Aaron Isaacs

Aaron Isaacs

Universiteit Maastricht

H-index: 77

Europe-Netherlands

About Aaron Isaacs

Aaron Isaacs, With an exceptional h-index of 77 and a recent h-index of 57 (since 2020), a distinguished researcher at Universiteit Maastricht,

His recent articles reflect a diverse array of research interests and contributions to the field:

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery: Prospective RACE V Cohort

Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death

PO-02-200 CIRCADIAN OCCURENCE PATTERNS OF ATRIAL FIBRILLATION AFTER CARDIAC SURGERY DURING 2.5 YEARS OF CONTINUOUS RHYTHM MONITORING

Genetic insights into resting heart rate and its role in cardiovascular disease

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Aaron Isaacs Information

University

Universiteit Maastricht

Position

CARIM Dept. of Physiology MaCSBio

Citations(all)

42500

Citations(since 2020)

19413

Cited By

31942

hIndex(all)

77

hIndex(since 2020)

57

i10Index(all)

152

i10Index(since 2020)

121

Email

University Profile Page

Universiteit Maastricht

Top articles of Aaron Isaacs

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

Authors

Thanh T Hoang,Yunsung Lee,Daniel L McCartney,Elin TG Kersten,Christian M Page,Paige M Hulls,Mikyeong Lee,Rosie M Walker,Charles E Breeze,Brian D Bennett,Adam B Burkholder,James Ward,Anne Lise Brantsæter,Ida H Caspersen,Alison A Motsinger-Reif,Marie Richards,Julie D White,Shanshan Zhao,Rebecca C Richmond,Maria C Magnus,Bastiaan Heijmans,Joyce van Meurs,Rick Jansen,Lude Franke,Dorret Boomsma,René Pool,Jenny van Dongen,Jouke Hottenga,Marleen van Greevenbroek,Coen Stehouwer,Carla van der Kallen,Casper Schalkwijk,Cisca Wijmenga,Sasha Zhernakova,Ettje Tigchelaar,P Eline Slagboom,Marian Beekman,Joris Deelen,Diana Van Heemst,Jan Veldink,Leonard van den Berg,Cornelia van Duijn,Bert Hofman,Aaron Isaacs,André Uitterlinden,P Mila Jhamai,Michael Verbiest,H Eka Suchiman,Marijn Verkerk,Ruud van der Breggen,Jeroen van Rooij,Nico Lakenberg,Hailiang Mei,Maarten van Iterson,Michiel van Galen,Jan Bot,Dasha Zhernakova,Peter van‘t Hof,Patrick Deelen,Irene Nooren,Matthijs Moed,Martijn Vermaat,René Luijk,Marc Bonder,Freerk van Dijk,Wibowo Arindrarto,Szymon Kielbasa,Morris Swertz,Erik van Zwet,Gerard H Koppelman,Kathryn L Evans,Riccardo E Marioni,Siri E Håberg,Stephanie J London

Journal

EBioMedicine

Published Date

2024/2/1

BackgroundSmoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero smoking exposure, and effects of environmental tobacco smoke (ETS).MethodsWe meta-analysed data from up to 15,014 adults across 5 cohorts with DNA methylation measured in blood using Illumina's EPIC array for current smoking (2560 exposed), quit < 1 year (500 exposed), in utero (286 exposed), and ETS exposure (676 exposed). We also evaluated the interaction of current smoking with sex or diet (fibre, folate, and vitamin C).FindingsUsing false discovery rate (FDR < 0.05), 65,857 CpGs were differentially methylated in relation to current smoking, 4025 with recent quitting, 594 with in utero exposure, and 6 with ETS. Most current smoking CpGs attenuated within a year of quitting. CpGs …

In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Authors

Anette Christ,Sanne L Maas,Han Jin,Chang Lu,Bart Legein,Erwin Wijnands,Lieve Temmerman,Jeroen Otten,Aaron Isaacs,Martin Zenke,Monika Stoll,Erik AL Biessen,Emiel PC van der Vorst

