Abbas Mohammadipour

About Abbas Mohammadipour

Abbas Mohammadipour, With an exceptional h-index of 15 and a recent h-index of 15 (since 2020), a distinguished researcher at Mashhad University of Medical Sciences, specializes in the field of toxiciology, neuroscience, neurodegenerative diseases.

His recent articles reflect a diverse array of research interests and contributions to the field:

Protective effects of crocin in cardiovascular diseases and stroke

The benefits of grape seed extract in neurological disorders and brain aging

Therapeutic Potentials of MicroRNA-126 in Cerebral Ischemia

Roles of the miR-155 in neuroinflammation and neurological disorders: a potent biological and therapeutic target

Hippocampal toxicity of metal base nanoparticles. Is there a relationship between nanoparticles and psychiatric disorders?

Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice

Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

Atrazine neural and reproductive toxicity

Abbas Mohammadipour Information

University

Mashhad University of Medical Sciences

Position

1Department of Anatomy and Cell Biology School of Medicine Iran

Citations(all)

738

Citations(since 2020)

616

Cited By

316

hIndex(all)

15

hIndex(since 2020)

15

i10Index(all)

19

i10Index(since 2020)

19

Email

University Profile Page

Mashhad University of Medical Sciences

Abbas Mohammadipour Skills & Research Interests

toxiciology

neuroscience

neurodegenerative diseases

Top articles of Abbas Mohammadipour

Protective effects of crocin in cardiovascular diseases and stroke

Authors

Esmaeil Ranjbar,Seyed HamidReza Rastegar-moghaddam,Abbas Mohammadipour

Published Date

2023/8/23

Background and aim Cardiovascular diseases and stroke are among the most common and fatal diseases in the world. These diseases are main cause of death and disability in Iran. Materials and methods This review article was conducted based on searching the related articles in international databases such as Scopus, PubMed, Web of Science, and Google Scholar by searching crocin, cardiovascular diseases, atherosclerosis, Arterial hypertension, infarction, and stroke keywords.Results Several factors such as oxidative stress, inflammation, apoptosis and pyroptosis, as well as mitochondrial disorder and endothelium dysfunction are involved in the occurrence and progression of these diseases. On the other hand, crocin has anti-oxidative stress, anti-inflammatory, anti-apoptotic and anti-pyroptosis effects and also can regulate autophagy in pathological conditions and has shown many protective effects …

The benefits of grape seed extract in neurological disorders and brain aging

Authors

Ramin Mahdipour,Alireza Ebrahimzadeh-Bideskan,Mahmoud Hosseini,Sara Shahba,Giovanni Lombardi,Amir Mohammad Malvandi,Abbas Mohammadipour

Published Date

2023/5/4

Common neurological disorders, including neurodegenerative diseases, stroke, epilepsy, autism and psychiatric disorders, affect many people worldwide and threaten their lives and health by inducing movement disorders, behavioral disorders, or a combination of both. Oxidative stress and neuroinflammation play a central role in neuronal damage and neurological diseases induction and progression. In addition, protein homeostasis (proteostasis) impairment occurs in many neurodegenerative diseases, which plays a critical role in the progression of the pathology. Grape seed contains several flavonoids and non-flavonoids and exerts potent antioxidant and anti-inflammatory effects. In addition, polyphenols and flavanols can maintain cellular proteostasis. Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable …

Therapeutic Potentials of MicroRNA-126 in Cerebral Ischemia

Authors

Vahid Ebrahimi,Seyed Hamidreza Rastegar-Moghaddam,Abbas Mohammadipour

Published Date

2023/4

Stroke is a leading cause of death and disability worldwide. It is among the most common neurological disorders with an 8–10% lifetime risk. Ischemic stroke accounts for about 85% of all strokes and damages the brain tissue via various damaging mechanisms. Following cerebral ischemia, the disrupted blood–brain barrier (BBB) leads to cerebral edema formation caused by activation of oxidative stress, inflammation, and apoptosis, targeting primarily endothelial cells. Activation of the protective mechanisms might favor fewer damages to the neural tissue. MicroRNA (miR)-126 is an endothelial cell-specific miR involved in angiogenesis. MiR-126 orchestrates endothelial progenitor cell functions under hypoxic conditions and could inhibit ischemia-induced oxidative stress and inflammation. It alleviates the BBB disruption by preventing an augment in matrix metalloproteinase level and halting the decrease in the …

