Abdelaziz E abdelaziz

Abdelaziz E abdelaziz

Kafrelsheikh University

H-index: 8

Africa-Egypt

Abdelaziz E abdelaziz Information

University

Kafrelsheikh University

Position

Professor of Pharmaceutical technology _faculty of pharmacy_

Citations(all)

317

Citations(since 2020)

277

Cited By

195

hIndex(all)

8

hIndex(since 2020)

8

i10Index(all)

8

i10Index(since 2020)

8

Email

University Profile Page

Kafrelsheikh University

Abdelaziz E abdelaziz Skills & Research Interests

nanopharmaceutical preparation

Top articles of Abdelaziz E abdelaziz

Preparation and in-vitro evaluation of dyphylline controlled release matrix tablets

The aim of this study was to create controlled release matrix tablets of Dyphylline, a xanthine derivative used for the management of various respiratory conditions such as asthma, cardiac dyspnea, chronic bronchitis, and emphysema. The researchers employed a direct compression method and various polymers to achieve this. The resulting matrix tablets were evaluated through infrared spectral analysis, differential thermal analysis, and evaluations of hardness, friability, content uniformity, and in-vitro drug release. The release profiles were also analyzed through different kinetic orders. The results showed that all Dyphylline formulae followed Higuchi's diffusion model, indicating that diffusion is the mechanism of drug release from the controlled matrix tablets. The infrared and differential thermal analyses demonstrated that there was no incompatibility between Dyphylline, and the polymers used in the formulations …

Authors

Heba A Yassin,Mohamed A Sharaf,Hanna A El-Ghamry,Abdelaziz E Abdelaziz

Journal

Research Journal of Pharmacy and Technology

Published Date

2023

Significance Advantages, and Disadvantages of Nanotechnology in Textile Finishing

Nanotechnology has emerged as one of the most significant fields of study in recent years. Due to its special synthesis methods and advantageous properties, nanotechnology is quickly taking over the textile sector. Various finishing, coating, and manufacturing procedures are utilized to create fibers or fabrics with nano-sized particles in the production of high-performance textiles. Nanomaterials have been used to provide antibacterial, UV-resistant, electric conductivity, photocatalytic and self-cleaning qualities to fabrics and clothing in a sustainable way. nanofibers, silver, gold, and zinc nanoparticles, as well as stretchable textiles and wearable solar textiles, triboelectric nanogenerators, and one-piece self-power/self-charging power textiles have all been used in smart wearable textiles.

Authors

Heba Ghazal,Nadeen Khaleed,Eman Abdelaziz

Journal

Egyptian Journal of Chemistry

Published Date

2023/12/1

Formulation and optimization of folate-bovine serum albumin-coated ethoniosomes of pterostilbene as a targeted drug delivery system for lung cancer: In vitro and in vivo …

This study aimed to overcome the poor solubility of pterostilbene (PTS) by developing promising reconstituted proethoniosomes (PENs). The reconstituted PENs loaded with PTS were fabricated according to a 23 factorial design by Design-Expert® software. The prepared ethoniosomes were assessed for entrapment efficiency (EE %) and % PTS released after 24 h (Q24h). According to the desirability criteria, the ethoniosomal formula (F4) was chosen as the optimized formulation with EE% of 93.19 ± 0.66 and Q24h of 75.10 ± 1.90%. The optimum ethoniosomal formulation was further coated with folic acid (FA) using bovine serum albumin (BSA) as a carrier and stabilizing agent and further evaluated for transmission electron microscopy (TEM), particle size, zeta potential, elasticity, Fourier transform infrared spectroscopy (FTIR), and stability. The targeted ethoniosomal formula appeared as spherical …

Authors

Nemany AN Hanafy,Reham H Abdelbadea,Abdelaziz E Abdelaziz,Eman A Mazyed

Journal

Cancer Nanotechnology

Published Date

2023/12

Co-processing of fluconazole with menthol for enhanced dissolution and anti-fungal activity: Preparation of orodispersable tablets

