Pankaj Deo

Characterization of outer membrane vesicles released by clinical isolates of Neisseria gonorrhoeae

A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation

Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability

Neisseria gonorrhoeae-derived outer membrane vesicles package β-lactamases to promote antibiotic resistance

Bacterial outer membrane vesicles and host cell death signaling

The periplasmic space cannot be artificially enlarged due to homeostatic regulation maintaining spatial constraints essential for membrane spanning processes and cell viability

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

Targeting NLRP3 and Staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages