Yudao Shen

Yudao Shen

Icahn School of Medicine at Mount Sinai

H-index: 20

North America-United States

Contact Yudao Shen

About Yudao Shen

Yudao Shen, With an exceptional h-index of 20 and a recent h-index of 20 (since 2020), a distinguished researcher at Icahn School of Medicine at Mount Sinai, specializes in the field of Medicinal chemistry and Organic chemistry.

His recent articles reflect a diverse array of research interests and contributions to the field:

Sox11 inhibitors for treating mantle cell lymphoma

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2

Abstract LB195: AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

Exploring degradation of mutant and wild-type epidermal growth factor receptors induced by proteolysis-targeting chimeras

Yudao Shen Information

University	Icahn School of Medicine at Mount Sinai
Position	/SIOC
Citations(all)	1570
Citations(since 2020)	1455
Cited By	393
hIndex(all)	20
hIndex(since 2020)	20
i10Index(all)	25
i10Index(since 2020)	24
Email	Access Email
University Profile Page	Icahn School of Medicine at Mount Sinai
Google Scholar	View Google Scholar Profile

Yudao Shen Skills & Research Interests

Medicinal chemistry and Organic chemistry

Top articles of Yudao Shen

Sox11 inhibitors for treating mantle cell lymphoma

2023/8/3

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Oncogene

2023/3/24

Xufen Yu

H-Index: 11

Jun Wang

H-Index: 10

Weida Gong

H-Index: 6

Yudao Shen

H-Index: 9

Chengwei Zhang

H-Index: 10

Ling Cai

H-Index: 16

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

Journal of medicinal chemistry

2022/10/5

Xufen Yu

H-Index: 11

Jia Xu

H-Index: 8

Ling Xie

H-Index: 2

Yudao Shen

H-Index: 9

Xian Chen

H-Index: 35

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Nature chemical biology

2022/8

Wail Ba-Alawi

H-Index: 15

Jocelyn Chen

H-Index: 3

Yudao Shen

H-Index: 9

Jing Liu

H-Index: 11

Sajid A Marhon

H-Index: 7

Nergiz Dogan-Artun

H-Index: 7

Wenjun Chen

H-Index: 14

Genevieve Deblois

H-Index: 16

Katlin B Massirer

H-Index: 11

Jian Jin

H-Index: 1

Benjamin Haibe-Kains

H-Index: 57

Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2

ACS Pharmacology & Translational Science

2022/6/24

Chris Anderson

H-Index: 19

Yudao Shen

H-Index: 9

Chengwei Zhang

H-Index: 10

Ling Xie

H-Index: 2

Xian Chen

H-Index: 35

Xufen Yu

H-Index: 11

Jian Jin

H-Index: 1

Abstract LB195: AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B

Cancer Research

2022/6/15

Jia Xu

H-Index: 8

Xufen Yu

H-Index: 11

Li Wang

H-Index: 0

Ling Xie

H-Index: 2

Yudao Shen

H-Index: 9

Xian Chen

H-Index: 35

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

Oncogene

2022/6/10

Dongxu Li

H-Index: 7

Xufen Yu

H-Index: 11

Weida Gong

H-Index: 6

Zhao Zhang

H-Index: 15

Yudao Shen

H-Index: 9

Ling Cai

H-Index: 16

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Exploring degradation of mutant and wild-type epidermal growth factor receptors induced by proteolysis-targeting chimeras

Journal of medicinal chemistry

2022/6/8

Xufen Yu

H-Index: 11

Meng Cheng

H-Index: 9

Yudao Shen

H-Index: 9

Yue Zhong

H-Index: 2

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Nature cell biology

2022/3

Jun Wang

H-Index: 10

Xufen Yu

H-Index: 11

Weida Gong

H-Index: 6

Yudao Shen

H-Index: 9

Jing Liu

H-Index: 11

Ling Cai

H-Index: 16

Jian Jin

H-Index: 1

Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure–activity relationship studies

