Abby Wilson

Abby Wilson

Loughborough University

H-index: 4

Europe-United Kingdom

About Abby Wilson

Abby Wilson, With an exceptional h-index of 4 and a recent h-index of 4 (since 2020), a distinguished researcher at Loughborough University, specializes in the field of Optical Devices, Medical Applications of Engineering, Biomedical optics, Corneal Biomechanics, Cancer.

His recent articles reflect a diverse array of research interests and contributions to the field:

A comparison of biomechanical changes after PRK, LASIK and SMILE

Biomechanical evaluation of decellularized and crosslinked corneal implants manufactured from porcine corneas as a treatment option for advanced keratoconus

The Potential Roles of Genetic Testing and Biomechanical Evaluation in Keratoconus

A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery

An interferometric ex vivo study of corneal biomechanics under physiologically representative loading, highlighting the role of the limbus in pressure compensation

Robustness to misalignment of low-cost, compact quantitative phase imaging architectures

Development of a compact multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissue (Conference Presentation)

Research data supporting'Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures'

Abby Wilson Information

University

Loughborough University

Position

Research Fellow

Citations(all)

68

Citations(since 2020)

63

Cited By

16

hIndex(all)

4

hIndex(since 2020)

4

i10Index(all)

3

i10Index(since 2020)

2

Email

University Profile Page

Loughborough University

Abby Wilson Skills & Research Interests

Optical Devices

Medical Applications of Engineering

Biomedical optics

Corneal Biomechanics

Cancer

Top articles of Abby Wilson

A comparison of biomechanical changes after PRK, LASIK and SMILE

Authors

Abby Wilson,Timothy J Archer,Dan Z Reinstein,John Marshall

Journal

Investigative Ophthalmology & Visual Science

Published Date

2023/6/1

Purpose: Several refractive surgery procedures, including, PRK, LASIK, and SMILE are now undertaken. Controversy exists regarding their biomechanical implications. PRK and SMILE, due to being flapless procedures, are hypothesized to better maintain the mechanical integrity of the cornea relative to LASIK. We performed an ex vivo interferometric study, to quantify the overall and spatial implications of PRK, LASIK and SMILE on corneal biomechanics.Methods: Interferometric imaging was conducted on 32 porcine corneal-scleral specimens (dissected from enucleated eyes< 48hrs post-mortem), before and immediately following refractive surgery. Each cornea was mounted into an artificial anterior chamber filled with phosphate-buffered saline solution to exert a pressure on the posterior corneal surface to simulate normal IOP. Baseline pressure was set to 17mmHg. A speckle interferometric device was used to …

Biomechanical evaluation of decellularized and crosslinked corneal implants manufactured from porcine corneas as a treatment option for advanced keratoconus

Authors

Abby Wilson,John Jones,John Marshall

Journal

Frontiers in bioengineering and biotechnology

Published Date

2022/4/14

Currently corneal transplantation is the main treatment for late-stage keratoconus; however, transplantation procedures are accompanied by significant risk of post-surgical complications; this in addition to supply limitations imposed by a worldwide shortage of human donor corneas, has driven the development of alternative therapies. One such therapy is the use of corneal implants derived from porcine corneas (Xenia®, Gebauer Medizintechnik GmbH, Neuhausen, DE). In contrast to human donor tissue, these implants can be produced on demand and due to the processes used pose no risks for host-immune rejection. Their use has already been demonstrated clinically in patients for preventing the progression of topographic changes in keratoconus whilst improving visual acuity. The implants are derived from natural tissue and not standardised synthetic material, whilst this likely reduces the risk of issues with bio-incompatibility, there is inevitably variability in their intrinsic mechanical properties which requires investigation. Here, speckle interferometry is employed to examine the biomechanical properties, in response to physiologically representative forces, of native porcine corneal tissue prior to processing and after a proprietary 4-stage process involving decellularization, washing, compression and crosslinking. The control lenticules had an average Young’s modulus (E) of 11.11 MPa (range 8.39 – 13.41 MPa), following processing average E of the lenticules increased by 127 % over that of the unprocessed tissue to 25.23 MPa (range 18.32 – 32.9 MPa). The variability in E of the lenticules increased significantly after processing suggesting …

The Potential Roles of Genetic Testing and Biomechanical Evaluation in Keratoconus

Authors

Abby Wilson,Larry DeDionisio,John Marshall,Tara Moore

Published Date

2022

Huge advances have been made in determining risk factors associated with genes potentially involved in causing Keratoconus and diagnosis of genetic defects via the introduction of simple techniques. Complimentary advances have also been made in non-invasive measuring techniques allowing assessment of the biomechanical properties of suspect eyes. The present chapter reviews the genetic advances in understanding and diagnosing risk factors and methods to determine changes in biomechanical properties in Keratoconus.