The objective was to enhance the dissolution rate and anti-fungal activity of fluconazole. Mixtures of fluconazole with menthol were subjected to ethanol aided kneading. The developed solids were characterized using Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction in addition to monitoring fluconazole dissolution. These investigations reflected formation of eutectic mixture. Eutexia was associated with enhancement in fluconazole dissolution. Formulation containing fluconazole with menthol at 1:1 M ratio was prepared as oral dispersible tablet which exhibited flash disintegration with subsequent fast dissolution of fluconazole. Mice oral candida model was used to assess the prophylactic and therapeutic effects of the developed menthol-containing tablet. Candida infection was achieved by swabbing the tongue and oral cavity of immunocompromised mouse using small …

Authors

Asmaa M El Shiekh Ali,Gamal M El Maghraby,Abdelaziz E Abdelaziz,Ahmed M Soliman,Eman M Saied,Eman A Mazyed

Journal

Journal of Drug Delivery Science and Technology

Published Date

2023/10/1

Scaling up and evaluation of Dyphylline controlled release matrix tablets

The aim of the current study was to scale up controlled release matrix tablets of Dyphylline, used for the management of various respiratory conditions such as asthma, cardiac dyspnea, chronic bronchitis, and emphysema. The tablets were scaled up to 3500 tablets scale then the optimized formulations were further scaled up to 35000 tablets. Tablets were manufactured using direct compression, wet granulation, and hot melt methods. The prepared tablets were evaluated for Hardness, Friability, content uniformity, in-vitro drug release, and stability study. The results obtained showed that the ten prepared tablets showed accepted values for the hardness, friability, and content uniformity tests. The formulations showed controlled drug release profiles with high similarity to our target release profile (f values ranged from 63.9 to 84.9). The release profiles showed a better fit to zero order than diffusion model. The …

Authors

Heba A Yassin,Mohamed A Sharaf,Hanna A El-Ghamry,Abdelaziz E Abdelaziz

Journal

Research Journal of Pharmacy and Technology

Published Date

2023

Post treatment of wastewater using recovered alum from water treatment sludge

Water resources limitation exhibited the emergency to explore a novel approach to reuse secondary wastewater effluent as a sustainable alternative water source. In this study, the feasibility of using the recovered alum from water treatment sludge as a coagulant for post treatment of wastewater was investigated then, its efficiency was compared with fresh one. Jar test was used to determine the optimum conditions for alum recovery and the ideal alum dose for post treatment of wastewater. Afterwards, post treatment of wastewater was conducted using clari-flocculation model. Results revealed that the optimum operating conditions for alum recovery were 60 min. and 2.0 for mixing time and pH, respectively. In addition, the optimum doses of recovered and fresh alum for post treatment process were even (10 mg Al/L). The results obtained from the fabricated model showed that removal efficiencies of BOD 5, COD, TSS, PO 4 and NO 3 using the recovered alum were 51.9, 39.8, 55.7, 33.8 and 19.7%, respectively, versus 54.4, 43.7, 58.9, 61.2 and 14.2%, respectively, harvested by using fresh alum. Consequently, recovered alum revealed lower efficiencies in removal of BOD 5, COD, TSS and PO 4. Conversely, recovered alum surpassed fresh one in NO 3 removal efficiency. Hence, post treated wastewater by recovered alum has the ability for reuse in irrigation process according to Egyptian standards.

Authors

Hassan Ramadan

Journal

Algae

Published Date

2022/7

Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein

Background Coadministration of statins and direct acting antiviral agents is frequently used. This study explored the effects of both atorvastatin and lovastatin on pharmacokinetics of a fixed-dose combination of sofosbuvir/ledipasvir “FDCSL”. Methods 12 healthy volunteers participated in a randomized, three-phase crossover trial and were administered a single atorvastatin dose 80 mg plus tablet containing 400/90 mg FDCSL, a single lovastatin dose 40 mg plus tablet containing 400/90 mg FDCSL, or tablets containing 400/90 mg FDCSL alone. Liquid chromatography-tandem mass spectrometry was used to analyze plasma samples of sofosbuvir, ledipasvir and sofosbuvir metabolite “GS-331007” and their pharmacokinetic parameters were determined. Results Atorvastatin caused a significant …

Authors

KS Abdelkawy,Fathalla Belal,AbdelazizE Abdelaziz,HA Elmekawy,MY Abdelgaied,NM El-Khodary

Journal

Drug Research

Published Date

2022/7

Ethanol-assisted kneading of apigenin with arginine for enhanced dissolution rate of apigenin: development of rapidly disintegrating tablets