Journal of medicinal chemistry

2022/2/4

Xufen Yu

H-Index: 11

Jia Xu

H-Index: 8

Yudao Shen

H-Index: 9

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

AKT degradation selectively inhibits the growth of PI3K/PTEN pathway–mutant cancers with wild-type KRAS and BRAF by destabilizing aurora kinase B

Cancer discovery

2021/12/1

Jia Xu

H-Index: 8

Xufen Yu

H-Index: 11

Li Wang

H-Index: 0

Ling Xie

H-Index: 2

Yudao Shen

H-Index: 9

Xian Chen

H-Index: 35

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Science translational medicine

2021/9/29

Xufen Yu

H-Index: 11

Dongxu Li

H-Index: 7

Yudao Shen

H-Index: 9

Weida Gong

H-Index: 6

Jun Wang

H-Index: 10

Joel Parker

H-Index: 109

Ling Cai

H-Index: 16

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Harnessing the E3 ligase KEAP1 for targeted protein degradation

Journal of the American Chemical Society

2021/9/14

Julia Velez

H-Index: 2

Li Wang

H-Index: 0

Ling Xie

H-Index: 2

He Chen

H-Index: 3

Yudao Shen

H-Index: 9

Dongxu Li

H-Index: 7

Xian Chen

H-Index: 35

H Umit Kaniskan

H-Index: 12

Jian Jin

H-Index: 1

Methylation of dual-specificity phosphatase 4 controls cell differentiation

Cell reports

2021/7/27

Ming Jiang

H-Index: 5

Tuo Zhang

H-Index: 13

Han Guo

H-Index: 3

Qing Zhao

H-Index: 6

Yudao Shen

H-Index: 9

Jing Liu

H-Index: 11

Yabing Chen

H-Index: 19

Jian Jin

H-Index: 1

Amit Verma

H-Index: 8

Xinyang Zhao

H-Index: 1

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Cell

2021/7/22

Benoit Rousseau

H-Index: 15

Arnab Ghosh

H-Index: 12

Michael Singer

H-Index: 17

Eric Wang

H-Index: 28

Bin Lu

H-Index: 13

Yudao Shen

H-Index: 9

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Cancer selective target degradation by folate-caged PROTACs

Journal of the American Chemical Society

2021/5/10

Jing Liu

H-Index: 11

He Chen

H-Index: 3

Yi Liu

H-Index: 21

Yudao Shen

H-Index: 9

H Umit Kaniskan

H-Index: 12

Jian Jin

H-Index: 1

Wenyi Wei

H-Index: 52

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6

Journal of medicinal chemistry

2021/2/16

Yudao Shen

H-Index: 9

He Chen

H-Index: 3

Hong Zeng

H-Index: 7

Hong Wu

H-Index: 10

Matthieu Schapira

H-Index: 34

H Umit Kaniskan

H-Index: 12

Masoud Vedadi

H-Index: 47

Jian Jin

H-Index: 1

Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders

Journal of medicinal chemistry

2021/12/2

Xufen Yu

H-Index: 11

Jia Xu

H-Index: 8

Ling Xie

H-Index: 2

Li Wang

H-Index: 0

Yudao Shen

H-Index: 9

Xian Chen

H-Index: 35

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders

Journal of medicinal chemistry

2020/8/11

Yudao Shen

H-Index: 9

Xufen Yu

H-Index: 11

Li Wang

H-Index: 0

Ling Xie

H-Index: 2

Xian Chen

H-Index: 35

Ernesto Guccione

H-Index: 33

Jing Liu

H-Index: 11

Jian Jin

H-Index: 1

Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

Journal of medicinal chemistry

2020/5/5

Yudao Shen

H-Index: 9

Hong Zeng

H-Index: 7

He Chen

H-Index: 3

Jing Liu

H-Index: 11

Masoud Vedadi

H-Index: 47

Jian Jin

H-Index: 1

See List of Professors in Yudao Shen University(Icahn School of Medicine at Mount Sinai)

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