Journal

Free Radical Biology and Medicine

Published Date

2024/1/1

Background and aimsDendritic cells (DCs), professional antigen-presenting cells, play an important role in pathologies by controlling adaptive immune responses. However, their adaptation to and functionality in hypercholesterolemia, a driving factor in disease onset and progression of atherosclerosis remains to be established.MethodsIn this study, we addressed the immediate impact of high fat diet-induced hypercholesterolemia in low-density lipoprotein receptor deficient (Ldlr−/−) mice on separate DC subsets, their compartmentalization and functionality.ResultsWhile hypercholesterolemia induced a significant rise in bone marrow myeloid and dendritic cell progenitor (MDP) frequency and proliferation rate after high fat diet feeding, it did not affect DC subset numbers in lymphoid tissue. Hypercholesterolemia led to almost immediate and persistent augmentation in granularity of conventional DCs (cDCs), in …

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Authors

Joris Winters,Michal J Kawczynski,Martijn D Gilbers,Aaron Isaacs,Stef Zeemering,Elham Bidar,Bart Maesen,Michiel Rienstra,Isabelle van Gelder,Sander Verheule,Jos G Maessen,Ulrich Schotten

Journal

JACC: Clinical Electrophysiology

Published Date

2024/4/1

BackgroundSerum bone morphogenetic protein 10 (BMP10) blood levels are a marker for history of atrial fibrillation (AF) and for major adverse cardiovascular events in patients with AF, including stroke, AF recurrences after catheter ablations, and mortality. The predictive value of BMP10 in patients undergoing cardiac surgery and association with morphologic properties of atrial tissues are unknown.ObjectivesThis study sought to study the correlation between BMP10 levels and preoperative clinical traits, occurrence of early and late postoperative atrial fibrillation (POAF), and atrial fibrosis in patients undergoing cardiac surgery.MethodsPatients with and without preoperative AF history undergoing first cardiac surgery were included (RACE V, n = 147). Preoperative blood biomarkers were analyzed, left (n = 114) and right (n = 125) atrial appendage biopsy specimens were histologically investigated after WGA …

Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery: Prospective RACE V Cohort

Authors

Martijn D Gilbers,Michal J Kawczynski,Elham Bidar,Bart Maesen,Aaron Isaacs,Joris Winters,Dominik Linz,Michiel Rienstra,Isabelle van Gelder,Jos G Maessen,Ulrich Schotten

Journal

JACC: Clinical Electrophysiology

Published Date

2024/3/13

BackgroundPostoperative atrial fibrillation (POAF) is a frequent complication after cardiac surgery that is associated with late atrial fibrillation (AF) recurrences (late-POAF) and increased morbidity and long-term mortality.ObjectivesThis study sought to determine device-detected POAF incidence and to identify clinical variables associated with POAF, both in patients with and without preoperative AF history.MethodsA total of 133 consecutive patients undergoing cardiac surgery were prospectively enrolled and continuously monitored with an implantable loop recorder for 2.5 years after surgery. Preoperative transthoracic echocardiography, 12-lead electrocardiogram, blood biomarkers, and clinical data were analyzed to develop prediction models for early- and late-POAF.ResultsIn patients without preoperative AF history, early-POAF within the first 90 postoperative days occurred in 41 (47.1%) of 87 patients. Late …

Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death

Authors

Aaron Isaacs,Andrei Barysenka,Rachel MA Ter Bekke,Apollonia TJM Helderman-van den Enden,Arthur van den Wijngaard,Paul GA Volders,Monika Stoll

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundThe Worm Study, ascertained from a multigeneration pedigree segregating a single amino acid deletion in SCN5A (c.4850_4852delTCT, p.(Phe1617del), rs749697698), is characterized by substantial phenotypic heterogeneity and overlap of sudden cardiac death, long-QT syndrome, cardiac conduction disease, Brugada syndrome, and isorhythmic atrioventricular dissociation. Linkage analysis for a synthetic trait derived from these phenotypes identified a single peak (logarithm of the odds [LOD] = 4.52) at the SCN5A/SCN10A/SCN11A locus on chromosome 3.ObjectiveThis study explored the role of additional genetic variation in the chromosome 3 locus as a source of phenotypic heterogeneity in the Worm Study population.MethodsGenotypes underlying the linkage peak (n = 70) were characterized using microarrays. Haplotypes were determined using family-aware phasing and a population-specific …

