Abdelgawad Shalkami

Abdelgawad Shalkami

Al-Azhar University

H-index: 9

Africa-Egypt

Professor Information

University

Al-Azhar University

Position

Associate Professor of pharmacology and Toxicology Faculty of Pharmacy

Citations(all)

390

Citations(since 2020)

377

Cited By

125

hIndex(all)

9

hIndex(since 2020)

9

i10Index(all)

8

i10Index(since 2020)

8

Email

University Profile Page

Al-Azhar University

Research & Interests List

Pharmacology

Top articles of Abdelgawad Shalkami

Edaravone and obeticholic acid protect against cisplatin-induced heart toxicity by suppressing oxidative stress and inflammation and modulating Nrf2, TLR4/p38MAPK, and JAK1 …

Cardiotoxicity is a significant adverse effect of cisplatin (CIS) that necessitates extensive medical care. The current study examines the cardioprotective effects of edaravone (EDV), obeticholic acid (OCA), and their combinations on CIS-induced cardiac damage. Rats were allocated into five groups: the normal control group, the remaining four groups received CIS (7.5 mg/kg, i.p.) as a single dose on the fifth day and were assigned to CIS, OCA (10 mg/kg/day) + CIS, EDV (20 mg/kg/day) + CIS, and the (EDV + OCA) + CIS group. Compared to the CIS-treated group, co-treating rats with EDV, OCA, or their combinations significantly decreased ALP, AST, LDH, CK-MB, and troponin-I serum levels and alleviated histopathological heart abnormalities. Biochemically, EDV, OCA, and EDV plus OCA administration mitigated cardiac oxidative stress as indicated by a marked decrease in heart MDA content with a rise in …

Authors

Ehab AM El-Shoura,Emad HM Hassanein,Hesham H Taha,Abdel-Gawad S Shalkami,Mohamed Mahmoud Hussein Hassanein,Fares EM Ali,Adel G Bakr

Journal

Naunyn-Schmiedeberg's Archives of Pharmacology

Published Date

2024/1/29

Alpha-Mangostin ameliorates acute kidney injury via modifying levels of circulating TNF-α and IL-6 in glycerol-induced rhabdomyolysis animal model

Alpha mangostin (AM), isolated from G. mangostana, showed beneficial effects in several disorders due to its antioxidant and anti-inflammatory properties. Acute kidney injury (AKI) due to different etiologies can develop into severe complications, resulting in high mortality rates. In this work, AM is tested for its ability to alleviate AKI in glycerol-induced AKI rat model, where 30 Male Sprague-Dawley rats were assigned to a healthy group, glycerol-treated group and AM-treated group. Glycerol-and AM groups received a single dose of glycerol (per IM, 50% glycerol in saline, 8 ml/kg), whereas control group was injected with saline. AM treatment (a single daily dose, per IP, 175mg/kg) was accomplished for three days. Animals were executed to collect blood samples and kidney tissue for biochemical and histological examination. It was found that glycerol induced increase in serum creatinine, blood urea nitrogen (BUN …

Authors

Heba M Eltahir,Hossein M Elbadawy,Ali Alalawi,Ahmed J Aldhafiri,Sabrin RM Ibrahim,Gamal A Mohamed,Abdel-Gawad S Shalkami,Mohannad A Almikhlafi,Muayad Albadrani,Yaser Alahmadi,Mekky M Abouzied,Maiiada H Nazmy

Journal

Acta Biochimica Polonica

Published Date

2023/4/17

Diallyl disulfide attenuates methotrexate-induced hepatic oxidative injury, inflammation and apoptosis and enhances its anti-tumor activity

Background Methotrexate (MTX) is used potently for a wide range of diseases. However, hepatic intoxication by MTX hinders its clinical use. Objectives The present study was conducted to investigate the diallyl disulfide (DADS) ability to ameliorate MTX-induced hepatotoxicity. Methods Thirty-two rats were randomly divided into four groups: normal control, DADS (50 mg/kg/day, orally), MTX (single i.p. injection of 20 mg/kg) and DADS+MTX. Liver function biomarkers, histopathological examinations, oxidative stress, inflammation, and apoptosis biomarkers were investigated. Besides, an in vitro cytotoxic activity study was conducted to explore the modulatory effects of DADS on MTX cytotoxic activity using Caco-2, MCF-7, and HepG2 cells. Results DADS significantly reduced the increased serum activities of ALT, AST, ALP, and LDH. These results were confirmed by the alleviation of liver histopathological changes. It …

Authors

Marwa M Khalaf,Emad HM Hassanein,Abdel-Gawad S Shalkami,Ramadan AM Hemeida,Wafaa R Mohamed

Journal

Current Molecular Pharmacology

Published Date

2022/1/1

Phytic acid potentiates oxaliplatin effects in colorectal cancer induced by 1, 2-DMH: The role of miR-224 and miR-200a

ResultsWe observed a chemoprotective role of PA. PA has a synergistic effect as an antitumour agent with oxaliplatin in CRC treatment. The miR-224, miR-200a, and-catenin expression, when treated with PA alone or with oxaliplatin, was decreased markedly in comparison with the positive control group. The histopathological investigations of colorectal tissues confirmed our molecular and biochemical findings.ConclusionsPhytic acid possessed efficient anti-carcinogenic properties alone or with oxaliplatin against 1, 2-DMH-induced CRC in rats through pathways of apoptosis, cell proliferation, and antioxidants.

