PrEP knowledge, but few (14.5%; n=197) reported ever using PrEP. Among 375 (47.7%) men and 169 (29.3%) women PrEP-eligible at time of survey, 18.9% (n=71) and 27.8% (n=47) reported ever using PrEP, respectively. Over half (52.3%, n=103) of those who had ever used PrEP, self-reported current use. Conclusion In this Lake Victoria fishing community, there were low levels of PrEP use despite high levels of PrEP awareness and eligibility, particularly among men. Efforts that enhance awareness of HIV …

Reevaluation of the medical necessity of washed red blood cell transfusion in chronically transfused adults

Authors

Tait Huso,Kristen Buban,Tayler A Van Denakker,Kathy Haddaway,Heather Smetana,Christi Marshall,Herleen Rai,Paul M Ness,Evan M Bloch,Aaron AR Tobian,Elizabeth P Crowe

Journal

Transfusion

Published Date

2024/2

Background Washing red blood cell (RBC) units mitigates severe allergic transfusion reactions. However, washing reduces the time to expiration and the effective dose. Automated washing is time‐ and labor‐intensive. A shortage of cell processor tubing sets prompted review of medical necessity for washed RBC for patients previously thought to require washing. Study Design and Methods A single‐center, retrospective study investigated discontinuing wash RBC protocols in chronically transfused adults. In select patients with prior requirements for washing, due to a history of allergic transfusion reactions, trials of unwashed transfusions were performed. Patient demographic, clinical, laboratory, and transfusion data were compiled. The per‐unit washing cost was the sum of the tubing set, saline, and technical labor costs. Results Fifteen patients (median age 34 years interquartile range [IQR] 23–53 years, 46.7 …

Detectable plasma severe acute respiratory syndrome coronavirus 2 spike antigen is associated with poor antibody response following third messenger RNA vaccination in kidney …

Authors

Andrew H Karaba,Zoe Swank,Sarah Hussain,Margaret Chahoud,Christine M Durand,Dorry L Segev,Mark A Robien,Peter S Heeger,Christian P Larsen,Aaron AR Tobian,David R Walt,William A Werbel

Journal

Transplant Infectious Disease

Published Date

2024/4/15

Background Kidney transplant recipients (KTRs) generate lower antibody responses to messenger RNA (mRNA)‐based severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination, yet precise mechanisms for this poor response remain uncertain. One potential contributor is suboptimal spike antigen (sAg) translation and expression owing to transplant immunosuppression, which might lead to insufficient exposure to develop humoral and/or cellular immune responses. Methods Within a single‐arm clinical trial, 65 KTRs underwent ultrasensitive plasma sAg testing before, and 3 and 14 days after, the third mRNA vaccine doses. Anti‐SARS‐CoV‐2 spike antibodies (anti‐receptor binding domain [anti‐RBD]) were serially measured at 14 and 30 days post‐vaccination. Associations between sAg detection and clinical factors were assessed. Day 30 anti‐RBD titer was compared among those with …

Poor sensitivity of anti-nucleocapsid antibody in detecting prior COVID-19 in vaccinated solid organ transplant recipients

Authors

Jennifer L Alejo,Teresa PY Chang,Sarah Frey,Goutham A Nair,Aura T Abedon,Zeba Nauroz,Andrew H Karaba,Robin K Avery,Aaron AR Tobian,William A Clarke,Jacqueline M Garonzik-Wang,Dorry L Segev,Allan B Massie,William A Werbel

Journal

Clinical transplantation

Published Date

2024/1

Letter to the editor: Poor sensitivity of anti-nucleocapsid antibody in detecting prior COVID-19 in vaccinated solid organ transplant recipients Letter to the editor: Poor sensitivity of anti-nucleocapsid antibody in detecting prior COVID-19 in vaccinated solid organ transplant recipients Clin Transplant. 2024 Jan;38(1):e15233. doi: 10.1111/ctr.15233. Authors Jennifer L Alejo 1 , Teresa Py Chang 2 , Sarah Frey 1 , Goutham A Nair 3 , Aura T Abedon 1 , Zeba Nauroz 1 , Andrew H Karaba 4 , Robin K Avery 4 , Aaron AR Tobian 5 , William A Clarke 4 , Jacqueline M Garonzik-Wang 6 , Dorry L Segev 2 , Allan B Massie 2 , William A Werbel 4 Affiliations 1 Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Department of Surgery, NYU Grossman School of Medicine, New York, New York, USA. 3 John Sealy School of Medicine, University of Texas Medical Branch at Galveston, …

