Aase B. Mikalsen

About Aase B. Mikalsen

Aase B. Mikalsen, With an exceptional h-index of 17 and a recent h-index of 12 (since 2020), a distinguished researcher at Norges miljø- og biovitenskapelige universitet, specializes in the field of Virology, RNA virus, protein characterization, genomic characterization.

His recent articles reflect a diverse array of research interests and contributions to the field:

Antiviral innate immune responses: Infectious pancreatic necrosis virus and salmonid alphavirus

Characterization of early phases of cardiomyopathy syndrome pathogenesis in Atlantic salmon (Salmo salar L.) through various diagnostic methods

Characterization of an outbreak of cardiomyopathy syndrome (CMS) in young Atlantic salmon, Salmo salar L

Emergence of Salmonid Alphavirus Genotype 2 in Norway—Molecular Characterization of Viral Strains Circulating in Norway and Scotland

Comparative molecular characterization of novel and known piscine Toti-Like viruses

Lack of evidence of vertical transmission of piscine myocarditis virus in Atlantic salmon (Salmo salar L.)

Aase B. Mikalsen Information

University

Norges miljø- og biovitenskapelige universitet

Position

Researcher at

Citations(all)

1242

Citations(since 2020)

440

Cited By

995

hIndex(all)

17

hIndex(since 2020)

12

i10Index(all)

20

i10Index(since 2020)

13

Email

University Profile Page

Norges miljø- og biovitenskapelige universitet

Aase B. Mikalsen Skills & Research Interests

Virology

RNA virus

protein characterization

genomic characterization

Top articles of Aase B. Mikalsen

Antiviral innate immune responses: Infectious pancreatic necrosis virus and salmonid alphavirus

Authors

Cheng Xu,Amr AA Gamil,Koestan Gadan,Aase B Mikalsen,Øystein Evensen

Published Date

2022/3/13

Infectious pancreatic necrosis virus (IPNV) and salmonid alphavirus (SAV) are important viral infections of salmonid fish. The impact and losses due to IPNV infection have been significantly reduced in Atlantic salmon through genetic selection for resistance, but infection with SAV in salmonid aquaculture causes major loss to the industry. Vaccination has been developed to reduce the impact of both diseases but with limited success so far. The innate immune responses are the first line of defense against infection and play crucial roles in directing adaptive immune responses. This chapter addresses the innate immune responses to IPNV and SAV infections in vitro and in vivo and summarizes the current knowledge. Understanding the detailed aspects of the innate host-virus interaction is crucial for developing prophylactic interventions.

Characterization of early phases of cardiomyopathy syndrome pathogenesis in Atlantic salmon (Salmo salar L.) through various diagnostic methods

Authors

Camilla Fritsvold,Aase B Mikalsen,Øyvind Haugland,Haitham Tartor,Hilde Sindre

Journal

Journal of Fish Diseases

Published Date

2022/9

Since the first description of cardiomyopathy syndrome (CMS) in Atlantic salmon, in 1985, the disease caused by piscine myocarditisvirus (PMCV) has become a common problem in Atlantic salmon farming, not only in Norway, but also in other salmon farming countries like Scotland and Ireland. In the last years, CMS has been ranked as the most important salmon viral disease in Norway regarding both mortality and economic losses. Detailed knowledge of infection and pathogenesis is still lacking, a decade after the causal agent was first described, and there is a need for a wider range of methods/tools for diagnostic and research purposes. In this study, we compared the detection of PMCV‐ and CMS‐related tissue lesions using previously used and well‐known methods like histopathology and real‐time RT‐PCR to immunohistochemistry (IHC), a less used method, and a new method, RNAscope in situ …

Characterization of an outbreak of cardiomyopathy syndrome (CMS) in young Atlantic salmon, Salmo salar L