PO-02-200 CIRCADIAN OCCURENCE PATTERNS OF ATRIAL FIBRILLATION AFTER CARDIAC SURGERY DURING 2.5 YEARS OF CONTINUOUS RHYTHM MONITORING

Authors

Michal Kawczynski,Martijn D Gilbers,Stef Zeemering,Aaron Isaacs,Jos Maessen,Sander Verheule,Elham Bidar,Ulrich Schotten

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundAtrial fibrillation (AF) is a frequent complication after cardiac surgery and current theories suggest that autonomic nervous system plays a major role in early-POAF development, but its role in late-recurrences is still unknown. Previous studies in non-surgical patients have shown distinct preferential AF-occurrence patterns, such as adrenergic/daytime AF, or nocturnal AF. However, the circadian onset patterns for POAF episodes have never been studied before.ObjectiveTo investigate POAF circadian onset patterns after cardiac surgery during 2.5 years of continuous rhythm monitoring.MethodsPatients with and without history of AF undergoing cardiac surgery were included. Continuous rhythm monitoring was performed over a period of 2.5 years. Circadian distribution of AF-episodes onset was presented in radial histograms for the whole FU period, early postoperative phase (first 90 days), and late …

Genetic insights into resting heart rate and its role in cardiovascular disease

Authors

Yordi J van de Vegte,Ruben N Eppinga,M Yldau van der Ende,Yanick P Hagemeijer,Yuvaraj Mahendran,Elias Salfati,Albert V Smith,Vanessa Y Tan,Dan E Arking,Ioanna Ntalla,Emil V Appel,Claudia Schurmann,Jennifer A Brody,Rico Rueedi,Ozren Polasek,Gardar Sveinbjornsson,Cecile Lecoeur,Claes Ladenvall,Jing Hua Zhao,Aaron Isaacs,Lihua Wang,Jian’an Luan,Shih-Jen Hwang,Nina Mononen,Kirsi Auro,Anne U Jackson,Lawrence F Bielak,Linyao Zeng,Nabi Shah,Maria Nethander,Archie Campbell,Tuomo Rankinen,Sonali Pechlivanis,Lu Qi,Wei Zhao,Federica Rizzi,Toshiko Tanaka,Antonietta Robino,Massimiliano Cocca,Leslie Lange,Martina Müller-Nurasyid,Carolina Roselli,Weihua Zhang,Marcus E Kleber,Xiuqing Guo,Henry J Lin,Francesca Pavani,Tessel E Galesloot,Raymond Noordam,Yuri Milaneschi,Katharina E Schraut,Marcel den Hoed,Frauke Degenhardt,Stella Trompet,Marten E van den Berg,Giorgio Pistis,Yih-Chung Tham,Stefan Weiss,Xueling S Sim,Hengtong L Li,Peter J van der Most,Ilja M Nolte,Leo-Pekka Lyytikäinen,M Abdullah Said,Daniel R Witte,Carlos Iribarren,Lenore Launer,Susan M Ring,Paul S de Vries,Peter Sever,Allan Linneberg,Erwin P Bottinger,Sandosh Padmanabhan,Bruce M Psaty,Nona Sotoodehnia,Ivana Kolcic,DCCT/EDIC Research Group Roshandel Delnaz 177 Paterson Andrew D. 177 178,David O Arnar,Daniel F Gudbjartsson,Hilma Holm,Beverley Balkau,Claudia T Silva,Christopher H Newton-Cheh,Kjell Nikus,Perttu Salo,Karen L Mohlke,Patricia A Peyser,Heribert Schunkert,Mattias Lorentzon,Jari Lahti,Dabeeru C Rao,Marilyn C Cornelis,Jessica D Faul,Jennifer A Smith,Katarzyna Stolarz-Skrzypek,Stefania Bandinelli,Maria Pina Concas,Gianfranco Sinagra,Thomas Meitinger,Melanie Waldenberger,Moritz F Sinner,Konstantin Strauch,Graciela E Delgado,Kent D Taylor,Jie Yao,Luisa Foco,Olle Melander,Jacqueline de Graaf,Renée de Mutsert,Eco JC de Geus,Åsa Johansson,Peter K Joshi,Lars Lind,Andre Franke,Peter W Macfarlane,Kirill V Tarasov,Nicholas Tan,Stephan B Felix,E-Shyong Tai,Debra Q Quek,Harold Snieder,Johan Ormel,Martin Ingelsson,Cecilia Lindgren,Andrew P Morris,Olli T Raitakari,Torben Hansen,Themistocles Assimes,Vilmundur Gudnason,Nicholas J Timpson,Alanna C Morrison,Patricia B Munroe,David P Strachan,Niels Grarup,Ruth JF Loos,Susan R Heckbert,Peter Vollenweider,Caroline Hayward,Kari Stefansson,Philippe Froguel,Leif Groop,Nicholas J Wareham,Cornelia M van Duijn,Mary F Feitosa,Christopher J O’Donnell,Mika Kähönen,Markus Perola,Michael Boehnke,Sharon LR Kardia,Jeanette Erdmann

