Jacqueline F Pelham

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Conformational changes in the negative arm of the circadian clock correlate with dynamic interactomes involved in post-transcriptional regulation

A fuzzy complex in the negative arm regulates circadian clock robustness.

The intrinsically disordered frequency isoforms of Neurospora crassa play a dynamic role in negative arm circadian clock regulation

LOCATE reveals electrostatic “islands” and “hotspots” are important for a disordered clock protein's interactions to regulate clock robustness

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock

Deciphering the contributions of protein disorder to the repressing complex of the circadian clock

Intrinsic disorder plays a role in conserving the circadian circuit