Philip Hinchliffe
University of Bristol
H-index: 26
Europe-United Kingdom
Top articles of Philip Hinchliffe
Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Extended Molecular Dynamics Simulations in the Membrane Environment
2024/4/25
Reynier Suardíaz
H-Index: 11
Philip Hinchliffe
H-Index: 18
Marc Van Der Kamp
H-Index: 21
Adrian Mulholland
H-Index: 35
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes
Journal of Medicinal Chemistry
2024/2/19
Philip Hinchliffe
H-Index: 18
Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme
bioRxiv
2024
Michael Beer
H-Index: 27
Philip Hinchliffe
H-Index: 18
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Journal of the American Chemical Society
2023/3/27
Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products
Journal of Biological Chemistry
2023/3/15
Philip Hinchliffe
H-Index: 18
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
Mbio
2022/6/28
A multiscale approach to predict the binding mode of metallo beta-lactamase inhibitors
Proteins: Structure, Function, and Bioinformatics
2022/2
Philip Hinchliffe
H-Index: 18
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Nature Chemistry
2022/1
Faropenem reacts with serine and metallo-β-lactamases to give multiple products
European journal of medicinal chemistry
2021/4/5
Philip Hinchliffe
H-Index: 18
2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases
Chemical Science
2021/1/5
Philip Hinchliffe
H-Index: 18
Ryan Smith
H-Index: 35
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance
Journal of Biological Chemistry
2021/1/1
Philip Hinchliffe
H-Index: 18
Catalytic mechanism of the colistin resistance protein MCR-1
Organic & biomolecular chemistry
2021
Crystallography and QM/MM Simulations Identify Preferential Binding of Hydrolyzed Carbapenem and Penem Antibiotics to the L1 Metallo-β-Lactamase in the Imine Form
Journal of chemical information and modeling
2021/10/12
Philip Hinchliffe
H-Index: 18
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode
ACS Infectious Diseases
2021/8/6
Philip Hinchliffe
H-Index: 18
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
Nature communications
2021/7/22
Philip Hinchliffe
H-Index: 18
Ali Ebrahim
H-Index: 19
Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes
Chemical communications
2020
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition
RSC medicinal chemistry
2020
Philip Hinchliffe
H-Index: 18
Alen Krajnc
H-Index: 4
Co-Authors