Trends in HPV Vaccination Before Age 13 Years in the US National Immunization Survey–Teen

Authors

Jodie L White,M Kate Grabowski,Thomas C Quinn,Aaron AR Tobian,Eshan U Patel

Journal

JAMA pediatrics

Published Date

2024/2/1

Methods| The National Immunization Survey (NIS)–Teen is a cross-sectional survey of parents and guardians of adolescents aged 13 to 17 years (eMethods in Supplement 1). 3 We examined percentages of these adolescents who initiated HPV vaccination and completed the series before age 13 years as separate outcomes and examined sex-specific trends. Analyses were then restricted to the last 4 survey years (2018-2021) given changes in survey procedures in 2018 and to ensure all participants were eligible to have been recommended HPV vaccination at age 11 to 12 years. We estimated annual percent change and prevalence difference (PD) in each outcome from 2018 to 2021, modeling survey year as a continuous and categorical variable in separate binomial regression models. Subgroup analyses were stratified by age at interview. Survey-weighted analyses were conducted in Stata/IC, version 15 …

Unethical not to recommend circumcision

Authors

Brian J Morris,Aaron AR Tobian,Catherine A Hankins,Jeffrey D Klausner,Joya Banerjee,Stefan A Bailis,Stephen Moses,Thomas E Wiswell,Laurie S Zoloth

Published Date

2024/4/2

Evidence-based policies [1-6] concur that medical male circumcision (MC), best performed early in life [7] under local anaesthesia by a trained provider, is a simple, safe procedure conferring lifetime protection against numerous adverse medical conditions that together affect half of all males [2, 7]. Data from numerous clinical trials and hundreds of research studies show benefits greatly exceeding risks [2, 7], particularly in resource-poor communities. Claims of adverse effects on sexual function, sensitivity, and satisfaction are not supported by scientific evidence [8]. Opponents often deny confirmed benefits and overstate or fabricate the harms [9]. While the AAP concluded that the benefits of neonatal MC exceed the risks, it nevertheless acknowledged that for some families other considerations might be more important [1]. This is also true for other neonatal interventions that physicians strongly recommend such as …

Insertive vaginal sex is associated with altered penile immunology and enrichment of Gardnerella vaginalis in uncircumcised Ugandan men

Authors

Erin Day,Ronald M Galiwango,Daniel Park,Sanja Huibner,Maliha Aziz,Aggrey Anok,James Nnamutete,Yahaya Isabirye,John Bosco Wasswa,Deo Male,Godfrey Kigozi,Aaron AR Tobian,Jessica L Prodger,Cindy M Liu,Rupert Kaul

Journal

American Journal of Reproductive Immunology

Published Date

2024/1

Problem HIV susceptibility is linked to the penile immune milieu (particularly IL‐8 levels) and microbiome. The effects of insertive vaginal sex itself on penile immunology and microbiota are not well described. Method of study We compared the immune milieu and microbiology of the coronal sulcus (CS) and distal urethra in 47 uncircumcised Ugandan men reporting ever (n = 42) or never (n = 5) having had vaginal intercourse. Soluble immune factors were assayed by multiplex ELISA, and penile bacteria abundance by 16S rRNA qPCR and sequencing. Co‐primary endpoints were penile levels of IL‐8 and soluble E‐cadherin. Results Independent of classical STIs, men reporting prior vaginal sex demonstrated elevated IL‐8 levels in both the coronal sulcus (1.78 vs. 0.81 log10 pg/mL, p = .021) and urethra (2.93 vs. 2.30 log10 pg/mL; p = .003), with a strong inverse relationship between urethral IL‐8 levels and the …

Pediatric firearm injury related emergency department visits and hospitalizations: a population-based study in the United States

Authors

Ruchika Goel,Xianming Zhu,Sarah Makhani,Cassandra D Josephson,Jodie L White,Oliver Karam,Marianne E Nellis,Eric A Gehrie,Mingmar Sherpa,Elizabeth P Crowe,Evan M Bloch,Aaron AR Tobian