Roles of the miR-155 in neuroinflammation and neurological disorders: a potent biological and therapeutic target

Authors

Seyed Hamidreza Rastegar-Moghaddam,Alireza Ebrahimzadeh-Bideskan,Sara Shahba,Amir Mohammad Malvandi,Abbas Mohammadipour

Published Date

2023/3

Neuroinflammation plays a crucial role in the development and progression of neurological disorders. MicroRNA-155 (miR-155), a miR is known to play in inflammatory responses, is associated with susceptibility to inflammatory neurological disorders and neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis as well as epilepsy, stroke, and brain malignancies. MiR-155 damages the central nervous system (CNS) by enhancing the expression of pro-inflammatory cytokines, like IL-1β, IL-6, TNF-α, and IRF3. It also disturbs the blood–brain barrier by decreasing junctional complex molecules such as claudin-1, annexin-2, syntenin-1, and dedicator of cytokinesis 1 (DOCK-1), a hallmark of many neurological disorders. This review discusses the molecular pathways which involve miR-155 as a critical component in the progression of neurological …

Hippocampal toxicity of metal base nanoparticles. Is there a relationship between nanoparticles and psychiatric disorders?

Authors

Abbas Mohammadipour,Mahmoud Abudayyak

Published Date

2022/3/28

Metal base nanoparticles are widely produced all over the world and used in many fields and products such as medicine, electronics, cosmetics, paints, ceramics, toys, kitchen utensils and toothpastes. They are able to enter the body through digestive, respiratory, and alimentary systems. These nanoparticles can also cross the blood brain barrier, enter the brain and aggregate in the hippocampus. After entering the hippocampus, they induce oxidative stress, neuro-inflammation, mitochondrial dysfunction, and gene expression alteration in hippocampal cells, which finally lead to neuronal apoptosis. Metal base nanoparticles can also affect hippocampal neurogenesis and synaptic plasticity that both of them play crucial role in memory and learning. On the one hand, hippocampal cells are severely vulnerable due to their high metabolic activity, and on the other hand, metal base nanoparticles have high potential to …

Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice

Authors

Somaieh Mansouri,Mahmoud Hosseini,Fatemeh Alipour,Farimah Beheshti,Hassan Rakhshandeh,Abbas Mohammadipour,Akbar Anaeigoudari,Mohammad Jalili-Nik,Mohammad Reza Khazdair,Amirali Jahani

Journal

Avicenna Journal of Phytomedicine

Published Date

2022/11

Objective:Neuroprotective and antioxidant effects of Ocimum basilicum (O. basilicum) against pentylenetetrazole (PTZ)-induced seizures were investigated.Materials and Methods:Mice were divided as follows:(Group 1) Control,(Group 2) PTZ,(Groups 3-5) 50,100 and 200 mg/kg hydro-ethanolic (HE) extract, and (Groups 6-8) 200 mg/kg ethyl-acetate (EAF), N-hexane (NHF) and water (WF) fractions. Minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) latencies were measured. Biochemical and histological studies were done.Results:MCS and GTCS latency in HE groups were longer than the PTZ group (p< 0.05 to p< 0.001). EAF and NHF prolonged the onset of MCS and GTCS (p< 0.001). PTZ increased malondialdehyde (MDA) and dark neuron (DN) production while decreased thiol, catalase (CAT) and superoxide dismutase (SOD)(p< 0.05 to p< 0.001). Pre-treatment by HE and all fractions …

Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

Authors

Ramin Mahdipour,Vahid Ebrahimi,Mahmoud Hosseini,Mohammad Soukhtanloo,Seyed HamidReza Rastegar-Moghaddam,Amir Mohammad Malvandi,Abbas Mohammadipour

Journal

Toxicology and Industrial Health

Published Date

2022/1

Silicon dioxide nanoparticles (SiO2-NPs) are among the most widely used nanoparticles because of their chemical-physical properties. Since most brain maturation occurs in the neonatal period in humans and many mammals, it is important to understand how NPs may affect this process. This study tested the hypothesis that SiO2-NPs from treated dams could affect the hippocampus of neonatal rats during lactation. Twenty-four pregnant rats, after delivery, were divided into three groups of control, SiO2-NPs (25 mg/kg) and SiO2-NPs (100 mg/kg). The rats were treated from 2nd to 21st days post-delivery by gavage and the effects of these NPs were evaluated in the offspring’s hippocampi to reveal the effects of maternal exposure to SiO2-NPs during lactation on the offspring’s hippocampi. The offspring in the SiO2-NPs groups had higher malondialdehyde concentration and lower antioxidant activity in the …

Atrazine neural and reproductive toxicity

Authors

Hamidreza Sadeghnia,Sara Shahba,Alireza Ebrahimzadeh-Bideskan,Shabnam Mohammadi,Amir Mohammad Malvandi,Abbas Mohammadipour

Published Date

2022/10/2

Atrazine is one of the common herbicides with an annual usage of 70,000–90,000 tons worldwide. Due to its long half-life (>60 days), atrazine persists in water and soil for long-term periods. This herbicide induces oxidative stress, inflammation, mitochondrial dysfunction and apoptosis in the exposed cells. It also passes the biological barriers, such as the blood-brain barrier and the blood-testis barrier. This review discusses, in detail, atrazine's detrimental effects on the different parts of the brain, including the cerebral cortex, hippocampus, substantia nigra, striatum, and cerebellum. Moreover, the current knowledge regarding the atrazine's effects on the reproductive system is also discussed.

Grape seed extract effects on hippocampal neurogenesis, synaptogenesis and dark neurons production in old mice. Can this extract improve learning and memory in aged animals?

Authors

Seyed Hamidreza Rastegar-Moghaddam,Maryam Bigham,Mahmoud Hosseini,Alireza Ebrahimzadeh-Bideskan,Amir Mohammad Malvandi,Abbas Mohammadipour

Journal

Nutritional Neuroscience

Published Date

2022/9/2

BackgroundDuring the elderly, hippocampal neurogenesis and synaptogenesis reduce and dark neurons (DNs) increase, leading to cognitive impairment. It is believed that natural products can protect the neural cells and system by protecting from damages or promoting regeneration. Therefore, the effects of grape seed extract (GSE) on the hippocampus of aged mice were investigated in this study.Methodstwelve old mice were divided into two groups of control and GSE. Animals in the GSE group received 300 mg/kg of GSE for eight weeks via gavage. At the end of treatment, cognition performance was evaluated by Morris water maze (MWM) and passive avoidance tests. Hippocampal neurogenesis, synaptogenesis and DNs production were evaluated with immunohistochemistry and histological evaluations on 5-micron coronal tissue sections.ResultsThe hippocampal mean number of double cortin positive …

MicroRNA-22: A novel and potent biological therapeutics in neurological disorders

Authors

Seyed Hamidreza Rastegar-Moghaddam,Alireza Ebrahimzadeh-Bideskan,Sara Shahba,Amir Mohammad Malvandi,Abbas Mohammadipour

Published Date

2022/5

MicroRNAs (miRs) are regulatory RNAs with 18–25 nucleotides lengths involved in various biological processes. Some miRs, including miR-22, play an essential role in regulating neurological disorders. MiR-22 is a brain-enriched regulatory element involved in angiogenesis, energy supply, adjustment of ionic channels, and suppression of malignant cell proliferation, migration, and invasion. This article discusses the protective and therapeutic effects of miR-22 on neurological diseases and injuries, including cerebral ischemia, neurodegenerative diseases, epilepsy, and brain malignancies. We also correlated miR-22 with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), panic disorders, schizophrenia, neural tube defect (anencephaly), and traumatic brain injury. This work provides a therapeutic perspective for miR-22 as a new approach in treating neurological disorders.