Apigenin is a natural flavonoid which is claimed to have many pharmacological activities ranging from simple anti-inflammatory to anticancer action. However, poor dissolution slowed the advancement of this drug through the development pipelines. The objective of this work was to probe ethanol-aided kneading of apigenin with arginine as a new strategy for enhanced dissolution rate. The work was extended to develop rapidly disintegrating tablets of apigenin. Apigenin was mixed with increasing molar ratios of arginine before ethanol-aided kneading. The resulting products were examined using Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction in addition to probing the dissolution characteristics of apigenin. The analytical techniques highlighted the existence of new crystalline species with a possibility of salt formation. The recorded alterations in the crystalline …

Authors

Fatma A Kassem,Abdelaziz E Abdelaziz,Gamal M El Maghraby

Journal

Pharmaceutical Development and Technology

Published Date

2021/7/3

Effect of Different Types of Polymers as Well as Different Preparation Techniques on the In-Vitro Release of Dyphylline Controlled Release Matrix Tablets

Dyphylline, xanthine derivatives, is used to manage asthma, cardiac dyspnea, chronic bronchitis, and emphysema. This work aimed to develop controlled release matrix tablets of Dyphylline using different types of polymers, and different preparation techniques such as direct compression, wet granulation, and hot melt methods. The prepared matrix tablets were evaluated by Infrared spectral analysis, differential thermal analysis, evaluation which included hardness, friability, content uniformity, and the in-vitro drug release. Kinetic analysis of the release profiles was investigated using different kinetic orders. All Dyphylline formulae obey Higuchi’s diffusion model. The diffusion is the mechanism of Dyphylline release from its controlled matrix tablets. IR and DSC revealed no incompatibility between Dyphylline and the polymers used in the prepared formulae. The obtained results revealed that the wet granulation technique using water as the granulating liquid is the best method for the formulation of Dyphylline hydrophilic matrix tablets compared with the other techniques. The high content of polymers led to the high value of T 1/2, and a decrease in Dyphylline's extent due to the improvement of the retention of drug release. A synergistic effect was obtained using PVP-K-25 in the hydrophilic matrix tablets, which led to the retention of the drug release.

Authors

Heba A Yassin,Mohamed A Sharaf,Hanna A El-Ghamry,Abdelaziz E Abdelaziz

Journal

Pharmaceutics

Published Date

2021

A randomized controlled trial comparing the effects of Vitamin E, Ursodeoxycholic acid and Pentoxifylline on Egyptian non-alcoholic steatohepatitis patients.

Background: Infants undergo various painful procedure such as vitamin K injection. Oral sucrose has been a standardized analgesia used during these procedures.Objective: To investigate the analgesic and anti-nociceptive properties of honey by using a locally derived Tualang honey. Methods: 78 newborns were randomized into 2 groups (using randomization software) for either 2 ml of Tualang honey or 2 ml of 24% sucrose. Enrolled neonates underwent venipuncture by an experienced medical doctors. Recording on the procedure started 30 seconds prior to venipuncture until 3 minutes after completion of venipuncture. Two observers assessed the pain scores of these neonates using Premature Infant Pain Profile (PIPP). Basic characteristics, PIPP score and sugar post procedure were also documented.Results: The cumulative PIPP score was analyzed by combining score at 30 seconds and 2 minutes 30 seconds giving a maxi-mum score of 42. 36 out of the 74 infants did not cry during and after venipuncture. The median duration of total audible cry after venipuncture was 4 seconds for sucrose group and 5.5 seconds for honey treated group. Only 1 infant from the sucrose treatment group developed hypoglycemia post treatmentConclusion: Tualang honey was as effective as 24% sucrose in reducing pain score during the venipuncture in neonates.

