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Brenton R Paolella

Brenton R Paolella

Harvard University

H-index: 18

North America-United States

Contact Brenton R Paolella

About Brenton R Paolella

Brenton R Paolella, With an exceptional h-index of 18 and a recent h-index of 16 (since 2020), a distinguished researcher at Harvard University, specializes in the field of Cancer Biology, Genomics, Neurobiology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Therapeutic targeting of phosphate dysregulation in cancer via the xpr1: kidins220 protein complex

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

Compositions and methods for treating neoplasia

Rapid prediction of drug responsiveness

Systematic profiling of conditional degron tag technologies for target validation studies

Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers

Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery

Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

Brenton R Paolella Information

University

Position

Broad Institute of MIT and Harvard

Citations(all)

3637

Citations(since 2020)

3208

Cited By

1328

hIndex(all)

18

hIndex(since 2020)

16

i10Index(all)

21

i10Index(since 2020)

20

Email

University Profile Page

Google Scholar

Brenton R Paolella Skills & Research Interests

Cancer Biology

Genomics

Neurobiology

Top articles of Brenton R Paolella

Therapeutic targeting of phosphate dysregulation in cancer via the xpr1: kidins220 protein complex

2023/9/7

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

Genome Biology

2023/8/23

Brenton R Paolella
Brenton R Paolella

H-Index: 11

James M Mcfarland
James M Mcfarland

H-Index: 16

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Compositions and methods for treating neoplasia

2023/6/15

Rapid prediction of drug responsiveness

2022/10/27

Systematic profiling of conditional degron tag technologies for target validation studies

Nature communications

2022/9/20

Jason Kwon
Jason Kwon

H-Index: 6

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Kevin Tran
Kevin Tran

H-Index: 8

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Zuzana Tothova
Zuzana Tothova

H-Index: 18

Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers

Cancer Research

2022/6/15

Daniel Bondeson
Daniel Bondeson

H-Index: 7

Michael Rothberg
Michael Rothberg

H-Index: 24

Alfredo Gonzalez
Alfredo Gonzalez

H-Index: 0

Kentaro Ito
Kentaro Ito

H-Index: 4

Joshua Dempster
Joshua Dempster

H-Index: 10

David Root
David Root

H-Index: 12

Jesse Boehm
Jesse Boehm

H-Index: 44

James Mcfarland
James Mcfarland

H-Index: 4

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Todd Golub
Todd Golub

H-Index: 116

Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery

Cancer Research

2022/6/15

Brenton R Paolella
Brenton R Paolella

H-Index: 11

James M Mcfarland
James M Mcfarland

H-Index: 16

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

Nature cancer

2022/6

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Alfredo Gonzalez
Alfredo Gonzalez

H-Index: 0

Kentaro Ito
Kentaro Ito

H-Index: 4

Jesse Boehm
Jesse Boehm

H-Index: 44

James M Mcfarland
James M Mcfarland

H-Index: 16

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

Nature genetics

2021/12

Takahiro Ito
Takahiro Ito

H-Index: 11

Michael J Young
Michael J Young

H-Index: 30

Ruitong Li
Ruitong Li

H-Index: 1

Diego J Rodriguez
Diego J Rodriguez

H-Index: 1

Liang Chang
Liang Chang

H-Index: 2

Debjani Pal
Debjani Pal

H-Index: 9

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Gad Getz
Gad Getz

H-Index: 174

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Mahdi Zamanighomi
Mahdi Zamanighomi

H-Index: 8

Abstract PR-006: Integrative genomic characterization of therapeutic targets for pancreatic cancer

Cancer Research

2021/11/15

Peter Chen
Peter Chen

H-Index: 2

James M Mcfarland
James M Mcfarland

H-Index: 16

Gad Getz
Gad Getz

H-Index: 174

Selective modulation of a pan-essential protein as a therapeutic strategy in cancer

Cancer discovery

2021/9/1

Alfredo Gonzalez
Alfredo Gonzalez

H-Index: 0

Miljan Kuljanin
Miljan Kuljanin

H-Index: 11

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Volker Hovestadt
Volker Hovestadt

H-Index: 50

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Cell reports

2021/7/13

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Annan Yang
Annan Yang

H-Index: 12

Alfredo Gonzalez
Alfredo Gonzalez

H-Index: 0

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Cancer Research

2021/7/1

Michael Burger
Michael Burger

H-Index: 0

Jeremie Kalfon
Jeremie Kalfon

H-Index: 3

Annan Yang
Annan Yang

H-Index: 12

Wenbo Wu
Wenbo Wu

H-Index: 1

Jesse Boehm
Jesse Boehm

H-Index: 44

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Todd Golub
Todd Golub

H-Index: 116

Francisca Vazquez
Francisca Vazquez

H-Index: 38

A first-generation pediatric cancer dependency map

Nature genetics

2021/4

Thomas P Howard
Thomas P Howard

H-Index: 11

Brenton R Paolella
Brenton R Paolella

H-Index: 11

James M Mcfarland
James M Mcfarland

H-Index: 16

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

Cancer Research

2020/8/15

Tsukasa Shibue
Tsukasa Shibue

H-Index: 15

Brenton R Paolella
Brenton R Paolella

H-Index: 11

James M Mcfarland
James M Mcfarland

H-Index: 16

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Cancer Research

2020/8/15

Brenton R Paolella
Brenton R Paolella

H-Index: 11

Jeremie Kalfon
Jeremie Kalfon

H-Index: 3

Annan Yang
Annan Yang

H-Index: 12

Alfredo Gonzalez
Alfredo Gonzalez

H-Index: 0

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Cancer Research

2020/7/15

Chuan Yan
Chuan Yan

H-Index: 1

Xiang Chen
Xiang Chen

H-Index: 18

Francisca Vazquez
Francisca Vazquez

H-Index: 38

Aviad Tsherniak
Aviad Tsherniak

H-Index: 36

Single-gene short-term CRISPR ko viability assay

2020/6/17

Tsukasa Shibue
Tsukasa Shibue

H-Index: 15

Francisca Vazquez
Francisca Vazquez

H-Index: 38

In vivo Nanopool: Pooled sgRNA competition assays to evaluate in vivo cancer dependencies

2020/6/17

Daniel Bondeson
Daniel Bondeson

H-Index: 7

Francisca Vazquez
Francisca Vazquez

H-Index: 38

shRNA Selection and Quality Control for Cancer Target Gene Validation

2020/6/17

Francisca Vazquez
Francisca Vazquez

H-Index: 38

See List of Professors in Brenton R Paolella University(Harvard University)