A S Hewage

A S Hewage

University of Colombo

H-index: 4

Asia-Sri Lanka

About A S Hewage

A S Hewage, With an exceptional h-index of 4 and a recent h-index of 3 (since 2020), a distinguished researcher at University of Colombo, specializes in the field of Epigenetics.

His recent articles reflect a diverse array of research interests and contributions to the field:

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicity

Association and impact of SNPs in PNPLA3, TM6SF2 and MBOAT7 genes on prognosis factors of hepatocellular carcinoma with non-viral etiology

A S Hewage Information

University

University of Colombo

Position

Lecturer IBMBB

Citations(all)

45

Citations(since 2020)

33

Cited By

30

hIndex(all)

4

hIndex(since 2020)

3

i10Index(all)

2

i10Index(since 2020)

2

Email

University Profile Page

University of Colombo

A S Hewage Skills & Research Interests

Epigenetics

Top articles of A S Hewage

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicity

Authors

Saumya Madushani Samarasinghe,Asanka Sudeshini Hewage,Rohan Chaminda Siriwardana,Kamani Hemamala Tennekoon,Madunil Anuk Niriella,Sumadee De Silva

Published Date

2023/8/29

BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease showing a rising prevalence globally. Genetic predisposition plays a key role in the development and progression of the disease pathogenicity.Main bodyThis paper summarizes genetic associations based on their influence on several metabolic aspects such as lipid metabolism, glucose metabolism, hepatic iron accumulation and cholesterol metabolism toward the NAFLD pathogenicity. Furthermore, we present variations in some epigenetic characters and the microRNA profile with regard to NAFLD.ConclusionAs reported in many studies, the PNPLA3 rs738409 variant seems to be significantly associated with NAFLD susceptibility. Other gene variants like TM6SF2 rs58542926, MBOAT7 rs641738 and GCKR variants also appear to be more prevalent among NAFLD patients. We believe these genetic variants may …

Association and impact of SNPs in PNPLA3, TM6SF2 and MBOAT7 genes on prognosis factors of hepatocellular carcinoma with non-viral etiology

Authors

Saumya Madushani Samarasinghe,Asanka Sudeshini Hewage,Rohan Siriwardena,Kamani Hemamala Tennekoon,Madunil Anuk Niriella,Sumadee de Silva,Sameera Dhananjaya Viswakula

Published Date

2022/12/15

Background: Hepatocellular carcinoma (HCC) is becoming a challenging global health concern with Asian and African countries carrying the highest burden of it. The rising prevalence of non-alcoholic steatohepatitis (NASH) associated HCC is linked with unhealthy dietary patterns and sedentary life styles. In addition, genetic predisposition may play a critical role in developing NASH-related HCC. Previous studies have identified that variants in patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2) and membrane bound O-acyltransferase domain containing 7 (MBOAT7) genes are significantly associated with non-alcoholic fatty liver disease (NAFLD) pathogenicity among different populations. But there are no published reports on their impact on Sri Lankan NASH-HCC patients.Methods: We conducted an exploratory study to evaluate the prevalence of five single nucleotide polymorphisms (SNPs)(PNPLA3 rs738409, PNPLA3rs2281135, PNPLA3 rs2294918, TM6SF2 rs58542926 and MBOAT7 rs641738) as genetic risk factors for NASH-HCC pathogenicity. We genotyped 48 NASH-HCC samples that were collected at a clinical setting and analyzed using statistical modelling to explore the impact of each SNP with tumor prognostic factors.Results: We observed high frequencies in four out of five polymorphisms, namely PNPLA3 rs738409 (0.79, 95% CI 0.650-0.895), PNPLA3 rs2281135 (0.77, 95% CI 0.627-0.880), PNPLA3 rs2294918 (0.9, 95% CI 0.773-0.965) and MBOAT7rs641738 (0.85, 95% CI 0.722-0.939) among Sri Lankan NASH-HCC patients. Our analyses further …

See List of Professors in A S Hewage University(University of Colombo)

A S Hewage FAQs

What is A S Hewage's h-index at University of Colombo?

The h-index of A S Hewage has been 3 since 2020 and 4 in total.

What are A S Hewage's top articles?

The articles with the titles of

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicity

Association and impact of SNPs in PNPLA3, TM6SF2 and MBOAT7 genes on prognosis factors of hepatocellular carcinoma with non-viral etiology

are the top articles of A S Hewage at University of Colombo.

What are A S Hewage's research interests?

The research interests of A S Hewage are: Epigenetics

What is A S Hewage's total number of citations?

A S Hewage has 45 citations in total.

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