Authors

Khanisa Md Khalid,Noraida Ramli,Ariffin Nasir,Hans Van Rostenberghe,Fahisham Taib,Nor Rosidah Ibrahim

Journal

International Medical Journal

Published Date

2019/12/1

Pharmacokinetic interaction between atorvastatin and fixed-dose combination of sofosbuvir/ledipasvir in healthy male Egyptian volunteers

Purpose Comorbid conditions of heart and liver disorders added to HCV-induced hepatic steatosis make co-administration of statins, and direct-acting antivirals is common in clinical practice. This study aimed to evaluate the pharmacokinetic interaction of atorvastatin and fixed-dose combination of sofosbuvir/ledipasvir “FDCSL” with rationalization to the underlying mechanism. Methods A randomized, three-phase crossover study that involves 12 healthy volunteers was performed. Participants received a single-dose of atorvastatin 80 mg alone, atorvastatin 80-mg plus tablets containing 400/90 mg FDCSL, or tablets containing 400/90 mg FDCSL alone. Plasma samples were analyzed using liquid chromatography–tandem mass spectrometry (LC–MS/MS) for atorvastatin, sofosbuvir, ledipasvir, and sofosbuvir metabolite “GS-331007,” and their …

Authors

HA Elmekawy,F Belal,AE Abdelaziz,KS Abdelkawy,AA Ali,F Elbarbry

Journal

European Journal of Clinical Pharmacology

Published Date

2021/9

Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats

Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral tablets due to very poor absorption through the skin. The current study intended to formulate and characterize a hydrogel loaded with nanostructured lipid carriers (NLCs) to enhance the transdermal delivery of TNX. Six formulations of TNX were formulated by slight modifications of high shear homogenization and ultrasonication method. The selected formula was characterized for their particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE), in-vitro drug release and ex-vivo skin permeation studies. Moreover, the effectiveness of the developed formula was studied in-vivo …

Authors

Saud Bawazeer,Dalia Farag A El-Telbany,Majid Mohammad Al-Sawahli,Gamal Zayed,Ahmed Abdallah A Keed,Abdelaziz E Abdelaziz,Doaa H Abdel-Naby

Journal

Drug Delivery

Published Date

2020/1/1

Development of provesicular nanodelivery system of curcumin as a safe and effective antiviral agent: statistical optimization, in vitro characterization, and antiviral …

Curcumin is a natural compound that has many medical applications. However, its low solubility and poor stability could impede its clinical applications. The present study aimed to formulate dry proniosomes to overcome these pitfalls and improve the therapeutic efficacy of Curcumin. Curcumin-loaded proniosomes were fabricated by the slurry method according to 32 factorial design using Design-Expert software to demonstrate the impact of different independent variables on entrapment efficiency (EE%) and % drug released after 12 h (Q12h). The optimized formula (F5) was selected according to the desirability criteria. F5 exhibited good flowability and appeared, after reconstitution, as spherical nanovesicles with EE% of 89.94 ± 2.31% and Q12h of 70.89 ± 1.62%. F5 demonstrated higher stability and a significant enhancement of Q12h than the corresponding niosomes. The docking study investigated the ability of Curcumin to bind effectively with the active site of DNA polymerase of Herpes simplex virus (HSV). The antiviral activity and the safety of F5 were significantly higher than Curcumin. F5 improved the safety of Acyclovir (ACV) and reduced its effective dose that produced a 100% reduction of viral plaques. Proniosomes could be promising stable carriers of Curcumin to be used as a safe and efficient antiviral agent.

Authors

Farid A Badria,Abdelaziz E Abdelaziz,Amira H Hassan,Abdullah A Elgazar,Eman A Mazyed

Journal

Molecules

Published Date

2020/12/1

Enhancing the oral bioavailability of candesartan cilexetil loaded nanostructured lipid carriers: In vitro characterization and absorption in rats after oral administration

Candesartan Cilexetil (CC) is a prodrug widely used in the treatment of hypertension and heart failure, but it has some limitations, such as very poor aqueous solubility, high affinity to P-glycoprotein efflux mechanism, and hepatic first-pass metabolism. Therefore, it has very low oral bioavailability. In this study, glyceryl monostearate (GMS) and Capryol™ 90 were selected as solid and liquid lipids, respectively, to develop CC-NLC (nanostructured lipid carrier). CC was successfully encapsulated into NLP (CC-NLC) to enhance its oral bioavailability. CC-NLC was formulated using a hot homogenization-ultrasonication technique, and the physicochemical properties were characterized. The developed CC-NLC formulation was showed in nanometric size (121.6 ± 6.2 nm) with high encapsulation efficiency (96.23 ± 3.14%). Furthermore, it appeared almost spherical in morphology under a transmission electron microscope. The surgical experiment of the designed CC-NLC for absorption from the gastrointestinal tract revealed that CC-NLC absorption in the stomach was only 15.26% of that in the intestine. Otherwise, cellular uptake study exhibit that CC-NLCs should be internalized through the enterocytes after that transported through the systemic circulation. The pharmacokinetic results indicated that the oral bioavailability of CC was remarkably improved above 2-fold after encapsulation into nanostructured lipid carriers. These results ensured that nanostructured lipid carriers have a highly beneficial effect on improving the oral bioavailability of poorly water-soluble drugs, such as CC.