A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery

Authors

Abby Wilson,John Marshall

Published Date

2020/12/1

Detailed clinical assessment of corneal biomechanics has the potential to revolutionize the ophthalmic industry through enabling quicker and more proficient diagnosis of corneal disease, safer and more effective surgical treatments, and the provision of customized and optimized care. Despite these wide-ranging benefits, and an outstanding clinical need, the provision of technology capable of the assessment of corneal biomechanics in the clinic is still in its infancy. While laboratory-based technologies have progressed significantly over the past decade, there remain significant gaps in our knowledge regarding corneal biomechanics and how they relate to shape and function, and how they change in disease and after surgical intervention. Here, we discuss the importance, relevance, and challenges associated with the assessment of corneal biomechanics and review the techniques currently available and …

An interferometric ex vivo study of corneal biomechanics under physiologically representative loading, highlighting the role of the limbus in pressure compensation

Authors

Abby Wilson,John Jones,John R Tyrer,John Marshall

Journal

Eye and Vision

Published Date

2020/12

Background The mechanical properties of the cornea are complex and regionally variable. This paper uses an original method to investigate the biomechanics of the cornea in response to hydrostatic loading over the typical physiological range of intra-ocular pressure (IOP) fluctuations thereby increasing understanding of clinically relevant corneal biomechanical properties and their contributions to the refractive properties of the cornea. Methods Displacement speckle pattern interferometry (DSPI) was used to measure the total surface displacement of 40 porcine and 6 human corneal-scleral specimens in response to pressure variations up to 1 mmHg from a baseline of 16.5 mmHg. All specimens were mounted in a modified artificial anterior chamber (AAC) and loaded hydrostatically. Areas of high strain in response to loading were identified by comparing the displacements across different regions. Results …

Robustness to misalignment of low-cost, compact quantitative phase imaging architectures

Authors

Catherine RM Fitzpatrick,Abby Wilson,Travis W Sawyer,Peter J Christopher,Timothy D Wilkinson,Sarah E Bohndiek,George SD Gordon

Journal

OSA continuum

Published Date

2020/10/15

Non-interferometric approaches to quantitative phase imaging could enable its application in low-cost, miniaturised settings such as capsule endoscopy. We present two possible architectures and both analyse and mitigate the effect of sensor misalignment on phase imaging performance. This is a crucial step towards determining the feasibility of implementing phase imaging in a capsule device. First, we investigate a design based on a folded 4f correlator, both in simulation and experimentally. We demonstrate a novel technique for identifying and compensating for axial misalignment and explore the limits of the approach. Next, we explore the implications of axial and transverse misalignment, and of manufacturing variations on the performance of a phase plate-based architecture, identifying a clear trade-off between phase plate resolution and algorithm convergence time. We conclude that while the phase plate …

Development of a compact multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissue (Conference Presentation)

Authors

Jonghee Yoon,Abby Wilson,Dale J Waterhouse,Travis W Sawyer,Massimiliano di Pietro,Rebecca C Fitzgerald,Sarah E Bohndiek

Published Date

2020/3/9

Advanced optical endoscopic imaging techniques, including hyperspectral and holographic endoscopy, have shown promise in the improved diagnosis of the early stage of cancer. However, clinical applications of these imaging systems are still limited due to unclear diagnostic optical properties. Here, we developed a compact multimodal imaging system that enables hyperspectral imaging, spatial-frequency domain imaging, and 3D profilometric imaging to characterise the optimal optical features for the early detection of lesions. Optical properties of fresh specimens obtained from patients were measured within 30 minutes, and then histopathological assessment of specimens was performed to link extracted optical features to gold-standard diagnosis. With further sample collection and system refinements, this system can be used for high-throughput optical characterisation of fresh tissue specimens, allowing us to …

Research data supporting'Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures'

Authors

Catherine Fitzpatrick,George Gordon,Abby Wilson,Travis Sawyer,Peter Christopher,Sarah Bohndiek,Timothy Wilkinson

Published Date

2020

Research data supporting 'Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures' University of Nottingham logo, linking to repository homepage Toggle navigation View Item Nottingham Research Data Management Repository University of Nottingham Research Data Management Service Research Data Catalogue View Item Nottingham Research Data Management Repository University of Nottingham Research Data Management Service Research Data Catalogue View Item × Please be aware that login to this service now goes via service.seamlessaccess.org, instead of the UK Federation. This means the initial stage of login will look different to how it previously did. Users should select their campus (UK, Malaysia or China) by searching for Nottingham. Once the correct campus has been found, selected and clicked on, login should follow the familiar process/…

See List of Professors in Abby Wilson University(Loughborough University)

Abby Wilson FAQs

What is Abby Wilson's h-index at Loughborough University?

The h-index of Abby Wilson has been 4 since 2020 and 4 in total.

What are Abby Wilson's top articles?

The articles with the titles of

A comparison of biomechanical changes after PRK, LASIK and SMILE

Biomechanical evaluation of decellularized and crosslinked corneal implants manufactured from porcine corneas as a treatment option for advanced keratoconus

The Potential Roles of Genetic Testing and Biomechanical Evaluation in Keratoconus

A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery

An interferometric ex vivo study of corneal biomechanics under physiologically representative loading, highlighting the role of the limbus in pressure compensation

Robustness to misalignment of low-cost, compact quantitative phase imaging architectures

Development of a compact multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissue (Conference Presentation)

Research data supporting'Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures'

are the top articles of Abby Wilson at Loughborough University.

What are Abby Wilson's research interests?

The research interests of Abby Wilson are: Optical Devices, Medical Applications of Engineering, Biomedical optics, Corneal Biomechanics, Cancer

What is Abby Wilson's total number of citations?

Abby Wilson has 68 citations in total.

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