Authors

Tarek M Okda,Mohamed A Katry,Noha M Ragab,Abdel-Gawad S Shalkami

Journal

Contemporary Oncology/Współczesna Onkologia

Published Date

2021/3/1

Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence

Chemotherapeutic drugs are used effectively to manage wide types of malignancies, but their therapeutic use is limited due to their associated hepatic intoxication. The current study sheds light on the effect of phytochemicals berberine (BBR) and umbelliferone (UMB) on methotrexate (MTX)–induced hepatic intoxication. Forty-eight rats were allocated to normal, BBR (50 mg/kg orally for 10 days), UMB (30 mg/kg orally for 10 days), MTX (20 mg/kg at the 5th day), BBR+MTX, and UMB+MTX. With regard to MTX, the results of this investigation reveal potent amelioration of MTX hepatotoxicity by BBR and UMB through reduction of the elevated serum levels of ALT, ALP, AST, and LDH confirmed by the attenuation of histopathological abrasion in liver tissues. BBR and UMB markedly restored antioxidant status. More importantly, BBR resulted in reducing P38 mitogen–activated protein kinase (P38MAPK), nuclear …

Authors

Abdel-Gawad S Shalkami,Emad HM Hassanein,Ahmed M Sayed,Wafaa R Mohamed,Marwa M Khalaf,Ramadan AM Hemeida

Journal

Environmental Science and Pollution Research

Published Date

2021/12

Synergistic degradation of phenanthrene by constructed Pseudomonas spp. consortium compared with pure strains

Polycyclic aromatic hydrocarbons (PAHs) are highly persistent compounds as well as they have a toxic impact to all living organisms. Removal of these xenobiotic compounds by mixed bacteria is achieving a maximum degradation rate over the pure strains. So, this study substantiates the application of constructed bacterial consortium for degradation of 400 mg/L phenanthrene within 30 days of incubation at 30 °C. The consortium consisted of two bacterial species Pseudomonas pseudoalcaligenes (B1) and Pseudomonas aeruginosa (B2). It exhibited a significantly higher phenanthrene degradation efficiency (97.5%) compared to pure strains B1 and B2 (52.5 and 47.6%), respectively. The phenanthrene degradation rate by the individual strains was enhanced in the presence of salicylic and phthalic acids as intermediates pathway. On the other side, the degradation rate was reduced in the presence of catechol …

Authors

Asmaa Mawad,Hiba Albasri,Abdel-Gawad Shalkami,Saad Alamri,Mohamed Hashem

Journal

Environmental Technology & Innovation

Published Date

2021/11/1

Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

Cyclophosphamide (CP) is a medication used as an anticancer drug and to suppress the immune system. However, its clinical applications are restricted because of the toxic and adverse side effects. The present study investigated the protective effect of acetovanillone (AV), a natural NADPH oxidase inhibitor, against acute lung injury (ALI) induced by CP. Rats were administered AV (100 mg/kg) for 10 days and a single injection of CP (200 mg/kg) at day 7. At the end of the experiment, the animals were sacrificed, and lung samples were collected for analyses. CP caused ALI manifested by the histopathological alterations. Lipid peroxidation and NADPH oxidase activity were increased, whereas GSH and antioxidant enzymes were decreased in the lung of CP‐intoxicated rats. Oral administration of AV prevented CP‐induced lung injury and oxidative stress and enhanced antioxidant defenses. AV downregulated …

Authors

Omnia AM Abd El‐Ghafar,Emad HM Hassanein,Ahmed M Sayed,Eman K Rashwan,Abdel‐Gawad S Shalkami,Ayman M Mahmoud

Journal

Phytotherapy Research

Published Date

2021/8

Role of TLR-4/IL-6/TNF-α, COX-II and eNOS/iNOS pathways in the impact of carvedilol against hepatic ischemia reperfusion injury

AimHepatic ischemia/reperfusion (I/R) injury is a syndrome involved in allograft dysfunction. This work aimed to elucidate carvedilol (CAR) role in hepatic I/R injury.MethodsMale rats were allocated to Sham group, CAR group, I/R group and CAR plus I/R group. Rats subjected to hepatic ischemia for 30 minutes then reperfused for 60 minutes. Oxidative stress markers, inflammatory cytokines and nitric oxide synthases were measured in hepatic tissues.ResultsHepatocyte injury following I/R was confirmed by a marked increase in liver enzymes. Also, hepatic I/R increased the contents of malondialdehyde however decreased glutathione contents and activities of antioxidant enzymes. Furthermore, hepatic I/R caused elevation of toll-like receptor-4 (TLR-4) expression and inflammatory mediators levels such as tumor necrosis factor-α, interleukin-6 and cyclooxygenase-II. Hepatic I/R caused down-regulation of …

Authors

Mohamed IA Hassan,Fares EM Ali,Abdel-Gawad S Shalkami

Journal

Human & Experimental Toxicology

Published Date

2021/8

Professor FAQs

What is Abdelgawad Shalkami's h-index at Al-Azhar University?

The h-index of Abdelgawad Shalkami has been 9 since 2020 and 9 in total.

What are Abdelgawad Shalkami's research interests?

The research interests of Abdelgawad Shalkami are: Pharmacology

What is Abdelgawad Shalkami's total number of citations?

Abdelgawad Shalkami has 390 citations in total.

academic-engine

Useful Links