Journal

Nature communications

Published Date

2023/8/2

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do …

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Authors

William J Young,Jeffrey Haessler,Jan-Walter Benjamins,Linda Repetto,Jie Yao,Aaron Isaacs,Andrew R Harper,Julia Ramirez,Sophie Garnier,Stefan van Duijvenboden,Antoine R Baldassari,Maria Pina Concas,ThuyVy Duong,Luisa Foco,Jonas L Isaksen,Hao Mei,Raymond Noordam,Casia Nursyifa,Anne Richmond,Meddly L Santolalla,Colleen M Sitlani,Negin Soroush,Sébastien Thériault,Stella Trompet,Stefanie Aeschbacher,Fariba Ahmadizar,Alvaro Alonso,Jennifer A Brody,Archie Campbell,Adolfo Correa,Dawood Darbar,Antonio De Luca,Jean-François Deleuze,Christina Ellervik,Christian Fuchsberger,Anuj Goel,Christopher Grace,Xiuqing Guo,Torben Hansen,Susan R Heckbert,Rebecca D Jackson,Jan A Kors,Maria Fernanda Lima-Costa,Allan Linneberg,Peter W Macfarlane,Alanna C Morrison,Pau Navarro,David J Porteous,Peter P Pramstaller,Alexander P Reiner,Lorenz Risch,Ulrich Schotten,Xia Shen,Gianfranco Sinagra,Elsayed Z Soliman,Monika Stoll,Eduardo Tarazona-Santos,Andrew Tinker,Katerina Trajanoska,Eric Villard,Helen R Warren,Eric A Whitsel,Kerri L Wiggins,Dan E Arking,Christy L Avery,David Conen,Giorgia Girotto,Niels Grarup,Caroline Hayward,J Wouter Jukema,Dennis O Mook-Kanamori,Morten Salling Olesen,Sandosh Padmanabhan,Bruce M Psaty,Cristian Pattaro,Antonio Luiz P Ribeiro,Jerome I Rotter,Bruno H Stricker,Pim van der Harst,Cornelia M van Duijn,Niek Verweij,James G Wilson,Michele Orini,Philippe Charron,Hugh Watkins,Charles Kooperberg,Henry J Lin,James F Wilson,Jørgen K Kanters,Nona Sotoodehnia,Borbala Mifsud,Pier D Lambiase,Larisa G Tereshchenko,Patricia B Munroe

Journal

Nature communications

Published Date

2023/3/14

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined …

AB-452665-3 DIFFERENCES IN BLOOD BIOMARKER PROFILE SUGGEST SEX-DIFFERENCES IN PATHOPHYSIOLOGY OF ATRIAL FIBRILLATION: FIRST RESULTS FROM THE ISOLATION AF ABLATION REGISTRY

