Dominik Paquet

About Dominik Paquet

Dominik Paquet, With an exceptional h-index of 18 and a recent h-index of 17 (since 2020), a distinguished researcher at Ludwig-Maximilians-Universität München, specializes in the field of iPSCs, CRISPR, Alzheimer, FTD.

His recent articles reflect a diverse array of research interests and contributions to the field:

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations

Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells

Membrane lipid remodeling modulates γ-secretase processivity

Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation

Dominik Paquet Information

University

Position

Institute for Stroke and Dementia Research Germany

Citations(all)

3053

Citations(since 2020)

1724

Cited By

1888

hIndex(all)

18

hIndex(since 2020)

17

i10Index(all)

21

i10Index(since 2020)

19

Email

University Profile Page

Google Scholar

Dominik Paquet Skills & Research Interests

iPSCs

CRISPR

Alzheimer

FTD

Top articles of Dominik Paquet

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Nature aging

2024/3/22

A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations

bioRxiv

2024

Zoltan Simandi
Zoltan Simandi

H-Index: 10

Dominik Paquet
Dominik Paquet

H-Index: 12

Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration

bioRxiv

2024

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Nature biotechnology

2023/11

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

Molecular Neurodegeneration

2023/9/29

Dominik Paquet
Dominik Paquet

H-Index: 12

Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells

STAR protocols

2023/6/16

Dominik Paquet
Dominik Paquet

H-Index: 12

Membrane lipid remodeling modulates γ-secretase processivity

Journal of Biological Chemistry

2023/4/1

Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation

bioRxiv

2023

Zoltan Simandi
Zoltan Simandi

H-Index: 10

Dominik Paquet
Dominik Paquet

H-Index: 12

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin

bioRxiv

2023

Georg Werner
Georg Werner

H-Index: 7

Dominik Paquet
Dominik Paquet

H-Index: 12

Enhancement of CRISPR gene editing or target destruction by co-expression of heterologous DNA repair protein

2022/9/27

TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease

EMBO molecular medicine

2022/9/7

P09. 01 Single-cell transcriptomic atlas-guided development of chimeric antigen-receptor (CAR) T cells for the treatment of acute myeloid leukemia

2022/9/1

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

The EMBO Journal

2022/2/15

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

EMBO molecular medicine

2021/10/7

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

bioRxiv

2021/7/10

Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping

2021/3

Detection of deleterious on-target effects after HDR-mediated CRISPR editing

Cell reports

2020/5/26

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer’s disease

2020/4/1

Dominik Paquet
Dominik Paquet

H-Index: 12

See List of Professors in Dominik Paquet University(Ludwig-Maximilians-Universität München)