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Paul Brear

Paul Brear

University of Cambridge

H-index: 14

Europe-United Kingdom

Contact Paul Brear

About Paul Brear

Paul Brear, With an exceptional h-index of 14 and a recent h-index of 13 (since 2020), a distinguished researcher at University of Cambridge, specializes in the field of Structural Biology.

His recent articles reflect a diverse array of research interests and contributions to the field:

CK2 Inhibitors Targeting Inside and Outside the Catalytic Box

Benzo [c][2, 6] naphthyridine derivatives, compositions and therapeutic uses thereof

Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2

Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control

Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators

Paul Brear Information

University

Position

___

Citations(all)

563

Citations(since 2020)

485

Cited By

273

hIndex(all)

14

hIndex(since 2020)

13

i10Index(all)

19

i10Index(since 2020)

17

Email

University Profile Page

Google Scholar

Paul Brear Skills & Research Interests

Structural Biology

Top articles of Paul Brear

CK2 Inhibitors Targeting Inside and Outside the Catalytic Box

2024/3/26

David R Spring
David R Spring

H-Index: 42

Benzo [c][2, 6] naphthyridine derivatives, compositions and therapeutic uses thereof

2024/1/9

Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins

2024

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Nature Chemical Biology

2023/10/30

Maria Reinecke
Maria Reinecke

H-Index: 7

Paul Brear
Paul Brear

H-Index: 9

Patroklos Samaras
Patroklos Samaras

H-Index: 8

Mathias Wilhelm
Mathias Wilhelm

H-Index: 23

Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2

Journal of Medicinal Chemistry

2023/7/11

Gustavo Arruda Bezerra
Gustavo Arruda Bezerra

H-Index: 14

Simone Pellegrino
Simone Pellegrino

H-Index: 10

Liuhong Chen
Liuhong Chen

H-Index: 9

Paul Brear
Paul Brear

H-Index: 9

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2

Nature communications

2023/6/16

Liuhong Chen
Liuhong Chen

H-Index: 9

Paul Brear
Paul Brear

H-Index: 9

Jo Sharp
Jo Sharp

H-Index: 12

Parul Sharma
Parul Sharma

H-Index: 3

James P Stewart
James P Stewart

H-Index: 22

Andrew Owen
Andrew Owen

H-Index: 33

Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control

Frontiers in Microbiology

2023/5/12

Paul Brear
Paul Brear

H-Index: 9

Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators

European Journal of Medicinal Chemistry

2023/3/15

Amalyn Nain-Perez
Amalyn Nain-Perez

H-Index: 5

Paul Brear
Paul Brear

H-Index: 9

Jan Borén
Jan Borén

H-Index: 58

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

Nature Communications

2023/2/11

Paul Brear
Paul Brear

H-Index: 9

Florian Hollfelder
Florian Hollfelder

H-Index: 36

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

bioRxiv

2023

Katrin Fischer
Katrin Fischer

H-Index: 1

Matthew Ij Raybould
Matthew Ij Raybould

H-Index: 7

Juan Carlos Yam-Puc
Juan Carlos Yam-Puc

H-Index: 8

Paul Brear
Paul Brear

H-Index: 9

Charlotte Deane
Charlotte Deane

H-Index: 34

Marko Hyvonen
Marko Hyvonen

H-Index: 25

Florian Hollfelder
Florian Hollfelder

H-Index: 36

Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa Reveals a Novel Path to Underground Metabolism

Mbio

2022/12/20

Michael Kohlstedt
Michael Kohlstedt

H-Index: 14

Paul Brear
Paul Brear

H-Index: 9

Rafael Silva-Rocha
Rafael Silva-Rocha

H-Index: 21

Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α

Acta Crystallographica Section F: Structural Biology Communications

2022/10/1

Paul Brear
Paul Brear

H-Index: 9

Functional metagenomic screening identifies an unexpected β-glucuronidase

Nature Chemical Biology

2022/10

Paul Brear
Paul Brear

H-Index: 9

Paul Dupree
Paul Dupree

H-Index: 48

Florian Hollfelder
Florian Hollfelder

H-Index: 36

Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics

bioRxiv

2022/5/15

So Yeon Kim
So Yeon Kim

H-Index: 6

Paul Brear
Paul Brear

H-Index: 9

Tom L Blundell
Tom L Blundell

H-Index: 57

Functional metagenomic screening in microfluidic droplets identifies a β-glucuronidase in an unprecedented sequence neighbourhood

bioRxiv

2022/4/25

Paul Brear
Paul Brear

H-Index: 9

Paul Dupree
Paul Dupree

H-Index: 48

Florian Hollfelder
Florian Hollfelder

H-Index: 36

Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase

European Journal of Medicinal Chemistry

2022/4/15

Amalyn Nain-Perez
Amalyn Nain-Perez

H-Index: 5

Chunxia Gao
Chunxia Gao

H-Index: 5

Alexandra Rodríguez
Alexandra Rodríguez

H-Index: 14

Paul Brear
Paul Brear

H-Index: 9

A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action

RSC Medicinal Chemistry

2022

Paul Brear
Paul Brear

H-Index: 9

David R Spring
David R Spring

H-Index: 42

Development of small cyclic peptides targeting the CK2α/β interface

Chemical Communications

2022

Paul Brear
Paul Brear

H-Index: 9

Mauro Salvi
Mauro Salvi

H-Index: 18

David R Spring
David R Spring

H-Index: 42

Chemical probes targeting the kinase CK2: A journey outside the catalytic box

2021

David R Spring
David R Spring

H-Index: 42

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Journal of Biological Chemistry

2021/1/1

Paul Brear
Paul Brear

H-Index: 9

See List of Professors in Paul Brear University(University of Cambridge)