Jayapal Reddy Mallareddy

About Jayapal Reddy Mallareddy

Jayapal Reddy Mallareddy, With an exceptional h-index of 12 and a recent h-index of 8 (since 2020), a distinguished researcher at University of Nebraska Medical Center, specializes in the field of Medicinal chemistry, Cancer therapeutics, PROTAC development, Drug discovery.

His recent articles reflect a diverse array of research interests and contributions to the field:

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

Proteolysis targeting chimera (PROTAC)-driven internalization of antibodies targeting oncogenic cell surface receptors

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

Phosphoproteomic profiling following MAP3K1 kinase inhibition identifies NPM1 as a novel substrate

Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding

Restored Ubiquitination and Degradation of Exon 14 Skipped MET with Proteolysis Targeting Chimeras

Systemic administration of a brain permeable Cdk5 inhibitor alters neurobehavior

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth

Jayapal Reddy Mallareddy Information

University

Position

Research Instructor

Citations(all)

346

Citations(since 2020)

236

Cited By

164

hIndex(all)

12

hIndex(since 2020)

8

i10Index(all)

13

i10Index(since 2020)

6

Email

University Profile Page

Google Scholar

Jayapal Reddy Mallareddy Skills & Research Interests

Medicinal chemistry

Cancer therapeutics

PROTAC development

Drug discovery

Top articles of Jayapal Reddy Mallareddy

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

bioRxiv

2024

Proteolysis targeting chimera (PROTAC)-driven internalization of antibodies targeting oncogenic cell surface receptors

Cancer Research

2024/3/22

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

bioRxiv

2023/4/5

Ravi Thakur
Ravi Thakur

H-Index: 10

Dezhen Wang
Dezhen Wang

H-Index: 14

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Phosphoproteomic profiling following MAP3K1 kinase inhibition identifies NPM1 as a novel substrate

Cancer Research

2023/4/4

Sarbjit Singh
Sarbjit Singh

H-Index: 2

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Akhilesh Pandey
Akhilesh Pandey

H-Index: 15

Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding

RSC Medicinal Chemistry

2023

Sarbjit Singh
Sarbjit Singh

H-Index: 2

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Sandeep Rana
Sandeep Rana

H-Index: 3

Restored Ubiquitination and Degradation of Exon 14 Skipped MET with Proteolysis Targeting Chimeras

Journal of Thoracic Oncology

2022/9/1

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

L Yang
L Yang

H-Index: 10

S Singh
S Singh

H-Index: 4

Systemic administration of a brain permeable Cdk5 inhibitor alters neurobehavior

Frontiers in Pharmacology

2022/5/12

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth

Proceedings of the National Academy of Sciences

2022/5/3

Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells

Journal of Biological Chemistry

2022/5/1

Sandeep Rana
Sandeep Rana

H-Index: 3

Sarbjit Singh
Sarbjit Singh

H-Index: 2

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy

2022/2

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Sarbjit Singh
Sarbjit Singh

H-Index: 2

Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents

Bioorganic & medicinal chemistry letters

2022/6/1

Sandeep Rana
Sandeep Rana

H-Index: 3

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Tom Huxford
Tom Huxford

H-Index: 15

Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA

RSC Chemical Biology

2022

Sandeep Rana
Sandeep Rana

H-Index: 3

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Tom Huxford
Tom Huxford

H-Index: 15

Inhibitors, PROTACs and molecular glues as diverse therapeutic modalities to target cyclin-dependent kinase

2021/11/2

Sandeep Rana
Sandeep Rana

H-Index: 3

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Sarbjit Singh
Sarbjit Singh

H-Index: 2

Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax

Bioorganic & medicinal chemistry letters

2021/7/1

Sandeep Rana
Sandeep Rana

H-Index: 3

Jayapal Reddy Mallareddy
Jayapal Reddy Mallareddy

H-Index: 6

Muhammad Zahid
Muhammad Zahid

H-Index: 2

Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy

European journal of medicinal chemistry

2021/10/15

See List of Professors in Jayapal Reddy Mallareddy University(University of Nebraska Medical Center)