Dinesh Thummuri

Dinesh Thummuri

University of Florida

H-index: 28

North America-United States

Contact Dinesh Thummuri

About Dinesh Thummuri

Dinesh Thummuri, With an exceptional h-index of 28 and a recent h-index of 24 (since 2020), a distinguished researcher at University of Florida, specializes in the field of Drug Discovery, Targeted Protein Degradation, Cancer Biology, Toxicology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Therapeutic agents and methods of treatment

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

THERAPEUTICS AND TREATMENT METHODS

A BCL-XL PROTAC degrader DT2216 synergizes with KRASG12C inhibitors for effectively treating KRASG12C-mutated cancers

BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers

XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

Hispolon inhibits RANKL induced osteoclast differentiation in vitro

Dinesh Thummuri Information

University	University of Florida
Position	___
Citations(all)	2353
Citations(since 2020)	1977
Cited By	955
hIndex(all)	28
hIndex(since 2020)	24
i10Index(all)	36
i10Index(since 2020)	36
Email	Access Email
University Profile Page	University of Florida
Google Scholar	View Google Scholar Profile

Dinesh Thummuri Skills & Research Interests

Drug Discovery

Targeted Protein Degradation

Cancer Biology

Toxicology

Top articles of Dinesh Thummuri

Therapeutic agents and methods of treatment

2023/10/26

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Cell Death Discovery

2023/1/2

Sajid Khan

H-Index: 14

Patrick Kellish

H-Index: 5

Nick Connis

H-Index: 6

Dinesh Thummuri

H-Index: 18

Peiyi Zhang

H-Index: 5

Xuan Zhang

H-Index: 2

Vivekananda Budamagunta

H-Index: 4

Nan Hua

H-Index: 13

Yang Yang

H-Index: 9

Weizhou Zhang

H-Index: 32

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

THERAPEUTICS AND TREATMENT METHODS

2022/10/26

A BCL-XL PROTAC degrader DT2216 synergizes with KRASG12C inhibitors for effectively treating KRASG12C-mutated cancers

Cancer Research

2022/6/15

Sajid Khan

H-Index: 14

Peiyi Zhang

H-Index: 5

Dinesh Thummuri

H-Index: 18

Vivekananda Budamagunta

H-Index: 4

Nan Hua

H-Index: 13

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers

Journal of Hematology & Oncology

2022/3/9

Sajid Khan

H-Index: 14

Peiyi Zhang

H-Index: 5

Dinesh Thummuri

H-Index: 18

Vivekananda Budamagunta

H-Index: 4

Nan Hua

H-Index: 13

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

Proceedings of the National Academy of Sciences

2022/1/25

Daniel R Principe

H-Index: 16

Rui Xiong

H-Index: 7

Kiira Ratia

H-Index: 18

Fei Huang

H-Index: 2

Dinesh Thummuri

H-Index: 18

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

Molecular cancer therapeutics

2022/1/1

Dinesh Thummuri

H-Index: 18

Sajid Khan

H-Index: 14

Peiyi Zhang

H-Index: 5

Xuan Zhang

H-Index: 2

Vivekananda Budamagunta

H-Index: 4

Amin Sobh

H-Index: 3

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

Hispolon inhibits RANKL induced osteoclast differentiation in vitro

Immunology Letters

2021/3/1

Pawan Sharma

H-Index: 2

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Nature communications

2021/11/25

Dongwen Lv

H-Index: 22

Pratik Pal

H-Index: 3

Xingui Liu

H-Index: 8

Dinesh Thummuri

H-Index: 18

Peiyi Zhang

H-Index: 5

Qi Zhang

H-Index: 5

Shuo Zhou

H-Index: 9

Sajid Khan

H-Index: 14

Xuan Zhang

H-Index: 2

Nan Hua

H-Index: 13

Weizhou Zhang

H-Index: 32

Yaxia Yuan

H-Index: 16

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition

Journal of medicinal chemistry

2021/9/17

Pratik Pal

H-Index: 3

Dinesh Thummuri

H-Index: 18

Dongwen Lv

H-Index: 22

Xingui Liu

H-Index: 8

Peiyi Zhang

H-Index: 5

Nan Hua

H-Index: 13

Sajid Khan

H-Index: 14

Yaxia Yuan

H-Index: 16

Xuan Zhang

H-Index: 2

Daohong Zhou

H-Index: 37

Guangrong Zheng

H-Index: 15

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

Journal of hematology & oncology

2020/12

Vivekananda Budamagunta

H-Index: 4

Peiyi Zhang

H-Index: 5

Xuan Zhang

H-Index: 2

Sajid Khan

H-Index: 14

Dinesh Thummuri

H-Index: 18

Xin Zhang

H-Index: 11

Dongwen Lv

H-Index: 22

Wen Li

H-Index: 1

Adam C Palmer

H-Index: 16

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

A facile synthesis of ligands for the von Hippel–Lindau E3 ligase

Synthesis

2020/9

Christian Steinebach

H-Index: 6

Izidor Sosič

H-Index: 17

Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis

International Immunopharmacology

2020/8/1

Dinesh Thummuri

H-Index: 18

Mattias Magnusson

H-Index: 15

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

European journal of medicinal chemistry

2020/8/1

Xuan Zhang

H-Index: 2

Peiyi Zhang

H-Index: 5

Vivekananda Budamagunta

H-Index: 4

Dongwen Lv

H-Index: 22

Dinesh Thummuri

H-Index: 18

Yang Yang

H-Index: 9

Yaxia Yuan

H-Index: 16

Daohong Zhou

H-Index: 37

Guangrong Zheng

H-Index: 15

Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy

Cancer Research

2020

S Kumar

H-Index: 25

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature communications

2020/4/24

Xuan Zhang

H-Index: 2

Jianhui Chang

H-Index: 1

Ha-Neui Kim

H-Index: 19

Peiyi Zhang

H-Index: 5

Yingying Wang

H-Index: 5

Sajid Khan

H-Index: 14

Xingui Liu

H-Index: 8

Xin Zhang

H-Index: 11

Dongwen Lv

H-Index: 22

Lin Song

H-Index: 1

Wen Li

H-Index: 1

Dinesh Thummuri

H-Index: 18

Yaxia Yuan

H-Index: 16

Vivekananda Budamagunta

H-Index: 4

Maria Almeida

H-Index: 36

Guangrong Zheng

H-Index: 15

Daohong Zhou

H-Index: 37

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

2020/4/15

Dinesh Thummuri

H-Index: 18

Xingui Liu

H-Index: 8

Peiyi Zhang

H-Index: 5

Sajid Khan

H-Index: 14

Yaxia Yuan

H-Index: 16

Daohong Zhou

H-Index: 37

Guangrong Zheng

H-Index: 15

See List of Professors in Dinesh Thummuri University(University of Florida)

Co-Authors

H-index: 20

Sajid Khan — Sajid Khan
University of Florida

Visit Sajid Khan Page

H-index: 17

Swarna Bale — Swarna Bale
University of Michigan-Dearborn

Visit Swarna Bale Page

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