A K M Mahbub Hasan

A K M Mahbub Hasan

University of Dhaka

H-index: 16

Asia-Bangladesh

About A K M Mahbub Hasan

A K M Mahbub Hasan, With an exceptional h-index of 16 and a recent h-index of 11 (since 2020), a distinguished researcher at University of Dhaka, specializes in the field of Biological science.

His recent articles reflect a diverse array of research interests and contributions to the field:

Association of Host Interferon-γ Gene Polymorphism with Toxoplasma gondii Infection in Pregnant Women of Bangladesh

Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV …

Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population

A K M Mahbub Hasan Information

University

University of Dhaka

Position

Professor

Citations(all)

792

Citations(since 2020)

380

Cited By

535

hIndex(all)

16

hIndex(since 2020)

11

i10Index(all)

20

i10Index(since 2020)

13

Email

University Profile Page

University of Dhaka

A K M Mahbub Hasan Skills & Research Interests

Biological science

Top articles of A K M Mahbub Hasan

Association of Host Interferon-γ Gene Polymorphism with Toxoplasma gondii Infection in Pregnant Women of Bangladesh

Authors

Nasrin Akter,Sonia Tamanna,Molie Rahman,Atiqur Rahman,Akm Mahbub Hasan,Taibur Rahman

Journal

American Journal of Molecular Biology

Published Date

2023/6/30

Human toxoplasmosis is caused by the intracellular protozoan parasite Toxoplasma gondii. Although T. gondii infection is generally asymptomatic for most of the immunocompetent adults, severe complications may occur particularly in pregnant women and immunocompromised individual. Host cell immunity plays a critical role in parasite differentiation and persistence in the host. Therefore, genetic polymorphism in the host immune genes, for instance interferon-γ gene could be linked with possibility of T. gondii infection. The objective of the study was to verify the link between the single nucleotide polymorphisms (SNPs) in the IFN-γ gene of pregnant women and T. gondii infection through correlating with anthropometric and sociodemographic parameters. In this study, ninety-two (N = 92) pregnant women (16 - 40 years) and healthy controls (N = 95) with similar age ranges were included. Among them, 25% (n = 23) pregnant women were seropositive for T. gondii IgG antibodies by Rapid Test Assay. Allelic and genotypic frequencies of IFN-γ +874T/A (rs2430561) SNPs were evaluated by using ARMS-PCR. The distribution of the A and T alleles in the specific position of the IFN-γ gene in the T. gondii-infected pregnant women and the control groups did not differ significantly, according to the data. However, we found a higher frequency (13.04%) of A/A genotype in T. gondii infected pregnant women as compared to non-infected individuals (8.70%), demonstrating that T. gondii infection susceptibility may be increased by homozygosity for the A allele. Further studies are to be needed to find out the link between host gene polymorphism and T …

Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh

Authors

Tamanna Ashraf,Pankaj Kumar Sarker,Md Ismail Hosen,Atiqur Rahman,AKM Hasan,Taibur Rahman

Journal

Journal of Parasitology Research

Published Date

2023/5/8

Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis in around one-third of the world population, particularly in pregnant women and immunocompromised individuals. Diabetes mellitus (DM) is one of the most severe global health challenges in the 21st century, and especially, type-2 diabetes mellitus (T2DM) accounts for 90% of the diabetes cases diagnosed globally. In Bangladesh, the rate of T2DM is rising gradually with the improvement in living standards. The aim of this study is to find out the correlation between latent toxoplasmosis and T2DM, emphasizing the pro-inflammatory cytokine immunity. For this, 100 () patients with T2DM and 100 () healthy controls were enrolled to determine the seroprevalence of toxoplasmosis using enzyme-linked immunosorbent assay (ELISA). In addition, ELISA was also performed to determine the level of pro-inflammatory cytokine, interleukin (IL)-12, to understand its role in the development of toxoplasmosis. In our study, 39.39% of the T2DM patients were positive with anti-T. gondii Immunoglobulin G by ELISA, whereas the rate of seropositivity in healthy controls was 39.73%. We did not find significant association between T. gondii infection and T2DM, but our data confirmed a high prevalence of chronic toxoplasmosis in Bangladeshi population. From hematology tests, it was found that the T2DM patients had significantly lower levels of total white blood cells (), circulating eosinophils (), and neutrophils () than the healthy controls. On the other hand, the levels of lymphocytes () and monocytes () were significantly higher in patients. Furthermore, T. gondii infected T2DM patients …