Authors

Zarina Habibi,Dominique Verhaert,Ben J Hermans,Suzanne Philippens,Sjoerd Westra,Marisevi Chaldoupi,Bart Maesen,Aaron Isaacs,Stef Zeemering,Dominik Linz,Kevin Vernooy,Ulrich Schotten

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundSex differences have been observed in epidemiology and pathophysiology of many cardiovascular diseases. Limited data is available on the influence of biological sex on the pathophysiology of atrial fibrillation (AF), such as inflammation, myocyte injury, collagen, and lipid infiltration. Different biomarkers reflect these pathophysiological pathways.Objective

New onset, recurrence and progression of atrial fibrillation after cardiac surgery during 2.5 years of continuous rhythm monitoring

Authors

Mr Kawczynski,MD Gilbers,S Zeemering,A Isaacs,JG Maessen,S Verheule,E Bidar,U Schotten

Journal

Europace

Published Date

2023/6

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This study was supported by the Netherlands Heart Foundation (CVON2014-09, RACE V: Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling, and Vascular destabilisation in the progression of AF). Background Atrial fibrillation (AF) in the early postoperative phase (POAF) is a frequent complication after cardiac surgery with an incidence of up to 50%. Recent studies have shown that early-POAF is a one of the strongest predictors of late recurrences. However, it is unknown how POAF-burden (percentage of time in AF) progresses in the months and years following surgery. Recent studies suggested that AF-burden is associated with increased risk of stroke and therefore identifying factors associated with a higher POAF …

PO-02-192 NEW ONSET, RECURRENCE AND PROGRESSION OF ATRIAL FIBRILLATION AFTER CARDIAC SURGERY DURING 2.5 YEARS OF CONTINUOUS RHYTHM MONITORING

Authors

Michal Kawczynski,Martijn D Gilbers,Stef Zeemering,Aaron Isaacs,Jos Maessen,Sander Verheule,Elham Bidar,Ulrich Schotten

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundAtrial fibrillation (AF) in the early postoperative phase (POAF) is a frequent complication after cardiac surgery which is also associated with late AF-recurrences. However, it is unknown how POAF-burden (percentage of time in AF) progresses in the time following surgery. Recent studies suggested that AF-burden is associated with increased risk of stroke and therefore identifying factors associated with a higher POAF-burden is desirable.ObjectiveTo investigate POAF-burden progression patterns and factors associated with increased POAF-burden after cardiac surgery during 2.5 years of continuous rhythm monitoring.MethodsPatients with and without history of AF undergoing cardiac surgery were included. Preoperatively, all patients underwent transthoracic echocardiography, electrocardiography, and blood biomarker analysis. Continuous rhythm monitoring was performed over a period of 2.5 years …

Atrial contractile and electrical remodeling is associated with more complex conduction patterns in patients without history of atrial fibrillation: a high-density epicardial …

Authors

Mr M Kawczynski,Doctor B Maesen,Doctor S Zeemering,Doctor A Isaacs,J Maessen,S Verheule,U Schotten,Doctor E Bidar

Journal

Europace

Published Date

2023/6

BackgroundEarly atrial remodeling refers to a concept where atrial structural, functional, and electrophysiological changes may be present without clinical manifestation of atrial arrhythmias.(1) However, it is currently unknown how electrophysiological and functional atrial properties are related, especially in the early stages of atrial remodeling.PurposeTo investigate the relationship between electrophysiological properties of the atria, determined by intraoperative high-density epicardial mapping after AF-induction, and echocardiographic and electrocardiographic parameters in patients without a history of AF undergoing cardiac surgery.MethodsAll patients underwent functional and electrophysiological analysis of both atria using preoperative transthoracic echocardiography, electrocardiography, and intraoperative biatrial high-density epicardial mapping. Postoperatively, all patients were continuously monitored for …

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

Authors

J Winters,S Zeemering,A Isaacs,M Kawczynski,B Casadei,L Fabritz,P Kirchhof,E Guasch,W Chua,S Hatem,MF Sinner,S Kaab,S Verheule,M Stoll,U Schotten