Journal

The Lancet Regional Health–Americas

Published Date

2023/6/1

BackgroundFirearm injury (FI) is the leading cause of death in children and adolescents in the United States (US). We describe the epidemiology of pediatric FI-associated emergency department (ED) visits and hospitalizations in the US stratified by race and ethnicity.MethodsData on pediatric (0–17-year-olds) FI were analyzed using the 2019 Nationwide Emergency Department Sample (NEDS) and Kids' Inpatient Database (KID), the largest all-payer databases in the US for ED visits and pediatric hospitalizations, respectively. FI encounters were stratified by race and ethnicity. Poisson regression was used to identify factors associated with in-hospital mortality. Sampling weights were applied to generate nationally representative estimates.FindingsThere were 7017 pediatric ED visits with FI (NEDS); 85.0% (5961/7017) were male and 73.0% (5125/7017) were adolescents (15–17 years). Overall, 5.5% (384/7017 …

Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization

Authors

Scott A McConnell,Jaiprasath Sachithanandham,Nathan J Mudrak,Xianming Zhu,Parsa Alba Farhang,Radames JB Cordero,Maggie P Wear,Janna R Shapiro,Han-Sol Park,Sabra L Klein,Aaron AR Tobian,Evan M Bloch,David J Sullivan,Andrew Pekosz,Arturo Casadevall

Journal

Cell Chemical Biology

Published Date

2023/7/20

Understanding the mechanisms of antibody-mediated neutralization of SARS-CoV-2 is critical in combating the COVID-19 pandemic. Based on previous reports of antibody catalysis, we investigated the proteolysis of spike (S) by antibodies in COVID-19 convalescent plasma (CCP) and its contribution to viral neutralization. Quenched fluorescent peptides were designed based on S epitopes to sensitively detect antibody-mediated proteolysis. We observed epitope cleavage by CCP from different donors which persisted when plasma was heat-treated or when IgG was isolated from plasma. Further, purified CCP antibodies proteolyzed recombinant S domains, as well as authentic viral S. Cleavage of S variants suggests CCP antibody-mediated proteolysis is a durable phenomenon despite antigenic drift. We differentiated viral neutralization occurring via direct interference with receptor binding from that occurring by …

Antibodies to SARS-CoV-2 Vary Due to Order and Frequency of Vaccination or Infection

Authors

O Baker,E Beck,A Karaba,EU Patel,A Cox,YC Manabe,Z Demko,M Prabhu,YH Hsieh,A Milstone,A Redd,A Tobian,TC Quinn,JN Blankson,O Laeyendecker

Journal

Topics in Antiviral Medicine

Published Date

2023

Background:Sero-studies of SARS-CoV-2 have used antibody (Ab) responses to spike (S) and nucleocapsid (N) antigens to differentiate mRNA vaccinated (S+/N-) from infected (S+/N+) individuals. We performed testing on wellcharacterized subjects to determine how repeated vaccination or infection, and time from those exposures, influence these Ab levels. Method (s) Samples from individuals with known infection status prepandemic negative controls n= 462; first-time infected n= 237 (~ 45 days post); vaccinated after infection n= 34 (~ 40 days post-vaccination and~ 180 days post-infection); fully vaccinated n= 158 (~ 50 days post); boosted n= 31 (~ 30 days post); breakthrough n= 18 (~ 14 days post-infection); reinfected n= 10 (varied). Longitudinal samples (n= 51) from subjects with evidence of reinfection (symptoms and/or positive rapid antigen test), were tested to determine the impact of the order of infection and/or vaccination on the magnitude of the anti-S and anti-N IgG Ab detected in the blood. Testing was performed with MesoScale Diagnostics (Gaithersburg, MD) assay. Outcomes are presented in WHO International Binding Antibody Units (BAU/mL). The cutoff for a positive result was 18 BAU for S and 12 BAU for N. Result (s) The median amount of Ab (IQR) in BAU for each group (Figure A) was pre-pandemic negative controls S 0.53 (0.27, 1.03), N 0.55 (0.18, 1.67); first-time infected S 114 (51,328), N 70 (29,229); vaccinated after infection S 4367 (2479, 4837), N 15 (7, 35); fully vaccinated S 998 (586, 1529), N 0.31 (0.16, 0.68); boosted S 2988 (1768, 3522), N 0.59 (0.32, 1.03); breakthrough S 2429 (2032, 3413), N 2.5 (0.93, 8.6 …