A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson’s disease

Authors

Abbas Mohammadipour

Published Date

2022/4

Mitochondria are considered the only source of energy production within cells. This organelle is vital for neural function and survival by producing energy (adenosine triphosphate (ATP)) and regulating intracellular calcium. Mitochondrial dysfunction, which significantly contributes to both idiopathic and familial types of Parkinson’s disease (PD), depletes cellular energy, disrupts homeostasis, and induces oxidative stress, leading to cell death. In recent years several natural products have been discovered to be protective against mitochondrial dysfunction. This review discusses the role of mitochondria in the progression of PD to define the path for using natural products to prevent and/or cure PD.Graphical abstract

Targeting miR-21 in spinal cord injuries: a game-changer?

Authors

Amir Mohammad Malvandi,Seyed Hamidreza Rastegar-Moghaddam,Saeede Ebrahimzadeh-Bideskan,Giovanni Lombardi,Alireza Ebrahimzadeh-Bideskan,Abbas Mohammadipour

Published Date

2022/12

Spinal cord injury (SCI) is a devastating neurological state causing physical disability, psychological stress and financial burden. SCI global rate is estimated between 250,000 and 500,000 individuals every year, of which 60% of victims are young, healthy males between 15 and 35 years. A variety of pathological conditions such as neuroinflammation, mitochondrial dysfunction, apoptosis, glial scar formation, blood-spinal cord barrier disruption, and angiogenesis disruption occur after SCI leading to a limitation in recovery. MicroRNAs (miRs) are endogenous and non-coding RNAs consisting of 22 nucleotides that regulate 60% of all human genes and involve several normal physiological processes and pathological conditions. miR-21 is among the most highly expressed miRs and its expression has been shown to increase one day after SCI and this elevation is sustained up to 28 days after injury. Overexpression …

Developmental regulation and lateralization of N-methyl-d-aspartate (NMDA) receptors in the rat hippocampus

Authors

Mostafa Peyvandi Karizbodagh,Ariane Sadr-Nabavi,Javad Hami,Abbas Mohammadipour,Hoda Khoshdel-Sarkarizi,Hamed Kheradmand,Somaye Fallahnezhad,Mahmoud Mahmoudi,Hossein Haghir

Journal

Neuropeptides

Published Date

2021/10/1

N-methyl-d-aspartate receptors (NMDARs) are expressed abundantly in the brain and play a crucial role in the regulation of central nervous system (CNS) development, learning, and memory. During early neuronal development, NMDARs modulate neurogenesis, neuronal differentiation and migration, and synaptogenesis. The present study aimed to examine the developmental expression of NMDARs subunits, NR1 and NR2B, in the developing hippocampus of neonatal rats during the first two postnatal weeks. Fifty-four male offspring were randomly divided into three age groups, postnatal days (P) 0, 7, and 14. Real-time-PCR, western blotting, and immunohistochemistry (IHC) analyses were employed to examine and compare the hippocampal expression of the NMDA receptor subunits. The highest mRNA expression of NR1 and NR2B subunits was observed at P7, regardless of its laterality. The mRNA …

Cell and molecular toxicity of lanthanum nanoparticles: are there possible risks to humans?

