Aaron C. Shang

Aaron C. Shang

University of Oxford

H-index: 5

Europe-United Kingdom

About Aaron C. Shang

Aaron C. Shang, With an exceptional h-index of 5 and a recent h-index of 5 (since 2020), a distinguished researcher at University of Oxford, specializes in the field of Oncology, Radiology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Epithelial Biology and Secretion: Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and …

Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice

Acute pseudogout presenting as an exception to Musculoskeletal Infection Society criteria in total knee arthroplasty: a case report

271 TARGETED DELETION OF THE CDC42/RAC NUCLEOTIDE EXCHANGE FACTOR, βPAK-INTERACTING EXCHANGE FACTOR (βPIX), IMPAIRS SMALL INTESTINAL EPITHELIAL CELL PROLIFERATION, DEVELOPMENT …

Aaron C. Shang Information

University

University of Oxford

Position

Graduate student

Citations(all)

149

Citations(since 2020)

122

Cited By

76

hIndex(all)

5

hIndex(since 2020)

5

i10Index(all)

5

i10Index(since 2020)

4

Email

University Profile Page

University of Oxford

Aaron C. Shang Skills & Research Interests

Oncology

Radiology

Top articles of Aaron C. Shang

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Authors

Kunrong Cheng,Ahmed Chahdi,Shannon M Larabee,Mazen Tolaymat,Margaret H Sundel,Cinthia B Drachenberg,Min Zhan,Shien Hu,Anan H Said,Aaron C Shang,Guofeng Xie,Madeline Alizadeh,Natalia Sampaio Moura,Andrea C Bafford,Richelle T Williams,Nader N Hanna,Jean-Pierre Raufman

Journal

Scientific Reports

Published Date

2023/10/7

M3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico, in vitro, and in vivo approaches, we explored whether these actions are regulated by M3R. At the invasive fronts of murine and human colon cancers, we detected co-localized nuclear expression of βPix and β-catenin in stem cells overexpressing M3R. Using immunohistochemistry, immunoprecipitation, proximity ligand, and fluorescent cell sorting assays in human tissues and established and primary human colon cancer cell cultures, we detected time-dependent M3R agonist-induced cytoplasmic and nuclear association of βPix with β-catenin. βPix knockdown attenuated M3R agonist-induced human colon cancer cell proliferation, migration, invasion, and expression of …

Epithelial Biology and Secretion: Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and …

Authors

Kunrong Cheng,Shannon M Larabee,Mazen Tolaymat,Marie Hanscom,Aaron C Shang,Alyssa Schledwitz,Shien Hu,Cinthia B Drachenberg,Min Zhan,Ahmed Chahdi,Jean-Pierre Raufman

Journal

American Journal of Physiology-Gastrointestinal and Liver Physiology

Published Date

2021/4/4

Rho guanine nucleotide exchange factors (RhoGEFs) regulate Rho GTPase activity and cytoskeletal and cell adhesion dynamics. βPix, a CDC42/RAC family RhoGEF encoded by ARHGEF7, is reported to modulate human colon cancer cell proliferation and postwounding restitution of rat intestinal epithelial monolayers. We hypothesized that βPix plays a role in maintaining intestinal epithelial homeostasis. To test this hypothesis, we examined βPix distribution in the human and murine intestine and created mice with intestinal epithelial-selective βPix deletion [βPix flox/flox/Tg (villin-Cre); Arhgef7 CKO mice]. Using Arhgef7 conditional knockout (CKO) and control mice, we investigated the consequences of βPix deficiency in vivo on intestinal epithelial and enteroid development, dextran sodium sulfate-induced mucosal injury, and gut permeability. In normal human and murine intestines, we observed diffuse …

Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice

Authors

Kunrong Cheng,Shannon M Larabee,Mazen Tolaymat,Marie Hanscom,Aaron C Shang,Alyssa Schledwitz,Shien Hu,Cinthia B Drachenberg,Min Zhan,Ahmed Chahdi,Jean-Pierre Raufman

Journal

American Journal of Physiology-Gastrointestinal and Liver Physiology

Published Date

2021/4/1

Rho guanine nucleotide exchange factors (RhoGEFs) regulate Rho GTPase activity and cytoskeletal and cell adhesion dynamics. βPix, a CDC42/RAC family RhoGEF encoded by ARHGEF7, is reported to modulate human colon cancer cell proliferation and postwounding restitution of rat intestinal epithelial monolayers. We hypothesized that βPix plays a role in maintaining intestinal epithelial homeostasis. To test this hypothesis, we examined βPix distribution in the human and murine intestine and created mice with intestinal epithelial-selective βPix deletion [βPixflox/flox/Tg(villin-Cre); Arhgef7 CKO mice]. Using Arhgef7 conditional knockout (CKO) and control mice, we investigated the consequences of βPix deficiency in vivo on intestinal epithelial and enteroid development, dextran sodium sulfate-induced mucosal injury, and gut permeability. In normal human and murine intestines, we observed diffuse …