Authors

Camilla Fritsvold,Aase B Mikalsen,Trygve T Poppe,Torunn Taksdal,Hilde Sindre

Journal

Journal of Fish Diseases

Published Date

2021/12

Cardiomyopathy syndrome (CMS) is the most common viral cardiac disease in Norwegian Atlantic salmon farming and typically affects large, market size fish. Only six months after seawater transfer, Atlantic salmon were diagnosed with CMS at a fish farm in the south‐western part of Norway. Due to the unexpected young age and the remarkable large amounts of virus‐specific RNA (Ct <10), the fish group was monitored with five additional samplings until slaughtered almost 10 months later. At three weeks after the first CMS diagnosis (weeks post‐diagnosis, wpd) and at slaughter (39 wpd), more comprehensive samplings were performed of the study cage, with specific focus on three different cardiac compartments. The clinical, autopsy and histopathological findings at first diagnosis and at all succeeding samplings were similar to previous descriptions of typical CMS. A slightly elevated mortality was observed in …

Emergence of Salmonid Alphavirus Genotype 2 in Norway—Molecular Characterization of Viral Strains Circulating in Norway and Scotland

Authors

Monika J Hjortaas,Elena Fringuelli,Adérito L Monjane,Aase B Mikalsen,Christine M Jonassen,Paul Savage,Hilde Sindre

Journal

Viruses

Published Date

2021/8/6

Pancreas disease (PD) and sleeping disease (SD), caused by an alphavirus, are endemic in European salmonid aquaculture, causing significant mortality, reduced growth and poor flesh quality. In 2010, a new variant of salmonid alphavirus emerged in Norway, marine salmonid alphavirus genotype 2 (SAV2). As this genotype is highly prevalent in Scotland, transmission through well boat traffic was hypothesized as one possible source of infection. In this study, we performed full-length genome sequencing of SAV2 sampled between 2006 and 2012 in Norway and Scotland, and present the first comprehensive full-length characterization of Norwegian marine SAV2 strains. We analyze their relationship with selected Scottish SAV2 strains and explore the genetic diversity of SAV. Our results show that all Norwegian marine SAV2 share a recent last common ancestor with marine SAV2 circulating in Scotland and a higher level of genomic diversity among the Scottish marine SAV2 strains compared to strains from Norway. These findings support the hypothesis of a single introduction of SAV2 to Norway sometime from 2006–2010, followed by horizontal spread along the coast.

Comparative molecular characterization of novel and known piscine Toti-Like viruses

Authors

Liv Sandlund,Sunil K Mor,Vikash K Singh,Soumesh K Padhi,Nicholas BD Phelps,Stian Nylund,Aase B Mikalsen

Journal

Viruses

Published Date

2021/6/3

Totiviridae is a virus family well known to infect uni-cellular organisms like fungi and protozoa. In more recent years, viruses characterized as toti-like viruses, have been found in primarily arthropods, but also a couple in planarians and piscine species. These toti-like viruses share phylogenetic similarities to totiviruses; however, their genomes also includes additional coding sequences in either 5′ or 3′ ends expected to relate to more advanced infection mechanisms in more advanced hosts. Here, we applied next generation sequencing (NGS) technologies and discovered three new toti-like viruses, one in wild common carp and one in bluegill from the USA and one in farmed lumpsucker from Norway. These are named common carp toti-like virus 1 (CCTLV-1), bluegill toti-like virus 1 (BGTLV-1), and Cyclopterus lumpus toti-like virus (CLuTLV), respectively. The genomes of these viruses have been characterized and compared to the three previously known piscine toti-like viruses, piscine myocarditis virus (PMCV) found in Atlantic salmon and the two from golden shiner, now named golden shiner toti-like virus 1 and 2 (GSTLV-1 and -2), and also to totiviruses and other toti-like viruses. We found that four piscine toti-like viruses had additional gene(s) in the 3′ end of the genome, and also clustered phylogenetically based on both capsid and RdRp-genes. This cluster constituted a distant branch in the Totiviridae, and we suggest this should be defined as a separate genus named Pistolvirus, to reflect this major cluster of piscine toti-like viruses. The remaining two piscine toti-like viruses differentiated from these by lacking any additional 3′ end …

Lack of evidence of vertical transmission of piscine myocarditis virus in Atlantic salmon (Salmo salar L.)