Authors

Amir Mohammad Malvandi,Sara Shahba,Abbas Mohammadipour,Seyed Hamidreza Rastegar-Moghaddam,Mahmoud Abudayyak

Published Date

2021/8/9

Lanthanum nanoparticles are widely used in industry, agriculture, and biomedicine. Over 900 kg of lanthanum is annually released into the environment only in Europe, 50 times higher than the metals, mercury, and cadmium’s environmental spread. Human health risk associated with long-term exposure to the abundant lanthanum nanoparticles is a concerning environmental issue. Due to lanthanum’s ability to disrupt the main biological barriers and interrupt various cells’ hemostasis, they seem to cause severe disruptions to various tissues. This review opens a new perspective regarding the cellular and molecular interaction of nanosized and ionic lanthanum with the possible toxicity on the nervous system and other tissues that would show lanthanum nanoparticles’ potential danger to follow in toxicological science.

Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non‐motor outcomes

Authors

Maryam Bigham,Abbas Mohammadipour,Mahmoud Hosseini,Amir Mohammad Malvandi,Alireza Ebrahimzadeh-Bideskan

Journal

Metabolic Brain Disease

Published Date

2021/6

Parkinson’s disease (PD) is a common and severe neurodegenerative disorder associated with a selective loss of dopaminergic neurons in substantia nigra pars compacta. The crucial role of oxidative stress and inflammation in PD onset and progression is evident. It has been proven that garlic extract (GE) protects the cells from oxidative stress, inflammation, mitochondrial dysfunction and apoptosis. That is, we aimed to investigate if GE reveals protective features on the preclinical model of PD. The study has been designed to evaluate both preventive (GE administered before 6-OHDA injection) and therapeutic (GE administered after 6-OHDA injection) effects of GE on the animal model. Forty male Wistar rats were divided into 4 groups including control, lesion, treatment I (received GE before 6-OHDA injection) and treatment II (received GE both before and after 6-OHDA injection). At the end of treatment …

Crocin Administration from Childhood to Adulthood Increases Hippocampal Neurogenesis and Synaptogenesis in Male Mice

Authors

Babak Ebrahimi,Shayan Vafaei,Seyed Hamid Reza Rastegar-Moghaddam,Mahmoud Hosseini,Fatemeh Tajik Yabr,Abbas Mohammadipour

Journal

Journal of Kerman University of Medical Sciences

Published Date

2021/6

Introduction: Adult hippocampal neurogenesis and synaptogenesis play a critical role in learning and memory. Crocin as a carotenoid has many neuroprotective effects but its effect on neurogenesis and synaptogenesis is unknown. In this study, the effects of crocin administration from post-lactation period to adulthood on the mice hippocampal neurogenesis and synaptogenesis were investigated. Methods: 12 mice offspring were divided into 2 groups of control and crocin. Animals in the crocin group received 30 mg/kg of crocin from postnatal day 30 to 75 through drinking water. At the same time, the control group received drinking water without crocin. At the end of the treatment, animals were sacrificed and their brains were removed. The brains were sectioned and stained by immunohistochemical technique to evaluate the effect of crocin on hippocampal doublecortin (DCX) positive cells and synaptophysin …

A link between nanoparticles and Parkinson’s disease. Which nanoparticles are most harmful?

Authors

Abbas Mohammadipour,Hossein Haghir,Alireza Ebrahimzadeh Bideskan

Published Date

2020/11/18

Nowadays, different kinds of nanoparticles (NPs) are produced around the world and used in many fields and products. NPs can enter the body and aggregate in the various organs including brain. They can damage neurons, in particular dopaminergic neurons in the substantia nigra (SN) and striatal neurons which their lesion is associated with Parkinson’s disease (PD). So, NPs can have a role in PD induction along with other agents and factors. PD is the second most common neurodegenerative disease in the world, and in patients, its symptoms progressively worsen day by day through different pathways including oxidative stress, neuroinflammation, mitochondrial dysfunction, α-synuclein increasing and aggregation, apoptosis and reduction of tyrosine hydroxylase positive cells. Unfortunately, there is no effective treatment for PD. So, prevention of this disease is very important. On the other hand, without …

