A. Aboelmagd

A. Aboelmagd

Suez Canal University

H-index: 5

Africa-Egypt

Professor Information

University

Suez Canal University

Position

Lecturer of organic chemistry

Citations(all)

118

Citations(since 2016)

90

Cited By

50

hIndex(all)

5

hIndex(since 2016)

5

i10Index(all)

3

i10Index(since 2016)

2

Email

University Profile Page

Suez Canal University

Research & Interests List

organic chemistry

synthetic chemistry

peptide synthesis

Co-Authors

H-index: 19
Mohamed S. Nafie, PhD, MRSC

Mohamed S. Nafie, PhD, MRSC

Suez Canal University

Professor FAQs

What is A. Aboelmagd's h-index at Suez Canal University?

The h-index of A. Aboelmagd has been 5 since 2016 and 5 in total.

What are A. Aboelmagd's research interests?

The research interests of A. Aboelmagd are: organic chemistry, synthetic chemistry, peptide synthesis

What is A. Aboelmagd's total number of citations?

A. Aboelmagd has 118 citations in total.

What are the co-authors of A. Aboelmagd?

The co-authors of A. Aboelmagd are Mohamed S. Nafie, PhD, MRSC.

Top articles of A. Aboelmagd

Discovery of Potent Indolyl-Hydrazones as Kinase Inhibitors for Breast Cancer: Synthesis, X-ray Single-Crystal Analysis, and In Vitro and In Vivo Anti-Cancer Activity Evaluation

According to data provided by the World Health Organization (WHO), a total of 2.3 million women across the globe received a diagnosis of breast cancer in the year 2020, and among these cases, 685,000 resulted in fatalities. As the incidence of breast cancer statistics continues to rise, it is imperative to explore new avenues in the ongoing battle against this disease. Therefore, a number of new indolyl-hydrazones were synthesized by reacting the ethyl 3-formyl-1H-indole-2-carboxylate 1 with thiosemicarbazide, semicarbazide.HCl, 4-nitrophenyl hydrazine, 2,4-dinitrophenyl hydrazine, and 4-amino-5-(1H-indol-2-yl)-1,2,4-triazole-3-thione to afford the new hit compounds, which were assigned chemical structures as thiosemicarbazone 3, bis(hydrazine derivative) 5, semicarbzone 6, Schiff base 8, and the corresponding hydrazones 10 and 12 by NMR, elemental analysis, and X-ray single-crystal analysis. The MTT assay was employed to investigate the compounds’ cytotoxicity against breast cancer cells (MCF-7). Cytotoxicity results disclosed potent IC50 values against MCF-7, especially compounds 5, 8, and 12, with IC50 values of 2.73 ± 0.14, 4.38 ± 0.23, and 7.03 ± 0.37 μM, respectively, compared to staurosproine (IC50 = 8.32 ± 0.43 μM). Consequently, the activities of compounds 5, 8, and 12 in relation to cell migration were investigated using the wound-healing test. The findings revealed notable wound-healing efficacy, with respective percentages of wound closure measured at 48.8%, 60.7%, and 51.8%. The impact of the hit compounds on cell proliferation was assessed by examining their apoptosis-inducing properties. Intriguingly …

Authors

Eid E Salama,Mohamed F Youssef,Ahmed Aboelmagd,Ahmed TA Boraei,Mohamed S Nafie,Matti Haukka,Assem Barakat,Ahmed AM Sarhan

Journal

Pharmaceuticals

Publish By

MDPI

Publish Date

2023/12/13

Stereoselective Synthesis of New 4-Aryl-5-indolyl-1,2,4-triazole S- and N-β-Galactosides: Characterizations, X-ray Crystal Structure and Hirshfeld Surface Analysis

5-(1H-Indol-2-yl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 1a and 4-(4-chlorophenyl)-5-(1H-indol-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 1b were galactosylated in the presence of NaHCO3 in ethanol to produce S-galactosides 3,4, whereas, in the presence of K2CO3 in acetone they produced a mixture of S- and N-galactosides 3-6 with a higher yield of S-galactosides over the respective N-galactosides. Improvement in the yields of N-galactosides was produced by thermal migration of the galactosyl moiety from sulfur to nitrogen using fusion. β-Stereoselectivity of galactosylation was determined using the coupling constant value 3J1,2, which exceeded 9.0 Hz in all prepared galactosides. The precursors 1a and 1b alkylated with 3-bromopropan-1-ol 7 in K2CO3 and acetone produced the S-alkylated products 8 and 9, respectively. Structural determinations of new compounds 5 and 9 are presented. The phenyl and indole moieties were found to be twisted from the triazole ring mean in both compounds. For compound 5, the twist angles were 66.24° and 18.86°, respectively, while the corresponding values for 9 were in the ranges of 73.15–77.29° and 13.96–20.70°, respectively. Hence, the crystal system of 9 is triclinic while the space group is P-1. Detailed analysis of the intermolecular interactions in the crystal structure of 5 is presented using Hirshfeld calculations. The O…H, N…H, C…H, and S…H contacts appeared as red spots in the dnorm Hirshfeld surface indicating short distance intermolecular interactions. Their percentages were estimated based on the decomposition of the fingerprint plot to be 25.6, 2.4, 14.0, and 6.3 …