Journal

Europace

Published Date

2023/6

Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): CATCH ME: Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly Background Atrial cardiomyopathy is emerging as independent prognostic factor in cardiovascular disease. Fibrotic remodeling, cardiomyocyte hypertrophy and a reduction in capillary density are histological hallmarks of atrial cardiomyopathy. The contribution of etiological factors to atrial cardiomyopathy has not been robustly quantified. Purpose To quantify the relation between histological features of atrial cardiomyopathy and the clinical profile of patients. Methods We examined left (LA, n=91) and right (RA, n=75) atrial appendages sampled from a European cohort of patients undergoing cardiac surgery. Quantification of …

MP-453085-5 ATRIAL FIBRILLATION, FEMALE SEX AND HEART HAILURE ARE THE MAIN DRIVERS OF ATRIAL CARDIOMYOPATHY IN CARDIAC SURGERY PATIENTS: RESULTS FROM THE CATCH ME CONSORTIUM

Authors

Joris Winters,Stef Zeemering,Aaron Isaacs,Michal Kawczynski,Bart Maesen,Barabara Casadei,Larissa Fabritz,Winnie Chua,Edu Guasch,Lluis Mont,Stephane Hatem,Paulus Kirchhof,Moritz F Sinner,Stefan Kaab,Monika Stoll,Sander Verheule,Ulrich Schotten

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundAtrial cardiomyopathy is emerging as independent prognostic factor in cardiovascular disease. Fibrotic remodeling, cardiomyocyte hypertrophy and a reduction in capillary density are histological hallmarks of atrial cardiomyopathy. The contribution of etiological factors to atrial cardiomyopathy has not been robustly quantified.ObjectiveTo quantify the relation between histological features of atrial cardiomyopathy and the clinical profile of patients.MethodsWe examined left (LAA, n= 91) and right (RAA, n= 75) atrial appendages sampled from a European cohort of patients undergoing cardiac surgery. Quantification of histological cardiomyopathy features was performed using a recently developed and validated imaging analysis algorithm following myocardial triple staining with wheat germ agglutinin (WGA), CD31 and vimentin. The contributions of AF, heart failure (HF), sex, age, and 4 principal …

Identifying (electrophysiological) predictors of atrial fibrillation recurrences after catheter ablation: first results from the ISOLATION registry

Authors

Z Habibi,DVM Verhaert,BMJ Hermans,Mr Kawczynski,S Philippens,SW Westra,SM Chaldoupi,B Maesen,A Isaacs,S Zeemering,D Linz,K Vernooy,U Schotten

Journal

Europace

Published Date

2023/6

Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): a.o. The European Union (ITN Network Personalize AF: Personalized Therapies for Atrial Fibrillation: a translational network, grant number 860974; MAESTRIA: Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation, grant number 965286). Background/Introduction Noninvasive quantification of electrophysiological properties of the atria is increasingly used for outcome prediction in atrial fibrillation (AF) patients. Data on the added value of ECG parameters to predict AF recurrences in patients undergoing AF ablation are scarce. Purpose To investigate the predictive performance of clinical and echocardiographic characteristics as well as features extracted from extended surface electrocardiogram (extECG) recordings for AF …

Biomarker BMP10 profiles suggest an association of female and age with atrial endomysial fibrosis: Results from the ISOLATION AF ablation registry

Authors

Z Habibi,DVM Verhaert,BJM Hermans,S Philippens,SW Westra,SM Chaldoupi,BAE Maesen,AJ Isaacs,S Zeemering,D Linz,K Vernooy,U Schotten

Journal

European Heart Journal

Published Date

2023/11

Background/Introduction Atrial fibrillation has a complex pathophysiology such as inflammation, myocyte injury, collagen and lipid infiltration. Different biomarkers reflect these pathophysiological pathways. The biomarker Bone Morphogenetic Protein 10 (BMP10) is a secreted protein, expressed by myocytes, and is required for myocyte growth and development. BMP10 is associated with PITX2 and endomysial fibrosis. We recently demonstrated that BMP10 is independently associated with left atrial andomysial fibrosis. Purpose To analyze the correlation between the blood-based biomarker BMP10 with sex and age in patients with atrial fibrillation. Methods A cross-sectional analysis was conducted of atrial fibrillation patients scheduled for catheter ablation included from July 2020 through May 2022 in the prospective multicenter ISOLATION cohort study …