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV …

Authors

Anika Tahsin,Rubaiat Ahmed,Piyash Bhattacharjee,Maisha Adiba,Abdullah Al Saba,Tahirah Yasmin,Sajib Chakraborty,AKM Mahbub Hasan,AHM Nurun Nabi

Journal

Computers in Biology and Medicine

Published Date

2022/9/1

Since the emergence of SARS-CoV-2 at Wuhan in the Hubei province of China in 2019, the virus has accumulated various mutations, giving rise to many variants. According to the combinations of mutations acquired, these variants are classified into lineages and greatly differ in infectivity and transmissibility. In 2021 alone, a variant of interest (VoI) Mu (B.1.621), as well as, variants of concern (VoC) Delta (B.1.617.2) and Omicron (BA.1, BA.2) and later in 2022, BA.4, BA.5, and BA.2.12.1 have emerged. Since then, the world has seen prominent surges in the rate of infection during short periods of time. However, not all populations have suffered equally, which suggests a possible role of host genetic factors. Here, we investigated the strength of binding of the spike glycoprotein receptor-binding domain (RBD) of the SARS-CoV-2 variants: Mu, Delta, Delta Plus (AY.1), Omicron sub-variants BA.1, BA.2, BA.4, BA.5, and …

Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population

Authors

Atoll Goswami,Nafiul Huda,Tahirah Yasmin,Md Ismail Hosen,AKM Mahbub Hasan,AHM Nurun Nabi

Journal

Molecular Biology Reports

Published Date

2021/1

Telomeres are protective cap on the ends of DNA of non-coding tandem repeats of TTAGGG. Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase that maintains the structure of telomeres. Type 2 diabetes (T2D) affects multi-organ and telomere length by altering telomerase activity. We aimed to evaluate the relative telomere length (RTL) and risk association of rs2853669 with T2D in Bangladeshi population. RTL was measured in 408 unrelated Bangladeshi (224 T2D and 184 healthy) using primers for target gene and reference gene albumin. Genotypic frequencies for rs2853669 were determined using TaqMan® probes. The mean level of age adjusted RTL (AARTL) varied significantly between the healthy and individuals with T2D for all the genotypes with respect to rs2853669. Moreover, healthy individuals had significantly higher AARTL than T2D. Similar findings were …

See List of Professors in A K M Mahbub Hasan University(University of Dhaka)

A K M Mahbub Hasan FAQs

What is A K M Mahbub Hasan's h-index at University of Dhaka?

The h-index of A K M Mahbub Hasan has been 11 since 2020 and 16 in total.

What are A K M Mahbub Hasan's top articles?

The articles with the titles of

Association of Host Interferon-γ Gene Polymorphism with Toxoplasma gondii Infection in Pregnant Women of Bangladesh

Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV …

Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population

are the top articles of A K M Mahbub Hasan at University of Dhaka.

What are A K M Mahbub Hasan's research interests?

The research interests of A K M Mahbub Hasan are: Biological science

What is A K M Mahbub Hasan's total number of citations?

A K M Mahbub Hasan has 792 citations in total.

What are the co-authors of A K M Mahbub Hasan?

The co-authors of A K M Mahbub Hasan are Ken-ichi Sato, AHM Nurun Nabi, Hossain Shekhar, Md. Ismail Hosen, Sabrina M Elias, Tahirah Yasmin.

    Co-Authors

    H-index: 45
    Ken-ichi Sato

    Ken-ichi Sato

    Nagoya University

    H-index: 24
    AHM Nurun Nabi

    AHM Nurun Nabi

    University of Dhaka

    H-index: 22
    Hossain Shekhar

    Hossain Shekhar

    University of Dhaka

    H-index: 20
    Md. Ismail Hosen

    Md. Ismail Hosen

    University of Dhaka

    H-index: 12
    Sabrina M Elias

    Sabrina M Elias

    Independent University, Bangladesh

    H-index: 8
    Tahirah Yasmin

    Tahirah Yasmin

    University of Dhaka

    academic-engine

    Useful Links