Acute pseudogout presenting as an exception to Musculoskeletal Infection Society criteria in total knee arthroplasty: a case report

Authors

JM Forlizzi,JM Ryan,KE Galow,AC Shang,DR Polakoff

Journal

AMECR

Published Date

2020

In this case, a 78-year-old female with no previous medical history of crystalline arthropathy presented with pain, effusion, and erythema about a total knee arthroplasty (TKA) performed 13 years prior. Implementation of a novel synovial fluid alpha-defensin assay ruled out periprosthetic joint infection (PJI) despite a positive 2018 Musculoskeletal Infection Society (MSIS) minor criteria score of 8 points, a significant diagnostic differentiation which prevented secondary invasive debridement or joint irrigation intervention. Confirmatory histologic study was positive for calcium pyrophosphate crystals, indicative of acute pseudogout inflammation rather than PJI or septic arthritis manifestation. The patient was then conservatively managed medically for a pseudogout flare and had no evidence of infection with normal physical exam and laboratory study at one-and two-years post treatment, respectively. Given the …

271 TARGETED DELETION OF THE CDC42/RAC NUCLEOTIDE EXCHANGE FACTOR, βPAK-INTERACTING EXCHANGE FACTOR (βPIX), IMPAIRS SMALL INTESTINAL EPITHELIAL CELL PROLIFERATION, DEVELOPMENT …

Authors

Shannon M Larabee,Kunrong Cheng,Aaron C Shang,Mazen Tolaymat,Jean-Pierre Raufman

Journal

Gastroenterology

Published Date

2020/5/1

AGA Abstracts mutant, but not control colonoids. Consistent with this phenotype, blocking TNFSF13 with neutralizing antibody in healthy and non-mutant VEO-IBD colonoids increased proliferation in response to TNFa or TRAIL. Finally, we found that expression of intestinal stem cell marker LGR5 was increased significantly in TNFSF13-mutant colonoids after treatment with TNFa or TRAIL compared to controls. Conclusions Our data suggest a phenotypic switch in proliferation and/or active stem cell expansion in TNFSF13-mutant colonoids in response to cytokines compared to control colonoids. The relationship between these findings and the patient's phenotype remains to be determined. Future studies will evaluate whether decreased TNFSF13 expression in IECs promotes increased proliferation, compromising epithelial barrier integrity. Ultimately, these data will shed light on IEC defects in VEOIBD, and provide …

See List of Professors in Aaron C. Shang University(University of Oxford)

Aaron C. Shang FAQs

What is Aaron C. Shang's h-index at University of Oxford?

The h-index of Aaron C. Shang has been 5 since 2020 and 5 in total.

What are Aaron C. Shang's top articles?

The articles with the titles of

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Epithelial Biology and Secretion: Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and …

Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice

Acute pseudogout presenting as an exception to Musculoskeletal Infection Society criteria in total knee arthroplasty: a case report

271 TARGETED DELETION OF THE CDC42/RAC NUCLEOTIDE EXCHANGE FACTOR, βPAK-INTERACTING EXCHANGE FACTOR (βPIX), IMPAIRS SMALL INTESTINAL EPITHELIAL CELL PROLIFERATION, DEVELOPMENT …

are the top articles of Aaron C. Shang at University of Oxford.

What are Aaron C. Shang's research interests?

The research interests of Aaron C. Shang are: Oncology, Radiology

What is Aaron C. Shang's total number of citations?

Aaron C. Shang has 149 citations in total.

What are the co-authors of Aaron C. Shang?

The co-authors of Aaron C. Shang are Cinthia Drachenberg, Grace L. Guo, Su Xu, shien hu.

    Co-Authors

    H-index: 73
    Cinthia Drachenberg

    Cinthia Drachenberg

    University of Maryland

    H-index: 54
    Grace L. Guo

    Grace L. Guo

    Rutgers, The State University of New Jersey

    H-index: 31
    Su Xu

    Su Xu

    University of Maryland, Baltimore

    H-index: 14
    shien hu

    shien hu

    University of Maryland, Baltimore

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