Authors

Mezna Saleh Altowyan,Matti Haukka,Saied M Soliman,Assem Barakat,Ahmed TA Boraei,Ahmed Aboelmagd

Journal

Crystals

Publish By

MDPI

Publish Date

2023/5/10

NiO‐Nanoparticles as green catalyst for an efficient synthesis of 4‐iminopyrido[1,2‐a]pyrimidine fluorophores via one pot cyclization of α‐aminonicotinonitrile

Utilization of the nano‐catalysts in synthesis of applicable heterocycles is a key focus of research in green chemistry. The present work describes a one‐pot, three‐component, simple, and efficient approach for the synthesis of a new series of N‐bridged pyrido[1,2‐a]pyrimidine candidates utilizing NiO‐NPs as a green catalyst. α‐Aminopyridine 1 was synthesized from one‐pot condensation of 4‐chlorobenzaldehyde, chloroacetyl chloride, and malononitrile in the presence of ammonium acetate. α‐Aminopyridine 1 was condensed with a variety of aromatic or/heteroaromatic aldehydes and malononitrile in the presence of NiO‐NPs to afford pyrido[1,2‐a]pyrimidine derivatives in good yield (75–92%) and with simple purification. Mild reaction conditions, no‐column purification, and high yield of the products are evident features of such an approach, in addition to the high efficiency, cheap, soft, chemically stable, and …

Authors

Ahmed Hamza,Hassan A El‐Sayed,Ahmed H Moustafa,Samir M El Rayes,Ahmed Aboelmaged,Reda A Haggam

Journal

Journal of Heterocyclic Chemistry

Publish By

John Wiley & Sons, Inc.

Publish Date

2023/5

A Novel Ibuprofen Derivative and Its Complexes: Physicochemical Characterization, DFT Modeling, Docking, In Vitro Anti-Inflammatory Studies, and DNA Interaction

A novel derivative of ibuprofen and salicylaldehyde N′-(4-hydroxybenzylidene)-2-(4-isobutylphenyl) propane hydrazide (HL) was synthesized, followed by its complexation with Cu, Ni, Co, Gd, and Sm. The compounds obtained were characterized by 1HNMR, mass spectrometry, UV-Vis spectroscopy, FT-IR spectroscopy, thermal analysis (DTA and TGA), conductivity measurements, and magnetic susceptibility measurements. The results indicate that the complexes formed were [Cu(L)(H2O)]Cl·2H2O, [Ni(L)2], [Co(L)2]·H2O, [Gd(L)2(H2O)2](NO3)·2H2O and [Sm(L)2(H2O)2](NO3)·2H2O. The surface characteristics of the produced compounds were evaluated by DFT calculations using the MOE environment. The docking was performed against the COX2 targeting protein (PDB code: 5IKT Homo sapiens). The binding energies were −7.52, −9.41, −9.51, −8.09, −10.04, and −8.05 kcal/mol for HL and the Co, Ni, Cu, Sm, and Gd complexes, respectively, which suggests the enhancement of anti-inflammatory behaviors compared with the binding energy of ibuprofen (−5.38 kcal/mol). The anti-inflammatory properties of the new compounds were assessed in vitro using the western blot analysis method and the enzyme-linked immunosorbent assay (ELISA), consistent with the outcomes obtained from docking. The half-maximal inhibitory concentration (IC50) values are 4.9, 1.7, 3.7, 5.6, 2.9, and 2.3 µM for HL and the Co, Ni, Cu, Sm, and Gd complexes, respectively, showing that they are more effective inhibitors of COX2 than ibuprofen (IC50 = 31.4 µM). The brain or intestinal estimated permeation method (BOILED-Egg) showed that HL and its Co complex …

Authors

Abbas M Abbas,Ahmed Aboelmagd,Safaa M Kishk,Hossam H Nasrallah,Warren Christopher Boyd,Haitham Kalil,Adel S Orabi

Journal

Molecules

Publish By

MDPI

Publish Date

2022/11/3

The synthesis and antiproliferative activity of new N-allyl quinoxalinecarboxamides and their O-regioisomers