Authors

Aase Beathe Mikalsen,Morten Lund,Farah Manji,Mari Viken Kjønstad,Per Helge Bergtun,Gordon Ritchie,Vidar Aspehaug,Magnus Devold,Øystein Evensen

Published Date

2020

Piscine myocarditis virus (PMCV) is the causal agent of cardiomyopathy syndrome (CMS), a disease affecting the heart of Atlantic salmon (Haugland et al., 2011). The disease has been found in Norwegian Atlantic salmon since 1988 (Amin & Trasti, 1988) and is primarily affecting adult Atlantic salmon 14–18 months after sea transfer and close to harvest, although recently outbreaks in young post-smolts have been reported (Svendsen et al., 2019; Wiik-Nielsen, Alarcon, Jensen, Haugland, & Mikalsen, 2016). PMCV has been detected at a high prevalence in broodfish in freshwater, including high levels of virus-specific RNA, but with varying presence of CMS disease (Bang Jensen, Nylund, Svendsen, Ski, & Takle, 2019; Wiik-Nielsen, Ski, Aunsmo, & Lovoll, 2012)(personal observation/communication Per Helge Bergtun, Mowi and Even Thoen, PatoGen AS).Horizontal transmission of virus and subsequent disease has been shown both in field studies and experimentally (Bang Jensen, Brun, Fineid, Larssen, & Kristoffersen, 2013; Fritsvold et al., 2009; Haugland et al., 2011). Two previous studies have also shown indications of vertical transmission of PMCV-specific RNA from broodfish to progeny, but the prevalence of positive individuals is low and CMS or other signs of disease have not been found in these individuals (Bang Jensen et al., 2019; Wiik-Nielsen, Ski, et al., 2012). Also, the virus has only been detected as virus-specific RNA using real-time

See List of Professors in Aase B. Mikalsen University(Norges miljø- og biovitenskapelige universitet)

Aase B. Mikalsen FAQs

What is Aase B. Mikalsen's h-index at Norges miljø- og biovitenskapelige universitet?

The h-index of Aase B. Mikalsen has been 12 since 2020 and 17 in total.

What are Aase B. Mikalsen's top articles?

The articles with the titles of

Antiviral innate immune responses: Infectious pancreatic necrosis virus and salmonid alphavirus

Characterization of early phases of cardiomyopathy syndrome pathogenesis in Atlantic salmon (Salmo salar L.) through various diagnostic methods

Characterization of an outbreak of cardiomyopathy syndrome (CMS) in young Atlantic salmon, Salmo salar L

Emergence of Salmonid Alphavirus Genotype 2 in Norway—Molecular Characterization of Viral Strains Circulating in Norway and Scotland

Comparative molecular characterization of novel and known piscine Toti-Like viruses

Lack of evidence of vertical transmission of piscine myocarditis virus in Atlantic salmon (Salmo salar L.)

are the top articles of Aase B. Mikalsen at Norges miljø- og biovitenskapelige universitet.

What are Aase B. Mikalsen's research interests?

The research interests of Aase B. Mikalsen are: Virology, RNA virus, protein characterization, genomic characterization

What is Aase B. Mikalsen's total number of citations?

Aase B. Mikalsen has 1,242 citations in total.

What are the co-authors of Aase B. Mikalsen?

The co-authors of Aase B. Mikalsen are Øystein Evensen, Norbert Roos, Tor Gjøen.

    Co-Authors

    H-index: 61
    Øystein Evensen

    Øystein Evensen

    Norges miljø- og biovitenskapelige universitet

    H-index: 36
    Norbert Roos

    Norbert Roos

    Universitetet i Oslo

    H-index: 35
    Tor Gjøen

    Tor Gjøen

    Universitetet i Oslo

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