PO-02-144 ETIOLOGICAL AND MOLECULAR DETERMINANTS OF ATRIAL ENDOMYSIAL FIBROSIS: RESULTS FROM THE CATCH ME CONSORTIUM

Authors

Joris Winters,Aaron Isaacs,Stef Zeemering,Michal Kawczynski,Barabara Casadei,Larissa Fabritz,Lluis Mont,Stephane Hatem,Paulus Kirchhof,Winnie Chua,Moritz F Sinner,Stefan Kaab,Monika Stoll,Sander Verheule,Ulrich Schotten

Journal

Heart Rhythm

Published Date

2023/5/1

BackgroundWe recently demonstrated that, in human atria, endomysial fibrosis causes conduction disturbances during atrial fibrillation (AF), while overall connective tissue content (over-all fibrosis) has no effect. Etiological and molecular determinants of endomysial fibrosis are largely unknown.Objective

Etiological and molecular determinants of atrial endomysial fibrosis: results from the CATCH ME consortium

Authors

J Winters,Mr Kawczynski,S Zeemering,A Isaacs,B Casadei,L Fabritz,P Kirchhof,W Chua,E Guasch,MF Sinner,S Kaab,S Hatem,S Verheule,M Stoll,U Schotten

Journal

Europace

Published Date

2023/6

Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): CATCH ME: Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly Background We recently demonstrated that in human atria, endomysial fibrosis causes conduction disturbances during atrial fibrillation (AF), while overall connective tissue content (over-all fibrosis) has no effect. Etiological and molecular determinants of endomysial fibrosis are largely unknown. Methods We quantified over-all and endomysial atrial fibrosis using staining with WGA in left (LA, n=95) and right (RA, n=76) atrial appendages sampled from a European cohort (CATCH ME) of patients undergoing cardiac surgery. The contributions of AF, heart failure (HF), sex, age, and 4 principal components accounting for confounding clinical …

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Authors

Vasiliki Lagou,Longda Jiang,Anna Ulrich,Liudmila Zudina,Karla Sofia Gutiérrez González,Zhanna Balkhiyarova,Alessia Faggian,Jared G Maina,Shiqian Chen,Petar V Todorov,Sodbo Sharapov,Alessia David,Letizia Marullo,Reedik Mägi,Roxana-Maria Rujan,Emma Ahlqvist,Gudmar Thorleifsson,Ηe Gao,Εvangelos Εvangelou,Beben Benyamin,Robert A Scott,Aaron Isaacs,Jing Hua Zhao,Sara M Willems,Toby Johnson,Christian Gieger,Harald Grallert,Christa Meisinger,Martina Müller-Nurasyid,Rona J Strawbridge,Anuj Goel,Denis Rybin,Eva Albrecht,Anne U Jackson,Heather M Stringham,Ivan R Corrêa Jr,Eric Farber-Eger,Valgerdur Steinthorsdottir,André G Uitterlinden,Patricia B Munroe,Morris J Brown,Julian Schmidberger,Oddgeir Holmen,Barbara Thorand,Kristian Hveem,Tom Wilsgaard,Karen L Mohlke,Zhe Wang,GWA-PA Consortium den Hoed Marcel 57,Aleksey Shmeliov,Marcel den Hoed,Ruth JF Loos,Wolfgang Kratzer,Mark Haenle,Wolfgang Koenig,Bernhard O Boehm,Tricia M Tan,Alejandra Tomas,Victoria Salem,Inês Barroso,Jaakko Tuomilehto,Michael Boehnke,Jose C Florez,Anders Hamsten,Hugh Watkins,Inger Njølstad,H-Erich Wichmann,Mark J Caulfield,Kay-Tee Khaw,Cornelia M van Duijn,Albert Hofman,Nicholas J Wareham,Claudia Langenberg,John B Whitfield,Nicholas G Martin,Grant Montgomery,Chiara Scapoli,Ioanna Tzoulaki,Paul Elliott,Unnur Thorsteinsdottir,Kari Stefansson,Evan L Brittain,Mark I McCarthy,Philippe Froguel,Patrick M Sexton,Denise Wootten,Leif Groop,Josée Dupuis,James B Meigs,Giuseppe Deganutti,Ayse Demirkan,Tune H Pers,Christopher A Reynolds,Yurii S Aulchenko,Marika A Kaakinen,Ben Jones,Inga Prokopenko,Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC) van Duijn Cornelia M. 7 72 73