We have designed a series of quinoxalinepeptidomimetic derivatives based on our previously reported scaffold in an attempt to find a promising lead compound. Quinoxalinepeptidomimetic derivatives, N-alkyl-3-(4-allyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)propanamides, methyl 2-[3-(4-allyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)propanamido] alkanoates, and their O-regioisomers, were prepared via the competing alkylation reaction of the ambient nucleophile, methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate, with allyl bromide to afford the corresponding O- and N-allyl quinoxaline ester derivatives. The esters gave the desired products through reactions with amines and amino acid esters via the azide coupling method. We have examined the antiproliferative activities of the 34 different synthesized compounds using human HCT-116 and HEH-293 cell lines. Out of 34 screened derivatives, 22 active compounds …

Authors

A Aboelmagd,SM El Rayes,MS Gomaa,Ibrahim AI Ali,Walid Fathalla,FH Pottoo,Firdos A Khan,Mohamed E Khalifa

Journal

New Journal of Chemistry

Publish By

Royal Society of Chemistry

Publish Date

2021

Synthesis and Anti proliferative Activity of New N‐Pentylquinoxaline carboxamides and Their O‐Regioisomer

We have designed a series of quinoxalinepeptidomimetic derivatives based on our previous reported scaffold in attempt to find a promising lead compound. Quinoxaline derivatives; N‐alkyl‐3‐(3‐oxo‐4‐pentyl‐3,4‐dihydro‐quinoxalin‐2‐yl)‐propanamides and methyl 2‐[3‐(3‐oxo‐4‐pentyl‐3,4‐dihydro‐quinoxalin‐2‐yl)propanamido]alkanoates and their O‐regioisomers were prepared by alkylation of the ambient nucleophile methyl 3‐(3‐oxo‐3,4‐dihydroquinoxalin‐2‐yl)propanoate with pentyl bromide to give the corresponding N‐ and O‐pentylquinoxaline ester derivatives. The N‐ and O‐pentyl‐quinoxaline ester derivatives gave the desired products by the reaction with amines and amino acid esters via azide coupling method. We have examined the anti proliferative activity of the 35 different synthesized compounds on human HCT‐116 and HEK‐293 cell lines. Out of 35 screened derivatives, 14 active …

Authors

Ahmed Aboelmagd,Saad H Alotaibi,Samir M El Rayes,Gomaa M Elsayed,Ibrahim AI Ali,Walid Fathalla,Faheem H Pottoo,Firdos A Khan

Journal

ChemistrySelect

Publish Date

2020/11/20

Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2, 2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was transformed into the corresponding trichloroacetimidate or acetate by the reaction with trichloroacetonitrile and acetic anhydride, respectively. N-Alkyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropan-amides and methyl-2-[(3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoyl)amino] alkanoates were obtained by the reaction of corresponding acid or hydrazide with amines and amino acid esters via DCC and azide coupling methods. Methyl-3-aryl-3-(4-chlorophenyl)-2,2-dimethylpropanoates were obtained in good yields and short reaction time from the corresponding trichloroacetimidate or acetate by the …

Authors

Samir M El Rayes,Ahmed Aboelmagd,Mohamed S Gomaa,Walid Fathalla,Ibrahim AI Ali,Faheem H Pottoo,Firdos Alam Khan

Journal

RSC advances

Publish By

Royal Society of Chemistry

Publish Date

2020

Convenient synthesis of some new 3-(4-chloro-phenyl)-3-hydroxy-2, 2-dimethyl-propionic acid methyl ester derivatives of expected Anticancer Activity

A series of 25 compounds were synthesized based on structure modification of the model methyl 3-(4-chlorophenyl)-3-hydroxy-2, 2-dimethylpropanoateas potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was transformed into corresponding trichloroacetimidate or acetate by the reaction with trichloroacetonitrile and acetic anhydride, respectively. N-alkyl-3-(4-chlorophenyl)-3-hydroxy-2, 2-dimethylpropan-amides and methyl 2-[(3-(4-chlorophenyl)-3-hydroxy-2, 2-dimethylpropanoyl) amino] alkanoates were obtained by the reaction ofcorresponding acid or hydrazide with amines and amino acid esters via DCC and azidecoupling methods. Methyl 3-aryl-3-(4-chlorophenyl)-2, 2-dimethylpropanoates were obtainedin good yields and short reaction timefrom the corresponding trichloroacetimidate or acetate by the reaction …

Authors

Samir El Rayes,Ahmed Aboelmagd,Mohamed Gomaa,Ibrahim Ali,Walid Fathalla

Publish By

MDPI AG

Publish Date

2019/11/14

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