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Giuseppe Melacini

Giuseppe Melacini

McMaster University

H-index: 46

North America-Canada

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About Giuseppe Melacini

Giuseppe Melacini, With an exceptional h-index of 46 and a recent h-index of 26 (since 2020), a distinguished researcher at McMaster University, specializes in the field of pre-clinical drug discovery, molecular pharmacology, NMR, signaling, amyloids.

His recent articles reflect a diverse array of research interests and contributions to the field:

Inhibition of toxic metal-alpha synuclein interactions by human serum albumin

Probing ligand selectivity in pathogens

Early-Onset Parkinson Mutation Remodels Monomer–Fibril Interactions to Allosterically Amplify Synuclein’s Amyloid Cascade

Fractionation factors reveal hidden frustration in an ancient allosteric module

Toward a molecular mechanism for the interaction of ATP with alpha-synuclein

Non-canonical allostery in cyclic nucleotide dependent kinases

An auto-inhibited state of protein kinase G and implications for selective activation

Identification of core allosteric sites through temperature-and nucleus-invariant chemical shift covariance

Giuseppe Melacini Information

University

Position

Professor

Citations(all)

5495

Citations(since 2020)

1942

Cited By

4278

hIndex(all)

46

hIndex(since 2020)

26

i10Index(all)

98

i10Index(since 2020)

66

Email

University Profile Page

Google Scholar

Giuseppe Melacini Skills & Research Interests

pre-clinical drug discovery

molecular pharmacology

NMR

signaling

amyloids

Top articles of Giuseppe Melacini

Inhibition of toxic metal-alpha synuclein interactions by human serum albumin

Chemical Science

2024

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Probing ligand selectivity in pathogens

Elife

2023/12/21

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Early-Onset Parkinson Mutation Remodels Monomer–Fibril Interactions to Allosterically Amplify Synuclein’s Amyloid Cascade

JACS Au

2023/12/13

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Fractionation factors reveal hidden frustration in an ancient allosteric module

The Journal of Chemical Physics

2023/3/28

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Toward a molecular mechanism for the interaction of ATP with alpha-synuclein

Chemical Science

2023

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Non-canonical allostery in cyclic nucleotide dependent kinases

2022/9/15

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

An auto-inhibited state of protein kinase G and implications for selective activation

bioRxiv

2022/1/1

Rajesh Sharma
Rajesh Sharma

H-Index: 9

Jeong Joo Kim
Jeong Joo Kim

H-Index: 13

Liying Qin
Liying Qin

H-Index: 3

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Identification of core allosteric sites through temperature-and nucleus-invariant chemical shift covariance

Biophysical Journal

2022/6/7

Hebatallah Mohamed
Hebatallah Mohamed

H-Index: 1

Rajeevan Selvaratnam
Rajeevan Selvaratnam

H-Index: 13

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Allosteric pluripotency: challenges and opportunities

2022/4/11

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Jung Ah Byun
Jung Ah Byun

H-Index: 3

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Erythro-VLPs: Anchoring SARS-CoV-2 spike proteins in erythrocyte liposomes

Plos one

2022/3/11

Sebastian Himbert
Sebastian Himbert

H-Index: 5

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Dushyant Jahagirdar
Dushyant Jahagirdar

H-Index: 4

Joaquin Ortega
Joaquin Ortega

H-Index: 26

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Allosteric regulation of cyclic nucleotide-dependent protein kinases

2022/3/9

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Jung Ah Byun
Jung Ah Byun

H-Index: 3

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Interactions of intrinsically disordered proteins with the unconventional chaperone human serum albumin: From mechanisms of amyloid inhibition to therapeutic opportunities

2022/3/1

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Divergent allostery reveals critical differences between structurally homologous regulatory domains of Plasmodium falciparum and human protein kinase G

Journal of Biological Chemistry

2022/3/1

Jung Ah Byun
Jung Ah Byun

H-Index: 3

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes

Journal of Biological Chemistry

2022/2/1

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Romi Lifshitz
Romi Lifshitz

H-Index: 1

Karla Martinez Pomier
Karla Martinez Pomier

H-Index: 1

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

QSAR models reveal new EPAC-selective allosteric modulators

RSC Chemical Biology

2022

Hebatallah Mohamed
Hebatallah Mohamed

H-Index: 1

Jakob Magolan
Jakob Magolan

H-Index: 14

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Mutual protein-ligand conformational selection drives CGMP vs. CAMP selectivity in protein kinase G

Journal of Molecular Biology

2021/10/15

Stephen Boulton
Stephen Boulton

H-Index: 10

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα

Biomolecular NMR Assignments

2021/10

Rahul Das
Rahul Das

H-Index: 16

Jung Ah Byun
Jung Ah Byun

H-Index: 3

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery

Bioinformatics

2021/4/15

Stephen Boulton
Stephen Boulton

H-Index: 10

Cristina Olivieri
Cristina Olivieri

H-Index: 6

Hebatallah Mohamed
Hebatallah Mohamed

H-Index: 1

Gianluigi Veglia
Gianluigi Veglia

H-Index: 30

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

Woonghee Lee
Woonghee Lee

H-Index: 19

Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N–R2 Correlation Matrices

Journal of the American Chemical Society

2021/3/18

Rashik Ahmed
Rashik Ahmed

H-Index: 7

Jinfeng Huang
Jinfeng Huang

H-Index: 10

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

α-Synuclein and neuronal membranes: Conformational flexibilities in health and disease

2021/3/1

Giuseppe Melacini
Giuseppe Melacini

H-Index: 25

See List of Professors in Giuseppe Melacini University(McMaster University)