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Yaxia Yuan

Yaxia Yuan

University of Florida

H-index: 21

North America-United States

Contact Yaxia Yuan

About Yaxia Yuan

Yaxia Yuan, With an exceptional h-index of 21 and a recent h-index of 19 (since 2020), a distinguished researcher at University of Florida, specializes in the field of Drug design, MD simulation, PROTACs, Molecular glue.

His recent articles reflect a diverse array of research interests and contributions to the field:

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Design and synthesis of indol-2-one derivatives as potential RET inhibitors

TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells

Therapeutic agents and methods of treatment

PELP1 inhibition by SMIP34 reduces endometrial cancer progression via attenuation of ribosomal biogenesis

Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor

Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

Piperlongumine conjugates induce targeted protein degradation

Yaxia Yuan Information

University

Position

___

Citations(all)

2353

Citations(since 2020)

1857

Cited By

996

hIndex(all)

21

hIndex(since 2020)

19

i10Index(all)

37

i10Index(since 2020)

33

Email

University Profile Page

Google Scholar

Yaxia Yuan Skills & Research Interests

Drug design

MD simulation

PROTACs

Molecular glue

Top articles of Yaxia Yuan

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature communications

2024/3/29

Dongwen Lv
Dongwen Lv

H-Index: 22

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Peiyi Zhang
Peiyi Zhang

H-Index: 5

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Daohong Zhou
Daohong Zhou

H-Index: 37

Design and synthesis of indol-2-one derivatives as potential RET inhibitors

Bioorganic & Medicinal Chemistry Letters

2023/12/15

Zhenzhu Li
Zhenzhu Li

H-Index: 18

Kai Sun
Kai Sun

H-Index: 10

Yang Wang
Yang Wang

H-Index: 11

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Lei Ma
Lei Ma

H-Index: 8

TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells

Nucleic acids research

2023/12/11

Arijit Dutta
Arijit Dutta

H-Index: 3

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Daohong Zhou
Daohong Zhou

H-Index: 37

Therapeutic agents and methods of treatment

2023/10/26

PELP1 inhibition by SMIP34 reduces endometrial cancer progression via attenuation of ribosomal biogenesis

Molecular oncology

2023/10/19

Xue Yang
Xue Yang

H-Index: 23

Weiwei Tang
Weiwei Tang

H-Index: 14

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Daohong Zhou
Daohong Zhou

H-Index: 37

Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor

European Journal of Medicinal Chemistry

2023/8/5

Weiwei Huang
Weiwei Huang

H-Index: 8

Jie Zhang
Jie Zhang

H-Index: 10

Lihui Wang
Lihui Wang

H-Index: 7

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Shurong Hou
Shurong Hou

H-Index: 6

Lei Ma
Lei Ma

H-Index: 8

Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

Signal transduction and targeted therapy

2023/2/27

Shurong Hou
Shurong Hou

H-Index: 6

Xiaoling Chen
Xiaoling Chen

H-Index: 4

Wenxin Wang
Wenxin Wang

H-Index: 36

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Tian Xie
Tian Xie

H-Index: 5

Piperlongumine conjugates induce targeted protein degradation

Cell Chemical Biology

2023/2/16

Yufeng Xiao
Yufeng Xiao

H-Index: 2

Xingui Liu
Xingui Liu

H-Index: 8

Amin Sobh
Amin Sobh

H-Index: 3

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Shuo Zhou
Shuo Zhou

H-Index: 9

Nan Hua
Nan Hua

H-Index: 13

Xuan Zhang
Xuan Zhang

H-Index: 2

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Daohong Zhou
Daohong Zhou

H-Index: 37

Dongwen Lv
Dongwen Lv

H-Index: 22

DyScore: A boosting scoring method with dynamic properties for identifying true binders and nonbinders in structure-based drug discovery

Journal of chemical information and modeling

2022/11/3

Yanjun Li
Yanjun Li

H-Index: 6

Daohong Zhou
Daohong Zhou

H-Index: 37

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Xiaolin Li
Xiaolin Li

H-Index: 41

Dapeng Wu
Dapeng Wu

H-Index: 23

Yaxia Yuan
Yaxia Yuan

H-Index: 16

A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer

Cancer research

2022/10/17

Dimple Chakravarty
Dimple Chakravarty

H-Index: 15

Junhao Liu
Junhao Liu

H-Index: 8

Behnam Ebrahimi
Behnam Ebrahimi

H-Index: 4

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Daohong Zhou
Daohong Zhou

H-Index: 37

Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

Plos one

2022/9/28

Steven Lin
Steven Lin

H-Index: 3

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Wei-Lun Sun
Wei-Lun Sun

H-Index: 5

Chang-Guo Zhan
Chang-Guo Zhan

H-Index: 30

Jun Zhu
Jun Zhu

H-Index: 2

Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice

Science signaling

2022/3/15

Ling Guo
Ling Guo

H-Index: 7

Minzhi Yu
Minzhi Yu

H-Index: 10

Ling Mei
Ling Mei

H-Index: 16

Qian Wang
Qian Wang

H-Index: 10

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Chang-Guo Zhan
Chang-Guo Zhan