Distribution pattern of nicotinic acetylcholine receptors in developing cerebellum of rat neonates born of diabetic mothers

Authors

Faeze Abbasi,Raheleh Baradaran,Hoda Khoshdel-Sarkarizi,Saeid Kargozar,Javad Hami,Abbas Mohammadipour,Hamed Kheradmand,Hossein Haghir

Journal

Journal of Chemical Neuroanatomy

Published Date

2020/10/1

Diabetes during pregnancy, is known as a common and crucial metabolic complication, which is associated with a high risk of congenital, neurocognitive and neurobehavioral abnormalities in newborns (Georgieff, 2006; Magaton et al., 2007; Ornoy, 2005; Persaud, 2007; Zhao and Reece, 2013). Hyperglycemia in the fetus has a negative impression on not only organ development and function but also neuronal development outcome (Mainardi et al., 2015; Xu et al., 2014). In particular, several studies suggest that the neonates born of diabetic mothers have a lower IQ, poorer general cognitive function, impaired recognition memory, and greater inattention and hyperactivity (Mainardi et al., 2015; Xu et al., 2014). Previous studies indicated that maternal diabetes during pregnancy had teratogenic effects on developing the central nervous system (Mainardi et al., 2015; Xu et al., 2014). A more specific group of studies …

Developmental regulation and lateralisation of the α7 and α4 subunits of nicotinic acetylcholine receptors in developing rat hippocampus

Authors

Raheleh Baradaran,Hoda Khoshdel‐Sarkarizi,Saeid Kargozar,Javad Hami,Abbas Mohammadipour,Ariane Sadr‐Nabavi,Mostafa Peyvandi Karizbodagh,Hamed Kheradmand,Hossein Haghir

Journal

International journal of developmental neuroscience

Published Date

2020/6

The purpose of this study was to describe the distinct regional distribution patterns of expression of the α7 and α4 subunits of nicotinic acetylcholine receptors (nAChRs) and their left‐right lateralisation in the rat hippocampus during the first 2 weeks of postnatal (P) development. Eighteen male pups were randomly divided into three groups: P0, P7, and P14. After removing the newborn brains, real‐time polymerase chain reaction, western blot, and immunohistochemistry techniques were used to evaluate expression of the receptors. Results indicated that the expression profile of these receptors were time‐ and spatially dependent. A significant increase was observed in the distribution of α7 and α4 nAChR subunits in the developing rat hippocampus from P0 to P7 (p < .001); however, there was a significant decrease from P7 to P14 (p < .05). As a spatial effect, the highest optical density (OD) was observed in the CA3 …

See List of Professors in Abbas Mohammadipour University(Mashhad University of Medical Sciences)

Abbas Mohammadipour FAQs

What is Abbas Mohammadipour's h-index at Mashhad University of Medical Sciences?

The h-index of Abbas Mohammadipour has been 15 since 2020 and 15 in total.

What are Abbas Mohammadipour's top articles?

The articles with the titles of

Protective effects of crocin in cardiovascular diseases and stroke

The benefits of grape seed extract in neurological disorders and brain aging

Therapeutic Potentials of MicroRNA-126 in Cerebral Ischemia

Roles of the miR-155 in neuroinflammation and neurological disorders: a potent biological and therapeutic target

Hippocampal toxicity of metal base nanoparticles. Is there a relationship between nanoparticles and psychiatric disorders?

Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice

Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

Atrazine neural and reproductive toxicity

...

are the top articles of Abbas Mohammadipour at Mashhad University of Medical Sciences.

What are Abbas Mohammadipour's research interests?

The research interests of Abbas Mohammadipour are: toxiciology, neuroscience, neurodegenerative diseases

What is Abbas Mohammadipour's total number of citations?

Abbas Mohammadipour has 738 citations in total.

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