Journal

Nature genetics

Published Date

2023/9

Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an underappreciated role of the gastrointestinal tract in controlling blood glucose. Functional follow-up and molecular …

Rationale and design of the ISOLATION study: a multicenter prospective cohort study identifying predictors for successful atrial fibrillation ablation in an integrated clinical …

Authors

Dominique VM Verhaert,Dominik Linz,Sevasti Maria Chaldoupi,Sjoerd W Westra,Dennis W den Uijl,Suzanne Philippens,Mijke Kerperien,Zarina Habibi,Bianca Vorstermans,Rachel MA Ter Bekke,Rypko J Beukema,Reinder Evertz,Martin EW Hemels,Justin GLM Luermans,Randolph Manusama,Theo AR Lankveld,Claudia AJ van der Heijden,Elham Bidar,Ben JM Hermans,Stef Zeemering,Geertruida P Bijvoet,Jesse Habets,Robert J Holtackers,Casper Mihl,Robin Nijveldt,Vanessa PM van Empel,Christian Knackstedt,Sami O Simons,Wolfgang FFA Buhre,Jan GP Tijssen,Aaron Isaacs,Harry JGM Crijns,Bart Maesen,Kevin Vernooy,Ulrich Schotten

Journal

Frontiers in cardiovascular medicine

Published Date

2022/6/30

Introduction Continuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30–50% of patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated in clinical care pathways may improve our understanding of the complex pathophysiology of AF and improve patient selection for AF ablation. Objectives Within the “IntenSive mOlecular and eLectropathological chAracterization of patienTs undergoIng atrial fibrillatiOn ablatioN” (ISOLATION) study, we aim to identify predictors of successful AF ablation in the following domains: (1) clinical factors, (2) AF patterns, (3) anatomical characteristics, (4) electrophysiological characteristics, (5) circulating biomarkers, and (6) genetic background. Herein, the design of the ISOLATION study and the integration of all study procedures into a standardized pathway for patients undergoing AF ablation are described. Methods ISOLATION (NCT04342312) is a two-center prospective cohort study including 650 patients undergoing AF ablation. Clinical characteristics and routine clinical test results will be collected, as well as results from the following additional diagnostics: determination of body composition, pre-procedural rhythm monitoring, extended surface electrocardiogram, biomarker testing, genetic analysis, and questionnaires. A multimodality model including a combination of established predictors and novel techniques will be developed to predict ablation success. Discussion In this study, several domains will be examined to identify predictors of …

See List of Professors in Aaron Isaacs University(Universiteit Maastricht)

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What is Aaron Isaacs's h-index at Universiteit Maastricht?

The h-index of Aaron Isaacs has been 57 since 2020 and 77 in total.

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The articles with the titles of

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery: Prospective RACE V Cohort

Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death

PO-02-200 CIRCADIAN OCCURENCE PATTERNS OF ATRIAL FIBRILLATION AFTER CARDIAC SURGERY DURING 2.5 YEARS OF CONTINUOUS RHYTHM MONITORING

Genetic insights into resting heart rate and its role in cardiovascular disease

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

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are the top articles of Aaron Isaacs at Universiteit Maastricht.

What is Aaron Isaacs's total number of citations?

Aaron Isaacs has 42,500 citations in total.

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