Authors

Walid Anwar,Hamdy M Dawaba,Mohsen I Afouna,Ahmed M Samy,Mohammed H Rashed,Abdelaziz E Abdelaziz

Journal

Pharmaceutics

Published Date

2020/10/31

Fabrication of transgelosomes for enhancing the ocular delivery of acetazolamide: Statistical optimization, in vitro characterization, and in vivo study

Acetazolamide (ACZ) is a potent carbonic anhydrase inhibitor that is used for the treatment of glaucoma. Its oral administration causes various undesirable side effects. This study aimed to formulate transgelosomes (TGS) for enhancing the ocular delivery of ACZ. ACZ-loaded transfersomes were formulated by the ethanol injection method, using phosphatidylcholine (PC) and different edge activators, including Tween 80, Span 60, and Cremophor RH 40. The effects of the ratio of lipid to surfactant and type of surfactant on % drug released after 8 h (Q8h) and entrapment efficiency (EE%) were investigated by using Design-Expert software. The optimized formula was formulated as TGS, using poloxamers as gelling agents. In vitro and in vivo characterization of ACZ-loaded TGS was performed. According to optimization study, F8 had the highest desirability value and was chosen as the optimized formula for preparing TGS. F8 appeared as spherical elastic nanovesicles with Q8h of 93.01 ± 3.76% and EE% of 84.44 ± 2.82. Compared to a free drug, TGS exhibited more prolonged drug release of 71.28 ± 0.46% after 8 h, higher ex vivo permeation of 66.82 ± 1.11% after 8 h and a significant lowering of intraocular pressure (IOP) for 24 h. Therefore, TGS provided a promising technique for improving the corneal delivery of ACZ.

Authors

Eman A Mazyed,Abdelaziz E Abdelaziz

Journal

Pharmaceutics

Published Date

2020/5/20

Abdelaziz E abdelaziz FAQs

What is Abdelaziz E abdelaziz's h-index at Kafrelsheikh University?

The h-index of Abdelaziz E abdelaziz has been 8 since 2020 and 8 in total.

What are Abdelaziz E abdelaziz's top articles?

The articles with the titles of

Preparation and in-vitro evaluation of dyphylline controlled release matrix tablets

Significance Advantages, and Disadvantages of Nanotechnology in Textile Finishing

Formulation and optimization of folate-bovine serum albumin-coated ethoniosomes of pterostilbene as a targeted drug delivery system for lung cancer: In vitro and in vivo …

Co-processing of fluconazole with menthol for enhanced dissolution and anti-fungal activity: Preparation of orodispersable tablets

Scaling up and evaluation of Dyphylline controlled release matrix tablets

Post treatment of wastewater using recovered alum from water treatment sludge

Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein

Ethanol-assisted kneading of apigenin with arginine for enhanced dissolution rate of apigenin: development of rapidly disintegrating tablets

...

are the top articles of Abdelaziz E abdelaziz at Kafrelsheikh University.

What are Abdelaziz E abdelaziz's research interests?

The research interests of Abdelaziz E abdelaziz are: nanopharmaceutical preparation

What is Abdelaziz E abdelaziz's total number of citations?

Abdelaziz E abdelaziz has 317 citations in total.

What are the co-authors of Abdelaziz E abdelaziz?

The co-authors of Abdelaziz E abdelaziz are Gamal El Maghraby, Khalid M. El-Say, Mohamed Nasr, k abdelkawy.

    Co-Authors

    H-index: 32
    Gamal El Maghraby

    Gamal El Maghraby

    Tanta University

    H-index: 26
    Khalid M. El-Say

    Khalid M. El-Say

    King AbdulAziz University

    H-index: 18
    Mohamed Nasr

    Mohamed Nasr

    Helwan University

    H-index: 9
    k  abdelkawy

    k abdelkawy

    Kafrelsheikh University

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