Comparison of allocation strategies of convalescent plasma to reduce excess infections and mortality from SARS‐CoV‐2 in a US‐like population

Authors

Natalya Kostandova,Emmanuel Fulgence Drabo,Karine Yenokyan,Amy Wesolowski,Shaun Truelove,Evan M Bloch,Aaron AR Tobian,Ralph R Vassallo,Marjorie D Bravo,Arturo Casadevall,Justin Lessler,Bryan Lau

Journal

Transfusion

Published Date

2023/1

Background While the use of convalescent plasma (CP) in the ongoing COVID‐19 pandemic has been inconsistent, CP has the potential to reduce excess morbidity and mortality in future pandemics. Given constraints on CP supply, decisions surrounding the allocation of CP must be made. Study Design and Methods Using a discrete‐time stochastic compartmental model, we simulated implementation of four potential allocation strategies: administering CP to individuals in early hospitalization with COVID‐19; administering CP to individuals in outpatient settings; administering CP to hospitalized individuals and administering any remaining CP to outpatient individuals and administering CP in both settings while prioritizing outpatient individuals. We examined the final size of SARS‐CoV‐2 infections, peak and cumulative hospitalizations, and cumulative deaths under each of the allocation scenarios over a 180 …

Heterologous versus homologous boosting elicits qualitatively distinct, BA. 5–cross-reactive T cells in transplant recipients

Authors

Elizabeth A Thompson,Wabathi Ngecu,Laila Stoddart,Trevor S Johnston,Amy Chang,Katherine Cascino,Jennifer L Alejo,Aura T Abedon,Hady Samaha,Nadine Rouphael,Aaron AR Tobian,Dorry L Segev,William A Werbel,Andrew H Karaba,Joel N Blankson,Andrea L Cox

Journal

JCI insight

Published Date

2023/5/5

BackgroundThe SARS-CoV-2 Omicron BA. 5 subvariant escapes vaccination-induced neutralizing antibodies because of mutations in the spike (S) protein. Solid organ transplant recipients (SOTRs) develop high COVID-19 morbidity and poor Omicron variant recognition after COVID-19 vaccination. T cell responses may provide a second line of defense. Therefore, understanding which vaccine regimens induce robust, conserved T cell responses is critical.MethodsWe evaluated anti-S IgG titers, subvariant pseudo-neutralization, and S-specific CD4+ and CD8+ T cell responses from SOTRs in a national, prospective, observational trial (n= 75). Participants were selected if they received 3 doses of mRNA (homologous boosting) or 2 doses of mRNA followed by Ad26. COV2. S (heterologous boosting).ResultsHomologous boosting with 3 mRNA doses induced the highest anti-S IgG titers. However, antibodies induced …

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The h-index of Aaron Tobian, M.D., Ph.D has been 51 since 2020 and 72 in total.

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The articles with the titles of

Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines

Temporal dynamics and drivers of durable HIV viral load suppression and persistent high‐and low‐level viraemia during Universal Test and Treat scale‐up in Uganda: a population …

Euvolemic automated transfusion to treat severe anemia in sickle cell disease patients at risk of circulatory overload

Effect of cryopreservation on CD4+ T cell subsets in foreskin tissue

Erratum for Gebo et al.,“Early antibody treatment, inflammation, and risk of post-COVID conditions”

HIV epidemiologic trends among occupational groups in Rakai, Uganda: A population-based longitudinal study, 1999–2016

Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012

Suspected autoimmune encephalitis: A retrospective study of patients referred for therapeutic plasma exchange

...

are the top articles of Aaron Tobian, M.D., Ph.D at Johns Hopkins University.

What are Aaron Tobian, M.D., Ph.D's research interests?

The research interests of Aaron Tobian, M.D., Ph.D are: Transfusion, Blood, Infectious Diseases, HIV

What is Aaron Tobian, M.D., Ph.D's total number of citations?

Aaron Tobian, M.D., Ph.D has 21,296 citations in total.

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