H-Index: 30

Identification of Piperlongumine (PL) as a new E3 ligase ligand to induce targeted protein degradation

Cell Chemical Biology

2022/1/23

Yufeng Xiao
Yufeng Xiao

H-Index: 2

Xingui Liu
Xingui Liu

H-Index: 8

Amin Sobh
Amin Sobh

H-Index: 3

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Shuo Zhou
Shuo Zhou

H-Index: 9

Nan Hua
Nan Hua

H-Index: 13

Xuan Zhang
Xuan Zhang

H-Index: 2

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Daohong Zhou
Daohong Zhou

H-Index: 37

Dongwen Lv
Dongwen Lv

H-Index: 22

Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat‐inhibited Dopamine Transport

Journal of Neuroimmune Pharmacology

2021/12/1

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Yi Zhou
Yi Zhou

H-Index: 36

Wei-Lun Sun
Wei-Lun Sun

H-Index: 5

Chang-Guo Zhan
Chang-Guo Zhan

H-Index: 30

Jun Zhu
Jun Zhu

H-Index: 2

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Nature communications

2021/11/25

Dongwen Lv
Dongwen Lv

H-Index: 22

Pratik Pal
Pratik Pal

H-Index: 3

Xingui Liu
Xingui Liu

H-Index: 8

Dinesh Thummuri
Dinesh Thummuri

H-Index: 18

Peiyi Zhang
Peiyi Zhang

H-Index: 5

Qi Zhang
Qi Zhang

H-Index: 5

Shuo Zhou
Shuo Zhou

H-Index: 9

Sajid Khan
Sajid Khan

H-Index: 14

Xuan Zhang
Xuan Zhang

H-Index: 2

Nan Hua
Nan Hua

H-Index: 13

Weizhou Zhang
Weizhou Zhang

H-Index: 32

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Daohong Zhou
Daohong Zhou

H-Index: 37

Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition

Journal of medicinal chemistry

2021/9/17

Pratik Pal
Pratik Pal

H-Index: 3

Dinesh Thummuri
Dinesh Thummuri

H-Index: 18

Dongwen Lv
Dongwen Lv

H-Index: 22

Xingui Liu
Xingui Liu

H-Index: 8

Peiyi Zhang
Peiyi Zhang

H-Index: 5

Nan Hua
Nan Hua

H-Index: 13

Sajid Khan
Sajid Khan

H-Index: 14

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Xuan Zhang
Xuan Zhang

H-Index: 2

Daohong Zhou
Daohong Zhou

H-Index: 37

Guangrong Zheng
Guangrong Zheng

H-Index: 15

Creation of an anti-inflammatory, leptin-dependent anti-obesity celastrol mimic with better druggability

Frontiers in Pharmacology

2021/8/30

Bo Zhou
Bo Zhou

H-Index: 11

Sheng Hu
Sheng Hu

H-Index: 2

Xiaohua Li
Xiaohua Li

H-Index: 11

Binding mode of human norepinephrine transporter interacting with HIV-1 tat

ACS chemical neuroscience

2021/4/22

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Jun Zhu
Jun Zhu

H-Index: 2

Chang-Guo Zhan
Chang-Guo Zhan

H-Index: 30

Multiple Target Drug Design Using LigBuilder 3

Protein-Ligand Interactions and Drug Design

2021

Xiaoyu Qing
Xiaoyu Qing

H-Index: 3

Shiwei Wang
Shiwei Wang

H-Index: 2

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Jianfeng Pei
Jianfeng Pei

H-Index: 23

Luhua Lai
Luhua Lai

H-Index: 38

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

European journal of medicinal chemistry

2020/8/1

Xuan Zhang
Xuan Zhang

H-Index: 2

Peiyi Zhang
Peiyi Zhang

H-Index: 5

Vivekananda Budamagunta
Vivekananda Budamagunta

H-Index: 4

Dongwen Lv
Dongwen Lv

H-Index: 22

Dinesh Thummuri
Dinesh Thummuri

H-Index: 18

Yang Yang
Yang Yang

H-Index: 9

Yaxia Yuan
Yaxia Yuan

H-Index: 16

Daohong Zhou
Daohong Zhou

H-Index: 37

Guangrong Zheng
Guangrong Zheng

H-Index: 15

See List of Professors in Yaxia Yuan University(University of Florida)